Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians.

Apical Membrane Antigen 1 (AMA1) of Plasmodium falciparum merozoites is a leading blood-stage malaria vaccine candidate. Protection of Aotus monkeys after vaccination with AMA1 correlates with antibody responses.A randomized, controlled, double-blind phase 1 clinical trial was conducted in 54 healthy Malian adults living in an area of intense seasonal malaria transmission to assess the safety and immunogenicity of the AMA1-C1 malaria vaccine. AMA1-C1 contains an equal mixture of yeast-expressed recombinant proteins based on sequences from the FVO and 3D7 clones of P. falciparum, adsorbed on Alhydrogel. The control vaccine was the hepatitis B vaccine (Recombivax). Participants were enrolled into 1 of 3 dose cohorts (n = 18 per cohort) and randomized 2:1 to receive either AMA1-C1 or Recombivax. Participants in the first, second, and third cohorts randomized to receive AMA1-C1 were vaccinated with 5, 20 and 80 microg of AMA1-C1, respectively. Vaccinations were administered on days 0, 28, and 360, and participants were followed until 6 months after the final vaccination. AMA1-C1 was well tolerated; no vaccine-related severe or serious adverse events were observed. AMA1 antibody responses to the 80 microg dose increased rapidly from baseline levels by days 14 and 28 after the first vaccination and continued to increase after the second vaccination. After a peak 14 days following the second vaccination, antibody levels decreased to baseline levels one year later at the time of the third vaccination that induced little or no increase in antibody levels.Although the AMA1-C1 vaccine candidate was well-tolerated and induced antibody responses to both vaccine and non-vaccine alleles, the antibody response after a third dose given at one year was lower than the response to the initial vaccinations. Additionally, post-vaccination increases in anti-AMA1 antibody levels were not associated with significant changes in in vitro growth inhibition of P. falciparum.ClinicalTrials.gov NCT00343005. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Alassane Dicko [verfasserIn] David J Diemert [verfasserIn] Issaka Sagara [verfasserIn] Moussa Sogoba [verfasserIn] Mohamed B Niambele [verfasserIn] Mahamadoun H Assadou [verfasserIn] Ousmane Guindo [verfasserIn] Beh Kamate [verfasserIn] Mounirou Baby [verfasserIn] Mady Sissoko [verfasserIn] Elissa M Malkin [verfasserIn] Michael P Fay [verfasserIn] Mahamadou A Thera [verfasserIn] Kazutoyo Miura [verfasserIn] Amagana Dolo [verfasserIn] Dapa A Diallo [verfasserIn] Gregory E Mullen [verfasserIn] Carole A Long [verfasserIn] Allan Saul [verfasserIn] Ogobara Doumbo [verfasserIn] Louis H Miller [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2007

Übergeordnetes Werk:	In: PLoS ONE - Public Library of Science (PLoS), 2007, 2(2007), 10, p e1045
Übergeordnetes Werk:	volume:2 ; year:2007 ; number:10, p e1045

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1371/journal.pone.0001045

Katalog-ID:	DOAJ025831429

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245	1	0	\|a Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians.
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520			\|a Apical Membrane Antigen 1 (AMA1) of Plasmodium falciparum merozoites is a leading blood-stage malaria vaccine candidate. Protection of Aotus monkeys after vaccination with AMA1 correlates with antibody responses.A randomized, controlled, double-blind phase 1 clinical trial was conducted in 54 healthy Malian adults living in an area of intense seasonal malaria transmission to assess the safety and immunogenicity of the AMA1-C1 malaria vaccine. AMA1-C1 contains an equal mixture of yeast-expressed recombinant proteins based on sequences from the FVO and 3D7 clones of P. falciparum, adsorbed on Alhydrogel. The control vaccine was the hepatitis B vaccine (Recombivax). Participants were enrolled into 1 of 3 dose cohorts (n = 18 per cohort) and randomized 2:1 to receive either AMA1-C1 or Recombivax. Participants in the first, second, and third cohorts randomized to receive AMA1-C1 were vaccinated with 5, 20 and 80 microg of AMA1-C1, respectively. Vaccinations were administered on days 0, 28, and 360, and participants were followed until 6 months after the final vaccination. AMA1-C1 was well tolerated; no vaccine-related severe or serious adverse events were observed. AMA1 antibody responses to the 80 microg dose increased rapidly from baseline levels by days 14 and 28 after the first vaccination and continued to increase after the second vaccination. After a peak 14 days following the second vaccination, antibody levels decreased to baseline levels one year later at the time of the third vaccination that induced little or no increase in antibody levels.Although the AMA1-C1 vaccine candidate was well-tolerated and induced antibody responses to both vaccine and non-vaccine alleles, the antibody response after a third dose given at one year was lower than the response to the initial vaccinations. Additionally, post-vaccination increases in anti-AMA1 antibody levels were not associated with significant changes in in vitro growth inhibition of P. falciparum.ClinicalTrials.gov NCT00343005.
