Impact of Age of Onset on Survival after Hepatectomy for Patients with Colorectal Cancer Liver Metastasis: A Real-World Single-Center Experience
Purpose: The incidence of early-onset CRC is increasing. However, the effect of age of onset on the long-term outcome of colorectal cancer liver metastasis (CRLM) remains unclear. This study aimed to evaluate the association between the age of onset and the oncological outcome of CRLM patients and t...
Ausführliche Beschreibung
Autor*in: |
Hong-Wei Wang [verfasserIn] Li-Jun Wang [verfasserIn] Ke-Min Jin [verfasserIn] Quan Bao [verfasserIn] Juan Li [verfasserIn] Si-Kai Ge [verfasserIn] Kun Wang [verfasserIn] Bao-Cai Xing [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Übergeordnetes Werk: |
In: Current Oncology - MDPI AG, 2021, 29(2022), 11, Seite 8456-8467 |
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Übergeordnetes Werk: |
volume:29 ; year:2022 ; number:11 ; pages:8456-8467 |
Links: |
Link aufrufen |
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DOI / URN: |
10.3390/curroncol29110666 |
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Katalog-ID: |
DOAJ025857886 |
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10.3390/curroncol29110666 doi (DE-627)DOAJ025857886 (DE-599)DOAJ10aba775decd4bcdb86909497d4db9f8 DE-627 ger DE-627 rakwb eng RC254-282 Hong-Wei Wang verfasserin aut Impact of Age of Onset on Survival after Hepatectomy for Patients with Colorectal Cancer Liver Metastasis: A Real-World Single-Center Experience 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: The incidence of early-onset CRC is increasing. However, the effect of age of onset on the long-term outcome of colorectal cancer liver metastasis (CRLM) remains unclear. This study aimed to evaluate the association between the age of onset and the oncological outcome of CRLM patients and to investigate whether the prognostic role of RAS mutation is altered with age. Methods: We retrospectively investigated consecutive patients at our institution who underwent initial liver resection between 2006 and 2020. The inverse probability of treatment weighting (IPTW) method was used to balance the confounders among early- (≤45 years; EOCRLM), intermediate- (46–70 years; IOCRLM), and late-onset (<70 years; LOCRLM) groups. The prognostic role of RAS was assessed based on age group. Results: A total of 1189 patients were enrolled: 162 in the EOCRLM group, 930 in the IOCRLM group, and 97 in the LOCRLM group. No difference in disease-free survival (DFS) was found between the three groups. However, EOCRLM were more likely to develop extrahepatic and extrapulmonary metastasis and had significantly lower five-year OS rates than IOCRLM. After IPTW, EOCRLM remained a negative prognostic predictor. RAS mutations were significantly associated with worse survival than wild-type RAS in EOCRLM and IOCRLM. However, RAS mutation did not predict the prognosis of patients with LOCRLM. Conclusions: Patients with EOCRLM had a significantly lower OS than IOCRLM patients and age influences the prognostic power of RAS status. These findings may be helpful for doctors to guide the clinical treatments and develop follow-up strategies. colorectal liver metastasis age of onset hepatectomy RAS status Neoplasms. Tumors. Oncology. Including cancer and carcinogens Li-Jun Wang verfasserin aut Ke-Min Jin verfasserin aut Quan Bao verfasserin aut Juan Li verfasserin aut Si-Kai Ge verfasserin aut Kun Wang verfasserin aut Bao-Cai Xing verfasserin aut In Current Oncology MDPI AG, 2021 29(2022), 11, Seite 8456-8467 (DE-627)524623112 (DE-600)2270777-3 17187729 nnns volume:29 year:2022 number:11 pages:8456-8467 https://doi.org/10.3390/curroncol29110666 kostenfrei https://doaj.org/article/10aba775decd4bcdb86909497d4db9f8 kostenfrei https://www.mdpi.com/1718-7729/29/11/666 kostenfrei https://doaj.org/toc/1198-0052 Journal toc kostenfrei https://doaj.org/toc/1718-7729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 29 2022 11 8456-8467 |
spelling |
