Comparative analysis of a BAC contig of porcine chromosome 13q31-q32 and human chromosome 3q21-q22

<p<Abstract</p< <p<Background</p< <p<The gene(s) encoding the ETEC F4ab/ac receptors, involved in neonatal diarrhoea in pigs (a disease not yet described in humans), is located close to the TF locus on Sscr13. In order to reveal and characterize possible candidate genes...
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Autor*in:	Van Zeveren Alex [verfasserIn] Mattheeuws Marc [verfasserIn] Piumi François [verfasserIn] Bourry David [verfasserIn] Van Poucke Mario [verfasserIn] Chardon Patrick [verfasserIn] Peelman Luc J [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2005

Übergeordnetes Werk:	In: BMC Genomics - BMC, 2003, 6(2005), 1, p 133
Übergeordnetes Werk:	volume:6 ; year:2005 ; number:1, p 133

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1471-2164-6-133

Katalog-ID:	DOAJ025127829

Internformat


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author_variant	v z a vza m m mm p f pf b d bd v p m vpm c p cp p l j plj
matchkey_str	article:14712164:2005----::oprtvaayioaacniopriehoooe33q2n
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callnumber-subject-code	TP
publishDate	2005
allfields	10.1186/1471-2164-6-133 doi (DE-627)DOAJ025127829 (DE-599)DOAJb14810bdd0124510909d6a663848aa53 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Van Zeveren Alex verfasserin aut Comparative analysis of a BAC contig of porcine chromosome 13q31-q32 and human chromosome 3q21-q22 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The gene(s) encoding the ETEC F4ab/ac receptors, involved in neonatal diarrhoea in pigs (a disease not yet described in humans), is located close to the TF locus on Sscr13. In order to reveal and characterize possible candidate genes encoding these receptors, a porcine physical map of the TF region is indispensable.</p< <p<Results</p< <p<A contig of 33 BAC clones, covering approximately 1.35 Mb surrounding the TF locus on Sscr13q31-q32, was built by chromosome walking. A total of 22,552 bp from the BAC contig were sequenced and compared with database sequences to identify genes, ESTs and repeat sequences, and to anchor the contig to the syntenic region of the human genome sequence (Hsap3q21-q22). The contig was further annotated based on this human/porcine comparative map, and was also anchored to the Sanger porcine framework map and the integrated map of Sscr13 by RH mapping.</p< <p<Conclusion</p< <p<The annotated contig, containing 10 genes and 2 ESTs, showed a complete conservation of linkage (gene order and orientation) with the human genome sequence, based on 46 anchor points. This underlines the importance of the human/porcine comparative map for the identification of porcine genes associated with genetic defects and economically important traits, and for assembly of the porcine genome sequence.</p< Biotechnology Genetics Mattheeuws Marc verfasserin aut Piumi François verfasserin aut Bourry David verfasserin aut Van Poucke Mario verfasserin aut Chardon Patrick verfasserin aut Peelman Luc J verfasserin aut In BMC Genomics BMC, 2003 6(2005), 1, p 133 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:6 year:2005 number:1, p 133 https://doi.org/10.1186/1471-2164-6-133 kostenfrei https://doaj.org/article/b14810bdd0124510909d6a663848aa53 kostenfrei http://www.biomedcentral.com/1471-2164/6/133 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2005 1, p 133
spelling	10.1186/1471-2164-6-133 doi (DE-627)DOAJ025127829 (DE-599)DOAJb14810bdd0124510909d6a663848aa53 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Van Zeveren Alex verfasserin aut Comparative analysis of a BAC contig of porcine chromosome 13q31-q32 and human chromosome 3q21-q22 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The gene(s) encoding the ETEC F4ab/ac receptors, involved in neonatal diarrhoea in pigs (a disease not yet described in humans), is located close to the TF locus on Sscr13. In order to reveal and characterize possible candidate genes encoding these receptors, a porcine physical map of the TF region is indispensable.</p< <p<Results</p< <p<A contig of 33 BAC clones, covering approximately 1.35 Mb surrounding the TF locus on Sscr13q31-q32, was built by chromosome walking. A total of 22,552 bp from the BAC contig were sequenced and compared with database sequences to identify genes, ESTs and repeat sequences, and to anchor the contig to the syntenic region of the human genome sequence (Hsap3q21-q22). The contig was further annotated based on this human/porcine comparative map, and was also anchored to the Sanger porcine framework map and the integrated map of Sscr13 by RH mapping.