Antifungal and Antivirulence Activity of Vaginal <i<Lactobacillus</i< Spp. Products against <i<Candida</i< Vaginal Isolates

<i<Candida</i< yeasts are generally found in the vaginal microbiota; however, disruption of the balance maintained by host factors and microorganisms results in vulvovaginal candidiasis (VVC). This study evaluated the antagonistic activity of vaginal <i<Lactobacillus</i< spp....
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Autor*in:	Camilla Itapary dos Santos [verfasserIn] Yasmine Ramos França [verfasserIn] Carmem Duarte Lima Campos [verfasserIn] Maria Rosa Quaresma Bomfim [verfasserIn] Bruna Oliveira Melo [verfasserIn] Rodrigo Assunção Holanda [verfasserIn] Vera Lucia Santos [verfasserIn] Sílvio Gomes Monteiro [verfasserIn] Eduardo Buozzi Moffa [verfasserIn] Andrea Souza Monteiro [verfasserIn] Cristina Andrade Monteiro [verfasserIn] Valério Monteiro-Neto [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	biofilm inhibition vulvovaginal candidiasis

Übergeordnetes Werk:	In: Pathogens - MDPI AG, 2012, 8(2019), 3, p 150
Übergeordnetes Werk:	volume:8 ; year:2019 ; number:3, p 150

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/pathogens8030150

Katalog-ID:	DOAJ025334743

Internformat


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Indexfelder

author_variant	c i d s cids y r f yrf c d l c cdlc m r q b mrqb b o m bom r a h rah v l s vls s g m sgm e b m ebm a s m asm c a m cam v m n vmn
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allfields	10.3390/pathogens8030150 doi (DE-627)DOAJ025334743 (DE-599)DOAJfc82174fbcb04f91860cc3d79827e14e DE-627 ger DE-627 rakwb eng Camilla Itapary dos Santos verfasserin aut Antifungal and Antivirulence Activity of Vaginal <i<Lactobacillus</i< Spp. Products against <i<Candida</i< Vaginal Isolates 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Candida</i< yeasts are generally found in the vaginal microbiota; however, disruption of the balance maintained by host factors and microorganisms results in vulvovaginal candidiasis (VVC). This study evaluated the antagonistic activity of vaginal <i<Lactobacillus</i< spp. on <i<Candida albicans</i< to verify whether active compounds of <i<Lactobacillus</i< spp. had antifungal and antivirulence activity. The antagonism assay showed that 15 out of 20 <i<Lactobacillus</i< strains had an inhibitory effect on <i<C. albicans.</i< Biosurfactants displayed surface-tension-reducing activity, with the best value obtained for <i<Lactobacillus gasseri</i< 1. <i<Lactobacillus rhamnosus</i< ATCC 9595, <i<Lactobacillus acidophilus</i< ATCC 4356, and <i<Lactobacillus paracasei</i< 11 produced biosurfactants that decreased <i<C. albicans</i< adhesion and disrupted biofilm formation. The best results were obtained in the pre-incubation assay for <i<L. gasseri</i< 1 and <i<L. paracasei</i< 11. Overall, <i<Lactobacillus</i< strains showed significant anti-<i<Candida</i< activity, and their biosurfactants exhibited considerable anti-adhesion and antibiofilm activity against <i<C. albicans</i<. To be considered safe for use in vivo, the safety of biosurfactant (BS) should be investigated using cytotoxicity assays. <i<Lactobacillus</i< biosurfactant production biofilm inhibition <i<Candida albicans</i< suppression <i<Lactobacillus</i< antivirulence vulvovaginal candidiasis Medicine R Yasmine Ramos França verfasserin aut Carmem Duarte Lima Campos verfasserin aut Maria Rosa Quaresma Bomfim verfasserin aut Bruna Oliveira Melo verfasserin aut Rodrigo Assunção Holanda verfasserin aut Vera Lucia Santos verfasserin aut Sílvio Gomes Monteiro verfasserin aut Eduardo Buozzi Moffa verfasserin aut Andrea Souza Monteiro verfasserin aut Cristina Andrade Monteiro verfasserin aut Valério Monteiro-Neto verfasserin aut In Pathogens MDPI AG, 2012 8(2019), 3, p 150 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:8 year:2019 number:3, p 150 https://doi.org/10.3390/pathogens8030150 kostenfrei https://doaj.org/article/fc82174fbcb04f91860cc3d79827e14e kostenfrei https://www.mdpi.com/2076-0817/8/3/150 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 3, p 150
