Cost-effectiveness of implementing HIV and HIV/syphilis dual testing among key populations in Viet Nam: a modelling analysis

Objectives Key populations, including sex workers, men who have sex with men, and people who inject drugs, have a high risk of HIV and sexually transmitted infections. We assessed the health and economic impacts of different HIV and syphilis testing strategies among three key populations in Viet Nam...
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Autor*in:	Alison L Drake [verfasserIn] Ruanne Barnabas [verfasserIn] Teodora Wi [verfasserIn] Cheryl Johnson [verfasserIn] Melanie Taylor [verfasserIn] Monisha Sharma [verfasserIn] Muhammad S Jamil [verfasserIn] R Baggaley [verfasserIn] Magdalena Barr-DiChiara [verfasserIn] David Coomes [verfasserIn] Dylan Green [verfasserIn] Morkor Newman Owiredu [verfasserIn] Virginia Macdonald [verfasserIn] Van Thi Thuy Nguyen [verfasserIn] Son Hai Vo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Übergeordnetes Werk:	In: BMJ Open - BMJ Publishing Group, 2011, 12(2022), 8
Übergeordnetes Werk:	volume:12 ; year:2022 ; number:8

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1136/bmjopen-2021-056887

Katalog-ID:	DOAJ026091038

Internformat


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245	1	0	\|a Cost-effectiveness of implementing HIV and HIV/syphilis dual testing among key populations in Viet Nam: a modelling analysis
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520			\|a Objectives Key populations, including sex workers, men who have sex with men, and people who inject drugs, have a high risk of HIV and sexually transmitted infections. We assessed the health and economic impacts of different HIV and syphilis testing strategies among three key populations in Viet Nam using a dual HIV/syphilis rapid diagnostic test (RDT).Setting We used the spectrum AIDS impact model to simulate the HIV epidemic in Viet Nam and evaluated five testing scenarios among key populations. We used a 15-year time horizon and a provider perspective for costs.Participants We simulate the entire population of Viet Nam in the model.Interventions We modelled five testing scenarios among key populations: (1) annual testing with an HIV RDT, (2) annual testing with a dual RDT, (3) biannual testing using dual RDT and HIV RDT, (4) biannual testing using HIV RDT and (5) biannual testing using dual RDT.Primary and secondary outcome measures The primary outcome is incremental cost-effectiveness ratios. Secondary outcomes include HIV and syphilis cases.Results Annual testing using a dual HIV/syphilis RDT was cost-effective (US$10 per disability-adjusted life year (DALY)) and averted 3206 HIV cases and treated 27 727 syphilis cases compared with baseline over 15 years. Biannual testing using one dual test and one HIV RDT (US$1166 per DALY), or two dual tests (US$5672 per DALY) both averted an additional 875 HIV cases, although only the former scenario was cost-effective. Annual or biannual HIV testing using HIV RDTs and separate syphilis tests were more costly and less effective than using one or two dual RDTs.Conclusions Annual HIV and syphilis testing using dual RDT among key populations is cost-effective in Vietnam and similar settings to reach global reduction goals for HIV and syphilis.
