Immune‐mediated thrombotic thrombocytopenic purpura prognosis is affected by blood pressure
Abstract Background The prevalence, prognostic role, and diagnostic value of blood pressure in immune‐mediated thrombotic thrombocytopenic purpura (iTTP) and other thrombotic microangiopathies (TMAs) remain unclear. Methods Using a national cohort of iTTP (n = 368), Shigatoxin‐induced hemolytic urem...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Adrien Joseph [verfasserIn] Martin Eloit [verfasserIn] Elie Azoulay [verfasserIn] Gilles Kaplanski [verfasserIn] François Provot [verfasserIn] Claire Presne [verfasserIn] Alain Wynckel [verfasserIn] Steven Grangé [verfasserIn] Éric Rondeau [verfasserIn] Frédéric Pène [verfasserIn] Yahsou Delmas [verfasserIn] Alexandre Lautrette [verfasserIn] Christelle Barbet [verfasserIn] Christiane Mousson [verfasserIn] Jean‐Philippe Coindre [verfasserIn] Pierre Perez [verfasserIn] Matthieu Jamme [verfasserIn] Jean‐François Augusto [verfasserIn] Pascale Poullin [verfasserIn] Frédéric Jacobs [verfasserIn] Khalil El Karoui [verfasserIn] Cécile Vigneau [verfasserIn] Marc Ulrich [verfasserIn] Tarik Kanouni [verfasserIn] Moglie Le Quintrec [verfasserIn] Mohamed Hamidou [verfasserIn] Simon Ville [verfasserIn] Anne Charvet‐Rumpler [verfasserIn] Mario Ojeda‐Uribe [verfasserIn] Pascal Godmer [verfasserIn] Véronique Fremeaux‐Bacchi [verfasserIn] Agnès Veyradier [verfasserIn] Jean‐Michel Halimi [verfasserIn] Paul Coppo [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Research and Practice in Thrombosis and Haemostasis - Elsevier, 2018, 6(2022), 4, Seite n/a-n/a |
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| Übergeordnetes Werk: |
volume:6 ; year:2022 ; number:4 ; pages:n/a-n/a |
| Links: |
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| DOI / URN: |
10.1002/rth2.12702 |
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| Katalog-ID: |
DOAJ025086111 |
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| 245 | 1 | 0 | |a Immune‐mediated thrombotic thrombocytopenic purpura prognosis is affected by blood pressure |
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| 520 | |a Abstract Background The prevalence, prognostic role, and diagnostic value of blood pressure in immune‐mediated thrombotic thrombocytopenic purpura (iTTP) and other thrombotic microangiopathies (TMAs) remain unclear. Methods Using a national cohort of iTTP (n = 368), Shigatoxin‐induced hemolytic uremic syndrome (n = 86), atypical hemolytic uremic syndrome (n = 84), and hypertension‐related thrombotic microangiopathy (n = 25), we sought to compare the cohort’s blood pressure profile to assess its impact on prognosis and diagnostic performances. Results Patients with iTTP had lower blood pressure than patients with other TMAs, systolic (130 [interquartile range (IQR) 118–143] vs 161 [IQR 142–180] mmHg) and diastolic (76 [IQR 69–83] vs 92 [IQR 79–105] mmHg, both p < 0.001). The best threshold for iTTP diagnosis corresponded to a systolic blood pressure <150 mmHg. iTTP patients presenting with hypertension had a significantly poorer survival (hazard ratio 1.80, 95% confidence interval 1.07–3.04), and this effect remained significant after multivariable adjustment (hazard ratio = 1.14, 95% confidence interval 1.00–1.30). Addition of a blood pressure criterion modestly improved the French clinical score to predict a severe A disintegrin and metalloprotease with thrombospondin type 1 deficiency in patients with an intermediate score (i.e., either platelet count <30 × 109/L or serum creatinine <200 µM). Conclusions Elevated blood pressure at admission affects the prognosis of iTTP patients and may help discriminate them from other TMA patients. Particular attention should be paid to blood pressure and its management in these patients. | ||
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| 650 | 4 | |a complement | |
| 650 | 4 | |a hemolytic uremic syndrome | |