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700	0		\|a Mohamed B Niambele \|e verfasserin \|4 aut
700	0		\|a Mahamadoun H Assadou \|e verfasserin \|4 aut
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700	0		\|a Beh Kamate \|e verfasserin \|4 aut
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700	0		\|a Mady Sissoko \|e verfasserin \|4 aut
700	0		\|a Elissa M Malkin \|e verfasserin \|4 aut
700	0		\|a Michael P Fay \|e verfasserin \|4 aut
700	0		\|a Mahamadou A Thera \|e verfasserin \|4 aut
700	0		\|a Kazutoyo Miura \|e verfasserin \|4 aut
700	0		\|a Amagana Dolo \|e verfasserin \|4 aut
700	0		\|a Dapa A Diallo \|e verfasserin \|4 aut
700	0		\|a Gregory E Mullen \|e verfasserin \|4 aut
700	0		\|a Carole A Long \|e verfasserin \|4 aut
700	0		\|a Allan Saul \|e verfasserin \|4 aut
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700	0		\|a Louis H Miller \|e verfasserin \|4 aut
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author_variant	a d ad d j d djd i s is m s ms m b n mbn m h a mha o g og b k bk m b mb m s ms e m m emm m p f mpf m a t mat k m km a d ad d a d dad g e m gem c a l cal a s as o d od l h m lhm
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allfields	10.1371/journal.pone.0001045 doi (DE-627)DOAJ025831429 (DE-599)DOAJ77e51bbf3ad746e08d3a6517f251c133 DE-627 ger DE-627 rakwb eng Alassane Dicko verfasserin aut Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians. 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Apical Membrane Antigen 1 (AMA1) of Plasmodium falciparum merozoites is a leading blood-stage malaria vaccine candidate. Protection of Aotus monkeys after vaccination with AMA1 correlates with antibody responses.A randomized, controlled, double-blind phase 1 clinical trial was conducted in 54 healthy Malian adults living in an area of intense seasonal malaria transmission to assess the safety and immunogenicity of the AMA1-C1 malaria vaccine. AMA1-C1 contains an equal mixture of yeast-expressed recombinant proteins based on sequences from the FVO and 3D7 clones of P. falciparum, adsorbed on Alhydrogel. The control vaccine was the hepatitis B vaccine (Recombivax). Participants were enrolled into 1 of 3 dose cohorts (n = 18 per cohort) and randomized 2:1 to receive either AMA1-C1 or Recombivax. Participants in the first, second, and third cohorts randomized to receive AMA1-C1 were vaccinated with 5, 20 and 80 microg of AMA1-C1, respectively. Vaccinations were administered on days 0, 28, and 360, and participants were followed until 6 months after the final vaccination. AMA1-C1 was well tolerated; no vaccine-related severe or serious adverse events were observed. AMA1 antibody responses to the 80 microg dose increased rapidly from baseline levels by days 14 and 28 after the first vaccination and continued to increase after the second vaccination. After a peak 14 days following the second vaccination, antibody levels decreased to baseline levels one year later at the time of the third vaccination that induced little or no increase in antibody levels.Although the AMA1-C1 vaccine candidate was well-tolerated and induced antibody responses to both vaccine and non-vaccine alleles, the antibody response after a third dose given at one year was lower than the response to the initial vaccinations. Additionally, post-vaccination increases in anti-AMA1 antibody levels were not associated with significant changes in in vitro growth inhibition of P. falciparum.ClinicalTrials.gov NCT00343005. Medicine R Science Q David J Diemert verfasserin aut Issaka Sagara verfasserin aut Moussa Sogoba verfasserin aut Mohamed B Niambele verfasserin aut Mahamadoun H Assadou verfasserin aut Ousmane Guindo verfasserin aut Beh Kamate verfasserin aut Mounirou Baby verfasserin aut Mady Sissoko verfasserin aut Elissa M Malkin verfasserin aut Michael P Fay verfasserin aut Mahamadou A Thera verfasserin aut Kazutoyo Miura verfasserin aut Amagana Dolo verfasserin aut Dapa A Diallo verfasserin aut Gregory E Mullen verfasserin aut Carole A Long verfasserin aut Allan Saul verfasserin aut Ogobara Doumbo verfasserin aut Louis H Miller verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 2(2007), 10, p e1045 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:2 year:2007 number:10, p e1045 https://doi.org/10.1371/journal.pone.0001045 kostenfrei https://doaj.org/article/77e51bbf3ad746e08d3a6517f251c133 kostenfrei http://europepmc.org/articles/PMC2013939?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2007 10, p e1045