spelling	10.3390/pathogens8030150 doi (DE-627)DOAJ025334743 (DE-599)DOAJfc82174fbcb04f91860cc3d79827e14e DE-627 ger DE-627 rakwb eng Camilla Itapary dos Santos verfasserin aut Antifungal and Antivirulence Activity of Vaginal <i<Lactobacillus</i< Spp. Products against <i<Candida</i< Vaginal Isolates 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Candida</i< yeasts are generally found in the vaginal microbiota; however, disruption of the balance maintained by host factors and microorganisms results in vulvovaginal candidiasis (VVC). This study evaluated the antagonistic activity of vaginal <i<Lactobacillus</i< spp. on <i<Candida albicans</i< to verify whether active compounds of <i<Lactobacillus</i< spp. had antifungal and antivirulence activity. The antagonism assay showed that 15 out of 20 <i<Lactobacillus</i< strains had an inhibitory effect on <i<C. albicans.</i< Biosurfactants displayed surface-tension-reducing activity, with the best value obtained for <i<Lactobacillus gasseri</i< 1. <i<Lactobacillus rhamnosus</i< ATCC 9595, <i<Lactobacillus acidophilus</i< ATCC 4356, and <i<Lactobacillus paracasei</i< 11 produced biosurfactants that decreased <i<C. albicans</i< adhesion and disrupted biofilm formation. The best results were obtained in the pre-incubation assay for <i<L. gasseri</i< 1 and <i<L. paracasei</i< 11. Overall, <i<Lactobacillus</i< strains showed significant anti-<i<Candida</i< activity, and their biosurfactants exhibited considerable anti-adhesion and antibiofilm activity against <i<C. albicans</i<. To be considered safe for use in vivo, the safety of biosurfactant (BS) should be investigated using cytotoxicity assays. <i<Lactobacillus</i< biosurfactant production biofilm inhibition <i<Candida albicans</i< suppression <i<Lactobacillus</i< antivirulence vulvovaginal candidiasis Medicine R Yasmine Ramos França verfasserin aut Carmem Duarte Lima Campos verfasserin aut Maria Rosa Quaresma Bomfim verfasserin aut Bruna Oliveira Melo verfasserin aut Rodrigo Assunção Holanda verfasserin aut Vera Lucia Santos verfasserin aut Sílvio Gomes Monteiro verfasserin aut Eduardo Buozzi Moffa verfasserin aut Andrea Souza Monteiro verfasserin aut Cristina Andrade Monteiro verfasserin aut Valério Monteiro-Neto verfasserin aut In Pathogens MDPI AG, 2012 8(2019), 3, p 150 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:8 year:2019 number:3, p 150 https://doi.org/10.3390/pathogens8030150 kostenfrei https://doaj.org/article/fc82174fbcb04f91860cc3d79827e14e kostenfrei https://www.mdpi.com/2076-0817/8/3/150 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 3, p 150
allfields_unstemmed	10.3390/pathogens8030150 doi (DE-627)DOAJ025334743 (DE-599)DOAJfc82174fbcb04f91860cc3d79827e14e DE-627 ger DE-627 rakwb eng Camilla Itapary dos Santos verfasserin aut Antifungal and Antivirulence Activity of Vaginal <i<Lactobacillus</i< Spp. Products against <i<Candida</i< Vaginal Isolates 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Candida</i< yeasts are generally found in the vaginal microbiota; however, disruption of the balance maintained by host factors and microorganisms results in vulvovaginal candidiasis (VVC). This study evaluated the antagonistic activity of vaginal <i<Lactobacillus</i< spp. on <i<Candida albicans</i< to verify whether active compounds of <i<Lactobacillus</i< spp. had antifungal and antivirulence activity. The antagonism assay showed that 15 out of 20 <i<Lactobacillus</i< strains had an inhibitory effect on <i<C. albicans.