</p< <p<Conclusion</p< <p<The annotated contig, containing 10 genes and 2 ESTs, showed a complete conservation of linkage (gene order and orientation) with the human genome sequence, based on 46 anchor points. This underlines the importance of the human/porcine comparative map for the identification of porcine genes associated with genetic defects and economically important traits, and for assembly of the porcine genome sequence.</p< Biotechnology Genetics Mattheeuws Marc verfasserin aut Piumi François verfasserin aut Bourry David verfasserin aut Van Poucke Mario verfasserin aut Chardon Patrick verfasserin aut Peelman Luc J verfasserin aut In BMC Genomics BMC, 2003 6(2005), 1, p 133 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:6 year:2005 number:1, p 133 https://doi.org/10.1186/1471-2164-6-133 kostenfrei https://doaj.org/article/b14810bdd0124510909d6a663848aa53 kostenfrei http://www.biomedcentral.com/1471-2164/6/133 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2005 1, p 133
allfields_unstemmed	10.1186/1471-2164-6-133 doi (DE-627)DOAJ025127829 (DE-599)DOAJb14810bdd0124510909d6a663848aa53 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Van Zeveren Alex verfasserin aut Comparative analysis of a BAC contig of porcine chromosome 13q31-q32 and human chromosome 3q21-q22 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The gene(s) encoding the ETEC F4ab/ac receptors, involved in neonatal diarrhoea in pigs (a disease not yet described in humans), is located close to the TF locus on Sscr13. In order to reveal and characterize possible candidate genes encoding these receptors, a porcine physical map of the TF region is indispensable.</p< <p<Results</p< <p<A contig of 33 BAC clones, covering approximately 1.35 Mb surrounding the TF locus on Sscr13q31-q32, was built by chromosome walking. A total of 22,552 bp from the BAC contig were sequenced and compared with database sequences to identify genes, ESTs and repeat sequences, and to anchor the contig to the syntenic region of the human genome sequence (Hsap3q21-q22). The contig was further annotated based on this human/porcine comparative map, and was also anchored to the Sanger porcine framework map and the integrated map of Sscr13 by RH mapping.</p< <p<Conclusion</p< <p<The annotated contig, containing 10 genes and 2 ESTs, showed a complete conservation of linkage (gene order and orientation) with the human genome sequence, based on 46 anchor points. This underlines the importance of the human/porcine comparative map for the identification of porcine genes associated with genetic defects and economically important traits, and for assembly of the porcine genome sequence.</p< Biotechnology Genetics Mattheeuws Marc verfasserin aut Piumi François verfasserin aut Bourry David verfasserin aut Van Poucke Mario verfasserin aut Chardon Patrick verfasserin aut Peelman Luc J verfasserin aut In BMC Genomics BMC, 2003 6(2005), 1, p 133 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:6 year:2005 number:1, p 133 https://doi.org/10.1186/1471-2164-6-133 kostenfrei https://doaj.org/article/b14810bdd0124510909d6a663848aa53 kostenfrei http://www.biomedcentral.com/1471-2164/6/133 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2005 1, p 133
allfieldsGer	10.1186/1471-2164-6-133 doi (DE-627)DOAJ025127829 (DE-599)DOAJb14810bdd0124510909d6a663848aa53 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Van Zeveren Alex verfasserin aut Comparative analysis of a BAC contig of porcine chromosome 13q31-q32 and human chromosome 3q21-q22 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The gene(s) encoding the ETEC F4ab/ac receptors, involved in neonatal diarrhoea in pigs (a disease not yet described in humans), is located close to the TF locus on Sscr13. In order to reveal and characterize possible candidate genes encoding these receptors, a porcine physical map of the TF region is indispensable.</p< <p<Results</p< <p<A contig of 33 BAC clones, covering approximately 1.35 Mb surrounding the TF locus on Sscr13q31-q32, was built by chromosome walking. A total of 22,552 bp from the BAC contig were sequenced and compared with database sequences to identify genes, ESTs and repeat sequences, and to anchor the contig to the syntenic region of the human genome sequence (Hsap3q21-q22). The contig was further annotated based on this human/porcine comparative map, and was also anchored to the Sanger porcine framework map and the integrated map of Sscr13 by RH mapping.</p< <p<Conclusion</p< <p<The annotated contig, containing 10 genes and 2 ESTs, showed a complete conservation of linkage (gene order and orientation) with the human genome sequence, based on 46 anchor points. This underlines the importance of the human/porcine comparative map for the identification of porcine genes associated with genetic defects and economically important traits, and for assembly of the porcine genome sequence.</p< Biotechnology Genetics Mattheeuws Marc verfasserin aut Piumi François verfasserin aut Bourry David verfasserin aut Van Poucke Mario verfasserin aut Chardon Patrick verfasserin aut Peelman Luc J verfasserin aut In BMC Genomics BMC, 2003 6(2005), 1, p 133 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:6 year:2005 number:1, p 133 https://doi.org/10.1186/1471-2164-6-133 kostenfrei https://doaj.org/article/b14810bdd0124510909d6a663848aa53 kostenfrei http://www.biomedcentral.com/1471-2164/6/133 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2005 1, p 133
