Protective Effect of UP446 on Ligature-Induced Periodontitis in Beagle Dogs

Periodontal disease is an inflammatory disease of the gum caused by a formation of a plaque that triggers immune responses and inflammation leading to the destruction of tissues surrounding and supporting the teeth. Chronic usage of synthetic chemicals and antibiotics is limited by undesired adverse...
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Autor*in:	Mesfin Yimam [verfasserIn] Lidia Brownell [verfasserIn] Seon-Gil Do [verfasserIn] Young-Chul Lee [verfasserIn] Dong Seon Kim [verfasserIn] Kangmoon Seo [verfasserIn] Manbok Jeong [verfasserIn] Seeun Kim [verfasserIn] Qi Jia [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	periodontitis periodontal disease beagle dogs UP446

Übergeordnetes Werk:	In: Dentistry Journal - MDPI AG, 2013, 7(2019), 2, p 33
Übergeordnetes Werk:	volume:7 ; year:2019 ; number:2, p 33

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/dj7020033

Katalog-ID:	DOAJ025849220

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callnumber-first	R - Medicine
author	Mesfin Yimam
spellingShingle	Mesfin Yimam misc RK1-715 misc periodontitis misc periodontal disease misc beagle dogs misc <i<Scutellaria baicalensis</i< misc <i<Acacia catechu</i< misc UP446 misc Dentistry Protective Effect of UP446 on Ligature-Induced Periodontitis in Beagle Dogs
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topic_title	RK1-715 Protective Effect of UP446 on Ligature-Induced Periodontitis in Beagle Dogs periodontitis periodontal disease beagle dogs <i<Scutellaria baicalensis</i< <i<Acacia catechu</i< UP446
topic	misc RK1-715 misc periodontitis misc periodontal disease misc beagle dogs misc <i<Scutellaria baicalensis</i< misc <i<Acacia catechu</i< misc UP446 misc Dentistry
topic_unstemmed	misc RK1-715 misc periodontitis misc periodontal disease misc beagle dogs misc <i<Scutellaria baicalensis</i< misc <i<Acacia catechu</i< misc UP446 misc Dentistry
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title	Protective Effect of UP446 on Ligature-Induced Periodontitis in Beagle Dogs
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title_full	Protective Effect of UP446 on Ligature-Induced Periodontitis in Beagle Dogs
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title_sort	protective effect of up446 on ligature-induced periodontitis in beagle dogs
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title_auth	Protective Effect of UP446 on Ligature-Induced Periodontitis in Beagle Dogs
abstract	Periodontal disease is an inflammatory disease of the gum caused by a formation of a plaque that triggers immune responses and inflammation leading to the destruction of tissues surrounding and supporting the teeth. Chronic usage of synthetic chemicals and antibiotics is limited by undesired adverse events to the host. A botanical composition (UP446), which consists primarily of bioflavonoids such as baicalin from roots of <i<Scutellaria baicalensis</i< and catechins from heartwoods of <i<Acacia catechu</i<, was evaluated for its effect on ligature-induced periodontal disease in beagle dogs. Disease model was induced in 20 male and female dogs. After a 12-week induction of periodontitis, animals were assigned to a placebo, positive control (doxycycline), and two treatment groups consisting of five animals each. The placebo group was only administrated to normal dog chow (25 g/kg/day). In the doxycycline treatment group, animals were fed a normal diet (25 g/kg/day) and doxycycline (5 mg/kg) was orally administrated every day. Treatment of UP446 was done by feeding the regular diet formulated with 0.1% and 0.2% of UP446 by weight. Clinical indices such as plaque index (PI), gingival index (GI), clinical attachment level (CAL), probing pocket depth (PPD), and bleeding on probing (BoP) were measured every two weeks for 12 weeks. UP446 administered to beagle dogs for 12 weeks at 0.1% and 0.2% resulted in statistically significant reductions in gingivitis, pocket depth, loss of attachment, and gum bleeding. UP446 could potentially be used alone or as an adjunct with other oral hygiene preparations for periodontal disease in both human and companion animals.