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700	0		\|a Ruanne Barnabas \|e verfasserin \|4 aut
700	0		\|a Teodora Wi \|e verfasserin \|4 aut
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700	0		\|a Melanie Taylor \|e verfasserin \|4 aut
700	0		\|a Monisha Sharma \|e verfasserin \|4 aut
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700	0		\|a Van Thi Thuy Nguyen \|e verfasserin \|4 aut
700	0		\|a Son Hai Vo \|e verfasserin \|4 aut
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allfields	10.1136/bmjopen-2021-056887 doi (DE-627)DOAJ026091038 (DE-599)DOAJ29c25eeb96ce4e979f3d837b839ba00a DE-627 ger DE-627 rakwb eng Alison L Drake verfasserin aut Cost-effectiveness of implementing HIV and HIV/syphilis dual testing among key populations in Viet Nam: a modelling analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives Key populations, including sex workers, men who have sex with men, and people who inject drugs, have a high risk of HIV and sexually transmitted infections. We assessed the health and economic impacts of different HIV and syphilis testing strategies among three key populations in Viet Nam using a dual HIV/syphilis rapid diagnostic test (RDT).Setting We used the spectrum AIDS impact model to simulate the HIV epidemic in Viet Nam and evaluated five testing scenarios among key populations. We used a 15-year time horizon and a provider perspective for costs.Participants We simulate the entire population of Viet Nam in the model.Interventions We modelled five testing scenarios among key populations: (1) annual testing with an HIV RDT, (2) annual testing with a dual RDT, (3) biannual testing using dual RDT and HIV RDT, (4) biannual testing using HIV RDT and (5) biannual testing using dual RDT.Primary and secondary outcome measures The primary outcome is incremental cost-effectiveness ratios. Secondary outcomes include HIV and syphilis cases.Results Annual testing using a dual HIV/syphilis RDT was cost-effective (US$10 per disability-adjusted life year (DALY)) and averted 3206 HIV cases and treated 27 727 syphilis cases compared with baseline over 15 years. Biannual testing using one dual test and one HIV RDT (US$1166 per DALY), or two dual tests (US$5672 per DALY) both averted an additional 875 HIV cases, although only the former scenario was cost-effective. Annual or biannual HIV testing using HIV RDTs and separate syphilis tests were more costly and less effective than using one or two dual RDTs.Conclusions Annual HIV and syphilis testing using dual RDT among key populations is cost-effective in Vietnam and similar settings to reach global reduction goals for HIV and syphilis. Medicine R Ruanne Barnabas verfasserin aut Teodora Wi verfasserin aut Cheryl Johnson verfasserin aut Melanie Taylor verfasserin aut Monisha Sharma verfasserin aut Muhammad S Jamil verfasserin aut R Baggaley verfasserin aut Magdalena Barr-DiChiara verfasserin aut David Coomes verfasserin aut Dylan Green verfasserin aut Morkor Newman Owiredu verfasserin aut Virginia Macdonald verfasserin aut Van Thi Thuy Nguyen verfasserin aut Son Hai Vo verfasserin aut In BMJ Open BMJ Publishing Group, 2011 12(2022), 8 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:12 year:2022 number:8 https://doi.org/10.1136/bmjopen-2021-056887 kostenfrei https://doaj.org/article/29c25eeb96ce4e979f3d837b839ba00a kostenfrei https://bmjopen.bmj.com/content/12/8/e056887.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 8
spelling	10.1136/bmjopen-2021-056887 doi (DE-627)DOAJ026091038 (DE-599)DOAJ29c25eeb96ce4e979f3d837b839ba00a DE-627 ger DE-627 rakwb eng Alison L Drake verfasserin aut Cost-effectiveness of implementing HIV and HIV/syphilis dual testing among key populations in Viet Nam: a modelling analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives Key populations, including sex workers, men who have sex with men, and people who inject drugs, have a high risk of HIV and sexually transmitted infections. We assessed the health and economic impacts of different HIV and syphilis testing strategies among three key populations in Viet Nam using a dual HIV/syphilis rapid diagnostic test (RDT).Setting We used the spectrum AIDS impact model to simulate the HIV epidemic in Viet Nam and evaluated five testing scenarios among key populations. We used a 15-year time horizon and