Current Advances in Lipid and Polymeric Antimicrobial Peptide Delivery Systems and Coatings for the Prevention and Treatment of Bacterial Infections

Bacterial infections constitute a threat to public health as antibiotics are becoming less effective due to the emergence of antimicrobial resistant strains and biofilm and persister formation. Antimicrobial peptides (AMPs) are considered excellent alternatives to antibiotics; however, they suffer f...
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Gespeichert in:

Autor*in:	Miriam E. van Gent [verfasserIn] Muhanad Ali [verfasserIn] Peter H. Nibbering [verfasserIn] Sylvia N. Kłodzińska [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	antimicrobial peptide drug delivery system liposome PLGA nanoparticle nanogel antimicrobial coating

Übergeordnetes Werk:	In: Pharmaceutics - MDPI AG, 2010, 13(2021), 11, p 1840
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:11, p 1840

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/pharmaceutics13111840

Katalog-ID:	DOAJ025729780

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language	English
source	In Pharmaceutics 13(2021), 11, p 1840 volume:13 year:2021 number:11, p 1840
sourceStr	In Pharmaceutics 13(2021), 11, p 1840 volume:13 year:2021 number:11, p 1840
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	antimicrobial peptide drug delivery system liposome PLGA nanoparticle nanogel antimicrobial coating Pharmacy and materia medica
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container_title	Pharmaceutics
authorswithroles_txt_mv	Miriam E. van Gent @@aut@@ Muhanad Ali @@aut@@ Peter H. Nibbering @@aut@@ Sylvia N. Kłodzińska @@aut@@
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callnumber-first	R - Medicine
author	Miriam E. van Gent
spellingShingle	Miriam E. van Gent misc RS1-441 misc antimicrobial peptide misc drug delivery system misc liposome misc PLGA nanoparticle misc nanogel misc antimicrobial coating misc Pharmacy and materia medica Current Advances in Lipid and Polymeric Antimicrobial Peptide Delivery Systems and Coatings for the Prevention and Treatment of Bacterial Infections
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topic_title	RS1-441 Current Advances in Lipid and Polymeric Antimicrobial Peptide Delivery Systems and Coatings for the Prevention and Treatment of Bacterial Infections antimicrobial peptide drug delivery system liposome PLGA nanoparticle nanogel antimicrobial coating
topic	misc RS1-441 misc antimicrobial peptide misc drug delivery system misc liposome misc PLGA nanoparticle misc nanogel misc antimicrobial coating misc Pharmacy and materia medica
topic_unstemmed	misc RS1-441 misc antimicrobial peptide misc drug delivery system misc liposome misc PLGA nanoparticle misc nanogel misc antimicrobial coating misc Pharmacy and materia medica
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title	Current Advances in Lipid and Polymeric Antimicrobial Peptide Delivery Systems and Coatings for the Prevention and Treatment of Bacterial Infections
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title_sort	current advances in lipid and polymeric antimicrobial peptide delivery systems and coatings for the prevention and treatment of bacterial infections
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title_auth	Current Advances in Lipid and Polymeric Antimicrobial Peptide Delivery Systems and Coatings for the Prevention and Treatment of Bacterial Infections
abstract	Bacterial infections constitute a threat to public health as antibiotics are becoming less effective due to the emergence of antimicrobial resistant strains and biofilm and persister formation. Antimicrobial peptides (AMPs) are considered excellent alternatives to antibiotics; however, they suffer from limitations related to their peptidic nature and possible toxicity. The present review critically evaluates the chemical characteristics and antibacterial effects of lipid and polymeric AMP delivery systems and coatings that offer the promise of enhancing the efficacy of AMPs, reducing their limitations and prolonging their half-life. Unfortunately, the antibacterial activities of these systems and coatings have mainly been evaluated in vitro against planktonic bacteria in less biologically relevant conditions, with only some studies focusing on the antibiofilm activities of the formulated AMPs and on the antibacterial effects in animal models. Further improvements of lipid and polymeric AMP delivery systems and coatings may involve the functionalization of these systems to better target the infections and an analysis of the antibacterial activities in biologically relevant environments. Based on the available data we proposed which polymeric AMP delivery system or coatings could be profitable for the treatment of the different hard-to-treat infections, such as bloodstream infections and catheter- or implant-related infections.
abstractGer	Bacterial infections constitute a threat to public health as antibiotics are becoming less effective due to the emergence of antimicrobial resistant strains and biofilm and persister formation. Antimicrobial peptides (AMPs) are considered excellent alternatives to antibiotics; however, they suffer from limitations related to their peptidic nature and possible toxicity. The present review critically evaluates the chemical characteristics and antibacterial effects of lipid and polymeric AMP delivery systems and coatings that offer the promise of enhancing the efficacy of AMPs, reducing their limitations and prolonging their half-life. Unfortunately, the antibacterial activities of these systems and coatings have mainly been evaluated in vitro against planktonic bacteria in less biologically relevant conditions, with only some studies focusing on the antibiofilm activities of the formulated AMPs and on the antibacterial effects in animal models. Further improvements of lipid and polymeric AMP delivery systems and coatings may involve the functionalization of these systems to better target the infections and an analysis of the antibacterial activities in biologically relevant environments. Based on the available data we proposed which polymeric AMP delivery system or coatings could be profitable for the treatment of the different hard-to-treat infections, such as bloodstream infections and catheter- or implant-related infections.
abstract_unstemmed	Bacterial infections constitute a threat to public health as antibiotics are becoming less effective due to the emergence of antimicrobial resistant strains and biofilm and persister formation. Antimicrobial peptides (AMPs) are considered excellent alternatives to antibiotics; however, they suffer from limitations related to their peptidic nature and possible toxicity. The present review critically evaluates the chemical characteristics and antibacterial effects of lipid and polymeric AMP delivery systems and coatings that offer the promise of enhancing the efficacy of AMPs, reducing their limitations and prolonging their half-life. Unfortunately, the antibacterial activities of these systems and coatings have mainly been evaluated in vitro against planktonic bacteria in less biologically relevant conditions, with only some studies focusing on the antibiofilm activities of the formulated AMPs and on the antibacterial effects in animal models. Further improvements of lipid and polymeric AMP delivery systems and coatings may involve the functionalization of these systems to better target the infections and an analysis of the antibacterial activities in biologically relevant environments. Based on the available data we proposed which polymeric AMP delivery system or coatings could be profitable for the treatment of the different hard-to-treat infections, such as bloodstream infections and catheter- or implant-related infections.
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title_short	Current Advances in Lipid and Polymeric Antimicrobial Peptide Delivery Systems and Coatings for the Prevention and Treatment of Bacterial Infections
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