The effects of T4 and A3R bacteriophages on differentiation of human myeloid dendritic cells

Bacteriophages (phages) are viruses of bacteria. Here we evaluated the effects of T4 and A3R bacteriophages, as well as phage-generated bacterial lysates, on differentiation of human myeloid dendritic cells (DCs) from monocytes. Neither of the phages significantly reduced the expression of markers a...
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Gespeichert in:

Autor*in:	Katarzyna Bocian [verfasserIn] Jan Borysowski [verfasserIn] Michał Zarzycki [verfasserIn] Magdalena Pacek [verfasserIn] Beata Weber-Dąbrowska [verfasserIn] Maja Machcińska [verfasserIn] Grażyna Korczak-Kowalska [verfasserIn] Andrzej Górski [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	dendritic cell differentiation Bacteriophage phage therapy T4 A3R

Übergeordnetes Werk:	In: Frontiers in Microbiology - Frontiers Media S.A., 2011, 7(2016)
Übergeordnetes Werk:	volume:7 ; year:2016

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fmicb.2016.01267

Katalog-ID:	DOAJ025609599

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spelling	10.3389/fmicb.2016.01267 doi (DE-627)DOAJ025609599 (DE-599)DOAJ74cc268100434d5d9c0d47949a06ef3c DE-627 ger DE-627 rakwb eng QR1-502 Katarzyna Bocian verfasserin aut The effects of T4 and A3R bacteriophages on differentiation of human myeloid dendritic cells 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bacteriophages (phages) are viruses of bacteria. Here we evaluated the effects of T4 and A3R bacteriophages, as well as phage-generated bacterial lysates, on differentiation of human myeloid dendritic cells (DCs) from monocytes. Neither of the phages significantly reduced the expression of markers associated with differentiation of DCs and their role in the activation of T cells (CD40, CD80, CD83, CD86, CD1c, CD11c, MHC II, PD-L1, PD-L2, TLR2, TLR4, and CCR7) and phagocytosis receptors (CD64 and DEC-205). By contrast, bacterial lysate of T4 phage significantly decreased the percentages of DEC-205- and CD1c-positive cells. The percentage of DEC-205-positive cells was also significantly reduced in DCs differentiated in the presence of lysate of A3R phage. Thus while bacteriophages do not substantially affect differentiation of DCs, some products of phage-induced lysis of bacterial cells may influence the differentiation and potentially also some functions of DCs. Our results have important implications for phage therapy of bacterial infections because during infections monocytes recruited to the site of inflammation are an important source of inflammatory DCs. dendritic cell differentiation Bacteriophage phage therapy T4 A3R Microbiology Jan Borysowski verfasserin aut Michał Zarzycki verfasserin aut Magdalena Pacek verfasserin aut Beata Weber-Dąbrowska verfasserin aut Maja Machcińska verfasserin aut Grażyna Korczak-Kowalska verfasserin aut Grażyna Korczak-Kowalska verfasserin aut Andrzej Górski verfasserin aut Andrzej Górski verfasserin aut In Frontiers in Microbiology Frontiers Media S.A., 2011 7(2016) (DE-627)642889384 (DE-600)2587354-4 1664302X nnns volume:7 year:2016 https://doi.org/10.3389/fmicb.2016.01267 kostenfrei https://doaj.org/article/74cc268100434d5d9c0d47949a06ef3c kostenfrei http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01267/full kostenfrei https://doaj.org/toc/1664-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016
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allfieldsGer	10.3389/fmicb.2016.01267 doi (DE-627)DOAJ025609599 (DE-599)DOAJ74cc268100434d5d9c0d47949a06ef3c DE-627 ger DE-627 rakwb eng QR1-502 Katarzyna Bocian verfasserin aut The effects of T4 and A3R bacteriophages on differentiation of human myeloid dendritic cells 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bacteriophages (phages) are viruses of bacteria. Here we evaluated the effects of T4 and A3R bacteriophages, as well as phage-generated bacterial lysates, on differentiation of human myeloid dendritic cells (DCs) from monocytes. Neither of the phages significantly reduced the expression of markers associated with differentiation of DCs and their role in the activation of T cells (CD40, CD80, CD83, CD86, CD1c, CD11c, MHC II, PD-L1, PD-L2, TLR2, TLR4, and CCR7) and phagocytosis receptors (CD64 and DEC-205). By contrast, bacterial lysate of T4 phage significantly decreased the percentages of DEC-205- and CD1c-positive cells. The percentage of DEC-205-positive cells was also significantly reduced in DCs differentiated in the presence of lysate of A3R phage. Thus while bacteriophages do not substantially affect differentiation of