Risk Analysis by Age on the Burden of Meningococcal Disease in Spain

We conducted an age-based risk analysis of meningococcal disease in Spain to provide prospects on a rational vaccine schedule in pediatrics. We used the National Hospital Registry to estimate meningococcal hospitalization rate. Population census for each year was used as the denominator in computing...
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Gespeichert in:

Autor*in:	Irene Rivero-Calle [verfasserIn] Peter Francis Raguindin [verfasserIn] Jacobo Pardo-Seco [verfasserIn] Federico Martinon-Torres [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	meningococcal vaccines meningococcal infections invasive diseases

Übergeordnetes Werk:	In: Vaccines - MDPI AG, 2013, 10(2022), 4, p 592
Übergeordnetes Werk:	volume:10 ; year:2022 ; number:4, p 592

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/vaccines10040592

Katalog-ID:	DOAJ02568602X

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allfields	10.3390/vaccines10040592 doi (DE-627)DOAJ02568602X (DE-599)DOAJf5cebfa00c1a49cb866d9216ff88cf4e DE-627 ger DE-627 rakwb eng Irene Rivero-Calle verfasserin aut Risk Analysis by Age on the Burden of Meningococcal Disease in Spain 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We conducted an age-based risk analysis of meningococcal disease in Spain to provide prospects on a rational vaccine schedule in pediatrics. We used the National Hospital Registry to estimate meningococcal hospitalization rate. Population census for each year was used as the denominator in computing the hospitalization rate. We computed the odds ratio of each age using <1 year old as a reference group. From 1998 to 2017, 13,554 hospitalized cases were diagnosed, with a declining trend across the years. Infants (<1 year, <i<n</i< = 2425) and children (1–14 years, <i<n</i< = 6053) comprised the majority of all hospitalized meningococcal disease in Spain (62.5% or 8474/13,554). The incidence of hospitalization decreased dramatically with age from 56.2/100,000 in <1-year-old children to 1.3/100,000 in <5-year-old children. There was a dramatic decline in risk in 1 year (OR 0.58) to 4 years of age (OR 0.21). The risk continued to decline until 13 years old. Afterward, it had a minimal upward trajectory observed at 14–17 years old (OR 0.08). Infants and adolescents are at continued risk of invasive meningococcal disease in Spain. The highest risk occurs in infants. Surveillance data, together with evidence on long-term immunogenicity and capacity for herd effect, should be considered for a more relevant immunization schedule. meningococcal vaccines meningococcal infections invasive diseases <i<Neisseria meningitides</i< Medicine R Peter Francis Raguindin verfasserin aut Jacobo Pardo-Seco verfasserin aut Federico Martinon-Torres verfasserin aut In Vaccines MDPI AG, 2013 10(2022), 4, p 592 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:10 year:2022 number:4, p 592 https://doi.org/10.3390/vaccines10040592 kostenfrei https://doaj.org/article/f5cebfa00c1a49cb866d9216ff88cf4e kostenfrei https://www.mdpi.com/2076-393X/10/4/592 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 4, p 592
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allfieldsSound	10.3390/vaccines10040592 doi (DE-627)DOAJ02568602X (DE-599)DOAJf5cebfa00c1a49cb866d9216ff88cf4e DE-627 ger DE-627 rakwb eng Irene Rivero-Calle verfasserin aut Risk Analysis by Age on the Burden of Meningococcal Disease in Spain 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We conducted an age-based risk analysis of meningococcal disease in Spain to provide prospects on a rational vaccine schedule in pediatrics. We used the National Hospital Registry to estimate meningococcal hospitalization rate. Population census for each year was used as the denominator in computing the hospitalization rate. We computed the odds ratio of each age using <1 year old as a reference group. From 1998 to 2017, 13,554 hospitalized cases were diagnosed, with a declining trend across the years. Infants (<1 year, <i<n</i< = 2425) and children (1–14 years, <i<n</i< = 6053) comprised the majority of all hospitalized meningococcal disease in Spain (62.5% or 8474/13,554). The incidence of hospitalization decreased dramatically with age from 56.2/100,000 in <1-year-old children to 1.3/100,000 in <5-year-old children. There was a dramatic decline in risk in 1 year (OR 0.58) to 4 years of age (OR 0.21). The risk continued to decline until 13 years old. Afterward, it had a minimal upward trajectory observed at 14–17 years old (OR 0.08). Infants and adolescents are at continued risk of invasive meningococcal disease in Spain. The highest risk occurs in infants. Surveillance data, together with evidence on long-term immunogenicity and capacity for herd effect, should be considered for a more relevant immunization schedule. meningococcal vaccines meningococcal infections invasive diseases <i<Neisseria meningitides</i< Medicine R Peter Francis Raguindin verfasserin aut Jacobo Pardo-Seco verfasserin aut Federico Martinon-Torres verfasserin aut In Vaccines MDPI AG, 2013 10(2022), 4, p 592 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:10 year:2022 number:4, p 592 https://doi.org/10.3390/vaccines10040592 kostenfrei https://doaj.org/article/f5cebfa00c1a49cb866d9216ff88cf4e kostenfrei https://www.mdpi.com/2076-393X/10/4/592 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 4, p 592
language	English
source	In Vaccines 10(2022), 4, p 592 volume:10 year:2022 number:4, p 592
sourceStr	In Vaccines 10(2022), 4, p 592 volume:10 year:2022 number:4, p 592
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authorswithroles_txt_mv	Irene Rivero-Calle @@aut@@ Peter Francis Raguindin @@aut@@ Jacobo Pardo-Seco @@aut@@ Federico Martinon-Torres @@aut@@
