Small Fibre Peripheral Alterations Following COVID-19 Detected by Corneal Confocal Microscopy
A large spectrum of neurological manifestations has been associated with coronavirus disease 2019 (COVID-19), and recently, the involvement of small fibers has been suggested. This study aims to investigate the involvement of small peripheral nervous fibers in recovered COVID-19 patients using in-vi...
Ausführliche Beschreibung
Autor*in: |
Edoardo Midena [verfasserIn] Eleonora Cosmo [verfasserIn] Anna Maria Cattelan [verfasserIn] Chiara Briani [verfasserIn] Davide Leoni [verfasserIn] Alfio Capizzi [verfasserIn] Vanessa Tabacchi [verfasserIn] Raffaele Parrozzani [verfasserIn] Giulia Midena [verfasserIn] Luisa Frizziero [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Journal of Personalized Medicine - MDPI AG, 2012, 12(2022), 4, p 563 |
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Übergeordnetes Werk: |
volume:12 ; year:2022 ; number:4, p 563 |
Links: |
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DOI / URN: |
10.3390/jpm12040563 |
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Katalog-ID: |
DOAJ025682415 |
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10.3390/jpm12040563 doi (DE-627)DOAJ025682415 (DE-599)DOAJ08e1d352b8c74dba87759521caee4713 DE-627 ger DE-627 rakwb eng Edoardo Midena verfasserin aut Small Fibre Peripheral Alterations Following COVID-19 Detected by Corneal Confocal Microscopy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A large spectrum of neurological manifestations has been associated with coronavirus disease 2019 (COVID-19), and recently, the involvement of small fibers has been suggested. This study aims to investigate the involvement of small peripheral nervous fibers in recovered COVID-19 patients using in-vivo corneal confocal microscopy (CCM). Patients recovered from COVID-19 and a control group of healthy subjects underwent in-vivo CCM. Corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), corneal nerve fiber length (CNFL), corneal nerve fiber total branch density (CTBD), corneal nerve fiber area (CNFA), corneal nerve fiber width (CNFW), fiber tortuosity (FT), number of beadings (NBe), and dendritic cells (DC) density were quantified. We enrolled 302 eyes of 151 patients. CNBD and FT were significantly higher (<i<p</i< = 0.0131, <i<p</i< < 0.0001), whereas CNFW and NBe were significantly lower (<i<p</i< = 0.0056, <i<p</i< = 0.0045) in the COVID-19 group compared to controls. Only CNBD and FT resulted significantly correlated to antiviral drugs (increased) and corticosteroids (decreased). No significant relationship with disease severity parameters was found. COVID-19 may induce peripheral neuropathy in small fibers even months after recovery, regardless of systemic conditions and therapy, and CCM may be a useful tool to identify and monitor these morphological changes. corneal confocal microscopy COVID-19 small fiber neuropathy cornea SARS-CoV-2 Medicine R Eleonora Cosmo verfasserin aut Anna Maria Cattelan verfasserin aut Chiara Briani verfasserin aut Davide Leoni verfasserin aut Alfio Capizzi verfasserin aut Vanessa Tabacchi verfasserin aut Raffaele Parrozzani verfasserin aut Giulia Midena verfasserin aut Luisa Frizziero verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 12(2022), 4, p 563 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:12 year:2022 number:4, p 563 https://doi.org/10.3390/jpm12040563 kostenfrei https://doaj.org/article/08e1d352b8c74dba87759521caee4713 kostenfrei https://www.mdpi.com/2075-4426/12/4/563 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 4, p 563 |
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10.3390/jpm12040563 doi (DE-627)DOAJ025682415 (DE-599)DOAJ08e1d352b8c74dba87759521caee4713 DE-627 ger DE-627 rakwb eng Edoardo Midena verfasserin aut Small Fibre Peripheral Alterations Following COVID-19 Detected by Corneal Confocal Microscopy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A large spectrum of neurological manifestations has been associated with coronavirus disease 2019 (COVID-19), and recently, the involvement of small fibers has been suggested. This study aims to investigate the involvement of small peripheral nervous fibers in recovered COVID-19 patients using in-vivo corneal confocal microscopy (CCM). Patients recovered from COVID-19 and a control group of healthy subjects underwent in-vivo CCM. Corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), corneal nerve fiber length (CNFL), corneal nerve fiber total branch density (CTBD), corneal nerve fiber area (CNFA), corneal nerve fiber width (CNFW), fiber tortuosity (FT), number of beadings (NBe), and dendritic cells (DC) density were quantified. We enrolled 302 eyes of 151 patients. CNBD and FT were significantly higher (<i<p</i< = 0.0131, <i<p</i< < 0.0001), whereas CNFW and NBe were significantly lower (<i<p</i< = 0.0056, <i<p</i< = 0.0045) in the COVID-19 group compared to controls. Only CNBD and FT resulted significantly correlated to antiviral drugs (increased) and corticosteroids (decreased). No significant relationship with disease severity parameters was found. COVID-19 may induce peripheral neuropathy in small fibers even months after recovery, regardless of systemic conditions and therapy, and CCM may be a useful tool to identify and monitor these morphological changes. corneal confocal microscopy COVID-19 small fiber neuropathy cornea SARS-CoV-2 Medicine R Eleonora Cosmo verfasserin aut Anna Maria Cattelan verfasserin aut Chiara Briani verfasserin aut Davide Leoni verfasserin aut Alfio Capizzi verfasserin aut Vanessa Tabacchi verfasserin aut Raffaele Parrozzani verfasserin aut Giulia Midena verfasserin aut Luisa Frizziero verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 12(2022), 4, p 563 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:12 year:2022 number:4, p 563 https://doi.org/10.3390/jpm12040563 kostenfrei https://doaj.org/article/08e1d352b8c74dba87759521caee4713 kostenfrei https://www.mdpi.com/2075-4426/12/4/563 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 4, p 563 |
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10.3390/jpm12040563 doi (DE-627)DOAJ025682415 (DE-599)DOAJ08e1d352b8c74dba87759521caee4713 DE-627 ger DE-627 rakwb eng Edoardo Midena verfasserin aut Small Fibre Peripheral Alterations Following COVID-19 Detected by Corneal Confocal Microscopy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A large spectrum of neurological manifestations has been associated with coronavirus disease 2019 (COVID-19), and recently, the involvement of small fibers has been suggested. This study aims to investigate the involvement of small peripheral nervous fibers in recovered COVID-19 patients using in-vivo corneal confocal microscopy (CCM). Patients recovered from COVID-19 and a control group of healthy subjects underwent in-vivo CCM. Corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), corneal nerve fiber length (CNFL), corneal nerve fiber total branch density (CTBD), corneal nerve fiber area (CNFA), corneal nerve fiber width (CNFW), fiber tortuosity (FT), number of beadings (NBe), and dendritic cells (DC) density were quantified. We enrolled 302 eyes of 151 patients. CNBD and FT were significantly higher (<i<p</i< = 0.0131, <i<p</i< < 0.0001), whereas CNFW and NBe were significantly lower (<i<p</i< = 0.0056, <i<p</i< = 0.0045) in the COVID-19 group compared to controls. Only CNBD and FT resulted significantly correlated to antiviral drugs (increased) and corticosteroids (decreased). No significant relationship with disease severity parameters was found. COVID-19 may induce peripheral neuropathy in small fibers even months after recovery, regardless of systemic conditions and therapy, and CCM may be a useful tool to identify and monitor these morphological changes. corneal confocal microscopy COVID-19 small fiber neuropathy cornea SARS-CoV-2 Medicine R Eleonora Cosmo verfasserin aut Anna Maria Cattelan verfasserin aut Chiara Briani verfasserin aut Davide Leoni verfasserin aut Alfio Capizzi verfasserin aut Vanessa Tabacchi verfasserin aut Raffaele Parrozzani verfasserin aut Giulia Midena verfasserin aut Luisa Frizziero verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 12(2022), 4, p 563 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:12 year:2022 number:4, p 563 https://doi.org/10.3390/jpm12040563 kostenfrei https://doaj.org/article/08e1d352b8c74dba87759521caee4713 kostenfrei https://www.mdpi.com/2075-4426/12/4/563 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 4, p 563 |