spelling	10.1371/journal.pone.0001045 doi (DE-627)DOAJ025831429 (DE-599)DOAJ77e51bbf3ad746e08d3a6517f251c133 DE-627 ger DE-627 rakwb eng Alassane Dicko verfasserin aut Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians. 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Apical Membrane Antigen 1 (AMA1) of Plasmodium falciparum merozoites is a leading blood-stage malaria vaccine candidate. Protection of Aotus monkeys after vaccination with AMA1 correlates with antibody responses.A randomized, controlled, double-blind phase 1 clinical trial was conducted in 54 healthy Malian adults living in an area of intense seasonal malaria transmission to assess the safety and immunogenicity of the AMA1-C1 malaria vaccine. AMA1-C1 contains an equal mixture of yeast-expressed recombinant proteins based on sequences from the FVO and 3D7 clones of P. falciparum, adsorbed on Alhydrogel. The control vaccine was the hepatitis B vaccine (Recombivax). Participants were enrolled into 1 of 3 dose cohorts (n = 18 per cohort) and randomized 2:1 to receive either AMA1-C1 or Recombivax. Participants in the first, second, and third cohorts randomized to receive AMA1-C1 were vaccinated with 5, 20 and 80 microg of AMA1-C1, respectively. Vaccinations were administered on days 0, 28, and 360, and participants were followed until 6 months after the final vaccination. AMA1-C1 was well tolerated; no vaccine-related severe or serious adverse events were observed. AMA1 antibody responses to the 80 microg dose increased rapidly from baseline levels by days 14 and 28 after the first vaccination and continued to increase after the second vaccination. After a peak 14 days following the second vaccination, antibody levels decreased to baseline levels one year later at the time of the third vaccination that induced little or no increase in antibody levels.Although the AMA1-C1 vaccine candidate was well-tolerated and induced antibody responses to both vaccine and non-vaccine alleles, the antibody response after a third dose given at one year was lower than the response to the initial vaccinations. Additionally, post-vaccination increases in anti-AMA1 antibody levels were not associated with significant changes in in vitro growth inhibition of P. falciparum.ClinicalTrials.gov NCT00343005. Medicine R Science Q David J Diemert verfasserin aut Issaka Sagara verfasserin aut Moussa Sogoba verfasserin aut Mohamed B Niambele verfasserin aut Mahamadoun H Assadou verfasserin aut Ousmane Guindo verfasserin aut Beh Kamate verfasserin aut Mounirou Baby verfasserin aut Mady Sissoko verfasserin aut Elissa M Malkin verfasserin aut Michael P Fay verfasserin aut Mahamadou A Thera verfasserin aut Kazutoyo Miura verfasserin aut Amagana Dolo verfasserin aut Dapa A Diallo verfasserin aut Gregory E Mullen verfasserin aut Carole A Long verfasserin aut Allan Saul verfasserin aut Ogobara Doumbo verfasserin aut Louis H Miller verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 2(2007), 10, p e1045 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:2 year:2007 number:10, p e1045 https://doi.org/10.1371/journal.pone.0001045 kostenfrei https://doaj.org/article/77e51bbf3ad746e08d3a6517f251c133 kostenfrei http://europepmc.org/articles/PMC2013939?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2007 10, p e1045
allfields_unstemmed	10.1371/journal.pone.0001045 doi (DE-627)DOAJ025831429 (DE-599)DOAJ77e51bbf3ad746e08d3a6517f251c133 DE-627 ger DE-627 rakwb eng Alassane Dicko verfasserin aut Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians. 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Apical Membrane Antigen 1 (AMA1) of Plasmodium falciparum merozoites is a leading blood-stage malaria vaccine candidate. Protection of Aotus monkeys after vaccination with AMA1 correlates with antibody responses.A randomized, controlled, double-blind phase 1 clinical trial was conducted in 54 healthy Malian adults living in an area of intense seasonal malaria transmission to assess the safety and immunogenicity of the AMA1-C1 malaria vaccine. AMA1-C1 contains an equal mixture of yeast-expressed recombinant proteins based on sequences from the FVO and 3D7 clones of P. falciparum, adsorbed on Alhydrogel. The control vaccine was the hepatitis