</i< Biosurfactants displayed surface-tension-reducing activity, with the best value obtained for <i<Lactobacillus gasseri</i< 1. <i<Lactobacillus rhamnosus</i< ATCC 9595, <i<Lactobacillus acidophilus</i< ATCC 4356, and <i<Lactobacillus paracasei</i< 11 produced biosurfactants that decreased <i<C. albicans</i< adhesion and disrupted biofilm formation. The best results were obtained in the pre-incubation assay for <i<L. gasseri</i< 1 and <i<L. paracasei</i< 11. Overall, <i<Lactobacillus</i< strains showed significant anti-<i<Candida</i< activity, and their biosurfactants exhibited considerable anti-adhesion and antibiofilm activity against <i<C. albicans</i<. To be considered safe for use in vivo, the safety of biosurfactant (BS) should be investigated using cytotoxicity assays. <i<Lactobacillus</i< biosurfactant production biofilm inhibition <i<Candida albicans</i< suppression <i<Lactobacillus</i< antivirulence vulvovaginal candidiasis Medicine R Yasmine Ramos França verfasserin aut Carmem Duarte Lima Campos verfasserin aut Maria Rosa Quaresma Bomfim verfasserin aut Bruna Oliveira Melo verfasserin aut Rodrigo Assunção Holanda verfasserin aut Vera Lucia Santos verfasserin aut Sílvio Gomes Monteiro verfasserin aut Eduardo Buozzi Moffa verfasserin aut Andrea Souza Monteiro verfasserin aut Cristina Andrade Monteiro verfasserin aut Valério Monteiro-Neto verfasserin aut In Pathogens MDPI AG, 2012 8(2019), 3, p 150 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:8 year:2019 number:3, p 150 https://doi.org/10.3390/pathogens8030150 kostenfrei https://doaj.org/article/fc82174fbcb04f91860cc3d79827e14e kostenfrei https://www.mdpi.com/2076-0817/8/3/150 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 3, p 150
allfieldsGer	10.3390/pathogens8030150 doi (DE-627)DOAJ025334743 (DE-599)DOAJfc82174fbcb04f91860cc3d79827e14e DE-627 ger DE-627 rakwb eng Camilla Itapary dos Santos verfasserin aut Antifungal and Antivirulence Activity of Vaginal <i<Lactobacillus</i< Spp. Products against <i<Candida</i< Vaginal Isolates 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Candida</i< yeasts are generally found in the vaginal microbiota; however, disruption of the balance maintained by host factors and microorganisms results in vulvovaginal candidiasis (VVC). This study evaluated the antagonistic activity of vaginal <i<Lactobacillus</i< spp. on <i<Candida albicans</i< to verify whether active compounds of <i<Lactobacillus</i< spp. had antifungal and antivirulence activity. The antagonism assay showed that 15 out of 20 <i<Lactobacillus</i< strains had an inhibitory effect on <i<C. albicans.</i< Biosurfactants displayed surface-tension-reducing activity, with the best value obtained for <i<Lactobacillus gasseri</i< 1. <i<Lactobacillus rhamnosus</i< ATCC 9595, <i<Lactobacillus acidophilus</i< ATCC 4356, and <i<Lactobacillus paracasei</i< 11 produced biosurfactants that decreased <i<C. albicans</i< adhesion and disrupted biofilm formation. The best results were obtained in the pre-incubation assay for <i<L. gasseri</i< 1 and <i<L. paracasei</i< 11. Overall, <i<Lactobacillus</i< strains showed significant anti-<i<Candida</i< activity, and their biosurfactants exhibited considerable anti-adhesion and antibiofilm activity against <i<C. albicans</i<. To be considered safe for use in vivo, the safety of biosurfactant (BS) should be investigated using cytotoxicity assays. <i<Lactobacillus</i< biosurfactant production biofilm inhibition <i<Candida albicans</i< suppression <i<Lactobacillus</i< antivirulence vulvovaginal candidiasis Medicine R Yasmine Ramos França verfasserin aut Carmem Duarte Lima Campos verfasserin aut Maria Rosa Quaresma Bomfim verfasserin aut Bruna Oliveira Melo verfasserin aut Rodrigo Assunção Holanda verfasserin aut Vera Lucia Santos verfasserin aut Sílvio Gomes Monteiro verfasserin aut Eduardo Buozzi Moffa verfasserin aut Andrea Souza Monteiro verfasserin aut Cristina Andrade Monteiro verfasserin aut Valério Monteiro-Neto verfasserin aut In Pathogens MDPI AG, 2012 8(2019), 3, p 150 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:8 year:2019 number:3, p 150 https://doi.org/10.3390/pathogens8030150 kostenfrei https://doaj.org/article/fc82174fbcb04f91860cc3d79827e14e kostenfrei https://www.mdpi.com/2076-0817/8/3/150 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 3, p 150