a provider perspective for costs.Participants We simulate the entire population of Viet Nam in the model.Interventions We modelled five testing scenarios among key populations: (1) annual testing with an HIV RDT, (2) annual testing with a dual RDT, (3) biannual testing using dual RDT and HIV RDT, (4) biannual testing using HIV RDT and (5) biannual testing using dual RDT.Primary and secondary outcome measures The primary outcome is incremental cost-effectiveness ratios. Secondary outcomes include HIV and syphilis cases.Results Annual testing using a dual HIV/syphilis RDT was cost-effective (US$10 per disability-adjusted life year (DALY)) and averted 3206 HIV cases and treated 27 727 syphilis cases compared with baseline over 15 years. Biannual testing using one dual test and one HIV RDT (US$1166 per DALY), or two dual tests (US$5672 per DALY) both averted an additional 875 HIV cases, although only the former scenario was cost-effective. Annual or biannual HIV testing using HIV RDTs and separate syphilis tests were more costly and less effective than using one or two dual RDTs.Conclusions Annual HIV and syphilis testing using dual RDT among key populations is cost-effective in Vietnam and similar settings to reach global reduction goals for HIV and syphilis. Medicine R Ruanne Barnabas verfasserin aut Teodora Wi verfasserin aut Cheryl Johnson verfasserin aut Melanie Taylor verfasserin aut Monisha Sharma verfasserin aut Muhammad S Jamil verfasserin aut R Baggaley verfasserin aut Magdalena Barr-DiChiara verfasserin aut David Coomes verfasserin aut Dylan Green verfasserin aut Morkor Newman Owiredu verfasserin aut Virginia Macdonald verfasserin aut Van Thi Thuy Nguyen verfasserin aut Son Hai Vo verfasserin aut In BMJ Open BMJ Publishing Group, 2011 12(2022), 8 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:12 year:2022 number:8 https://doi.org/10.1136/bmjopen-2021-056887 kostenfrei https://doaj.org/article/29c25eeb96ce4e979f3d837b839ba00a kostenfrei https://bmjopen.bmj.com/content/12/8/e056887.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 8
allfields_unstemmed	10.1136/bmjopen-2021-056887 doi (DE-627)DOAJ026091038 (DE-599)DOAJ29c25eeb96ce4e979f3d837b839ba00a DE-627 ger DE-627 rakwb eng Alison L Drake verfasserin aut Cost-effectiveness of implementing HIV and HIV/syphilis dual testing among key populations in Viet Nam: a modelling analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives Key populations, including sex workers, men who have sex with men, and people who inject drugs, have a high risk of HIV and sexually transmitted infections. We assessed the health and economic impacts of different HIV and syphilis testing strategies among three key populations in Viet Nam using a dual HIV/syphilis rapid diagnostic test (RDT).Setting We used the spectrum AIDS impact model to simulate the HIV epidemic in Viet Nam and evaluated five testing scenarios among key populations. We used a 15-year time horizon and a provider perspective for costs.Participants We simulate the entire population of Viet Nam in the model.Interventions We modelled five testing scenarios among key populations: (1) annual testing with an HIV RDT, (2) annual testing with a dual RDT, (3) biannual testing using dual RDT and HIV RDT, (4) biannual testing using HIV RDT and (5) biannual testing using dual RDT.Primary and secondary outcome measures The primary outcome is incremental cost-effectiveness ratios. Secondary outcomes include HIV and syphilis cases.Results Annual testing using a dual HIV/syphilis RDT was cost-effective (US$10 per disability-adjusted life year (DALY)) and averted 3206 HIV cases and treated 27 727 syphilis cases compared with baseline over 15 years. Biannual testing using one dual test and one HIV RDT (US$1166 per DALY), or two dual tests (US$5672 per DALY) both averted an additional 875 HIV cases, although only the former scenario was cost-effective. Annual or biannual HIV testing using HIV RDTs and separate syphilis tests were more costly and less effective than using one or two dual RDTs.Conclusions Annual HIV and syphilis testing using dual RDT among key populations is cost-effective in Vietnam and similar settings to reach global reduction goals for HIV and syphilis. Medicine R Ruanne Barnabas verfasserin aut Teodora Wi verfasserin aut Cheryl Johnson verfasserin