| 650 | 4 | |a hypertension | |
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| 653 | 0 | |a Diseases of the blood and blood-forming organs | |
| 700 | 0 | |a Martin Eloit |e verfasserin |4 aut | |
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10.1002/rth2.12702 doi (DE-627)DOAJ025086111 (DE-599)DOAJ0bd0757c396849008e228ac2e5bc41be DE-627 ger DE-627 rakwb eng RC633-647.5 Adrien Joseph verfasserin aut Immune‐mediated thrombotic thrombocytopenic purpura prognosis is affected by blood pressure 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The prevalence, prognostic role, and diagnostic value of blood pressure in immune‐mediated thrombotic thrombocytopenic purpura (iTTP) and other thrombotic microangiopathies (TMAs) remain unclear. Methods Using a national cohort of iTTP (n = 368), Shigatoxin‐induced hemolytic uremic syndrome (n = 86), atypical hemolytic uremic syndrome (n = 84), and hypertension‐related thrombotic microangiopathy (n = 25), we sought to compare the cohort’s blood pressure profile to assess its impact on prognosis and diagnostic performances. Results Patients with iTTP had lower blood pressure than patients with other TMAs, systolic (130 [interquartile range (IQR) 118–143] vs 161 [IQR 142–180] mmHg) and diastolic (76 [IQR 69–83] vs 92 [IQR 79–105] mmHg, both p < 0.001). The best threshold for iTTP diagnosis corresponded to a systolic blood pressure <150 mmHg. iTTP patients presenting with hypertension had a significantly poorer survival (hazard ratio 1.80, 95% confidence interval 1.07–3.04), and this effect remained significant after multivariable adjustment (hazard ratio = 1.14, 95% confidence interval 1.00–1.30). Addition of a blood pressure criterion modestly improved the French clinical score to predict a severe A disintegrin and metalloprotease with thrombospondin type 1 deficiency in patients with an intermediate score (i.e., either platelet count <30 × 109/L or serum creatinine <200 µM). Conclusions Elevated blood pressure at admission affects the prognosis of iTTP patients and may help discriminate them from other TMA patients. Particular attention should be paid to blood pressure and its management in these patients. ADAMTS13 blood pressure complement hemolytic uremic syndrome hypertension prognosis Diseases of the blood and blood-forming organs Martin Eloit verfasserin aut Elie Azoulay verfasserin aut Gilles Kaplanski verfasserin aut François Provot verfasserin aut Claire Presne verfasserin aut Alain Wynckel verfasserin aut Steven Grangé verfasserin aut Éric Rondeau verfasserin aut Frédéric Pène verfasserin aut Yahsou Delmas verfasserin aut Alexandre Lautrette verfasserin aut Christelle Barbet verfasserin aut Christiane Mousson verfasserin aut Jean‐Philippe Coindre verfasserin aut Pierre Perez verfasserin aut Matthieu Jamme verfasserin aut Jean‐François Augusto verfasserin aut Pascale Poullin verfasserin aut Frédéric Jacobs verfasserin aut Khalil El Karoui verfasserin aut Cécile Vigneau verfasserin aut Marc Ulrich verfasserin aut Tarik Kanouni verfasserin aut Moglie Le Quintrec verfasserin aut Mohamed Hamidou verfasserin aut Simon Ville verfasserin aut Anne Charvet‐Rumpler verfasserin aut Mario Ojeda‐Uribe verfasserin aut Pascal Godmer verfasserin aut Véronique Fremeaux‐Bacchi verfasserin aut Agnès Veyradier verfasserin aut Jean‐Michel Halimi verfasserin aut Paul Coppo verfasserin aut In Research and Practice in Thrombosis and Haemostasis Elsevier, 2018 6(2022), 4, Seite n/a-n/a (DE-627)895113414 (DE-600)2901840-7 24750379 nnns volume:6 year:2022 number:4 pages:n/a-n/a https://doi.org/10.1002/rth2.12702 kostenfrei https://doaj.org/article/0bd0757c396849008e228ac2e5bc41be kostenfrei https://doi.org/10.1002/rth2.12702 kostenfrei https://doaj.org/toc/2475-0379 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 6 2022 4 n/a-n/a |