allfieldsSound	10.3390/pathogens8030150 doi (DE-627)DOAJ025334743 (DE-599)DOAJfc82174fbcb04f91860cc3d79827e14e DE-627 ger DE-627 rakwb eng Camilla Itapary dos Santos verfasserin aut Antifungal and Antivirulence Activity of Vaginal <i<Lactobacillus</i< Spp. Products against <i<Candida</i< Vaginal Isolates 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Candida</i< yeasts are generally found in the vaginal microbiota; however, disruption of the balance maintained by host factors and microorganisms results in vulvovaginal candidiasis (VVC). This study evaluated the antagonistic activity of vaginal <i<Lactobacillus</i< spp. on <i<Candida albicans</i< to verify whether active compounds of <i<Lactobacillus</i< spp. had antifungal and antivirulence activity. The antagonism assay showed that 15 out of 20 <i<Lactobacillus</i< strains had an inhibitory effect on <i<C. albicans.</i< Biosurfactants displayed surface-tension-reducing activity, with the best value obtained for <i<Lactobacillus gasseri</i< 1. <i<Lactobacillus rhamnosus</i< ATCC 9595, <i<Lactobacillus acidophilus</i< ATCC 4356, and <i<Lactobacillus paracasei</i< 11 produced biosurfactants that decreased <i<C. albicans</i< adhesion and disrupted biofilm formation. The best results were obtained in the pre-incubation assay for <i<L. gasseri</i< 1 and <i<L. paracasei</i< 11. Overall, <i<Lactobacillus</i< strains showed significant anti-<i<Candida</i< activity, and their biosurfactants exhibited considerable anti-adhesion and antibiofilm activity against <i<C. albicans</i<. To be considered safe for use in vivo, the safety of biosurfactant (BS) should be investigated using cytotoxicity assays. <i<Lactobacillus</i< biosurfactant production biofilm inhibition <i<Candida albicans</i< suppression <i<Lactobacillus</i< antivirulence vulvovaginal candidiasis Medicine R Yasmine Ramos França verfasserin aut Carmem Duarte Lima Campos verfasserin aut Maria Rosa Quaresma Bomfim verfasserin aut Bruna Oliveira Melo verfasserin aut Rodrigo Assunção Holanda verfasserin aut Vera Lucia Santos verfasserin aut Sílvio Gomes Monteiro verfasserin aut Eduardo Buozzi Moffa verfasserin aut Andrea Souza Monteiro verfasserin aut Cristina Andrade Monteiro verfasserin aut Valério Monteiro-Neto verfasserin aut In Pathogens MDPI AG, 2012 8(2019), 3, p 150 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:8 year:2019 number:3, p 150 https://doi.org/10.3390/pathogens8030150 kostenfrei https://doaj.org/article/fc82174fbcb04f91860cc3d79827e14e kostenfrei https://www.mdpi.com/2076-0817/8/3/150 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 3, p 150
language	English
source	In Pathogens 8(2019), 3, p 150 volume:8 year:2019 number:3, p 150
sourceStr	In Pathogens 8(2019), 3, p 150 volume:8 year:2019 number:3, p 150
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	<i<Lactobacillus</i< biosurfactant production biofilm inhibition <i<Candida albicans</i< suppression <i<Lactobacillus</i< antivirulence vulvovaginal candidiasis Medicine R
isfreeaccess_bool	true
container_title	Pathogens
authorswithroles_txt_mv	Camilla Itapary dos Santos @@aut@@ Yasmine Ramos França @@aut@@ Carmem Duarte Lima Campos @@aut@@ Maria Rosa Quaresma Bomfim @@aut@@ Bruna Oliveira Melo @@aut@@ Rodrigo Assunção Holanda @@aut@@ Vera Lucia Santos @@aut@@ Sílvio Gomes Monteiro @@aut@@ Eduardo Buozzi Moffa @@aut@@ Andrea Souza Monteiro @@aut@@ Cristina Andrade Monteiro @@aut@@ Valério Monteiro-Neto @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	732627885
id	DOAJ025334743
language_de	englisch
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author	Camilla Itapary dos Santos