B vaccine (Recombivax). Participants were enrolled into 1 of 3 dose cohorts (n = 18 per cohort) and randomized 2:1 to receive either AMA1-C1 or Recombivax. Participants in the first, second, and third cohorts randomized to receive AMA1-C1 were vaccinated with 5, 20 and 80 microg of AMA1-C1, respectively. Vaccinations were administered on days 0, 28, and 360, and participants were followed until 6 months after the final vaccination. AMA1-C1 was well tolerated; no vaccine-related severe or serious adverse events were observed. AMA1 antibody responses to the 80 microg dose increased rapidly from baseline levels by days 14 and 28 after the first vaccination and continued to increase after the second vaccination. After a peak 14 days following the second vaccination, antibody levels decreased to baseline levels one year later at the time of the third vaccination that induced little or no increase in antibody levels.Although the AMA1-C1 vaccine candidate was well-tolerated and induced antibody responses to both vaccine and non-vaccine alleles, the antibody response after a third dose given at one year was lower than the response to the initial vaccinations. Additionally, post-vaccination increases in anti-AMA1 antibody levels were not associated with significant changes in in vitro growth inhibition of P. falciparum.ClinicalTrials.gov NCT00343005. Medicine R Science Q David J Diemert verfasserin aut Issaka Sagara verfasserin aut Moussa Sogoba verfasserin aut Mohamed B Niambele verfasserin aut Mahamadoun H Assadou verfasserin aut Ousmane Guindo verfasserin aut Beh Kamate verfasserin aut Mounirou Baby verfasserin aut Mady Sissoko verfasserin aut Elissa M Malkin verfasserin aut Michael P Fay verfasserin aut Mahamadou A Thera verfasserin aut Kazutoyo Miura verfasserin aut Amagana Dolo verfasserin aut Dapa A Diallo verfasserin aut Gregory E Mullen verfasserin aut Carole A Long verfasserin aut Allan Saul verfasserin aut Ogobara Doumbo verfasserin aut Louis H Miller verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 2(2007), 10, p e1045 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:2 year:2007 number:10, p e1045 https://doi.org/10.1371/journal.pone.0001045 kostenfrei https://doaj.org/article/77e51bbf3ad746e08d3a6517f251c133 kostenfrei http://europepmc.org/articles/PMC2013939?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2007 10, p e1045
allfieldsGer	10.1371/journal.pone.0001045 doi (DE-627)DOAJ025831429 (DE-599)DOAJ77e51bbf3ad746e08d3a6517f251c133 DE-627 ger DE-627 rakwb eng Alassane Dicko verfasserin aut Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians. 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Apical Membrane Antigen 1 (AMA1) of Plasmodium falciparum merozoites is a leading blood-stage malaria vaccine candidate. Protection of Aotus monkeys after vaccination with AMA1 correlates with antibody responses.A randomized, controlled, double-blind phase 1 clinical trial was conducted in 54 healthy Malian adults living in an area of intense seasonal malaria transmission to assess the safety and immunogenicity of the AMA1-C1 malaria vaccine. AMA1-C1 contains an equal mixture of yeast-expressed recombinant proteins based on sequences from the FVO and 3D7 clones of P. falciparum, adsorbed on Alhydrogel. The control vaccine was the hepatitis B vaccine (Recombivax). Participants were enrolled into 1 of 3 dose cohorts (n = 18 per cohort) and randomized 2:1 to receive either AMA1-C1 or Recombivax. Participants in the first, second, and third cohorts randomized to receive AMA1-C1 were vaccinated with 5, 20 and 80 microg of AMA1-C1, respectively. Vaccinations were administered on days 0, 28, and 360, and participants were followed until 6 months after the final vaccination. AMA1-C1 was well tolerated; no vaccine-related severe or serious adverse events were observed. AMA1 antibody responses to the 80 microg dose increased rapidly from baseline levels by days 14 and 28 after the first vaccination and continued to increase after the second vaccination. After a peak 14 days following the second vaccination, antibody levels decreased to baseline levels one year later at the time of the third vaccination that induced little or no increase in antibody levels.Although the AMA1-C1 vaccine candidate was well-tolerated and induced antibody responses to both vaccine and non-vaccine alleles, the antibody