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10.1002/rth2.12702 doi (DE-627)DOAJ025086111 (DE-599)DOAJ0bd0757c396849008e228ac2e5bc41be DE-627 ger DE-627 rakwb eng RC633-647.5 Adrien Joseph verfasserin aut Immune‐mediated thrombotic thrombocytopenic purpura prognosis is affected by blood pressure 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The prevalence, prognostic role, and diagnostic value of blood pressure in immune‐mediated thrombotic thrombocytopenic purpura (iTTP) and other thrombotic microangiopathies (TMAs) remain unclear. Methods Using a national cohort of iTTP (n = 368), Shigatoxin‐induced hemolytic uremic syndrome (n = 86), atypical hemolytic uremic syndrome (n = 84), and hypertension‐related thrombotic microangiopathy (n = 25), we sought to compare the cohort’s blood pressure profile to assess its impact on prognosis and diagnostic performances. Results Patients with iTTP had lower blood pressure than patients with other TMAs, systolic (130 [interquartile range (IQR) 118–143] vs 161 [IQR 142–180] mmHg) and diastolic (76 [IQR 69–83] vs 92 [IQR 79–105] mmHg, both p < 0.001). The best threshold for iTTP diagnosis corresponded to a systolic blood pressure <150 mmHg. iTTP patients presenting with hypertension had a significantly poorer survival (hazard ratio 1.80, 95% confidence interval 1.07–3.04), and this effect remained significant after multivariable adjustment (hazard ratio = 1.14, 95% confidence interval 1.00–1.30). Addition of a blood pressure criterion modestly improved the French clinical score to predict a severe A disintegrin and metalloprotease with thrombospondin type 1 deficiency in patients with an intermediate score (i.e., either platelet count <30 × 109/L or serum creatinine <200 µM). Conclusions Elevated blood pressure at admission affects the prognosis of iTTP patients and may help discriminate them from other TMA patients. Particular attention should be paid to blood pressure and its management in these patients. ADAMTS13 blood pressure complement hemolytic uremic syndrome hypertension prognosis Diseases of the blood and blood-forming organs Martin Eloit verfasserin aut Elie Azoulay verfasserin aut Gilles Kaplanski verfasserin aut François Provot verfasserin aut Claire Presne verfasserin aut Alain Wynckel verfasserin aut Steven Grangé verfasserin aut Éric Rondeau verfasserin aut Frédéric Pène verfasserin aut Yahsou Delmas verfasserin aut Alexandre Lautrette verfasserin aut Christelle Barbet verfasserin aut Christiane Mousson verfasserin aut Jean‐Philippe Coindre verfasserin aut Pierre Perez verfasserin aut Matthieu Jamme verfasserin aut Jean‐François Augusto verfasserin aut Pascale Poullin verfasserin aut Frédéric Jacobs verfasserin aut Khalil El Karoui verfasserin aut Cécile Vigneau verfasserin aut Marc Ulrich verfasserin aut Tarik Kanouni verfasserin aut Moglie Le Quintrec verfasserin aut Mohamed Hamidou verfasserin aut Simon Ville verfasserin aut Anne Charvet‐Rumpler verfasserin aut Mario Ojeda‐Uribe verfasserin aut Pascal Godmer verfasserin aut Véronique Fremeaux‐Bacchi verfasserin aut Agnès Veyradier verfasserin aut Jean‐Michel Halimi verfasserin aut Paul Coppo verfasserin aut In Research and Practice in Thrombosis and Haemostasis Elsevier, 2018 6(2022), 4, Seite n/a-n/a (DE-627)895113414 (DE-600)2901840-7 24750379 nnns volume:6 year:2022 number:4 pages:n/a-n/a https://doi.org/10.1002/rth2.12702 kostenfrei https://doaj.org/article/0bd0757c396849008e228ac2e5bc41be kostenfrei https://doi.org/10.1002/rth2.12702 kostenfrei https://doaj.org/toc/2475-0379 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 6 2022 4 n/a-n/a |
| allfields_unstemmed |