spellingShingle	Camilla Itapary dos Santos misc <i<Lactobacillus</i< biosurfactant production misc biofilm inhibition misc <i<Candida albicans</i< suppression misc <i<Lactobacillus</i< antivirulence misc vulvovaginal candidiasis misc Medicine misc R Antifungal and Antivirulence Activity of Vaginal <i<Lactobacillus</i< Spp. Products against <i<Candida</i< Vaginal Isolates
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topic_title	Antifungal and Antivirulence Activity of Vaginal <i<Lactobacillus</i< Spp. Products against <i<Candida</i< Vaginal Isolates <i<Lactobacillus</i< biosurfactant production biofilm inhibition <i<Candida albicans</i< suppression <i<Lactobacillus</i< antivirulence vulvovaginal candidiasis
topic	misc <i<Lactobacillus</i< biosurfactant production misc biofilm inhibition misc <i<Candida albicans</i< suppression misc <i<Lactobacillus</i< antivirulence misc vulvovaginal candidiasis misc Medicine misc R
topic_unstemmed	misc <i<Lactobacillus</i< biosurfactant production misc biofilm inhibition misc <i<Candida albicans</i< suppression misc <i<Lactobacillus</i< antivirulence misc vulvovaginal candidiasis misc Medicine misc R
topic_browse	misc <i<Lactobacillus</i< biosurfactant production misc biofilm inhibition misc <i<Candida albicans</i< suppression misc <i<Lactobacillus</i< antivirulence misc vulvovaginal candidiasis misc Medicine misc R
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title	Antifungal and Antivirulence Activity of Vaginal <i<Lactobacillus</i< Spp. Products against <i<Candida</i< Vaginal Isolates
ctrlnum	(DE-627)DOAJ025334743 (DE-599)DOAJfc82174fbcb04f91860cc3d79827e14e
title_full	Antifungal and Antivirulence Activity of Vaginal <i<Lactobacillus</i< Spp. Products against <i<Candida</i< Vaginal Isolates
author_sort	Camilla Itapary dos Santos
journal	Pathogens
journalStr	Pathogens
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author_browse	Camilla Itapary dos Santos Yasmine Ramos França Carmem Duarte Lima Campos Maria Rosa Quaresma Bomfim Bruna Oliveira Melo Rodrigo Assunção Holanda Vera Lucia Santos Sílvio Gomes Monteiro Eduardo Buozzi Moffa Andrea Souza Monteiro Cristina Andrade Monteiro Valério Monteiro-Neto
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author-letter	Camilla Itapary dos Santos
doi_str_mv	10.3390/pathogens8030150
author2-role	verfasserin
title_sort	antifungal and antivirulence activity of vaginal <i<lactobacillus</i< spp. products against <i<candida</i< vaginal isolates
title_auth	Antifungal and Antivirulence Activity of Vaginal <i<Lactobacillus</i< Spp. Products against <i<Candida</i< Vaginal Isolates
abstract	<i<Candida</i< yeasts are generally found in the vaginal microbiota; however, disruption of the balance maintained by host factors and microorganisms results in vulvovaginal candidiasis (VVC). This study evaluated the antagonistic activity of vaginal <i<Lactobacillus</i< spp. on <i<Candida albicans</i< to verify whether active compounds of <i<Lactobacillus</i< spp. had antifungal and antivirulence activity. The antagonism assay showed that 15 out of 20 <i<Lactobacillus</i< strains had an inhibitory effect on <i<C. albicans.</i< Biosurfactants displayed surface-tension-reducing activity, with the best value obtained for <i<Lactobacillus gasseri</i< 1. <i<Lactobacillus rhamnosus</i< ATCC 9595, <i<Lactobacillus acidophilus</i< ATCC 4356, and <i<Lactobacillus paracasei</i< 11 produced biosurfactants that decreased <i<C. albicans</i< adhesion and disrupted biofilm formation. The best results were obtained in the pre-incubation assay for <i<L. gasseri</i< 1 and <i<L. paracasei</i< 11. Overall, <i<Lactobacillus</i< strains showed significant anti-<i<Candida</i< activity, and their biosurfactants exhibited considerable anti-adhesion and antibiofilm activity against <i<C. albicans</i<. To be considered safe for use in vivo, the safety of biosurfactant (BS) should be investigated using cytotoxicity assays.
