Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier

The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from passing from the blood to the brain; only tiny molecules can pass across the BBB. The BBB is disturbed in specific p...
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Autor*in:	Raluca Ioana Teleanu [verfasserIn] Manuela Daniela Preda [verfasserIn] Adelina-Gabriela Niculescu [verfasserIn] Oana Vladâcenco [verfasserIn] Crina Ioana Radu [verfasserIn] Alexandru Mihai Grumezescu [verfasserIn] Daniel Mihai Teleanu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	blood–brain barrier medication delivery techniques nanoparticles

Übergeordnetes Werk:	In: Pharmaceutics - MDPI AG, 2010, 14(2022), 5, p 987
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:5, p 987

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/pharmaceutics14050987

Katalog-ID:	DOAJ025300911

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allfields	10.3390/pharmaceutics14050987 doi (DE-627)DOAJ025300911 (DE-599)DOAJ16687242d5a1454997d59386f058ce92 DE-627 ger DE-627 rakwb eng RS1-441 Raluca Ioana Teleanu verfasserin aut Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from passing from the blood to the brain; only tiny molecules can pass across the BBB. The BBB is disturbed in specific pathological illnesses such as stroke, diabetes, seizures, multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. The goal of this study is to offer a general overview of current brain medication delivery techniques and associated topics from the last five years. It is anticipated that this review will stimulate readers to look into new ways to deliver medications to the brain. Following an introduction of the construction and function of the BBB in both healthy and pathological conditions, this review revisits certain contested questions, such as whether nanoparticles may cross the BBB on their own and if medications are selectively delivered to the brain by deliberately targeted nanoparticles. Current non-nanoparticle options are also discussed, including drug delivery via the permeable BBB under pathological circumstances and the use of non-invasive approaches to improve brain medication absorption. blood–brain barrier medication delivery techniques nanoparticles Pharmacy and materia medica Manuela Daniela Preda verfasserin aut Adelina-Gabriela Niculescu verfasserin aut Oana Vladâcenco verfasserin aut Crina Ioana Radu verfasserin aut Alexandru Mihai Grumezescu verfasserin aut Daniel Mihai Teleanu verfasserin aut In Pharmaceutics MDPI AG, 2010 14(2022), 5, p 987 (DE-627)614096529 (DE-600)2527217-2 19994923 nnns volume:14 year:2022 number:5, p 987 https://doi.org/10.3390/pharmaceutics14050987 kostenfrei https://doaj.org/article/16687242d5a1454997d59386f058ce92 kostenfrei https://www.mdpi.com/1999-4923/14/5/987 kostenfrei https://doaj.org/toc/1999-4923 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 5, p 987
spelling	10.3390/pharmaceutics14050987 doi (DE-627)DOAJ025300911 (DE-599)DOAJ16687242d5a1454997d59386f058ce92 DE-627 ger DE-627 rakwb eng RS1-441 Raluca Ioana Teleanu verfasserin aut Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from passing from the blood to the brain; only tiny molecules can pass across the BBB. The BBB is disturbed in specific pathological illnesses such as stroke, diabetes, seizures, multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. The goal of this study is to offer a general overview of current brain medication delivery techniques and associated topics from the last five years. It is anticipated that this review will stimulate readers to look into new ways to deliver medications to the brain. Following an introduction of the construction and function of the BBB in both healthy and pathological conditions, this review revisits certain contested questions, such as whether nanoparticles may cross the BBB on their own and if medications are selectively delivered to the brain by deliberately targeted nanoparticles. Current non-nanoparticle options are also discussed, including drug delivery via the permeable BBB under pathological circumstances and the use of non-invasive approaches to improve brain medication absorption. blood–brain barrier medication delivery techniques nanoparticles Pharmacy and materia medica Manuela Daniela Preda verfasserin aut Adelina-Gabriela Niculescu verfasserin aut Oana Vladâcenco verfasserin aut Crina Ioana Radu verfasserin aut Alexandru Mihai Grumezescu verfasserin aut Daniel Mihai Teleanu verfasserin aut In Pharmaceutics MDPI AG, 2010 14(2022), 5, p 987 (DE-627)614096529 (DE-600)2527217-2 19994923 nnns volume:14 year:2022 number:5, p 987 https://doi.org/10.3390/pharmaceutics14050987 kostenfrei https://doaj.org/article/16687242d5a1454997d59386f058ce92 kostenfrei https://www.mdpi.com/1999-4923/14/5/987 kostenfrei https://doaj.org/toc/1999-4923 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 5, p 987