10.1002/rth2.12702 doi (DE-627)DOAJ025086111 (DE-599)DOAJ0bd0757c396849008e228ac2e5bc41be DE-627 ger DE-627 rakwb eng RC633-647.5 Adrien Joseph verfasserin aut Immune‐mediated thrombotic thrombocytopenic purpura prognosis is affected by blood pressure 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The prevalence, prognostic role, and diagnostic value of blood pressure in immune‐mediated thrombotic thrombocytopenic purpura (iTTP) and other thrombotic microangiopathies (TMAs) remain unclear. Methods Using a national cohort of iTTP (n = 368), Shigatoxin‐induced hemolytic uremic syndrome (n = 86), atypical hemolytic uremic syndrome (n = 84), and hypertension‐related thrombotic microangiopathy (n = 25), we sought to compare the cohort’s blood pressure profile to assess its impact on prognosis and diagnostic performances. Results Patients with iTTP had lower blood pressure than patients with other TMAs, systolic (130 [interquartile range (IQR) 118–143] vs 161 [IQR 142–180] mmHg) and diastolic (76 [IQR 69–83] vs 92 [IQR 79–105] mmHg, both p < 0.001). The best threshold for iTTP diagnosis corresponded to a systolic blood pressure <150 mmHg. iTTP patients presenting with hypertension had a significantly poorer survival (hazard ratio 1.80, 95% confidence interval 1.07–3.04), and this effect remained significant after multivariable adjustment (hazard ratio = 1.14, 95% confidence interval 1.00–1.30). Addition of a blood pressure criterion modestly improved the French clinical score to predict a severe A disintegrin and metalloprotease with thrombospondin type 1 deficiency in patients with an intermediate score (i.e., either platelet count <30 × 109/L or serum creatinine <200 µM). Conclusions Elevated blood pressure at admission affects the prognosis of iTTP patients and may help discriminate them from other TMA patients. Particular attention should be paid to blood pressure and its management in these patients. ADAMTS13 blood pressure complement hemolytic uremic syndrome hypertension prognosis Diseases of the blood and blood-forming organs Martin Eloit verfasserin aut Elie Azoulay verfasserin aut Gilles Kaplanski verfasserin aut François Provot verfasserin aut Claire Presne verfasserin aut Alain Wynckel verfasserin aut Steven Grangé verfasserin aut Éric Rondeau verfasserin aut Frédéric Pène verfasserin aut Yahsou Delmas verfasserin aut Alexandre Lautrette verfasserin aut Christelle Barbet verfasserin aut Christiane Mousson verfasserin aut Jean‐Philippe Coindre verfasserin aut Pierre Perez verfasserin aut Matthieu Jamme verfasserin aut Jean‐François Augusto verfasserin aut Pascale Poullin verfasserin aut Frédéric Jacobs verfasserin aut Khalil El Karoui verfasserin aut Cécile Vigneau verfasserin aut Marc Ulrich verfasserin aut Tarik Kanouni verfasserin aut Moglie Le Quintrec verfasserin aut Mohamed Hamidou verfasserin aut Simon Ville verfasserin aut Anne Charvet‐Rumpler verfasserin aut Mario Ojeda‐Uribe verfasserin aut Pascal Godmer verfasserin aut Véronique Fremeaux‐Bacchi verfasserin aut Agnès Veyradier verfasserin aut Jean‐Michel Halimi verfasserin aut Paul Coppo verfasserin aut In Research and Practice in Thrombosis and Haemostasis Elsevier, 2018 6(2022), 4, Seite n/a-n/a (DE-627)895113414 (DE-600)2901840-7 24750379 nnns volume:6 year:2022 number:4 pages:n/a-n/a https://doi.org/10.1002/rth2.12702 kostenfrei https://doaj.org/article/0bd0757c396849008e228ac2e5bc41be kostenfrei https://doi.org/10.1002/rth2.12702 kostenfrei https://doaj.org/toc/2475-0379 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 6 2022 4 n/a-n/a |
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10.1002/rth2.12702 doi (DE-627)DOAJ025086111 (DE-599)DOAJ0bd0757c396849008e228ac2e5bc41be DE-627 ger DE-627 rakwb eng RC633-647.5 Adrien Joseph verfasserin aut Immune‐mediated thrombotic thrombocytopenic purpura prognosis is affected by blood pressure 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The prevalence, prognostic role, and diagnostic value of blood pressure in immune‐mediated thrombotic thrombocytopenic purpura (iTTP) and other thrombotic microangiopathies (TMAs) remain unclear. Methods Using a national cohort of iTTP (n = 368), Shigatoxin‐induced hemolytic uremic syndrome (n = 86), atypical hemolytic uremic syndrome (n = 84), and hypertension‐related thrombotic microangiopathy (n = 25), we sought to compare the cohort’s blood pressure profile to assess its impact on prognosis and diagnostic performances. Results Patients with iTTP had lower blood pressure than patients with other TMAs, systolic (130 [interquartile range (IQR) 118–143] vs 161 [IQR 142–180] mmHg) and diastolic (76 [IQR 69–83] vs 92 [IQR 79–105] mmHg, both p < 0.001). The best threshold for iTTP diagnosis corresponded to a systolic blood pressure <150 mmHg. iTTP patients presenting with hypertension had a significantly poorer survival (hazard ratio 1.80, 95% confidence interval 1.07–3.04), and this effect remained significant after multivariable adjustment (hazard ratio = 1.14, 95% confidence interval 1.00–1.30). Addition of a blood pressure criterion modestly improved the French clinical score to predict a severe A disintegrin and metalloprotease with thrombospondin type 1 deficiency in patients with an intermediate score (i.e., either platelet count <30 × 109/L or serum creatinine <200 µM). Conclusions Elevated blood pressure at admission affects the prognosis of iTTP patients and may help discriminate them from other TMA patients. Particular attention should be paid to blood pressure and its management in these patients. ADAMTS13 blood pressure complement hemolytic uremic syndrome hypertension prognosis Diseases of the blood and blood-forming organs Martin Eloit verfasserin aut Elie Azoulay verfasserin aut Gilles Kaplanski verfasserin aut François Provot verfasserin aut Claire Presne verfasserin aut Alain Wynckel verfasserin aut Steven Grangé verfasserin aut Éric Rondeau verfasserin aut Frédéric Pène verfasserin aut Yahsou Delmas verfasserin aut Alexandre Lautrette verfasserin aut Christelle Barbet verfasserin aut Christiane Mousson verfasserin aut Jean‐Philippe Coindre verfasserin aut Pierre Perez verfasserin aut Matthieu Jamme verfasserin aut Jean‐François Augusto verfasserin aut Pascale Poullin verfasserin aut Frédéric Jacobs verfasserin aut Khalil El Karoui verfasserin aut Cécile Vigneau verfasserin aut Marc Ulrich verfasserin aut Tarik Kanouni verfasserin aut Moglie Le Quintrec verfasserin aut Mohamed Hamidou verfasserin aut Simon Ville verfasserin aut Anne Charvet‐Rumpler verfasserin aut Mario Ojeda‐Uribe verfasserin aut Pascal Godmer verfasserin aut Véronique Fremeaux‐Bacchi verfasserin aut Agnès Veyradier verfasserin aut Jean‐Michel Halimi verfasserin aut Paul Coppo verfasserin aut In Research and Practice in Thrombosis and Haemostasis Elsevier, 2018 6(2022), 4, Seite n/a-n/a (DE-627)895113414 (DE-600)2901840-7 24750379 nnns volume:6 year:2022 number:4 pages:n/a-n/a https://doi.org/10.1002/rth2.12702 kostenfrei https://doaj.org/article/0bd0757c396849008e228ac2e5bc41be kostenfrei https://doi.org/10.1002/rth2.12702 kostenfrei https://doaj.org/toc/2475-0379 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 6 2022 4 n/a-n/a |
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10.1002/rth2.12702 doi (DE-627)DOAJ025086111 (DE-599)DOAJ0bd0757c396849008e228ac2e5bc41be DE-627 ger DE-627 rakwb eng RC633-647.5 Adrien Joseph verfasserin aut Immune‐mediated thrombotic thrombocytopenic purpura prognosis is affected by blood pressure 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The prevalence, prognostic role, and diagnostic value of blood pressure in immune‐mediated thrombotic thrombocytopenic purpura (iTTP) and other thrombotic microangiopathies (TMAs) remain unclear. Methods Using a national cohort of iTTP (n = 368), Shigatoxin‐induced hemolytic uremic syndrome (n = 86), atypical hemolytic uremic syndrome (n = 84), and hypertension‐related thrombotic microangiopathy (n = 25), we sought to compare the cohort’s blood pressure profile to assess its impact on prognosis and diagnostic performances. Results Patients with iTTP had lower blood pressure than patients with other TMAs, systolic (130 [interquartile range (IQR) 118–143] vs 161 [IQR 142–180] mmHg) and diastolic (76 [IQR 69–83] vs 92 [IQR 79–105] mmHg, both p < 0.001). The best threshold for iTTP diagnosis corresponded to a systolic blood pressure <150 mmHg. iTTP patients presenting with hypertension had a significantly poorer survival (hazard ratio 1.80, 95% confidence interval 1.07–3.04), and this effect remained significant after multivariable adjustment (hazard ratio = 1.14, 95% confidence interval 1.00–1.30). Addition of a blood pressure criterion modestly improved the French clinical score to predict a severe A disintegrin and metalloprotease with thrombospondin type 1 deficiency in patients with an intermediate score (i.e., either platelet count <30 × 109/L or serum creatinine <200 µM). Conclusions Elevated blood pressure at admission affects the prognosis of iTTP patients and may help discriminate them from other TMA patients. Particular attention should be paid to blood pressure and its management in these patients. ADAMTS13 blood pressure complement hemolytic uremic syndrome hypertension prognosis Diseases of the blood and blood-forming organs Martin Eloit verfasserin aut Elie Azoulay verfasserin aut Gilles Kaplanski verfasserin aut François Provot verfasserin aut Claire Presne verfasserin aut Alain Wynckel verfasserin aut Steven Grangé verfasserin aut Éric Rondeau verfasserin aut Frédéric Pène verfasserin aut Yahsou Delmas verfasserin aut Alexandre Lautrette verfasserin aut Christelle Barbet verfasserin aut Christiane Mousson verfasserin aut Jean‐Philippe Coindre verfasserin aut Pierre Perez verfasserin aut Matthieu Jamme verfasserin aut Jean‐François Augusto verfasserin aut Pascale Poullin verfasserin aut Frédéric Jacobs verfasserin aut Khalil El Karoui verfasserin aut Cécile Vigneau verfasserin aut Marc Ulrich verfasserin aut Tarik Kanouni verfasserin aut Moglie Le Quintrec verfasserin aut Mohamed Hamidou verfasserin aut Simon Ville verfasserin aut Anne Charvet‐Rumpler verfasserin aut Mario Ojeda‐Uribe verfasserin aut Pascal Godmer verfasserin aut Véronique Fremeaux‐Bacchi verfasserin aut Agnès Veyradier verfasserin aut Jean‐Michel Halimi verfasserin aut Paul Coppo verfasserin aut In Research and Practice in Thrombosis and Haemostasis Elsevier, 2018 6(2022), 4, Seite n/a-n/a (DE-627)895113414 (DE-600)2901840-7 24750379 nnns volume:6 year:2022 number:4 pages:n/a-n/a https://doi.org/10.1002/rth2.12702 kostenfrei https://doaj.org/article/0bd0757c396849008e228ac2e5bc41be kostenfrei https://doi.org/10.1002/rth2.12702 kostenfrei https://doaj.org/toc/2475-0379 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 6 2022 4 n/a-n/a |
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Adrien Joseph @@aut@@ Martin Eloit @@aut@@ Elie Azoulay @@aut@@ Gilles Kaplanski @@aut@@ François Provot @@aut@@ Claire Presne @@aut@@ Alain Wynckel @@aut@@ Steven Grangé @@aut@@ Éric Rondeau @@aut@@ Frédéric Pène @@aut@@ Yahsou Delmas @@aut@@ Alexandre Lautrette @@aut@@ Christelle Barbet @@aut@@ Christiane Mousson @@aut@@ Jean‐Philippe Coindre @@aut@@ Pierre Perez @@aut@@ Matthieu Jamme @@aut@@ Jean‐François Augusto @@aut@@ Pascale Poullin @@aut@@ Frédéric Jacobs @@aut@@ Khalil El Karoui @@aut@@ Cécile Vigneau @@aut@@ Marc Ulrich @@aut@@ Tarik Kanouni @@aut@@ Moglie Le Quintrec @@aut@@ Mohamed Hamidou @@aut@@ Simon Ville @@aut@@ Anne Charvet‐Rumpler @@aut@@ Mario Ojeda‐Uribe @@aut@@ Pascal Godmer @@aut@@ Véronique Fremeaux‐Bacchi @@aut@@ Agnès Veyradier @@aut@@ Jean‐Michel Halimi @@aut@@ Paul Coppo @@aut@@ |
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Adrien Joseph Martin Eloit Elie Azoulay Gilles Kaplanski François Provot Claire Presne Alain Wynckel Steven Grangé Éric Rondeau Frédéric Pène Yahsou Delmas Alexandre Lautrette Christelle Barbet Christiane Mousson Jean‐Philippe Coindre Pierre Perez Matthieu Jamme Jean‐François Augusto Pascale Poullin Frédéric Jacobs Khalil El Karoui Cécile Vigneau Marc Ulrich Tarik Kanouni Moglie Le Quintrec Mohamed Hamidou Simon Ville Anne Charvet‐Rumpler Mario Ojeda‐Uribe Pascal Godmer Véronique Fremeaux‐Bacchi Agnès Veyradier Jean‐Michel Halimi Paul Coppo |