abstractGer	<i<Candida</i< yeasts are generally found in the vaginal microbiota; however, disruption of the balance maintained by host factors and microorganisms results in vulvovaginal candidiasis (VVC). This study evaluated the antagonistic activity of vaginal <i<Lactobacillus</i< spp. on <i<Candida albicans</i< to verify whether active compounds of <i<Lactobacillus</i< spp. had antifungal and antivirulence activity. The antagonism assay showed that 15 out of 20 <i<Lactobacillus</i< strains had an inhibitory effect on <i<C. albicans.</i< Biosurfactants displayed surface-tension-reducing activity, with the best value obtained for <i<Lactobacillus gasseri</i< 1. <i<Lactobacillus rhamnosus</i< ATCC 9595, <i<Lactobacillus acidophilus</i< ATCC 4356, and <i<Lactobacillus paracasei</i< 11 produced biosurfactants that decreased <i<C. albicans</i< adhesion and disrupted biofilm formation. The best results were obtained in the pre-incubation assay for <i<L. gasseri</i< 1 and <i<L. paracasei</i< 11. Overall, <i<Lactobacillus</i< strains showed significant anti-<i<Candida</i< activity, and their biosurfactants exhibited considerable anti-adhesion and antibiofilm activity against <i<C. albicans</i<. To be considered safe for use in vivo, the safety of biosurfactant (BS) should be investigated using cytotoxicity assays.
abstract_unstemmed	<i<Candida</i< yeasts are generally found in the vaginal microbiota; however, disruption of the balance maintained by host factors and microorganisms results in vulvovaginal candidiasis (VVC). This study evaluated the antagonistic activity of vaginal <i<Lactobacillus</i< spp. on <i<Candida albicans</i< to verify whether active compounds of <i<Lactobacillus</i< spp. had antifungal and antivirulence activity. The antagonism assay showed that 15 out of 20 <i<Lactobacillus</i< strains had an inhibitory effect on <i<C. albicans.</i< Biosurfactants displayed surface-tension-reducing activity, with the best value obtained for <i<Lactobacillus gasseri</i< 1. <i<Lactobacillus rhamnosus</i< ATCC 9595, <i<Lactobacillus acidophilus</i< ATCC 4356, and <i<Lactobacillus paracasei</i< 11 produced biosurfactants that decreased <i<C. albicans</i< adhesion and disrupted biofilm formation. The best results were obtained in the pre-incubation assay for <i<L. gasseri</i< 1 and <i<L. paracasei</i< 11. Overall, <i<Lactobacillus</i< strains showed significant anti-<i<Candida</i< activity, and their biosurfactants exhibited considerable anti-adhesion and antibiofilm activity against <i<C. albicans</i<. To be considered safe for use in vivo, the safety of biosurfactant (BS) should be investigated using cytotoxicity assays.
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container_issue	3, p 150
title_short	Antifungal and Antivirulence Activity of Vaginal <i<Lactobacillus</i< Spp. Products against <i<Candida</i< Vaginal Isolates
url	https://doi.org/10.3390/pathogens8030150 https://doaj.org/article/fc82174fbcb04f91860cc3d79827e14e https://www.mdpi.com/2076-0817/8/3/150 https://doaj.org/toc/2076-0817
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author2	Yasmine Ramos França Carmem Duarte Lima Campos Maria Rosa Quaresma Bomfim Bruna Oliveira Melo Rodrigo Assunção Holanda Vera Lucia Santos Sílvio Gomes Monteiro Eduardo Buozzi Moffa Andrea Souza Monteiro Cristina Andrade Monteiro Valério Monteiro-Neto
author2Str	Yasmine Ramos França Carmem Duarte Lima Campos Maria Rosa Quaresma Bomfim Bruna Oliveira Melo Rodrigo Assunção Holanda Vera Lucia Santos Sílvio Gomes Monteiro Eduardo Buozzi Moffa Andrea Souza Monteiro Cristina Andrade Monteiro Valério Monteiro-Neto
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doi_str	10.3390/pathogens8030150
up_date	2024-07-03T14:23:48.323Z
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