Reviving the RNA world: An insight into the appearance of RNA methyltransferases

RNA, the earliest genetic and catalytic molecule, has a relatively delicate and labile chemical structure, when compared to DNA. It is prone to be damaged by alkali, heat, nucleases or stress conditions. One mechanism to protect RNA or DNA from damage is through site-specific methylation. Here, we p...
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Autor*in:	Ajay Kumar Rana [verfasserIn] Serge eAnkri [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	DNA Methylation RNA world RNA methylation Evolution. RNA-DNA transition

Übergeordnetes Werk:	In: Frontiers in Genetics - Frontiers Media S.A., 2011, 7(2016)
Übergeordnetes Werk:	volume:7 ; year:2016

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fgene.2016.00099

Katalog-ID:	DOAJ025420755

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callnumber-first	Q - Science
author	Ajay Kumar Rana
spellingShingle	Ajay Kumar Rana misc QH426-470 misc DNA Methylation misc RNA world misc RNA methylation misc Evolution. misc RNA-DNA transition misc Genetics Reviving the RNA world: An insight into the appearance of RNA methyltransferases
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topic_title	QH426-470 Reviving the RNA world: An insight into the appearance of RNA methyltransferases DNA Methylation RNA world RNA methylation Evolution RNA-DNA transition
topic	misc QH426-470 misc DNA Methylation misc RNA world misc RNA methylation misc Evolution. misc RNA-DNA transition misc Genetics
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title_sort	reviving the rna world: an insight into the appearance of rna methyltransferases
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title_auth	Reviving the RNA world: An insight into the appearance of RNA methyltransferases
abstract	RNA, the earliest genetic and catalytic molecule, has a relatively delicate and labile chemical structure, when compared to DNA. It is prone to be damaged by alkali, heat, nucleases or stress conditions. One mechanism to protect RNA or DNA from damage is through site-specific methylation. Here, we propose that RNA methylation began prior to DNA methylation in the early forms of life evolving on Earth. In this article, the biochemical properties of some RNA methyltransferases (MTases), such as 2’-O-MTases (Rlml/RlmN), spOUT MTases and the NSun2 MTases are dissected for the insight they provide on the transition from an RNA world to our present RNA/DNA/protein world.
abstractGer	RNA, the earliest genetic and catalytic molecule, has a relatively delicate and labile chemical structure, when compared to DNA. It is prone to be damaged by alkali, heat, nucleases or stress conditions. One mechanism to protect RNA or DNA from damage is through site-specific methylation. Here, we propose that RNA methylation began prior to DNA methylation in the early forms of life evolving on Earth. In this article, the biochemical properties of some RNA methyltransferases (MTases), such as 2’-O-MTases (Rlml/RlmN), spOUT MTases and the NSun2 MTases are dissected for the insight they provide on the transition from an RNA world to our present RNA/DNA/protein world.
abstract_unstemmed	RNA, the earliest genetic and catalytic molecule, has a relatively delicate and labile chemical structure, when compared to DNA. It is prone to be damaged by alkali, heat, nucleases or stress conditions. One mechanism to protect RNA or DNA from damage is through site-specific methylation. Here, we propose that RNA methylation began prior to DNA methylation in the early forms of life evolving on Earth. In this article, the biochemical properties of some RNA methyltransferases (MTases), such as 2’-O-MTases (Rlml/RlmN), spOUT MTases and the NSun2 MTases are dissected for the insight they provide on the transition from an RNA world to our present RNA/DNA/protein world.
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title_short	Reviving the RNA world: An insight into the appearance of RNA methyltransferases
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