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immune‐mediated thrombotic thrombocytopenic purpura prognosis is affected by blood pressure |
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Immune‐mediated thrombotic thrombocytopenic purpura prognosis is affected by blood pressure |
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Abstract Background The prevalence, prognostic role, and diagnostic value of blood pressure in immune‐mediated thrombotic thrombocytopenic purpura (iTTP) and other thrombotic microangiopathies (TMAs) remain unclear. Methods Using a national cohort of iTTP (n = 368), Shigatoxin‐induced hemolytic uremic syndrome (n = 86), atypical hemolytic uremic syndrome (n = 84), and hypertension‐related thrombotic microangiopathy (n = 25), we sought to compare the cohort’s blood pressure profile to assess its impact on prognosis and diagnostic performances. Results Patients with iTTP had lower blood pressure than patients with other TMAs, systolic (130 [interquartile range (IQR) 118–143] vs 161 [IQR 142–180] mmHg) and diastolic (76 [IQR 69–83] vs 92 [IQR 79–105] mmHg, both p < 0.001). The best threshold for iTTP diagnosis corresponded to a systolic blood pressure <150 mmHg. iTTP patients presenting with hypertension had a significantly poorer survival (hazard ratio 1.80, 95% confidence interval 1.07–3.04), and this effect remained significant after multivariable adjustment (hazard ratio = 1.14, 95% confidence interval 1.00–1.30). Addition of a blood pressure criterion modestly improved the French clinical score to predict a severe A disintegrin and metalloprotease with thrombospondin type 1 deficiency in patients with an intermediate score (i.e., either platelet count <30 × 109/L or serum creatinine <200 µM). Conclusions Elevated blood pressure at admission affects the prognosis of iTTP patients and may help discriminate them from other TMA patients. Particular attention should be paid to blood pressure and its management in these patients. |
| abstractGer |
Abstract Background The prevalence, prognostic role, and diagnostic value of blood pressure in immune‐mediated thrombotic thrombocytopenic purpura (iTTP) and other thrombotic microangiopathies (TMAs) remain unclear. Methods Using a national cohort of iTTP (n = 368), Shigatoxin‐induced hemolytic uremic syndrome (n = 86), atypical hemolytic uremic syndrome (n = 84), and hypertension‐related thrombotic microangiopathy (n = 25), we sought to compare the cohort’s blood pressure profile to assess its impact on prognosis and diagnostic performances. Results Patients with iTTP had lower blood pressure than patients with other TMAs, systolic (130 [interquartile range (IQR) 118–143] vs 161 [IQR 142–180] mmHg) and diastolic (76 [IQR 69–83] vs 92 [IQR 79–105] mmHg, both p < 0.001). The best threshold for iTTP diagnosis corresponded to a systolic blood pressure <150 mmHg. iTTP patients presenting with hypertension had a significantly poorer survival (hazard ratio 1.80, 95% confidence interval 1.07–3.04), and this effect remained significant after multivariable adjustment (hazard ratio = 1.14, 95% confidence interval 1.00–1.30). Addition of a blood pressure criterion modestly improved the French clinical score to predict a severe A disintegrin and metalloprotease with thrombospondin type 1 deficiency in patients with an intermediate score (i.e., either platelet count <30 × 109/L or serum creatinine <200 µM). Conclusions Elevated blood pressure at admission affects the prognosis of iTTP patients and may help discriminate them from other TMA patients. Particular attention should be paid to blood pressure and its management in these patients. |
| abstract_unstemmed |