10.3390/curroncol29110666 doi (DE-627)DOAJ025857886 (DE-599)DOAJ10aba775decd4bcdb86909497d4db9f8 DE-627 ger DE-627 rakwb eng RC254-282 Hong-Wei Wang verfasserin aut Impact of Age of Onset on Survival after Hepatectomy for Patients with Colorectal Cancer Liver Metastasis: A Real-World Single-Center Experience 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: The incidence of early-onset CRC is increasing. However, the effect of age of onset on the long-term outcome of colorectal cancer liver metastasis (CRLM) remains unclear. This study aimed to evaluate the association between the age of onset and the oncological outcome of CRLM patients and to investigate whether the prognostic role of RAS mutation is altered with age. Methods: We retrospectively investigated consecutive patients at our institution who underwent initial liver resection between 2006 and 2020. The inverse probability of treatment weighting (IPTW) method was used to balance the confounders among early- (≤45 years; EOCRLM), intermediate- (46–70 years; IOCRLM), and late-onset (<70 years; LOCRLM) groups. The prognostic role of RAS was assessed based on age group. Results: A total of 1189 patients were enrolled: 162 in the EOCRLM group, 930 in the IOCRLM group, and 97 in the LOCRLM group. No difference in disease-free survival (DFS) was found between the three groups. However, EOCRLM were more likely to develop extrahepatic and extrapulmonary metastasis and had significantly lower five-year OS rates than IOCRLM. After IPTW, EOCRLM remained a negative prognostic predictor. RAS mutations were significantly associated with worse survival than wild-type RAS in EOCRLM and IOCRLM. However, RAS mutation did not predict the prognosis of patients with LOCRLM. Conclusions: Patients with EOCRLM had a significantly lower OS than IOCRLM patients and age influences the prognostic power of RAS status. These findings may be helpful for doctors to guide the clinical treatments and develop follow-up strategies. colorectal liver metastasis age of onset hepatectomy RAS status Neoplasms. Tumors. Oncology. Including cancer and carcinogens Li-Jun Wang verfasserin aut Ke-Min Jin verfasserin aut Quan Bao verfasserin aut Juan Li verfasserin aut Si-Kai Ge verfasserin aut Kun Wang verfasserin aut Bao-Cai Xing verfasserin aut In Current Oncology MDPI AG, 2021 29(2022), 11, Seite 8456-8467 (DE-627)524623112 (DE-600)2270777-3 17187729 nnns volume:29 year:2022 number:11 pages:8456-8467 https://doi.org/10.3390/curroncol29110666 kostenfrei https://doaj.org/article/10aba775decd4bcdb86909497d4db9f8 kostenfrei https://www.mdpi.com/1718-7729/29/11/666 kostenfrei https://doaj.org/toc/1198-0052 Journal toc kostenfrei https://doaj.org/toc/1718-7729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 29 2022 11 8456-8467 |
allfields_unstemmed |
10.3390/curroncol29110666 doi (DE-627)DOAJ025857886 (DE-599)DOAJ10aba775decd4bcdb86909497d4db9f8 DE-627 ger DE-627 rakwb eng RC254-282 Hong-Wei Wang verfasserin aut Impact of Age of Onset on Survival after Hepatectomy for Patients with Colorectal Cancer Liver Metastasis: A Real-World Single-Center Experience 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: The incidence of early-onset CRC is increasing. However, the effect of age of onset on the long-term outcome of colorectal cancer liver metastasis (CRLM) remains unclear. This study aimed to evaluate the association between the age of onset and the oncological outcome of CRLM patients and to investigate whether the prognostic role of RAS mutation is altered with age. Methods: We retrospectively investigated consecutive patients at our institution who underwent initial liver resection between 2006 and 2020. The inverse probability of treatment weighting (IPTW) method was used to balance the confounders among early- (≤45 years; EOCRLM), intermediate- (46–70 years; IOCRLM), and late-onset (<70 years; LOCRLM) groups. The prognostic role of RAS was assessed based on age group. Results: A total of 1189 patients were enrolled: 162 in the EOCRLM group, 930 in the IOCRLM group, and 97 in the LOCRLM group. No difference in disease-free survival (DFS) was found between the three groups. However, EOCRLM were more likely to develop extrahepatic and extrapulmonary metastasis and had significantly lower five-year OS rates than IOCRLM. After IPTW, EOCRLM remained a negative prognostic predictor. RAS mutations were significantly associated with worse survival than wild-type RAS in EOCRLM and IOCRLM. However, RAS mutation did not predict the prognosis of patients with