DCs, some products of phage-induced lysis of bacterial cells may influence the differentiation and potentially also some functions of DCs. Our results have important implications for phage therapy of bacterial infections because during infections monocytes recruited to the site of inflammation are an important source of inflammatory DCs. dendritic cell differentiation Bacteriophage phage therapy T4 A3R Microbiology Jan Borysowski verfasserin aut Michał Zarzycki verfasserin aut Magdalena Pacek verfasserin aut Beata Weber-Dąbrowska verfasserin aut Maja Machcińska verfasserin aut Grażyna Korczak-Kowalska verfasserin aut Grażyna Korczak-Kowalska verfasserin aut Andrzej Górski verfasserin aut Andrzej Górski verfasserin aut In Frontiers in Microbiology Frontiers Media S.A., 2011 7(2016) (DE-627)642889384 (DE-600)2587354-4 1664302X nnns volume:7 year:2016 https://doi.org/10.3389/fmicb.2016.01267 kostenfrei https://doaj.org/article/74cc268100434d5d9c0d47949a06ef3c kostenfrei http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01267/full kostenfrei https://doaj.org/toc/1664-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016
allfieldsSound	10.3389/fmicb.2016.01267 doi (DE-627)DOAJ025609599 (DE-599)DOAJ74cc268100434d5d9c0d47949a06ef3c DE-627 ger DE-627 rakwb eng QR1-502 Katarzyna Bocian verfasserin aut The effects of T4 and A3R bacteriophages on differentiation of human myeloid dendritic cells 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bacteriophages (phages) are viruses of bacteria. Here we evaluated the effects of T4 and A3R bacteriophages, as well as phage-generated bacterial lysates, on differentiation of human myeloid dendritic cells (DCs) from monocytes. Neither of the phages significantly reduced the expression of markers associated with differentiation of DCs and their role in the activation of T cells (CD40, CD80, CD83, CD86, CD1c, CD11c, MHC II, PD-L1, PD-L2, TLR2, TLR4, and CCR7) and phagocytosis receptors (CD64 and DEC-205). By contrast, bacterial lysate of T4 phage significantly decreased the percentages of DEC-205- and CD1c-positive cells. The percentage of DEC-205-positive cells was also significantly reduced in DCs differentiated in the presence of lysate of A3R phage. Thus while bacteriophages do not substantially affect differentiation of DCs, some products of phage-induced lysis of bacterial cells may influence the differentiation and potentially also some functions of DCs. Our results have important implications for phage therapy of bacterial infections because during infections monocytes recruited to the site of inflammation are an important source of inflammatory DCs. dendritic cell differentiation Bacteriophage phage therapy T4 A3R Microbiology Jan Borysowski verfasserin aut Michał Zarzycki verfasserin aut Magdalena Pacek verfasserin aut Beata Weber-Dąbrowska verfasserin aut Maja Machcińska verfasserin aut Grażyna Korczak-Kowalska verfasserin aut Grażyna Korczak-Kowalska verfasserin aut Andrzej Górski verfasserin aut Andrzej Górski verfasserin aut In Frontiers in Microbiology Frontiers Media S.A., 2011 7(2016) (DE-627)642889384 (DE-600)2587354-4 1664302X nnns volume:7 year:2016 https://doi.org/10.3389/fmicb.2016.01267 kostenfrei https://doaj.org/article/74cc268100434d5d9c0d47949a06ef3c kostenfrei http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01267/full kostenfrei https://doaj.org/toc/1664-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016
language	English
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container_title	Frontiers in Microbiology
authorswithroles_txt_mv	Katarzyna Bocian @@aut@@ Jan Borysowski @@aut@@ Michał Zarzycki @@aut@@ Magdalena Pacek @@aut@@ Beata Weber-Dąbrowska @@aut@@ Maja Machcińska @@aut@@ Grażyna Korczak-Kowalska @@aut@@ Andrzej Górski @@aut@@
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author	Katarzyna Bocian
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topic_title	QR1-502 The effects of T4 and A3R bacteriophages on differentiation of human myeloid dendritic cells dendritic cell differentiation Bacteriophage phage therapy T4 A3R
topic	misc QR1-502 misc dendritic cell misc differentiation misc Bacteriophage misc phage therapy misc T4 misc A3R misc Microbiology
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title	The effects of T4 and A3R bacteriophages on differentiation of human myeloid dendritic cells
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title_full	The effects of T4 and A3R bacteriophages on differentiation of human myeloid dendritic cells
