A novel circular RNA, hsa_circ_0043278, acts as a potential biomarker and promotes non-small cell lung cancer cell proliferation and migration by regulating miR-520f

More and more circular RNAs (circRNAs) revealed to play a critical role in the initiation and progression of cancer, however, the effects of circRNAs on non-small cell lung cancer (NSCLC) remain largely undetermined. In the present study, we screened the dysregulated circRNAs in paired NSCLC and nor...
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Autor*in:	Jinggang Cui [verfasserIn] Wei Li [verfasserIn] Guohua Liu [verfasserIn] Xiaojun Chen [verfasserIn] Xiaolai Gao [verfasserIn] Huiling Lu [verfasserIn] Dang Lin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Non-small cell lung cancer circ_0043278 miR-520f proliferation invasion migration

Übergeordnetes Werk:	In: Artificial Cells, Nanomedicine, and Biotechnology - Taylor & Francis Group, 2019, 47(2019), 1, Seite 810-821
Übergeordnetes Werk:	volume:47 ; year:2019 ; number:1 ; pages:810-821

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/21691401.2019.1575847

Katalog-ID:	DOAJ025527312

Internformat


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author_variant	j c jc w l wl g l gl x c xc x g xg h l hl d l dl
matchkey_str	article:2169141X:2019----::nvliclrnhacr_037ataaoetaboakrnpooennmlcllncneclpoie
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allfields	10.1080/21691401.2019.1575847 doi (DE-627)DOAJ025527312 (DE-599)DOAJ5d546b75bde44b98b78582d9cf1b1cd3 DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Jinggang Cui verfasserin aut A novel circular RNA, hsa_circ_0043278, acts as a potential biomarker and promotes non-small cell lung cancer cell proliferation and migration by regulating miR-520f 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier More and more circular RNAs (circRNAs) revealed to play a critical role in the initiation and progression of cancer, however, the effects of circRNAs on non-small cell lung cancer (NSCLC) remain largely undetermined. In the present study, we screened the dysregulated circRNAs in paired NSCLC and normal samples from GEO database and identified circ_0043278 was to be significantly up-regulated in NSCLC and demonstrated it promotes NSCLC progression in vitro and in vivo. Then, we revealed the expression of miR-520f, a downstream factor of circ_0043278, was significantly down-regulated in NSCLC and acted as a tumor inhibitor. In addition, we revealed that circ_0043278 sponged miR-520f, which was demonstrated to target ROCK1, CDKN1B, and AKT3 in NSCLC cells. In conclusion, circ_0043278 promoted NSCLC cell proliferation, invasion, and migration by increasing ROCK1, CDKN1B, and AKT3 expressions through direct inhibition of miR-520f. Non-small cell lung cancer circ_0043278 miR-520f proliferation invasion migration Biotechnology Medical technology Wei Li verfasserin aut Guohua Liu verfasserin aut Xiaojun Chen verfasserin aut Xiaolai Gao verfasserin aut Huiling Lu verfasserin aut Dang Lin verfasserin aut In Artificial Cells, Nanomedicine, and Biotechnology Taylor & Francis Group, 2019 47(2019), 1, Seite 810-821 (DE-627)742222489 (DE-600)2711415-6 2169141X nnns volume:47 year:2019 number:1 pages:810-821 https://doi.org/10.1080/21691401.2019.1575847 kostenfrei https://doaj.org/article/5d546b75bde44b98b78582d9cf1b1cd3 kostenfrei https://www.tandfonline.com/doi/10.1080/21691401.2019.1575847 kostenfrei https://doaj.org/toc/2169-1401 Journal toc kostenfrei https://doaj.org/toc/2169-141X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 47 2019 1 810-821
spelling	10.1080/21691401.2019.1575847 doi (DE-627)DOAJ025527312 (DE-599)DOAJ5d546b75bde44b98b78582d9cf1b1cd3 DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Jinggang Cui verfasserin aut A novel circular RNA, hsa_circ_0043278, acts as a potential biomarker and promotes non-small cell lung cancer cell proliferation and migration by regulating miR-520f 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier More and more circular RNAs (circRNAs) revealed to play a critical role in the initiation and progression of cancer, however, the effects of circRNAs on non-small cell lung cancer (NSCLC) remain largely undetermined. In the present study, we screened the dysregulated circRNAs in paired NSCLC and normal samples from GEO database and identified circ_0043278 was to be significantly up-regulated in NSCLC and demonstrated it promotes NSCLC progression in vitro and in vivo. Then, we revealed the expression of miR-520f, a downstream factor of circ_0043278, was significantly down-regulated in NSCLC and acted as a tumor inhibitor. In addition, we revealed that circ_0043278 sponged miR-520f, which was demonstrated to target ROCK1, CDKN1B, and