abstractGer	Periodontal disease is an inflammatory disease of the gum caused by a formation of a plaque that triggers immune responses and inflammation leading to the destruction of tissues surrounding and supporting the teeth. Chronic usage of synthetic chemicals and antibiotics is limited by undesired adverse events to the host. A botanical composition (UP446), which consists primarily of bioflavonoids such as baicalin from roots of <i<Scutellaria baicalensis</i< and catechins from heartwoods of <i<Acacia catechu</i<, was evaluated for its effect on ligature-induced periodontal disease in beagle dogs. Disease model was induced in 20 male and female dogs. After a 12-week induction of periodontitis, animals were assigned to a placebo, positive control (doxycycline), and two treatment groups consisting of five animals each. The placebo group was only administrated to normal dog chow (25 g/kg/day). In the doxycycline treatment group, animals were fed a normal diet (25 g/kg/day) and doxycycline (5 mg/kg) was orally administrated every day. Treatment of UP446 was done by feeding the regular diet formulated with 0.1% and 0.2% of UP446 by weight. Clinical indices such as plaque index (PI), gingival index (GI), clinical attachment level (CAL), probing pocket depth (PPD), and bleeding on probing (BoP) were measured every two weeks for 12 weeks. UP446 administered to beagle dogs for 12 weeks at 0.1% and 0.2% resulted in statistically significant reductions in gingivitis, pocket depth, loss of attachment, and gum bleeding. UP446 could potentially be used alone or as an adjunct with other oral hygiene preparations for periodontal disease in both human and companion animals.
abstract_unstemmed	Periodontal disease is an inflammatory disease of the gum caused by a formation of a plaque that triggers immune responses and inflammation leading to the destruction of tissues surrounding and supporting the teeth. Chronic usage of synthetic chemicals and antibiotics is limited by undesired adverse events to the host. A botanical composition (UP446), which consists primarily of bioflavonoids such as baicalin from roots of <i<Scutellaria baicalensis</i< and catechins from heartwoods of <i<Acacia catechu</i<, was evaluated for its effect on ligature-induced periodontal disease in beagle dogs. Disease model was induced in 20 male and female dogs. After a 12-week induction of periodontitis, animals were assigned to a placebo, positive control (doxycycline), and two treatment groups consisting of five animals each. The placebo group was only administrated to normal dog chow (25 g/kg/day). In the doxycycline treatment group, animals were fed a normal diet (25 g/kg/day) and doxycycline (5 mg/kg) was orally administrated every day. Treatment of UP446 was done by feeding the regular diet formulated with 0.1% and 0.2% of UP446 by weight. Clinical indices such as plaque index (PI), gingival index (GI), clinical attachment level (CAL), probing pocket depth (PPD), and bleeding on probing (BoP) were measured every two weeks for 12 weeks. UP446 administered to beagle dogs for 12 weeks at 0.1% and 0.2% resulted in statistically significant reductions in gingivitis, pocket depth, loss of attachment, and gum bleeding. UP446 could potentially be used alone or as an adjunct with other oral hygiene preparations for periodontal disease in both human and companion animals.
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container_issue	2, p 33
title_short	Protective Effect of UP446 on Ligature-Induced Periodontitis in Beagle Dogs
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Clinical indices such as plaque index (PI), gingival index (GI), clinical attachment level (CAL), probing pocket depth (PPD), and bleeding on probing (BoP) were measured every two weeks for 12 weeks. UP446 administered to beagle dogs for 12 weeks at 0.1% and 0.2% resulted in statistically significant reductions in gingivitis, pocket depth, loss of attachment, and gum bleeding. 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Protective Effect of UP446 on Ligature-Induced Periodontitis in Beagle Dogs

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