aut Melanie Taylor verfasserin aut Monisha Sharma verfasserin aut Muhammad S Jamil verfasserin aut R Baggaley verfasserin aut Magdalena Barr-DiChiara verfasserin aut David Coomes verfasserin aut Dylan Green verfasserin aut Morkor Newman Owiredu verfasserin aut Virginia Macdonald verfasserin aut Van Thi Thuy Nguyen verfasserin aut Son Hai Vo verfasserin aut In BMJ Open BMJ Publishing Group, 2011 12(2022), 8 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:12 year:2022 number:8 https://doi.org/10.1136/bmjopen-2021-056887 kostenfrei https://doaj.org/article/29c25eeb96ce4e979f3d837b839ba00a kostenfrei https://bmjopen.bmj.com/content/12/8/e056887.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 8
allfieldsGer	10.1136/bmjopen-2021-056887 doi (DE-627)DOAJ026091038 (DE-599)DOAJ29c25eeb96ce4e979f3d837b839ba00a DE-627 ger DE-627 rakwb eng Alison L Drake verfasserin aut Cost-effectiveness of implementing HIV and HIV/syphilis dual testing among key populations in Viet Nam: a modelling analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives Key populations, including sex workers, men who have sex with men, and people who inject drugs, have a high risk of HIV and sexually transmitted infections. We assessed the health and economic impacts of different HIV and syphilis testing strategies among three key populations in Viet Nam using a dual HIV/syphilis rapid diagnostic test (RDT).Setting We used the spectrum AIDS impact model to simulate the HIV epidemic in Viet Nam and evaluated five testing scenarios among key populations. We used a 15-year time horizon and a provider perspective for costs.Participants We simulate the entire population of Viet Nam in the model.Interventions We modelled five testing scenarios among key populations: (1) annual testing with an HIV RDT, (2) annual testing with a dual RDT, (3) biannual testing using dual RDT and HIV RDT, (4) biannual testing using HIV RDT and (5) biannual testing using dual RDT.Primary and secondary outcome measures The primary outcome is incremental cost-effectiveness ratios. Secondary outcomes include HIV and syphilis cases.Results Annual testing using a dual HIV/syphilis RDT was cost-effective (US$10 per disability-adjusted life year (DALY)) and averted 3206 HIV cases and treated 27 727 syphilis cases compared with baseline over 15 years. Biannual testing using one dual test and one HIV RDT (US$1166 per DALY), or two dual tests (US$5672 per DALY) both averted an additional 875 HIV cases, although only the former scenario was cost-effective. Annual or biannual HIV testing using HIV RDTs and separate syphilis tests were more costly and less effective than using one or two dual RDTs.Conclusions Annual HIV and syphilis testing using dual RDT among key populations is cost-effective in Vietnam and similar settings to reach global reduction goals for HIV and syphilis. Medicine R Ruanne Barnabas verfasserin aut Teodora Wi verfasserin aut Cheryl Johnson verfasserin aut Melanie Taylor verfasserin aut Monisha Sharma verfasserin aut Muhammad S Jamil verfasserin aut R Baggaley verfasserin aut Magdalena Barr-DiChiara verfasserin aut David Coomes verfasserin aut Dylan Green verfasserin aut Morkor Newman Owiredu verfasserin aut Virginia Macdonald verfasserin aut Van Thi Thuy Nguyen verfasserin aut Son Hai Vo verfasserin aut In BMJ Open BMJ Publishing Group, 2011 12(2022), 8 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:12 year:2022 number:8 https://doi.org/10.1136/bmjopen-2021-056887 kostenfrei https://doaj.org/article/29c25eeb96ce4e979f3d837b839ba00a kostenfrei https://bmjopen.bmj.com/content/12/8/e056887.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 8
allfieldsSound	10.1136/bmjopen-2021-056887 doi (DE-627)DOAJ026091038 (DE-599)DOAJ29c25eeb96ce4e979f3d837b839ba00a DE-627 ger DE-627 rakwb eng Alison L Drake verfasserin aut Cost-effectiveness of implementing HIV and HIV/syphilis dual testing among key populations in Viet Nam: a modelling analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives Key populations, including sex workers, men who have sex with men, and people who inject drugs, have a high risk of HIV and sexually transmitted infections. We assessed the health and economic impacts of different HIV and syphilis testing strategies among three key populations in Viet Nam using a dual HIV/syphilis