response after a third dose given at one year was lower than the response to the initial vaccinations. Additionally, post-vaccination increases in anti-AMA1 antibody levels were not associated with significant changes in in vitro growth inhibition of P. falciparum.ClinicalTrials.gov NCT00343005. Medicine R Science Q David J Diemert verfasserin aut Issaka Sagara verfasserin aut Moussa Sogoba verfasserin aut Mohamed B Niambele verfasserin aut Mahamadoun H Assadou verfasserin aut Ousmane Guindo verfasserin aut Beh Kamate verfasserin aut Mounirou Baby verfasserin aut Mady Sissoko verfasserin aut Elissa M Malkin verfasserin aut Michael P Fay verfasserin aut Mahamadou A Thera verfasserin aut Kazutoyo Miura verfasserin aut Amagana Dolo verfasserin aut Dapa A Diallo verfasserin aut Gregory E Mullen verfasserin aut Carole A Long verfasserin aut Allan Saul verfasserin aut Ogobara Doumbo verfasserin aut Louis H Miller verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 2(2007), 10, p e1045 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:2 year:2007 number:10, p e1045 https://doi.org/10.1371/journal.pone.0001045 kostenfrei https://doaj.org/article/77e51bbf3ad746e08d3a6517f251c133 kostenfrei http://europepmc.org/articles/PMC2013939?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2007 10, p e1045
allfieldsSound	10.1371/journal.pone.0001045 doi (DE-627)DOAJ025831429 (DE-599)DOAJ77e51bbf3ad746e08d3a6517f251c133 DE-627 ger DE-627 rakwb eng Alassane Dicko verfasserin aut Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians. 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Apical Membrane Antigen 1 (AMA1) of Plasmodium falciparum merozoites is a leading blood-stage malaria vaccine candidate. Protection of Aotus monkeys after vaccination with AMA1 correlates with antibody responses.A randomized, controlled, double-blind phase 1 clinical trial was conducted in 54 healthy Malian adults living in an area of intense seasonal malaria transmission to assess the safety and immunogenicity of the AMA1-C1 malaria vaccine. AMA1-C1 contains an equal mixture of yeast-expressed recombinant proteins based on sequences from the FVO and 3D7 clones of P. falciparum, adsorbed on Alhydrogel. The control vaccine was the hepatitis B vaccine (Recombivax). Participants were enrolled into 1 of 3 dose cohorts (n = 18 per cohort) and randomized 2:1 to receive either AMA1-C1 or Recombivax. Participants in the first, second, and third cohorts randomized to receive AMA1-C1 were vaccinated with 5, 20 and 80 microg of AMA1-C1, respectively. Vaccinations were administered on days 0, 28, and 360, and participants were followed until 6 months after the final vaccination. AMA1-C1 was well tolerated; no vaccine-related severe or serious adverse events were observed. AMA1 antibody responses to the 80 microg dose increased rapidly from baseline levels by days 14 and 28 after the first vaccination and continued to increase after the second vaccination. After a peak 14 days following the second vaccination, antibody levels decreased to baseline levels one year later at the time of the third vaccination that induced little or no increase in antibody levels.Although the AMA1-C1 vaccine candidate was well-tolerated and induced antibody responses to both vaccine and non-vaccine alleles, the antibody response after a third dose given at one year was lower than the response to the initial vaccinations. Additionally, post-vaccination increases in anti-AMA1 antibody levels were not associated with significant changes in in vitro growth inhibition of P. falciparum.ClinicalTrials.gov NCT00343005. Medicine R Science Q David J Diemert verfasserin aut Issaka Sagara verfasserin aut Moussa Sogoba verfasserin aut Mohamed B Niambele verfasserin aut Mahamadoun H Assadou verfasserin aut Ousmane Guindo verfasserin aut Beh Kamate verfasserin aut Mounirou Baby verfasserin aut Mady Sissoko verfasserin aut Elissa M Malkin verfasserin aut Michael P Fay verfasserin aut Mahamadou A Thera verfasserin aut Kazutoyo Miura verfasserin aut Amagana Dolo verfasserin aut Dapa A Diallo verfasserin aut Gregory E Mullen verfasserin aut Carole A Long verfasserin aut Allan Saul verfasserin aut Ogobara Doumbo verfasserin aut Louis H Miller verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 2(2007), 10, p e1045 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:2 year:2007 number:10, p e1045 https://doi.org/10.1371/journal.pone.0001045 kostenfrei https://doaj.org/article/77e51bbf3ad746e08d3a6517f251c133 kostenfrei http://europepmc.org/articles/PMC2013939?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2007 10, p e1045