AKT3 in NSCLC cells. In conclusion, circ_0043278 promoted NSCLC cell proliferation, invasion, and migration by increasing ROCK1, CDKN1B, and AKT3 expressions through direct inhibition of miR-520f. Non-small cell lung cancer circ_0043278 miR-520f proliferation invasion migration Biotechnology Medical technology Wei Li verfasserin aut Guohua Liu verfasserin aut Xiaojun Chen verfasserin aut Xiaolai Gao verfasserin aut Huiling Lu verfasserin aut Dang Lin verfasserin aut In Artificial Cells, Nanomedicine, and Biotechnology Taylor & Francis Group, 2019 47(2019), 1, Seite 810-821 (DE-627)742222489 (DE-600)2711415-6 2169141X nnns volume:47 year:2019 number:1 pages:810-821 https://doi.org/10.1080/21691401.2019.1575847 kostenfrei https://doaj.org/article/5d546b75bde44b98b78582d9cf1b1cd3 kostenfrei https://www.tandfonline.com/doi/10.1080/21691401.2019.1575847 kostenfrei https://doaj.org/toc/2169-1401 Journal toc kostenfrei https://doaj.org/toc/2169-141X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 47 2019 1 810-821
allfields_unstemmed	10.1080/21691401.2019.1575847 doi (DE-627)DOAJ025527312 (DE-599)DOAJ5d546b75bde44b98b78582d9cf1b1cd3 DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Jinggang Cui verfasserin aut A novel circular RNA, hsa_circ_0043278, acts as a potential biomarker and promotes non-small cell lung cancer cell proliferation and migration by regulating miR-520f 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier More and more circular RNAs (circRNAs) revealed to play a critical role in the initiation and progression of cancer, however, the effects of circRNAs on non-small cell lung cancer (NSCLC) remain largely undetermined. In the present study, we screened the dysregulated circRNAs in paired NSCLC and normal samples from GEO database and identified circ_0043278 was to be significantly up-regulated in NSCLC and demonstrated it promotes NSCLC progression in vitro and in vivo. Then, we revealed the expression of miR-520f, a downstream factor of circ_0043278, was significantly down-regulated in NSCLC and acted as a tumor inhibitor. In addition, we revealed that circ_0043278 sponged miR-520f, which was demonstrated to target ROCK1, CDKN1B, and AKT3 in NSCLC cells. In conclusion, circ_0043278 promoted NSCLC cell proliferation, invasion, and migration by increasing ROCK1, CDKN1B, and AKT3 expressions through direct inhibition of miR-520f. Non-small cell lung cancer circ_0043278 miR-520f proliferation invasion migration Biotechnology Medical technology Wei Li verfasserin aut Guohua Liu verfasserin aut Xiaojun Chen verfasserin aut Xiaolai Gao verfasserin aut Huiling Lu verfasserin aut Dang Lin verfasserin aut In Artificial Cells, Nanomedicine, and Biotechnology Taylor & Francis Group, 2019 47(2019), 1, Seite 810-821 (DE-627)742222489 (DE-600)2711415-6 2169141X nnns volume:47 year:2019 number:1 pages:810-821 https://doi.org/10.1080/21691401.2019.1575847 kostenfrei https://doaj.org/article/5d546b75bde44b98b78582d9cf1b1cd3 kostenfrei https://www.tandfonline.com/doi/10.1080/21691401.2019.1575847 kostenfrei https://doaj.org/toc/2169-1401 Journal toc kostenfrei https://doaj.org/toc/2169-141X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 47 2019 1 810-821
allfieldsGer	10.1080/21691401.2019.1575847 doi (DE-627)DOAJ025527312 (DE-599)DOAJ5d546b75bde44b98b78582d9cf1b1cd3 DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Jinggang Cui verfasserin aut A novel circular RNA, hsa_circ_0043278, acts as a potential biomarker and promotes non-small cell lung cancer cell proliferation and migration by regulating miR-520f 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier More and more circular RNAs (circRNAs) revealed to play a critical role in the initiation and progression of cancer, however, the effects of circRNAs on non-small cell lung cancer (NSCLC) remain largely undetermined. In the present study, we screened the dysregulated circRNAs in paired NSCLC and normal samples from GEO database and identified circ_0043278 was to be significantly up-regulated in NSCLC and demonstrated it promotes NSCLC progression in vitro and in vivo. Then, we revealed the expression of miR-520f, a downstream factor of circ_0043278, was significantly down-regulated in NSCLC and acted as a tumor inhibitor. In addition, we revealed that circ_0043278 sponged miR-520f, which was demonstrated to target ROCK1, CDKN1B, and AKT3 in NSCLC cells. In conclusion, circ_0043278 promoted NSCLC cell proliferation, invasion, and migration by increasing ROCK1, CDKN1B, and AKT3 expressions through direct inhibition of miR-520f. Non-small cell lung cancer circ_0043278 miR-520f proliferation invasion migration Biotechnology Medical technology Wei Li verfasserin aut Guohua Liu verfasserin aut Xiaojun Chen verfasserin aut Xiaolai Gao verfasserin aut Huiling Lu verfasserin aut Dang Lin verfasserin aut In Artificial Cells, Nanomedicine, and Biotechnology Taylor & Francis Group, 2019 47(2019), 1, Seite 810-821 (DE-627)742222489 (DE-600)2711415-6 2169141X nnns volume:47 year:2019 number:1 pages:810-821 https://doi.org/10.1080/21691401.2019.1575847 kostenfrei https://doaj.org/article/5d546b75bde44b98b78582d9cf1b1cd3 kostenfrei https://www.tandfonline.com/doi/10.1080/21691401.2019.1575847 kostenfrei https://doaj.org/toc/2169-1401 Journal toc kostenfrei https://doaj.org/toc/2169-141X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 47 2019 1 810-821