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author	Irene Rivero-Calle
spellingShingle	Irene Rivero-Calle misc meningococcal vaccines misc meningococcal infections misc invasive diseases misc <i<Neisseria meningitides</i< misc Medicine misc R Risk Analysis by Age on the Burden of Meningococcal Disease in Spain
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topic_title	Risk Analysis by Age on the Burden of Meningococcal Disease in Spain meningococcal vaccines meningococcal infections invasive diseases <i<Neisseria meningitides</i<
topic	misc meningococcal vaccines misc meningococcal infections misc invasive diseases misc <i<Neisseria meningitides</i< misc Medicine misc R
topic_unstemmed	misc meningococcal vaccines misc meningococcal infections misc invasive diseases misc <i<Neisseria meningitides</i< misc Medicine misc R
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title	Risk Analysis by Age on the Burden of Meningococcal Disease in Spain
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title_full	Risk Analysis by Age on the Burden of Meningococcal Disease in Spain
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title_sort	risk analysis by age on the burden of meningococcal disease in spain
title_auth	Risk Analysis by Age on the Burden of Meningococcal Disease in Spain
abstract	We conducted an age-based risk analysis of meningococcal disease in Spain to provide prospects on a rational vaccine schedule in pediatrics. We used the National Hospital Registry to estimate meningococcal hospitalization rate. Population census for each year was used as the denominator in computing the hospitalization rate. We computed the odds ratio of each age using <1 year old as a reference group. From 1998 to 2017, 13,554 hospitalized cases were diagnosed, with a declining trend across the years. Infants (<1 year, <i<n</i< = 2425) and children (1–14 years, <i<n</i< = 6053) comprised the majority of all hospitalized meningococcal disease in Spain (62.5% or 8474/13,554). The incidence of hospitalization decreased dramatically with age from 56.2/100,000 in <1-year-old children to 1.3/100,000 in <5-year-old children. There was a dramatic decline in risk in 1 year (OR 0.58) to 4 years of age (OR 0.21). The risk continued to decline until 13 years old. Afterward, it had a minimal upward trajectory observed at 14–17 years old (OR 0.08). Infants and adolescents are at continued risk of invasive meningococcal disease in Spain. The highest risk occurs in infants. Surveillance data, together with evidence on long-term immunogenicity and capacity for herd effect, should be considered for a more relevant immunization schedule.
abstractGer	We conducted an age-based risk analysis of meningococcal disease in Spain to provide prospects on a rational vaccine schedule in pediatrics. We used the National Hospital Registry to estimate meningococcal hospitalization rate. Population census for each year was used as the denominator in computing the hospitalization rate. We computed the odds ratio of each age using <1 year old as a reference group. From 1998 to 2017, 13,554 hospitalized cases were diagnosed, with a declining trend across the years. Infants (<1 year, <i<n</i< = 2425) and children (1–14 years, <i<n</i< = 6053) comprised the majority of all hospitalized meningococcal disease in Spain (62.5% or 8474/13,554). The incidence of hospitalization decreased dramatically with age from 56.2/100,000 in <1-year-old children to 1.3/100,000 in <5-year-old children. There was a dramatic decline in risk in 1 year (OR 0.58) to 4 years of age (OR 0.21). The risk continued to decline until 13 years old. Afterward, it had a minimal upward trajectory observed at 14–17 years old (OR 0.08). Infants and adolescents are at continued risk of invasive meningococcal disease in Spain. The highest risk occurs in infants. Surveillance data, together with evidence on long-term immunogenicity and capacity for herd effect, should be considered for a more relevant immunization schedule.
abstract_unstemmed	We conducted an age-based risk analysis of meningococcal disease in Spain to provide prospects on a rational vaccine schedule in pediatrics. We used the National Hospital Registry to estimate meningococcal hospitalization rate. Population census for each year was used as the denominator in computing the hospitalization rate. We computed the odds ratio of each age using <1 year old as a reference group. From 1998 to 2017, 13,554 hospitalized cases were diagnosed, with a declining trend across the years. Infants (<1 year, <i<n</i< = 2425) and children (1–14 years, <i<n</i< = 6053) comprised the majority of all hospitalized meningococcal disease in Spain (62.5% or 8474/13,554). The incidence of hospitalization decreased dramatically with age from 56.2/100,000 in <1-year-old children to 1.3/100,000 in <5-year-old children. There was a dramatic decline in risk in 1 year (OR 0.58) to 4 years of age (OR 0.21). The risk continued to decline until 13 years old. Afterward, it had a minimal upward trajectory observed at 14–17 years old (OR 0.08). Infants and adolescents are at continued risk of invasive meningococcal disease in Spain. The highest risk occurs in infants. Surveillance data, together with evidence on long-term immunogenicity and capacity for herd effect, should be considered for a more relevant immunization schedule.
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title_short	Risk Analysis by Age on the Burden of Meningococcal Disease in Spain
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Risk Analysis by Age on the Burden of Meningococcal Disease in Spain

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