allfieldsSound	10.1186/1471-2164-6-133 doi (DE-627)DOAJ025127829 (DE-599)DOAJb14810bdd0124510909d6a663848aa53 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Van Zeveren Alex verfasserin aut Comparative analysis of a BAC contig of porcine chromosome 13q31-q32 and human chromosome 3q21-q22 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The gene(s) encoding the ETEC F4ab/ac receptors, involved in neonatal diarrhoea in pigs (a disease not yet described in humans), is located close to the TF locus on Sscr13. In order to reveal and characterize possible candidate genes encoding these receptors, a porcine physical map of the TF region is indispensable.</p< <p<Results</p< <p<A contig of 33 BAC clones, covering approximately 1.35 Mb surrounding the TF locus on Sscr13q31-q32, was built by chromosome walking. A total of 22,552 bp from the BAC contig were sequenced and compared with database sequences to identify genes, ESTs and repeat sequences, and to anchor the contig to the syntenic region of the human genome sequence (Hsap3q21-q22). The contig was further annotated based on this human/porcine comparative map, and was also anchored to the Sanger porcine framework map and the integrated map of Sscr13 by RH mapping.</p< <p<Conclusion</p< <p<The annotated contig, containing 10 genes and 2 ESTs, showed a complete conservation of linkage (gene order and orientation) with the human genome sequence, based on 46 anchor points. This underlines the importance of the human/porcine comparative map for the identification of porcine genes associated with genetic defects and economically important traits, and for assembly of the porcine genome sequence.</p< Biotechnology Genetics Mattheeuws Marc verfasserin aut Piumi François verfasserin aut Bourry David verfasserin aut Van Poucke Mario verfasserin aut Chardon Patrick verfasserin aut Peelman Luc J verfasserin aut In BMC Genomics BMC, 2003 6(2005), 1, p 133 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:6 year:2005 number:1, p 133 https://doi.org/10.1186/1471-2164-6-133 kostenfrei https://doaj.org/article/b14810bdd0124510909d6a663848aa53 kostenfrei http://www.biomedcentral.com/1471-2164/6/133 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2005 1, p 133
language	English
source	In BMC Genomics 6(2005), 1, p 133 volume:6 year:2005 number:1, p 133
sourceStr	In BMC Genomics 6(2005), 1, p 133 volume:6 year:2005 number:1, p 133
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Biotechnology Genetics
isfreeaccess_bool	true
container_title	BMC Genomics
authorswithroles_txt_mv	Van Zeveren Alex @@aut@@ Mattheeuws Marc @@aut@@ Piumi François @@aut@@ Bourry David @@aut@@ Van Poucke Mario @@aut@@ Chardon Patrick @@aut@@ Peelman Luc J @@aut@@
publishDateDaySort_date	2005-01-01T00:00:00Z
hierarchy_top_id	326644954
id	DOAJ025127829
language_de	englisch
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callnumber-first	T - Technology
author	Van Zeveren Alex
spellingShingle	Van Zeveren Alex misc TP248.13-248.65 misc QH426-470 misc Biotechnology misc Genetics Comparative analysis of a BAC contig of porcine chromosome 13q31-q32 and human chromosome 3q21-q22
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topic_title	TP248.13-248.65 QH426-470 Comparative analysis of a BAC contig of porcine chromosome 13q31-q32 and human chromosome 3q21-q22
topic	misc TP248.13-248.65 misc QH426-470 misc Biotechnology misc Genetics
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title	Comparative analysis of a BAC contig of porcine chromosome 13q31-q32 and human chromosome 3q21-q22
ctrlnum	(DE-627)DOAJ025127829 (DE-599)DOAJb14810bdd0124510909d6a663848aa53
title_full	Comparative analysis of a BAC contig of porcine chromosome 13q31-q32 and human chromosome 3q21-q22
author_sort	Van Zeveren Alex
journal	BMC Genomics
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author_browse	Van Zeveren Alex Mattheeuws Marc Piumi François Bourry David Van Poucke Mario Chardon Patrick Peelman Luc J
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format_se	Elektronische Aufsätze
author-letter	Van Zeveren Alex
doi_str_mv	10.1186/1471-2164-6-133