allfields_unstemmed	10.3390/pharmaceutics14050987 doi (DE-627)DOAJ025300911 (DE-599)DOAJ16687242d5a1454997d59386f058ce92 DE-627 ger DE-627 rakwb eng RS1-441 Raluca Ioana Teleanu verfasserin aut Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from passing from the blood to the brain; only tiny molecules can pass across the BBB. The BBB is disturbed in specific pathological illnesses such as stroke, diabetes, seizures, multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. The goal of this study is to offer a general overview of current brain medication delivery techniques and associated topics from the last five years. It is anticipated that this review will stimulate readers to look into new ways to deliver medications to the brain. Following an introduction of the construction and function of the BBB in both healthy and pathological conditions, this review revisits certain contested questions, such as whether nanoparticles may cross the BBB on their own and if medications are selectively delivered to the brain by deliberately targeted nanoparticles. Current non-nanoparticle options are also discussed, including drug delivery via the permeable BBB under pathological circumstances and the use of non-invasive approaches to improve brain medication absorption. blood–brain barrier medication delivery techniques nanoparticles Pharmacy and materia medica Manuela Daniela Preda verfasserin aut Adelina-Gabriela Niculescu verfasserin aut Oana Vladâcenco verfasserin aut Crina Ioana Radu verfasserin aut Alexandru Mihai Grumezescu verfasserin aut Daniel Mihai Teleanu verfasserin aut In Pharmaceutics MDPI AG, 2010 14(2022), 5, p 987 (DE-627)614096529 (DE-600)2527217-2 19994923 nnns volume:14 year:2022 number:5, p 987 https://doi.org/10.3390/pharmaceutics14050987 kostenfrei https://doaj.org/article/16687242d5a1454997d59386f058ce92 kostenfrei https://www.mdpi.com/1999-4923/14/5/987 kostenfrei https://doaj.org/toc/1999-4923 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 5, p 987
allfieldsGer	10.3390/pharmaceutics14050987 doi (DE-627)DOAJ025300911 (DE-599)DOAJ16687242d5a1454997d59386f058ce92 DE-627 ger DE-627 rakwb eng RS1-441 Raluca Ioana Teleanu verfasserin aut Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from passing from the blood to the brain; only tiny molecules can pass across the BBB. The BBB is disturbed in specific pathological illnesses such as stroke, diabetes, seizures, multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. The goal of this study is to offer a general overview of current brain medication delivery techniques and associated topics from the last five years. It is anticipated that this review will stimulate readers to look into new ways to deliver medications to the brain. Following an introduction of the construction and function of the BBB in both healthy and pathological conditions, this review revisits certain contested questions, such as whether nanoparticles may cross the BBB on their own and if medications are selectively delivered to the brain by deliberately targeted nanoparticles. Current non-nanoparticle options are also discussed, including drug delivery via the permeable BBB under pathological circumstances and the use of non-invasive approaches to improve brain medication absorption. blood–brain barrier medication delivery techniques nanoparticles Pharmacy and materia medica Manuela Daniela Preda verfasserin aut Adelina-Gabriela Niculescu verfasserin aut Oana Vladâcenco verfasserin aut Crina Ioana Radu verfasserin aut Alexandru Mihai Grumezescu verfasserin aut Daniel Mihai Teleanu verfasserin aut In Pharmaceutics MDPI AG, 2010 14(2022), 5, p 987 (DE-627)614096529 (DE-600)2527217-2 19994923 nnns volume:14 year:2022 number:5, p 987 https://doi.org/10.3390/pharmaceutics14050987 kostenfrei https://doaj.org/article/16687242d5a1454997d59386f058ce92 kostenfrei https://www.mdpi.com/1999-4923/14/5/987 kostenfrei https://doaj.org/toc/1999-4923 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 5, p 987
allfieldsSound	10.3390/pharmaceutics14050987 doi (DE-627)DOAJ025300911 (DE-599)DOAJ16687242d5a1454997d59386f058ce92 DE-627 ger DE-627 rakwb eng RS1-441 Raluca Ioana Teleanu verfasserin aut Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from passing from the blood to the brain; only tiny molecules can pass across the BBB. The BBB is disturbed in specific pathological illnesses such as stroke, diabetes, seizures, multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. The goal of this study is to offer a general overview of current brain medication delivery techniques and associated topics from the last five years. It is anticipated that this review will stimulate readers to look into new ways to deliver medications to the brain. Following an introduction of the construction and function of the BBB in both healthy and pathological conditions, this review revisits certain contested questions, such as whether nanoparticles may cross the BBB on their own and if medications are selectively delivered to the brain by deliberately targeted nanoparticles. Current non-nanoparticle options are also discussed, including drug delivery via the permeable BBB under pathological