allfieldsSound	10.1080/21691401.2019.1575847 doi (DE-627)DOAJ025527312 (DE-599)DOAJ5d546b75bde44b98b78582d9cf1b1cd3 DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Jinggang Cui verfasserin aut A novel circular RNA, hsa_circ_0043278, acts as a potential biomarker and promotes non-small cell lung cancer cell proliferation and migration by regulating miR-520f 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier More and more circular RNAs (circRNAs) revealed to play a critical role in the initiation and progression of cancer, however, the effects of circRNAs on non-small cell lung cancer (NSCLC) remain largely undetermined. In the present study, we screened the dysregulated circRNAs in paired NSCLC and normal samples from GEO database and identified circ_0043278 was to be significantly up-regulated in NSCLC and demonstrated it promotes NSCLC progression in vitro and in vivo. Then, we revealed the expression of miR-520f, a downstream factor of circ_0043278, was significantly down-regulated in NSCLC and acted as a tumor inhibitor. In addition, we revealed that circ_0043278 sponged miR-520f, which was demonstrated to target ROCK1, CDKN1B, and AKT3 in NSCLC cells. In conclusion, circ_0043278 promoted NSCLC cell proliferation, invasion, and migration by increasing ROCK1, CDKN1B, and AKT3 expressions through direct inhibition of miR-520f. Non-small cell lung cancer circ_0043278 miR-520f proliferation invasion migration Biotechnology Medical technology Wei Li verfasserin aut Guohua Liu verfasserin aut Xiaojun Chen verfasserin aut Xiaolai Gao verfasserin aut Huiling Lu verfasserin aut Dang Lin verfasserin aut In Artificial Cells, Nanomedicine, and Biotechnology Taylor & Francis Group, 2019 47(2019), 1, Seite 810-821 (DE-627)742222489 (DE-600)2711415-6 2169141X nnns volume:47 year:2019 number:1 pages:810-821 https://doi.org/10.1080/21691401.2019.1575847 kostenfrei https://doaj.org/article/5d546b75bde44b98b78582d9cf1b1cd3 kostenfrei https://www.tandfonline.com/doi/10.1080/21691401.2019.1575847 kostenfrei https://doaj.org/toc/2169-1401 Journal toc kostenfrei https://doaj.org/toc/2169-141X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 47 2019 1 810-821
language	English
source	In Artificial Cells, Nanomedicine, and Biotechnology 47(2019), 1, Seite 810-821 volume:47 year:2019 number:1 pages:810-821
sourceStr	In Artificial Cells, Nanomedicine, and Biotechnology 47(2019), 1, Seite 810-821 volume:47 year:2019 number:1 pages:810-821
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Non-small cell lung cancer circ_0043278 miR-520f proliferation invasion migration Biotechnology Medical technology
isfreeaccess_bool	true
container_title	Artificial Cells, Nanomedicine, and Biotechnology
authorswithroles_txt_mv	Jinggang Cui @@aut@@ Wei Li @@aut@@ Guohua Liu @@aut@@ Xiaojun Chen @@aut@@ Xiaolai Gao @@aut@@ Huiling Lu @@aut@@ Dang Lin @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	742222489
id	DOAJ025527312
language_de	englisch
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callnumber-first	T - Technology
author	Jinggang Cui
spellingShingle	Jinggang Cui misc TP248.13-248.65 misc R855-855.5 misc Non-small cell lung cancer misc circ_0043278 misc miR-520f misc proliferation misc invasion misc migration misc Biotechnology misc Medical technology A novel circular RNA, hsa_circ_0043278, acts as a potential biomarker and promotes non-small cell lung cancer cell proliferation and migration by regulating miR-520f
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topic_title	TP248.13-248.65 R855-855.5 A novel circular RNA, hsa_circ_0043278, acts as a potential biomarker and promotes non-small cell lung cancer cell proliferation and migration by regulating miR-520f Non-small cell lung cancer circ_0043278 miR-520f proliferation invasion migration
topic	misc TP248.13-248.65 misc R855-855.5 misc Non-small cell lung cancer misc circ_0043278 misc miR-520f misc proliferation misc invasion misc migration misc Biotechnology misc Medical technology