rapid diagnostic test (RDT).Setting We used the spectrum AIDS impact model to simulate the HIV epidemic in Viet Nam and evaluated five testing scenarios among key populations. We used a 15-year time horizon and a provider perspective for costs.Participants We simulate the entire population of Viet Nam in the model.Interventions We modelled five testing scenarios among key populations: (1) annual testing with an HIV RDT, (2) annual testing with a dual RDT, (3) biannual testing using dual RDT and HIV RDT, (4) biannual testing using HIV RDT and (5) biannual testing using dual RDT.Primary and secondary outcome measures The primary outcome is incremental cost-effectiveness ratios. Secondary outcomes include HIV and syphilis cases.Results Annual testing using a dual HIV/syphilis RDT was cost-effective (US$10 per disability-adjusted life year (DALY)) and averted 3206 HIV cases and treated 27 727 syphilis cases compared with baseline over 15 years. Biannual testing using one dual test and one HIV RDT (US$1166 per DALY), or two dual tests (US$5672 per DALY) both averted an additional 875 HIV cases, although only the former scenario was cost-effective. Annual or biannual HIV testing using HIV RDTs and separate syphilis tests were more costly and less effective than using one or two dual RDTs.Conclusions Annual HIV and syphilis testing using dual RDT among key populations is cost-effective in Vietnam and similar settings to reach global reduction goals for HIV and syphilis. Medicine R Ruanne Barnabas verfasserin aut Teodora Wi verfasserin aut Cheryl Johnson verfasserin aut Melanie Taylor verfasserin aut Monisha Sharma verfasserin aut Muhammad S Jamil verfasserin aut R Baggaley verfasserin aut Magdalena Barr-DiChiara verfasserin aut David Coomes verfasserin aut Dylan Green verfasserin aut Morkor Newman Owiredu verfasserin aut Virginia Macdonald verfasserin aut Van Thi Thuy Nguyen verfasserin aut Son Hai Vo verfasserin aut In BMJ Open BMJ Publishing Group, 2011 12(2022), 8 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:12 year:2022 number:8 https://doi.org/10.1136/bmjopen-2021-056887 kostenfrei https://doaj.org/article/29c25eeb96ce4e979f3d837b839ba00a kostenfrei https://bmjopen.bmj.com/content/12/8/e056887.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 8
language	English
source	In BMJ Open 12(2022), 8 volume:12 year:2022 number:8
sourceStr	In BMJ Open 12(2022), 8 volume:12 year:2022 number:8
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Medicine R
isfreeaccess_bool	true
container_title	BMJ Open
authorswithroles_txt_mv	Alison L Drake @@aut@@ Ruanne Barnabas @@aut@@ Teodora Wi @@aut@@ Cheryl Johnson @@aut@@ Melanie Taylor @@aut@@ Monisha Sharma @@aut@@ Muhammad S Jamil @@aut@@ R Baggaley @@aut@@ Magdalena Barr-DiChiara @@aut@@ David Coomes @@aut@@ Dylan Green @@aut@@ Morkor Newman Owiredu @@aut@@ Virginia Macdonald @@aut@@ Van Thi Thuy Nguyen @@aut@@ Son Hai Vo @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	654747075
id	DOAJ026091038
language_de	englisch
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Secondary outcomes include HIV and syphilis cases.Results Annual testing using a dual HIV/syphilis RDT was cost-effective (US$10 per disability-adjusted life year (DALY)) and averted 3206 HIV cases and treated 27 727 syphilis cases compared with baseline over 15 years. Biannual testing using one dual test and one HIV RDT (US$1166 per DALY), or two dual tests (US$5672 per DALY) both averted an additional 875 HIV cases, although only the former scenario was cost-effective. 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author	Alison L Drake
spellingShingle	Alison L Drake misc Medicine misc R Cost-effectiveness of implementing HIV and HIV/syphilis dual testing among key populations in Viet Nam: a modelling analysis
authorStr	Alison L Drake
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topic_title	Cost-effectiveness of implementing HIV and HIV/syphilis dual testing among key populations in Viet Nam: a modelling analysis
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title	Cost-effectiveness of implementing HIV and HIV/syphilis dual testing among key populations in Viet Nam: a modelling analysis
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title_full	Cost-effectiveness of implementing HIV and HIV/syphilis dual testing among key populations in Viet Nam: a modelling analysis
