Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A

In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells wit...
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Autor*in:	Johannes F. Imhoff [verfasserIn] Kerstin Nagel [verfasserIn] Jutta Wiese [verfasserIn] RÃƒÂ¼diger StÃƒÂ¶hr [verfasserIn] Stefanie Schmitt [verfasserIn] Gerhard Lang [verfasserIn] Tobias A. M. Gulder [verfasserIn] Gerhard Bringmann [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2007

Schlagwörter:	sorbicillactone A anti-leukemic activity large-scale production BIOTECmarin.

Übergeordnetes Werk:	In: Marine Drugs - MDPI AG, 2005, 5(2007), 2, Seite 23-30
Übergeordnetes Werk:	volume:5 ; year:2007 ; number:2 ; pages:23-30

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/md502023

Katalog-ID:	DOAJ025912968

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spelling	10.3390/md502023 doi (DE-627)DOAJ025912968 (DE-599)DOAJ21d49b5586704b8da2877f3138be536d DE-627 ger DE-627 rakwb eng QH301-705.5 Johannes F. Imhoff verfasserin aut Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies. sorbicillactone A anti-leukemic activity large-scale production BIOTECmarin. Biology (General) Kerstin Nagel verfasserin aut Jutta Wiese verfasserin aut RÃƒÂ¼diger StÃƒÂ¶hr verfasserin aut Stefanie Schmitt verfasserin aut Gerhard Lang verfasserin aut Tobias A. M. Gulder verfasserin aut Gerhard Bringmann verfasserin aut In Marine Drugs MDPI AG, 2005 5(2007), 2, Seite 23-30 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:5 year:2007 number:2 pages:23-30 https://doi.org/10.3390/md502023 kostenfrei https://doaj.org/article/21d49b5586704b8da2877f3138be536d kostenfrei http://www.mdpi.com/1660-3397/5/2/23/ kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2007 2 23-30
allfields_unstemmed	10.3390/md502023 doi (DE-627)DOAJ025912968 (DE-599)DOAJ21d49b5586704b8da2877f3138be536d DE-627 ger DE-627 rakwb eng QH301-705.5 Johannes F. Imhoff verfasserin aut Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies. sorbicillactone A anti-leukemic activity large-scale production BIOTECmarin. Biology (General) Kerstin Nagel verfasserin aut Jutta Wiese verfasserin aut RÃƒÂ¼diger StÃƒÂ¶hr verfasserin aut Stefanie Schmitt verfasserin aut Gerhard Lang verfasserin aut Tobias A. M. Gulder verfasserin aut Gerhard Bringmann verfasserin aut In Marine Drugs MDPI AG, 2005 5(2007), 2, Seite 23-30 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:5 year:2007 number:2 pages:23-30 https://doi.org/10.3390/md502023 kostenfrei https://doaj.org/article/21d49b5586704b8da2877f3138be536d kostenfrei http://www.mdpi.com/1660-3397/5/2/23/ kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2007 2 23-30
allfieldsGer	10.3390/md502023 doi (DE-627)DOAJ025912968 (DE-599)DOAJ21d49b5586704b8da2877f3138be536d DE-627 ger DE-627 rakwb eng QH301-705.5 Johannes F. Imhoff verfasserin aut Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies. sorbicillactone A anti-leukemic activity large-scale production BIOTECmarin. Biology (General) Kerstin Nagel verfasserin aut Jutta Wiese verfasserin aut RÃƒÂ¼diger StÃƒÂ¶hr verfasserin aut Stefanie Schmitt verfasserin aut Gerhard Lang verfasserin aut Tobias A. M. Gulder verfasserin aut Gerhard Bringmann verfasserin aut In Marine Drugs MDPI AG, 2005 5(2007), 2, Seite 23-30 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:5 year:2007 number:2 pages:23-30 https://doi.org/10.3390/md502023 kostenfrei https://doaj.org/article/21d49b5586704b8da2877f3138be536d kostenfrei http://www.mdpi.com/1660-3397/5/2/23/ kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2007 2 23-30
allfieldsSound	10.3390/md502023 doi (DE-627)DOAJ025912968 (DE-599)DOAJ21d49b5586704b8da2877f3138be536d DE-627 ger DE-627 rakwb eng QH301-705.5 Johannes F. Imhoff verfasserin aut Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies. sorbicillactone A anti-leukemic activity large-scale production BIOTECmarin. Biology (General) Kerstin Nagel verfasserin aut Jutta Wiese verfasserin aut RÃƒÂ¼diger StÃƒÂ¶hr verfasserin aut Stefanie Schmitt verfasserin aut Gerhard Lang verfasserin aut Tobias A. M. Gulder verfasserin aut Gerhard Bringmann verfasserin aut In Marine Drugs MDPI AG, 2005 5(2007), 2, Seite 23-30 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:5 year:2007 number:2 pages:23-30 https://doi.org/10.3390/md502023 kostenfrei https://doaj.org/article/21d49b5586704b8da2877f3138be536d kostenfrei http://www.mdpi.com/1660-3397/5/2/23/ kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2007 2 23-30
language	English
source	In Marine Drugs 5(2007), 2, Seite 23-30 volume:5 year:2007 number:2 pages:23-30
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author	Johannes F. Imhoff
spellingShingle	Johannes F. Imhoff misc QH301-705.5 misc sorbicillactone A misc anti-leukemic activity misc large-scale production misc BIOTECmarin. misc Biology (General) Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A
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topic_title	QH301-705.5 Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A sorbicillactone A anti-leukemic activity large-scale production BIOTECmarin
topic	misc QH301-705.5 misc sorbicillactone A misc anti-leukemic activity misc large-scale production misc BIOTECmarin. misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc sorbicillactone A misc anti-leukemic activity misc large-scale production misc BIOTECmarin. misc Biology (General)
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title	Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A
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title_full	Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A
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author_browse	Johannes F. Imhoff Kerstin Nagel Jutta Wiese RÃƒÂ¼diger StÃƒÂ¶hr Stefanie Schmitt Gerhard Lang Tobias A. M. Gulder Gerhard Bringmann
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title_sort	large-scale biotechnological production of the antileukemic marine natural product sorbicillactone a
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title_auth	Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A
abstract	In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies.
abstractGer	In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies.
abstract_unstemmed	In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies.
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title_short	Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A
url	https://doi.org/10.3390/md502023 https://doaj.org/article/21d49b5586704b8da2877f3138be536d http://www.mdpi.com/1660-3397/5/2/23/ https://doaj.org/toc/1660-3397
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up_date	2024-07-03T17:54:43.290Z
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Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A

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