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10.3390/jpm12040563 doi (DE-627)DOAJ025682415 (DE-599)DOAJ08e1d352b8c74dba87759521caee4713 DE-627 ger DE-627 rakwb eng Edoardo Midena verfasserin aut Small Fibre Peripheral Alterations Following COVID-19 Detected by Corneal Confocal Microscopy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A large spectrum of neurological manifestations has been associated with coronavirus disease 2019 (COVID-19), and recently, the involvement of small fibers has been suggested. This study aims to investigate the involvement of small peripheral nervous fibers in recovered COVID-19 patients using in-vivo corneal confocal microscopy (CCM). Patients recovered from COVID-19 and a control group of healthy subjects underwent in-vivo CCM. Corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), corneal nerve fiber length (CNFL), corneal nerve fiber total branch density (CTBD), corneal nerve fiber area (CNFA), corneal nerve fiber width (CNFW), fiber tortuosity (FT), number of beadings (NBe), and dendritic cells (DC) density were quantified. We enrolled 302 eyes of 151 patients. CNBD and FT were significantly higher (<i<p</i< = 0.0131, <i<p</i< < 0.0001), whereas CNFW and NBe were significantly lower (<i<p</i< = 0.0056, <i<p</i< = 0.0045) in the COVID-19 group compared to controls. Only CNBD and FT resulted significantly correlated to antiviral drugs (increased) and corticosteroids (decreased). No significant relationship with disease severity parameters was found. COVID-19 may induce peripheral neuropathy in small fibers even months after recovery, regardless of systemic conditions and therapy, and CCM may be a useful tool to identify and monitor these morphological changes. corneal confocal microscopy COVID-19 small fiber neuropathy cornea SARS-CoV-2 Medicine R Eleonora Cosmo verfasserin aut Anna Maria Cattelan verfasserin aut Chiara Briani verfasserin aut Davide Leoni verfasserin aut Alfio Capizzi verfasserin aut Vanessa Tabacchi verfasserin aut Raffaele Parrozzani verfasserin aut Giulia Midena verfasserin aut Luisa Frizziero verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 12(2022), 4, p 563 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:12 year:2022 number:4, p 563 https://doi.org/10.3390/jpm12040563 kostenfrei https://doaj.org/article/08e1d352b8c74dba87759521caee4713 kostenfrei https://www.mdpi.com/2075-4426/12/4/563 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 4, p 563 |
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10.3390/jpm12040563 doi (DE-627)DOAJ025682415 (DE-599)DOAJ08e1d352b8c74dba87759521caee4713 DE-627 ger DE-627 rakwb eng Edoardo Midena verfasserin aut Small Fibre Peripheral Alterations Following COVID-19 Detected by Corneal Confocal Microscopy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A large spectrum of neurological manifestations has been associated with coronavirus disease 2019 (COVID-19), and recently, the involvement of small fibers has been suggested. This study aims to investigate the involvement of small peripheral nervous fibers in recovered COVID-19 patients using in-vivo corneal confocal microscopy (CCM). Patients recovered from COVID-19 and a control group of healthy subjects underwent in-vivo CCM. Corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), corneal nerve fiber length (CNFL), corneal nerve fiber total branch density (CTBD), corneal nerve fiber area (CNFA), corneal nerve fiber width (CNFW), fiber tortuosity (FT), number of beadings (NBe), and dendritic cells (DC) density were quantified. We enrolled 302 eyes of 151 patients. CNBD and FT were significantly higher (<i<p</i< = 0.0131, <i<p</i< < 0.0001), whereas CNFW and NBe were significantly lower (<i<p</i< = 0.0056, <i<p</i< = 0.0045) in the COVID-19 group compared to controls. Only CNBD and FT resulted significantly correlated to antiviral drugs (increased) and corticosteroids (decreased). No significant relationship with disease severity parameters was found. COVID-19 may induce peripheral neuropathy in small fibers even months after recovery, regardless of systemic conditions and therapy, and CCM may be a useful tool to identify and monitor these morphological changes. corneal confocal microscopy COVID-19 small fiber neuropathy cornea SARS-CoV-2 Medicine R Eleonora Cosmo verfasserin aut Anna Maria Cattelan verfasserin aut Chiara Briani verfasserin aut Davide Leoni verfasserin aut Alfio Capizzi verfasserin aut Vanessa Tabacchi verfasserin aut Raffaele Parrozzani verfasserin aut Giulia Midena verfasserin aut Luisa Frizziero verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 12(2022), 4, p 563 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:12 year:2022 number:4, p 563 https://doi.org/10.3390/jpm12040563 kostenfrei https://doaj.org/article/08e1d352b8c74dba87759521caee4713 kostenfrei https://www.mdpi.com/2075-4426/12/4/563 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 4, p 563 |