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author_browse	Alison L Drake Ruanne Barnabas Teodora Wi Cheryl Johnson Melanie Taylor Monisha Sharma Muhammad S Jamil R Baggaley Magdalena Barr-DiChiara David Coomes Dylan Green Morkor Newman Owiredu Virginia Macdonald Van Thi Thuy Nguyen Son Hai Vo
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title_sort	cost-effectiveness of implementing hiv and hiv/syphilis dual testing among key populations in viet nam: a modelling analysis
title_auth	Cost-effectiveness of implementing HIV and HIV/syphilis dual testing among key populations in Viet Nam: a modelling analysis
abstract	Objectives Key populations, including sex workers, men who have sex with men, and people who inject drugs, have a high risk of HIV and sexually transmitted infections. We assessed the health and economic impacts of different HIV and syphilis testing strategies among three key populations in Viet Nam using a dual HIV/syphilis rapid diagnostic test (RDT).Setting We used the spectrum AIDS impact model to simulate the HIV epidemic in Viet Nam and evaluated five testing scenarios among key populations. We used a 15-year time horizon and a provider perspective for costs.Participants We simulate the entire population of Viet Nam in the model.Interventions We modelled five testing scenarios among key populations: (1) annual testing with an HIV RDT, (2) annual testing with a dual RDT, (3) biannual testing using dual RDT and HIV RDT, (4) biannual testing using HIV RDT and (5) biannual testing using dual RDT.Primary and secondary outcome measures The primary outcome is incremental cost-effectiveness ratios. Secondary outcomes include HIV and syphilis cases.Results Annual testing using a dual HIV/syphilis RDT was cost-effective (US$10 per disability-adjusted life year (DALY)) and averted 3206 HIV cases and treated 27 727 syphilis cases compared with baseline over 15 years. Biannual testing using one dual test and one HIV RDT (US$1166 per DALY), or two dual tests (US$5672 per DALY) both averted an additional 875 HIV cases, although only the former scenario was cost-effective. Annual or biannual HIV testing using HIV RDTs and separate syphilis tests were more costly and less effective than using one or two dual RDTs.Conclusions Annual HIV and syphilis testing using dual RDT among key populations is cost-effective in Vietnam and similar settings to reach global reduction goals for HIV and syphilis.
abstractGer	Objectives Key populations, including sex workers, men who have sex with men, and people who inject drugs, have a high risk of HIV and sexually transmitted infections. We assessed the health and economic impacts of different HIV and syphilis testing strategies among three key populations in Viet Nam using a dual HIV/syphilis rapid diagnostic test (RDT).Setting We used the spectrum AIDS impact model to simulate the HIV epidemic in Viet Nam and evaluated five testing scenarios among key populations. We used a 15-year time horizon and a provider perspective for costs.Participants We simulate the entire population of Viet Nam in the model.Interventions We modelled five testing scenarios among key populations: (1) annual testing with an HIV RDT, (2) annual testing with a dual RDT, (3) biannual testing using dual RDT and HIV RDT, (4) biannual testing using HIV RDT and (5) biannual testing using dual RDT.Primary and secondary outcome measures The primary outcome is incremental cost-effectiveness ratios. Secondary outcomes include HIV and syphilis cases.Results Annual testing using a dual HIV/syphilis RDT was cost-effective (US$10 per disability-adjusted life year (DALY)) and averted 3206 HIV cases and treated 27 727 syphilis cases compared with baseline over 15 years. Biannual testing using one dual test and one HIV RDT (US$1166 per DALY), or two dual tests (US$5672 per DALY) both averted an additional 875 HIV cases, although only the former scenario was cost-effective. Annual or biannual HIV testing using HIV RDTs and separate syphilis tests were more costly and less effective than using one or two dual RDTs.Conclusions Annual HIV and syphilis testing using dual RDT among key populations is cost-effective in Vietnam and similar settings to reach global reduction goals for HIV and syphilis.
