Global perspectives on CYP2D6 associations with primaquine metabolism and Plasmodium vivax radical cure

Clinical trial and individual patient treatment outcomes have produced accumulating evidence that effective primaquine (PQ) treatment of Plasmodium vivax and P. ovale liver stage hypnozoites is associated with genetic variation in the human cytochrome P450 gene, CYP2D6. Successful PQ treatment of in...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Jasmine M. Olvany [verfasserIn] Scott M. Williams [verfasserIn] Peter A. Zimmerman [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	malaria hypnozoite CYP2D6 activity score primaquine

Übergeordnetes Werk:	In: Frontiers in Pharmacology - Frontiers Media S.A., 2010, 13(2022)
Übergeordnetes Werk:	volume:13 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphar.2022.752314

Katalog-ID:	DOAJ02599882X

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language	English
source	In Frontiers in Pharmacology 13(2022) volume:13 year:2022
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author	Jasmine M. Olvany
spellingShingle	Jasmine M. Olvany misc RM1-950 misc malaria misc hypnozoite misc CYP2D6 misc activity score misc primaquine misc Therapeutics. Pharmacology Global perspectives on CYP2D6 associations with primaquine metabolism and Plasmodium vivax radical cure
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topic_title	RM1-950 Global perspectives on CYP2D6 associations with primaquine metabolism and Plasmodium vivax radical cure malaria hypnozoite CYP2D6 activity score primaquine
topic	misc RM1-950 misc malaria misc hypnozoite misc CYP2D6 misc activity score misc primaquine misc Therapeutics. Pharmacology
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title	Global perspectives on CYP2D6 associations with primaquine metabolism and Plasmodium vivax radical cure
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title_sort	global perspectives on cyp2d6 associations with primaquine metabolism and plasmodium vivax radical cure
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title_auth	Global perspectives on CYP2D6 associations with primaquine metabolism and Plasmodium vivax radical cure
abstract	Clinical trial and individual patient treatment outcomes have produced accumulating evidence that effective primaquine (PQ) treatment of Plasmodium vivax and P. ovale liver stage hypnozoites is associated with genetic variation in the human cytochrome P450 gene, CYP2D6. Successful PQ treatment of individual and population-wide infections by the Plasmodium species that generate these dormant liver stage forms is likely to be necessary to reach elimination of malaria caused by these parasites globally. Optimizing safe and effective PQ treatment will require coordination of efforts between the malaria and pharmacogenomics research communities.
abstractGer	Clinical trial and individual patient treatment outcomes have produced accumulating evidence that effective primaquine (PQ) treatment of Plasmodium vivax and P. ovale liver stage hypnozoites is associated with genetic variation in the human cytochrome P450 gene, CYP2D6. Successful PQ treatment of individual and population-wide infections by the Plasmodium species that generate these dormant liver stage forms is likely to be necessary to reach elimination of malaria caused by these parasites globally. Optimizing safe and effective PQ treatment will require coordination of efforts between the malaria and pharmacogenomics research communities.
abstract_unstemmed	Clinical trial and individual patient treatment outcomes have produced accumulating evidence that effective primaquine (PQ) treatment of Plasmodium vivax and P. ovale liver stage hypnozoites is associated with genetic variation in the human cytochrome P450 gene, CYP2D6. Successful PQ treatment of individual and population-wide infections by the Plasmodium species that generate these dormant liver stage forms is likely to be necessary to reach elimination of malaria caused by these parasites globally. Optimizing safe and effective PQ treatment will require coordination of efforts between the malaria and pharmacogenomics research communities.
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title_short	Global perspectives on CYP2D6 associations with primaquine metabolism and Plasmodium vivax radical cure
url	https://doi.org/10.3389/fphar.2022.752314 https://doaj.org/article/27766527b43945aa8520ab2b74e56e6b https://www.frontiersin.org/articles/10.3389/fphar.2022.752314/full https://doaj.org/toc/1663-9812
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Global perspectives on CYP2D6 associations with primaquine metabolism and Plasmodium vivax radical cure

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