LOCRLM. Conclusions: Patients with EOCRLM had a significantly lower OS than IOCRLM patients and age influences the prognostic power of RAS status. These findings may be helpful for doctors to guide the clinical treatments and develop follow-up strategies. colorectal liver metastasis age of onset hepatectomy RAS status Neoplasms. Tumors. Oncology. Including cancer and carcinogens Li-Jun Wang verfasserin aut Ke-Min Jin verfasserin aut Quan Bao verfasserin aut Juan Li verfasserin aut Si-Kai Ge verfasserin aut Kun Wang verfasserin aut Bao-Cai Xing verfasserin aut In Current Oncology MDPI AG, 2021 29(2022), 11, Seite 8456-8467 (DE-627)524623112 (DE-600)2270777-3 17187729 nnns volume:29 year:2022 number:11 pages:8456-8467 https://doi.org/10.3390/curroncol29110666 kostenfrei https://doaj.org/article/10aba775decd4bcdb86909497d4db9f8 kostenfrei https://www.mdpi.com/1718-7729/29/11/666 kostenfrei https://doaj.org/toc/1198-0052 Journal toc kostenfrei https://doaj.org/toc/1718-7729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 29 2022 11 8456-8467 |
allfieldsGer |
10.3390/curroncol29110666 doi (DE-627)DOAJ025857886 (DE-599)DOAJ10aba775decd4bcdb86909497d4db9f8 DE-627 ger DE-627 rakwb eng RC254-282 Hong-Wei Wang verfasserin aut Impact of Age of Onset on Survival after Hepatectomy for Patients with Colorectal Cancer Liver Metastasis: A Real-World Single-Center Experience 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: The incidence of early-onset CRC is increasing. However, the effect of age of onset on the long-term outcome of colorectal cancer liver metastasis (CRLM) remains unclear. This study aimed to evaluate the association between the age of onset and the oncological outcome of CRLM patients and to investigate whether the prognostic role of RAS mutation is altered with age. Methods: We retrospectively investigated consecutive patients at our institution who underwent initial liver resection between 2006 and 2020. The inverse probability of treatment weighting (IPTW) method was used to balance the confounders among early- (≤45 years; EOCRLM), intermediate- (46–70 years; IOCRLM), and late-onset (<70 years; LOCRLM) groups. The prognostic role of RAS was assessed based on age group. Results: A total of 1189 patients were enrolled: 162 in the EOCRLM group, 930 in the IOCRLM group, and 97 in the LOCRLM group. No difference in disease-free survival (DFS) was found between the three groups. However, EOCRLM were more likely to develop extrahepatic and extrapulmonary metastasis and had significantly lower five-year OS rates than IOCRLM. After IPTW, EOCRLM remained a negative prognostic predictor. RAS mutations were significantly associated with worse survival than wild-type RAS in EOCRLM and IOCRLM. However, RAS mutation did not predict the prognosis of patients with LOCRLM. Conclusions: Patients with EOCRLM had a significantly lower OS than IOCRLM patients and age influences the prognostic power of RAS status. These findings may be helpful for doctors to guide the clinical treatments and develop follow-up strategies. colorectal liver metastasis age of onset hepatectomy RAS status Neoplasms. Tumors. Oncology. Including cancer and carcinogens Li-Jun Wang verfasserin aut Ke-Min Jin verfasserin aut Quan Bao verfasserin aut Juan Li verfasserin aut Si-Kai Ge verfasserin aut Kun Wang verfasserin aut Bao-Cai Xing verfasserin aut In Current Oncology MDPI AG, 2021 29(2022), 11, Seite 8456-8467 (DE-627)524623112 (DE-600)2270777-3 17187729 nnns volume:29 year:2022 number:11 pages:8456-8467 https://doi.org/10.3390/curroncol29110666 kostenfrei https://doaj.org/article/10aba775decd4bcdb86909497d4db9f8 kostenfrei https://www.mdpi.com/1718-7729/29/11/666 kostenfrei https://doaj.org/toc/1198-0052 Journal toc kostenfrei https://doaj.org/toc/1718-7729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 29 2022 11 8456-8467 |