abstract_unstemmed	Objectives Key populations, including sex workers, men who have sex with men, and people who inject drugs, have a high risk of HIV and sexually transmitted infections. We assessed the health and economic impacts of different HIV and syphilis testing strategies among three key populations in Viet Nam using a dual HIV/syphilis rapid diagnostic test (RDT).Setting We used the spectrum AIDS impact model to simulate the HIV epidemic in Viet Nam and evaluated five testing scenarios among key populations. We used a 15-year time horizon and a provider perspective for costs.Participants We simulate the entire population of Viet Nam in the model.Interventions We modelled five testing scenarios among key populations: (1) annual testing with an HIV RDT, (2) annual testing with a dual RDT, (3) biannual testing using dual RDT and HIV RDT, (4) biannual testing using HIV RDT and (5) biannual testing using dual RDT.Primary and secondary outcome measures The primary outcome is incremental cost-effectiveness ratios. Secondary outcomes include HIV and syphilis cases.Results Annual testing using a dual HIV/syphilis RDT was cost-effective (US$10 per disability-adjusted life year (DALY)) and averted 3206 HIV cases and treated 27 727 syphilis cases compared with baseline over 15 years. Biannual testing using one dual test and one HIV RDT (US$1166 per DALY), or two dual tests (US$5672 per DALY) both averted an additional 875 HIV cases, although only the former scenario was cost-effective. Annual or biannual HIV testing using HIV RDTs and separate syphilis tests were more costly and less effective than using one or two dual RDTs.Conclusions Annual HIV and syphilis testing using dual RDT among key populations is cost-effective in Vietnam and similar settings to reach global reduction goals for HIV and syphilis.
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title_short	Cost-effectiveness of implementing HIV and HIV/syphilis dual testing among key populations in Viet Nam: a modelling analysis
url	https://doi.org/10.1136/bmjopen-2021-056887 https://doaj.org/article/29c25eeb96ce4e979f3d837b839ba00a https://bmjopen.bmj.com/content/12/8/e056887.full https://doaj.org/toc/2044-6055
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author2	Ruanne Barnabas Teodora Wi Cheryl Johnson Melanie Taylor Monisha Sharma Muhammad S Jamil R Baggaley Magdalena Barr-DiChiara David Coomes Dylan Green Morkor Newman Owiredu Virginia Macdonald Van Thi Thuy Nguyen Son Hai Vo
author2Str	Ruanne Barnabas Teodora Wi Cheryl Johnson Melanie Taylor Monisha Sharma Muhammad S Jamil R Baggaley Magdalena Barr-DiChiara David Coomes Dylan Green Morkor Newman Owiredu Virginia Macdonald Van Thi Thuy Nguyen Son Hai Vo
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Secondary outcomes include HIV and syphilis cases.Results Annual testing using a dual HIV/syphilis RDT was cost-effective (US$10 per disability-adjusted life year (DALY)) and averted 3206 HIV cases and treated 27 727 syphilis cases compared with baseline over 15 years. Biannual testing using one dual test and one HIV RDT (US$1166 per DALY), or two dual tests (US$5672 per DALY) both averted an additional 875 HIV cases, although only the former scenario was cost-effective. 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