topic_unstemmed	misc TP248.13-248.65 misc R855-855.5 misc Non-small cell lung cancer misc circ_0043278 misc miR-520f misc proliferation misc invasion misc migration misc Biotechnology misc Medical technology
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title	A novel circular RNA, hsa_circ_0043278, acts as a potential biomarker and promotes non-small cell lung cancer cell proliferation and migration by regulating miR-520f
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title_full	A novel circular RNA, hsa_circ_0043278, acts as a potential biomarker and promotes non-small cell lung cancer cell proliferation and migration by regulating miR-520f
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author_browse	Jinggang Cui Wei Li Guohua Liu Xiaojun Chen Xiaolai Gao Huiling Lu Dang Lin
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title_sort	novel circular rna, hsa_circ_0043278, acts as a potential biomarker and promotes non-small cell lung cancer cell proliferation and migration by regulating mir-520f
callnumber	TP248.13-248.65
title_auth	A novel circular RNA, hsa_circ_0043278, acts as a potential biomarker and promotes non-small cell lung cancer cell proliferation and migration by regulating miR-520f
abstract	More and more circular RNAs (circRNAs) revealed to play a critical role in the initiation and progression of cancer, however, the effects of circRNAs on non-small cell lung cancer (NSCLC) remain largely undetermined. In the present study, we screened the dysregulated circRNAs in paired NSCLC and normal samples from GEO database and identified circ_0043278 was to be significantly up-regulated in NSCLC and demonstrated it promotes NSCLC progression in vitro and in vivo. Then, we revealed the expression of miR-520f, a downstream factor of circ_0043278, was significantly down-regulated in NSCLC and acted as a tumor inhibitor. In addition, we revealed that circ_0043278 sponged miR-520f, which was demonstrated to target ROCK1, CDKN1B, and AKT3 in NSCLC cells. In conclusion, circ_0043278 promoted NSCLC cell proliferation, invasion, and migration by increasing ROCK1, CDKN1B, and AKT3 expressions through direct inhibition of miR-520f.
abstractGer	More and more circular RNAs (circRNAs) revealed to play a critical role in the initiation and progression of cancer, however, the effects of circRNAs on non-small cell lung cancer (NSCLC) remain largely undetermined. In the present study, we screened the dysregulated circRNAs in paired NSCLC and normal samples from GEO database and identified circ_0043278 was to be significantly up-regulated in NSCLC and demonstrated it promotes NSCLC progression in vitro and in vivo. Then, we revealed the expression of miR-520f, a downstream factor of circ_0043278, was significantly down-regulated in NSCLC and acted as a tumor inhibitor. In addition, we revealed that circ_0043278 sponged miR-520f, which was demonstrated to target ROCK1, CDKN1B, and AKT3 in NSCLC cells. In conclusion, circ_0043278 promoted NSCLC cell proliferation, invasion, and migration by increasing ROCK1, CDKN1B, and AKT3 expressions through direct inhibition of miR-520f.
abstract_unstemmed	More and more circular RNAs (circRNAs) revealed to play a critical role in the initiation and progression of cancer, however, the effects of circRNAs on non-small cell lung cancer (NSCLC) remain largely undetermined. In the present study, we screened the dysregulated circRNAs in paired NSCLC and normal samples from GEO database and identified circ_0043278 was to be significantly up-regulated in NSCLC and demonstrated it promotes NSCLC progression in vitro and in vivo. Then, we revealed the expression of miR-520f, a downstream factor of circ_0043278, was significantly down-regulated in NSCLC and acted as a tumor inhibitor. In addition, we revealed that circ_0043278 sponged miR-520f, which was demonstrated to target ROCK1, CDKN1B, and AKT3 in NSCLC cells. In conclusion, circ_0043278 promoted NSCLC cell proliferation, invasion, and migration by increasing ROCK1, CDKN1B, and AKT3 expressions through direct inhibition of miR-520f.
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title_short	A novel circular RNA, hsa_circ_0043278, acts as a potential biomarker and promotes non-small cell lung cancer cell proliferation and migration by regulating miR-520f
url	https://doi.org/10.1080/21691401.2019.1575847 https://doaj.org/article/5d546b75bde44b98b78582d9cf1b1cd3 https://www.tandfonline.com/doi/10.1080/21691401.2019.1575847 https://doaj.org/toc/2169-1401 https://doaj.org/toc/2169-141X
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A novel circular RNA, hsa_circ_0043278, acts as a potential biomarker and promotes non-small cell lung cancer cell proliferation and migration by regulating miR-520f

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