language	English
source	In PLoS ONE 2(2007), 10, p e1045 volume:2 year:2007 number:10, p e1045
sourceStr	In PLoS ONE 2(2007), 10, p e1045 volume:2 year:2007 number:10, p e1045
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Medicine R Science Q
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container_title	PLoS ONE
authorswithroles_txt_mv	Alassane Dicko @@aut@@ David J Diemert @@aut@@ Issaka Sagara @@aut@@ Moussa Sogoba @@aut@@ Mohamed B Niambele @@aut@@ Mahamadoun H Assadou @@aut@@ Ousmane Guindo @@aut@@ Beh Kamate @@aut@@ Mounirou Baby @@aut@@ Mady Sissoko @@aut@@ Elissa M Malkin @@aut@@ Michael P Fay @@aut@@ Mahamadou A Thera @@aut@@ Kazutoyo Miura @@aut@@ Amagana Dolo @@aut@@ Dapa A Diallo @@aut@@ Gregory E Mullen @@aut@@ Carole A Long @@aut@@ Allan Saul @@aut@@ Ogobara Doumbo @@aut@@ Louis H Miller @@aut@@
publishDateDaySort_date	2007-01-01T00:00:00Z
hierarchy_top_id	523574592
id	DOAJ025831429
language_de	englisch
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author	Alassane Dicko
spellingShingle	Alassane Dicko misc Medicine misc R misc Science misc Q Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians.
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topic_title	Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians
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title	Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians.
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title_full	Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians
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author_browse	Alassane Dicko David J Diemert Issaka Sagara Moussa Sogoba Mohamed B Niambele Mahamadoun H Assadou Ousmane Guindo Beh Kamate Mounirou Baby Mady Sissoko Elissa M Malkin Michael P Fay Mahamadou A Thera Kazutoyo Miura Amagana Dolo Dapa A Diallo Gregory E Mullen Carole A Long Allan Saul Ogobara Doumbo Louis H Miller
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title_sort	impact of a plasmodium falciparum ama1 vaccine on antibody responses in adult malians
title_auth	Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians.
abstract	Apical Membrane Antigen 1 (AMA1) of Plasmodium falciparum merozoites is a leading blood-stage malaria vaccine candidate. Protection of Aotus monkeys after vaccination with AMA1 correlates with antibody responses.A randomized, controlled, double-blind phase 1 clinical trial was conducted in 54 healthy Malian adults living in an area of intense seasonal malaria transmission to assess the safety and immunogenicity of the AMA1-C1 malaria vaccine. AMA1-C1 contains an equal mixture of yeast-expressed recombinant proteins based on sequences from the FVO and 3D7 clones of P. falciparum, adsorbed on Alhydrogel. The control vaccine was the hepatitis B vaccine (Recombivax). Participants were enrolled into 1 of 3 dose cohorts (n = 18 per cohort) and randomized 2:1 to receive either AMA1-C1 or Recombivax. Participants in the first, second, and third cohorts randomized to receive AMA1-C1 were vaccinated with 5, 20 and 80 microg of AMA1-C1, respectively. Vaccinations were administered on days 0, 28, and 360, and participants were followed until 6 months after the final vaccination. AMA1-C1 was well tolerated; no vaccine-related severe or serious adverse events were observed. AMA1 antibody responses to the 80 microg dose increased rapidly from baseline levels by days 14 and 28 after the first vaccination and continued to increase after the second vaccination. After a peak 14 days following the second vaccination, antibody levels decreased to baseline levels one year later at the time of the third vaccination that induced little or no increase in antibody levels.Although the AMA1-C1 vaccine candidate was well-tolerated and induced antibody responses to both vaccine and non-vaccine alleles, the antibody response after a third dose given at one year was lower than the response to the initial vaccinations. Additionally, post-vaccination increases in anti-AMA1 antibody levels were not associated with significant changes in in vitro growth inhibition of P. falciparum.ClinicalTrials.gov NCT00343005.