author2-role	verfasserin
title_sort	comparative analysis of a bac contig of porcine chromosome 13q31-q32 and human chromosome 3q21-q22
callnumber	TP248.13-248.65
title_auth	Comparative analysis of a BAC contig of porcine chromosome 13q31-q32 and human chromosome 3q21-q22
abstract	<p<Abstract</p< <p<Background</p< <p<The gene(s) encoding the ETEC F4ab/ac receptors, involved in neonatal diarrhoea in pigs (a disease not yet described in humans), is located close to the TF locus on Sscr13. In order to reveal and characterize possible candidate genes encoding these receptors, a porcine physical map of the TF region is indispensable.</p< <p<Results</p< <p<A contig of 33 BAC clones, covering approximately 1.35 Mb surrounding the TF locus on Sscr13q31-q32, was built by chromosome walking. A total of 22,552 bp from the BAC contig were sequenced and compared with database sequences to identify genes, ESTs and repeat sequences, and to anchor the contig to the syntenic region of the human genome sequence (Hsap3q21-q22). The contig was further annotated based on this human/porcine comparative map, and was also anchored to the Sanger porcine framework map and the integrated map of Sscr13 by RH mapping.</p< <p<Conclusion</p< <p<The annotated contig, containing 10 genes and 2 ESTs, showed a complete conservation of linkage (gene order and orientation) with the human genome sequence, based on 46 anchor points. This underlines the importance of the human/porcine comparative map for the identification of porcine genes associated with genetic defects and economically important traits, and for assembly of the porcine genome sequence.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<The gene(s) encoding the ETEC F4ab/ac receptors, involved in neonatal diarrhoea in pigs (a disease not yet described in humans), is located close to the TF locus on Sscr13. In order to reveal and characterize possible candidate genes encoding these receptors, a porcine physical map of the TF region is indispensable.</p< <p<Results</p< <p<A contig of 33 BAC clones, covering approximately 1.35 Mb surrounding the TF locus on Sscr13q31-q32, was built by chromosome walking. A total of 22,552 bp from the BAC contig were sequenced and compared with database sequences to identify genes, ESTs and repeat sequences, and to anchor the contig to the syntenic region of the human genome sequence (Hsap3q21-q22). The contig was further annotated based on this human/porcine comparative map, and was also anchored to the Sanger porcine framework map and the integrated map of Sscr13 by RH mapping.</p< <p<Conclusion</p< <p<The annotated contig, containing 10 genes and 2 ESTs, showed a complete conservation of linkage (gene order and orientation) with the human genome sequence, based on 46 anchor points. This underlines the importance of the human/porcine comparative map for the identification of porcine genes associated with genetic defects and economically important traits, and for assembly of the porcine genome sequence.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<The gene(s) encoding the ETEC F4ab/ac receptors, involved in neonatal diarrhoea in pigs (a disease not yet described in humans), is located close to the TF locus on Sscr13. In order to reveal and characterize possible candidate genes encoding these receptors, a porcine physical map of the TF region is indispensable.</p< <p<Results</p< <p<A contig of 33 BAC clones, covering approximately 1.35 Mb surrounding the TF locus on Sscr13q31-q32, was built by chromosome walking. A total of 22,552 bp from the BAC contig were sequenced and compared with database sequences to identify genes, ESTs and repeat sequences, and to anchor the contig to the syntenic region of the human genome sequence (Hsap3q21-q22). The contig was further annotated based on this human/porcine comparative map, and was also anchored to the Sanger porcine framework map and the integrated map of Sscr13 by RH mapping.</p< <p<Conclusion</p< <p<The annotated contig, containing 10 genes and 2 ESTs, showed a complete conservation of linkage (gene order and orientation) with the human genome sequence, based on 46 anchor points. This underlines the importance of the human/porcine comparative map for the identification of porcine genes associated with genetic defects and economically important traits, and for assembly of the porcine genome sequence.</p<
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title_short	Comparative analysis of a BAC contig of porcine chromosome 13q31-q32 and human chromosome 3q21-q22
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Comparative analysis of a BAC contig of porcine chromosome 13q31-q32 and human chromosome 3q21-q22

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