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10.3390/curroncol29110666 doi (DE-627)DOAJ025857886 (DE-599)DOAJ10aba775decd4bcdb86909497d4db9f8 DE-627 ger DE-627 rakwb eng RC254-282 Hong-Wei Wang verfasserin aut Impact of Age of Onset on Survival after Hepatectomy for Patients with Colorectal Cancer Liver Metastasis: A Real-World Single-Center Experience 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: The incidence of early-onset CRC is increasing. However, the effect of age of onset on the long-term outcome of colorectal cancer liver metastasis (CRLM) remains unclear. This study aimed to evaluate the association between the age of onset and the oncological outcome of CRLM patients and to investigate whether the prognostic role of RAS mutation is altered with age. Methods: We retrospectively investigated consecutive patients at our institution who underwent initial liver resection between 2006 and 2020. The inverse probability of treatment weighting (IPTW) method was used to balance the confounders among early- (≤45 years; EOCRLM), intermediate- (46–70 years; IOCRLM), and late-onset (<70 years; LOCRLM) groups. The prognostic role of RAS was assessed based on age group. Results: A total of 1189 patients were enrolled: 162 in the EOCRLM group, 930 in the IOCRLM group, and 97 in the LOCRLM group. No difference in disease-free survival (DFS) was found between the three groups. However, EOCRLM were more likely to develop extrahepatic and extrapulmonary metastasis and had significantly lower five-year OS rates than IOCRLM. After IPTW, EOCRLM remained a negative prognostic predictor. RAS mutations were significantly associated with worse survival than wild-type RAS in EOCRLM and IOCRLM. However, RAS mutation did not predict the prognosis of patients with LOCRLM. Conclusions: Patients with EOCRLM had a significantly lower OS than IOCRLM patients and age influences the prognostic power of RAS status. These findings may be helpful for doctors to guide the clinical treatments and develop follow-up strategies. colorectal liver metastasis age of onset hepatectomy RAS status Neoplasms. Tumors. Oncology. Including cancer and carcinogens Li-Jun Wang verfasserin aut Ke-Min Jin verfasserin aut Quan Bao verfasserin aut Juan Li verfasserin aut Si-Kai Ge verfasserin aut Kun Wang verfasserin aut Bao-Cai Xing verfasserin aut In Current Oncology MDPI AG, 2021 29(2022), 11, Seite 8456-8467 (DE-627)524623112 (DE-600)2270777-3 17187729 nnns volume:29 year:2022 number:11 pages:8456-8467 https://doi.org/10.3390/curroncol29110666 kostenfrei https://doaj.org/article/10aba775decd4bcdb86909497d4db9f8 kostenfrei https://www.mdpi.com/1718-7729/29/11/666 kostenfrei https://doaj.org/toc/1198-0052 Journal toc kostenfrei https://doaj.org/toc/1718-7729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 29 2022 11 8456-8467 |
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Impact of Age of Onset on Survival after Hepatectomy for Patients with Colorectal Cancer Liver Metastasis: A Real-World Single-Center Experience |
abstract |
Purpose: The incidence of early-onset CRC is increasing. However, the effect of age of onset on the long-term outcome of colorectal cancer liver metastasis (CRLM) remains unclear. This study aimed to evaluate the association between the age of onset and the oncological outcome of CRLM patients and to investigate whether the prognostic role of RAS mutation is altered with age. Methods: We retrospectively investigated consecutive patients at our institution who underwent initial liver resection between 2006 and 2020. The inverse probability of treatment weighting (IPTW) method was used to balance the confounders among early- (≤45 years; EOCRLM), intermediate- (46–70 years; IOCRLM), and late-onset (<70 years; LOCRLM) groups. The prognostic role of RAS was assessed based on age group. Results: A total of 1189 patients were enrolled: 162 in the EOCRLM group, 930 in the IOCRLM group, and 97 in the LOCRLM group. No difference in disease-free survival (DFS) was found between the three groups. However, EOCRLM were more likely to develop extrahepatic and extrapulmonary metastasis and had significantly lower five-year OS rates than IOCRLM. After IPTW, EOCRLM remained a negative prognostic predictor. RAS mutations were significantly associated with worse survival than wild-type RAS in EOCRLM and IOCRLM. However, RAS mutation did not predict the prognosis of patients with LOCRLM. Conclusions: Patients with EOCRLM had a significantly lower OS than IOCRLM patients and age influences the prognostic power of RAS status. These findings may be helpful for doctors to guide the clinical treatments and develop follow-up strategies. |