abstractGer	Apical Membrane Antigen 1 (AMA1) of Plasmodium falciparum merozoites is a leading blood-stage malaria vaccine candidate. Protection of Aotus monkeys after vaccination with AMA1 correlates with antibody responses.A randomized, controlled, double-blind phase 1 clinical trial was conducted in 54 healthy Malian adults living in an area of intense seasonal malaria transmission to assess the safety and immunogenicity of the AMA1-C1 malaria vaccine. AMA1-C1 contains an equal mixture of yeast-expressed recombinant proteins based on sequences from the FVO and 3D7 clones of P. falciparum, adsorbed on Alhydrogel. The control vaccine was the hepatitis B vaccine (Recombivax). Participants were enrolled into 1 of 3 dose cohorts (n = 18 per cohort) and randomized 2:1 to receive either AMA1-C1 or Recombivax. Participants in the first, second, and third cohorts randomized to receive AMA1-C1 were vaccinated with 5, 20 and 80 microg of AMA1-C1, respectively. Vaccinations were administered on days 0, 28, and 360, and participants were followed until 6 months after the final vaccination. AMA1-C1 was well tolerated; no vaccine-related severe or serious adverse events were observed. AMA1 antibody responses to the 80 microg dose increased rapidly from baseline levels by days 14 and 28 after the first vaccination and continued to increase after the second vaccination. After a peak 14 days following the second vaccination, antibody levels decreased to baseline levels one year later at the time of the third vaccination that induced little or no increase in antibody levels.Although the AMA1-C1 vaccine candidate was well-tolerated and induced antibody responses to both vaccine and non-vaccine alleles, the antibody response after a third dose given at one year was lower than the response to the initial vaccinations. Additionally, post-vaccination increases in anti-AMA1 antibody levels were not associated with significant changes in in vitro growth inhibition of P. falciparum.ClinicalTrials.gov NCT00343005.
abstract_unstemmed	Apical Membrane Antigen 1 (AMA1) of Plasmodium falciparum merozoites is a leading blood-stage malaria vaccine candidate. Protection of Aotus monkeys after vaccination with AMA1 correlates with antibody responses.A randomized, controlled, double-blind phase 1 clinical trial was conducted in 54 healthy Malian adults living in an area of intense seasonal malaria transmission to assess the safety and immunogenicity of the AMA1-C1 malaria vaccine. AMA1-C1 contains an equal mixture of yeast-expressed recombinant proteins based on sequences from the FVO and 3D7 clones of P. falciparum, adsorbed on Alhydrogel. The control vaccine was the hepatitis B vaccine (Recombivax). Participants were enrolled into 1 of 3 dose cohorts (n = 18 per cohort) and randomized 2:1 to receive either AMA1-C1 or Recombivax. Participants in the first, second, and third cohorts randomized to receive AMA1-C1 were vaccinated with 5, 20 and 80 microg of AMA1-C1, respectively. Vaccinations were administered on days 0, 28, and 360, and participants were followed until 6 months after the final vaccination. AMA1-C1 was well tolerated; no vaccine-related severe or serious adverse events were observed. AMA1 antibody responses to the 80 microg dose increased rapidly from baseline levels by days 14 and 28 after the first vaccination and continued to increase after the second vaccination. After a peak 14 days following the second vaccination, antibody levels decreased to baseline levels one year later at the time of the third vaccination that induced little or no increase in antibody levels.Although the AMA1-C1 vaccine candidate was well-tolerated and induced antibody responses to both vaccine and non-vaccine alleles, the antibody response after a third dose given at one year was lower than the response to the initial vaccinations. Additionally, post-vaccination increases in anti-AMA1 antibody levels were not associated with significant changes in in vitro growth inhibition of P. falciparum.ClinicalTrials.gov NCT00343005.
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title_short	Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians.
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AMA1-C1 was well tolerated; no vaccine-related severe or serious adverse events were observed. AMA1 antibody responses to the 80 microg dose increased rapidly from baseline levels by days 14 and 28 after the first vaccination and continued to increase after the second vaccination. After a peak 14 days following the second vaccination, antibody levels decreased to baseline levels one year later at the time of the third vaccination that induced little or no increase in antibody levels.Although the AMA1-C1 vaccine candidate was well-tolerated and induced antibody responses to both vaccine and non-vaccine alleles, the antibody response after a third dose given at one year was lower than the response to the initial vaccinations. 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Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians.

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