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Small Fibre Peripheral Alterations Following COVID-19 Detected by Corneal Confocal Microscopy |
abstract |
A large spectrum of neurological manifestations has been associated with coronavirus disease 2019 (COVID-19), and recently, the involvement of small fibers has been suggested. This study aims to investigate the involvement of small peripheral nervous fibers in recovered COVID-19 patients using in-vivo corneal confocal microscopy (CCM). Patients recovered from COVID-19 and a control group of healthy subjects underwent in-vivo CCM. Corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), corneal nerve fiber length (CNFL), corneal nerve fiber total branch density (CTBD), corneal nerve fiber area (CNFA), corneal nerve fiber width (CNFW), fiber tortuosity (FT), number of beadings (NBe), and dendritic cells (DC) density were quantified. We enrolled 302 eyes of 151 patients. CNBD and FT were significantly higher (<i<p</i< = 0.0131, <i<p</i< < 0.0001), whereas CNFW and NBe were significantly lower (<i<p</i< = 0.0056, <i<p</i< = 0.0045) in the COVID-19 group compared to controls. Only CNBD and FT resulted significantly correlated to antiviral drugs (increased) and corticosteroids (decreased). No significant relationship with disease severity parameters was found. COVID-19 may induce peripheral neuropathy in small fibers even months after recovery, regardless of systemic conditions and therapy, and CCM may be a useful tool to identify and monitor these morphological changes. |
abstractGer |
A large spectrum of neurological manifestations has been associated with coronavirus disease 2019 (COVID-19), and recently, the involvement of small fibers has been suggested. This study aims to investigate the involvement of small peripheral nervous fibers in recovered COVID-19 patients using in-vivo corneal confocal microscopy (CCM). Patients recovered from COVID-19 and a control group of healthy subjects underwent in-vivo CCM. Corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), corneal nerve fiber length (CNFL), corneal nerve fiber total branch density (CTBD), corneal nerve fiber area (CNFA), corneal nerve fiber width (CNFW), fiber tortuosity (FT), number of beadings (NBe), and dendritic cells (DC) density were quantified. We enrolled 302 eyes of 151 patients. CNBD and FT were significantly higher (<i<p</i< = 0.0131, <i<p</i< < 0.0001), whereas CNFW and NBe were significantly lower (<i<p</i< = 0.0056, <i<p</i< = 0.0045) in the COVID-19 group compared to controls. Only CNBD and FT resulted significantly correlated to antiviral drugs (increased) and corticosteroids (decreased). No significant relationship with disease severity parameters was found. COVID-19 may induce peripheral neuropathy in small fibers even months after recovery, regardless of systemic conditions and therapy, and CCM may be a useful tool to identify and monitor these morphological changes. |
abstract_unstemmed |
A large spectrum of neurological manifestations has been associated with coronavirus disease 2019 (COVID-19), and recently, the involvement of small fibers has been suggested. This study aims to investigate the involvement of small peripheral nervous fibers in recovered COVID-19 patients using in-vivo corneal confocal microscopy (CCM). Patients recovered from COVID-19 and a control group of healthy subjects underwent in-vivo CCM. Corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), corneal nerve fiber length (CNFL), corneal nerve fiber total branch density (CTBD), corneal nerve fiber area (CNFA), corneal nerve fiber width (CNFW), fiber tortuosity (FT), number of beadings (NBe), and dendritic cells (DC) density were quantified. We enrolled 302 eyes of 151 patients. CNBD and FT were significantly higher (<i<p</i< = 0.0131, <i<p</i< < 0.0001), whereas CNFW and NBe were significantly lower (<i<p</i< = 0.0056, <i<p</i< = 0.0045) in the COVID-19 group compared to controls. Only CNBD and FT resulted significantly correlated to antiviral drugs (increased) and corticosteroids (decreased). No significant relationship with disease severity parameters was found. COVID-19 may induce peripheral neuropathy in small fibers even months after recovery, regardless of systemic conditions and therapy, and CCM may be a useful tool to identify and monitor these morphological changes. |
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