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author_browse	Katarzyna Bocian Jan Borysowski Michał Zarzycki Magdalena Pacek Beata Weber-Dąbrowska Maja Machcińska Grażyna Korczak-Kowalska Andrzej Górski
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title_sort	effects of t4 and a3r bacteriophages on differentiation of human myeloid dendritic cells
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title_auth	The effects of T4 and A3R bacteriophages on differentiation of human myeloid dendritic cells
abstract	Bacteriophages (phages) are viruses of bacteria. Here we evaluated the effects of T4 and A3R bacteriophages, as well as phage-generated bacterial lysates, on differentiation of human myeloid dendritic cells (DCs) from monocytes. Neither of the phages significantly reduced the expression of markers associated with differentiation of DCs and their role in the activation of T cells (CD40, CD80, CD83, CD86, CD1c, CD11c, MHC II, PD-L1, PD-L2, TLR2, TLR4, and CCR7) and phagocytosis receptors (CD64 and DEC-205). By contrast, bacterial lysate of T4 phage significantly decreased the percentages of DEC-205- and CD1c-positive cells. The percentage of DEC-205-positive cells was also significantly reduced in DCs differentiated in the presence of lysate of A3R phage. Thus while bacteriophages do not substantially affect differentiation of DCs, some products of phage-induced lysis of bacterial cells may influence the differentiation and potentially also some functions of DCs. Our results have important implications for phage therapy of bacterial infections because during infections monocytes recruited to the site of inflammation are an important source of inflammatory DCs.
abstractGer	Bacteriophages (phages) are viruses of bacteria. Here we evaluated the effects of T4 and A3R bacteriophages, as well as phage-generated bacterial lysates, on differentiation of human myeloid dendritic cells (DCs) from monocytes. Neither of the phages significantly reduced the expression of markers associated with differentiation of DCs and their role in the activation of T cells (CD40, CD80, CD83, CD86, CD1c, CD11c, MHC II, PD-L1, PD-L2, TLR2, TLR4, and CCR7) and phagocytosis receptors (CD64 and DEC-205). By contrast, bacterial lysate of T4 phage significantly decreased the percentages of DEC-205- and CD1c-positive cells. The percentage of DEC-205-positive cells was also significantly reduced in DCs differentiated in the presence of lysate of A3R phage. Thus while bacteriophages do not substantially affect differentiation of DCs, some products of phage-induced lysis of bacterial cells may influence the differentiation and potentially also some functions of DCs. Our results have important implications for phage therapy of bacterial infections because during infections monocytes recruited to the site of inflammation are an important source of inflammatory DCs.
abstract_unstemmed	Bacteriophages (phages) are viruses of bacteria. Here we evaluated the effects of T4 and A3R bacteriophages, as well as phage-generated bacterial lysates, on differentiation of human myeloid dendritic cells (DCs) from monocytes. Neither of the phages significantly reduced the expression of markers associated with differentiation of DCs and their role in the activation of T cells (CD40, CD80, CD83, CD86, CD1c, CD11c, MHC II, PD-L1, PD-L2, TLR2, TLR4, and CCR7) and phagocytosis receptors (CD64 and DEC-205). By contrast, bacterial lysate of T4 phage significantly decreased the percentages of DEC-205- and CD1c-positive cells. The percentage of DEC-205-positive cells was also significantly reduced in DCs differentiated in the presence of lysate of A3R phage. Thus while bacteriophages do not substantially affect differentiation of DCs, some products of phage-induced lysis of bacterial cells may influence the differentiation and potentially also some functions of DCs. Our results have important implications for phage therapy of bacterial infections because during infections monocytes recruited to the site of inflammation are an important source of inflammatory DCs.
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title_short	The effects of T4 and A3R bacteriophages on differentiation of human myeloid dendritic cells
url	https://doi.org/10.3389/fmicb.2016.01267 https://doaj.org/article/74cc268100434d5d9c0d47949a06ef3c http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01267/full https://doaj.org/toc/1664-302X
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up_date	2024-07-03T16:02:14.454Z
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The effects of T4 and A3R bacteriophages on differentiation of human myeloid dendritic cells

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