circumstances and the use of non-invasive approaches to improve brain medication absorption. blood–brain barrier medication delivery techniques nanoparticles Pharmacy and materia medica Manuela Daniela Preda verfasserin aut Adelina-Gabriela Niculescu verfasserin aut Oana Vladâcenco verfasserin aut Crina Ioana Radu verfasserin aut Alexandru Mihai Grumezescu verfasserin aut Daniel Mihai Teleanu verfasserin aut In Pharmaceutics MDPI AG, 2010 14(2022), 5, p 987 (DE-627)614096529 (DE-600)2527217-2 19994923 nnns volume:14 year:2022 number:5, p 987 https://doi.org/10.3390/pharmaceutics14050987 kostenfrei https://doaj.org/article/16687242d5a1454997d59386f058ce92 kostenfrei https://www.mdpi.com/1999-4923/14/5/987 kostenfrei https://doaj.org/toc/1999-4923 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 5, p 987
language	English
source	In Pharmaceutics 14(2022), 5, p 987 volume:14 year:2022 number:5, p 987
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authorswithroles_txt_mv	Raluca Ioana Teleanu @@aut@@ Manuela Daniela Preda @@aut@@ Adelina-Gabriela Niculescu @@aut@@ Oana Vladâcenco @@aut@@ Crina Ioana Radu @@aut@@ Alexandru Mihai Grumezescu @@aut@@ Daniel Mihai Teleanu @@aut@@
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callnumber-first	R - Medicine
author	Raluca Ioana Teleanu
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title_sort	current strategies to enhance delivery of drugs across the blood–brain barrier
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title_auth	Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier
abstract	The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from passing from the blood to the brain; only tiny molecules can pass across the BBB. The BBB is disturbed in specific pathological illnesses such as stroke, diabetes, seizures, multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. The goal of this study is to offer a general overview of current brain medication delivery techniques and associated topics from the last five years. It is anticipated that this review will stimulate readers to look into new ways to deliver medications to the brain. Following an introduction of the construction and function of the BBB in both healthy and pathological conditions, this review revisits certain contested questions, such as whether nanoparticles may cross the BBB on their own and if medications are selectively delivered to the brain by deliberately targeted nanoparticles. Current non-nanoparticle options are also discussed, including drug delivery via the permeable BBB under pathological circumstances and the use of non-invasive approaches to improve brain medication absorption.
abstractGer	The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from passing from the blood to the brain; only tiny molecules can pass across the BBB. The BBB is disturbed in specific pathological illnesses such as stroke, diabetes, seizures, multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. The goal of this study is to offer a general overview of current brain medication delivery techniques and associated topics from the last five years. It is anticipated that this review will stimulate readers to look into new ways to deliver medications to the brain. Following an introduction of the construction and function of the BBB in both healthy and pathological conditions, this review revisits certain contested questions, such as whether nanoparticles may cross the BBB on their own and if medications are selectively delivered to the brain by deliberately targeted nanoparticles. Current non-nanoparticle options are also discussed, including drug delivery via the permeable BBB under pathological circumstances and the use of non-invasive approaches to improve brain medication absorption.
abstract_unstemmed	The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from passing from the blood to the brain; only tiny molecules can pass across the BBB. The BBB is disturbed in specific pathological illnesses such as stroke, diabetes, seizures, multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. The goal of this study is to offer a general overview of current brain medication delivery techniques and associated topics from the last five years. It is anticipated that this review will stimulate readers to look into new ways to deliver medications to the brain. Following an introduction of the construction and function of the BBB in both healthy and pathological conditions, this review revisits certain contested questions, such as whether nanoparticles may cross the BBB on their own and if medications are selectively delivered to the brain by deliberately targeted nanoparticles. Current non-nanoparticle options are also discussed, including drug delivery via the permeable BBB under pathological circumstances and the use of non-invasive approaches to improve brain medication absorption.
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title_short	Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier
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