Abstract Background The prevalence, prognostic role, and diagnostic value of blood pressure in immune‐mediated thrombotic thrombocytopenic purpura (iTTP) and other thrombotic microangiopathies (TMAs) remain unclear. Methods Using a national cohort of iTTP (n = 368), Shigatoxin‐induced hemolytic uremic syndrome (n = 86), atypical hemolytic uremic syndrome (n = 84), and hypertension‐related thrombotic microangiopathy (n = 25), we sought to compare the cohort’s blood pressure profile to assess its impact on prognosis and diagnostic performances. Results Patients with iTTP had lower blood pressure than patients with other TMAs, systolic (130 [interquartile range (IQR) 118–143] vs 161 [IQR 142–180] mmHg) and diastolic (76 [IQR 69–83] vs 92 [IQR 79–105] mmHg, both p < 0.001). The best threshold for iTTP diagnosis corresponded to a systolic blood pressure <150 mmHg. iTTP patients presenting with hypertension had a significantly poorer survival (hazard ratio 1.80, 95% confidence interval 1.07–3.04), and this effect remained significant after multivariable adjustment (hazard ratio = 1.14, 95% confidence interval 1.00–1.30). Addition of a blood pressure criterion modestly improved the French clinical score to predict a severe A disintegrin and metalloprotease with thrombospondin type 1 deficiency in patients with an intermediate score (i.e., either platelet count <30 × 109/L or serum creatinine <200 µM). Conclusions Elevated blood pressure at admission affects the prognosis of iTTP patients and may help discriminate them from other TMA patients. Particular attention should be paid to blood pressure and its management in these patients. |
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1803610208008667136 |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ025086111</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230503002842.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230226s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1002/rth2.12702</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ025086111</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ0bd0757c396849008e228ac2e5bc41be</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC633-647.5</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Adrien Joseph</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Immune‐mediated thrombotic thrombocytopenic purpura prognosis is affected by blood pressure</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background The prevalence, prognostic role, and diagnostic value of blood pressure in immune‐mediated thrombotic thrombocytopenic purpura (iTTP) and other thrombotic microangiopathies (TMAs) remain unclear. Methods Using a national cohort of iTTP (n = 368), Shigatoxin‐induced hemolytic uremic syndrome (n = 86), atypical hemolytic uremic syndrome (n = 84), and hypertension‐related thrombotic microangiopathy (n = 25), we sought to compare the cohort’s blood pressure profile to assess its impact on prognosis and diagnostic performances. Results Patients with iTTP had lower blood pressure than patients with other TMAs, systolic (130 [interquartile range (IQR) 118–143] vs 161 [IQR 142–180] mmHg) and diastolic (76 [IQR 69–83] vs 92 [IQR 79–105] mmHg, both p < 0.001). The best threshold for iTTP diagnosis corresponded to a systolic blood pressure <150 mmHg. iTTP patients presenting with hypertension had a significantly poorer survival (hazard ratio 1.80, 95% confidence interval 1.07–3.04), and this effect remained significant after multivariable adjustment (hazard ratio = 1.14, 95% confidence interval 1.00–1.30). Addition of a blood pressure criterion modestly improved the French clinical score to predict a severe A disintegrin and metalloprotease with thrombospondin type 1 deficiency in patients with an intermediate score (i.e., either platelet count <30 × 109/L or serum creatinine <200 µM). Conclusions Elevated blood pressure at admission affects the prognosis of iTTP patients and may help discriminate them from other TMA patients. 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