abstractGer |
Purpose: The incidence of early-onset CRC is increasing. However, the effect of age of onset on the long-term outcome of colorectal cancer liver metastasis (CRLM) remains unclear. This study aimed to evaluate the association between the age of onset and the oncological outcome of CRLM patients and to investigate whether the prognostic role of RAS mutation is altered with age. Methods: We retrospectively investigated consecutive patients at our institution who underwent initial liver resection between 2006 and 2020. The inverse probability of treatment weighting (IPTW) method was used to balance the confounders among early- (≤45 years; EOCRLM), intermediate- (46–70 years; IOCRLM), and late-onset (<70 years; LOCRLM) groups. The prognostic role of RAS was assessed based on age group. Results: A total of 1189 patients were enrolled: 162 in the EOCRLM group, 930 in the IOCRLM group, and 97 in the LOCRLM group. No difference in disease-free survival (DFS) was found between the three groups. However, EOCRLM were more likely to develop extrahepatic and extrapulmonary metastasis and had significantly lower five-year OS rates than IOCRLM. After IPTW, EOCRLM remained a negative prognostic predictor. RAS mutations were significantly associated with worse survival than wild-type RAS in EOCRLM and IOCRLM. However, RAS mutation did not predict the prognosis of patients with LOCRLM. Conclusions: Patients with EOCRLM had a significantly lower OS than IOCRLM patients and age influences the prognostic power of RAS status. These findings may be helpful for doctors to guide the clinical treatments and develop follow-up strategies. |
abstract_unstemmed |
Purpose: The incidence of early-onset CRC is increasing. However, the effect of age of onset on the long-term outcome of colorectal cancer liver metastasis (CRLM) remains unclear. This study aimed to evaluate the association between the age of onset and the oncological outcome of CRLM patients and to investigate whether the prognostic role of RAS mutation is altered with age. Methods: We retrospectively investigated consecutive patients at our institution who underwent initial liver resection between 2006 and 2020. The inverse probability of treatment weighting (IPTW) method was used to balance the confounders among early- (≤45 years; EOCRLM), intermediate- (46–70 years; IOCRLM), and late-onset (<70 years; LOCRLM) groups. The prognostic role of RAS was assessed based on age group. Results: A total of 1189 patients were enrolled: 162 in the EOCRLM group, 930 in the IOCRLM group, and 97 in the LOCRLM group. No difference in disease-free survival (DFS) was found between the three groups. However, EOCRLM were more likely to develop extrahepatic and extrapulmonary metastasis and had significantly lower five-year OS rates than IOCRLM. After IPTW, EOCRLM remained a negative prognostic predictor. RAS mutations were significantly associated with worse survival than wild-type RAS in EOCRLM and IOCRLM. However, RAS mutation did not predict the prognosis of patients with LOCRLM. Conclusions: Patients with EOCRLM had a significantly lower OS than IOCRLM patients and age influences the prognostic power of RAS status. These findings may be helpful for doctors to guide the clinical treatments and develop follow-up strategies. |
collection_details |
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container_issue |
11 |
title_short |
Impact of Age of Onset on Survival after Hepatectomy for Patients with Colorectal Cancer Liver Metastasis: A Real-World Single-Center Experience |
url |
https://doi.org/10.3390/curroncol29110666 https://doaj.org/article/10aba775decd4bcdb86909497d4db9f8 https://www.mdpi.com/1718-7729/29/11/666 https://doaj.org/toc/1198-0052 https://doaj.org/toc/1718-7729 |
remote_bool |
true |
author2 |
Li-Jun Wang Ke-Min Jin Quan Bao Juan Li Si-Kai Ge Kun Wang Bao-Cai Xing |
author2Str |
Li-Jun Wang Ke-Min Jin Quan Bao Juan Li Si-Kai Ge Kun Wang Bao-Cai Xing |
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callnumber-subject |
RC - Internal Medicine |
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doi_str |
10.3390/curroncol29110666 |
callnumber-a |
RC254-282 |
up_date |
2024-07-03T17:34:30.918Z |
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