Tumor-Stroma Ratio and Programmed Cell Death Ligand 1 Expression in Preoperative Biopsy and Matched Laryngeal Carcinoma Surgical Specimen

Programmed cell death ligand 1 (PD-L1) seems to rely on close relations between neoplastic and immune cells in the tumor microenvironment. Tumor to stroma ratio (TSR) has been associated with prognosis in different malignancies. The aims of this exploratory investigation were to analyze for the firs...
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Autor*in:	Lara Alessandrini [verfasserIn] Leonardo Franz [verfasserIn] Marta Sbaraglia [verfasserIn] Tommaso Saccardo [verfasserIn] Filippo Cappello [verfasserIn] Alessandro Drigo [verfasserIn] Anna Chiara Frigo [verfasserIn] Gino Marioni [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	laryngeal squamous cell carcinoma tumor-stroma ratio programmed cell death ligand 1 PD-L1 biopsy prognosis

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 23(2022), 14, p 8053
Übergeordnetes Werk:	volume:23 ; year:2022 ; number:14, p 8053

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms23148053

Katalog-ID:	DOAJ02615739X

Internformat


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allfields	10.3390/ijms23148053 doi (DE-627)DOAJ02615739X (DE-599)DOAJf812b6f8e1af4f15bdfe4577e3ab919a DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Lara Alessandrini verfasserin aut Tumor-Stroma Ratio and Programmed Cell Death Ligand 1 Expression in Preoperative Biopsy and Matched Laryngeal Carcinoma Surgical Specimen 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Programmed cell death ligand 1 (PD-L1) seems to rely on close relations between neoplastic and immune cells in the tumor microenvironment. Tumor to stroma ratio (TSR) has been associated with prognosis in different malignancies. The aims of this exploratory investigation were to analyze for the first time the: (i) association between TSR, PD-L1 expression and other clinical–pathological features in laryngeal squamous cell carcinoma (LSCC) biopsies and paired surgical specimens; (ii) prognostic and predictive role of TSR and PD-L1. TSR, PD-L1 expression (in terms of combined positive score [CPS]), and other clinical–pathological features were analyzed in biopsies and surgical specimens of 43 consecutive LSCC cases. A CPS < 1 evaluated on surgical specimens was associated with a low TSR (stroma rich) on both biopsies and surgical specimens (<i<p</i< = 0.0143 and <i<p</i< = 0.0063). Low TSR showed a significant negative prognostic value when evaluated on both biopsies and surgical specimens (HR = 8.808, <i<p</i< = 0.0003 and HR = 11.207, <i<p</i< = 0.0002). CPS ≥ 1 appeared to be a favorable prognostic factor (HR = 0.100, <i<p</i< = 0.0265). The association between bioptic and surgical specimen TSR and PD-L1 expression should be further investigated for a potential impact on targeted treatments, also with regard to immunotherapeutic protocols. laryngeal squamous cell carcinoma tumor-stroma ratio programmed cell death ligand 1 PD-L1 biopsy prognosis Biology (General) Chemistry Leonardo Franz verfasserin aut Marta Sbaraglia verfasserin aut Tommaso Saccardo verfasserin aut Filippo Cappello verfasserin aut Alessandro Drigo verfasserin aut Anna Chiara Frigo verfasserin aut Gino Marioni verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 14, p 8053 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:14, p 8053 https://doi.org/10.3390/ijms23148053 kostenfrei https://doaj.org/article/f812b6f8e1af4f15bdfe4577e3ab919a kostenfrei https://www.mdpi.com/1422-0067/23/14/8053 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 14, p 8053
spelling	10.3390/ijms23148053 doi (DE-627)DOAJ02615739X (DE-599)DOAJf812b6f8e1af4f15bdfe4577e3ab919a DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Lara Alessandrini verfasserin aut Tumor-Stroma Ratio and Programmed Cell Death Ligand 1 Expression in Preoperative Biopsy and Matched Laryngeal Carcinoma Surgical Specimen 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Programmed cell death ligand 1 (PD-L1) seems to rely on close relations between neoplastic and immune cells in the tumor microenvironment. Tumor to stroma ratio (TSR) has been associated with prognosis in different malignancies. The aims of this exploratory investigation were to analyze for the first time the: (i) association between TSR, PD-L1 expression and other clinical–pathological features in laryngeal squamous cell carcinoma (LSCC) biopsies and paired surgical specimens; (ii) prognostic and predictive role of TSR and PD-L1. TSR, PD-L1 expression (in terms of combined positive score [CPS]), and other clinical–pathological features were analyzed in biopsies and surgical specimens of 43 consecutive LSCC cases. A CPS < 1 evaluated on surgical specimens was associated with a low TSR (stroma rich) on both biopsies and surgical specimens (<i<p</i< = 0.0143 and <i<p</i< = 0.0063). Low TSR showed a significant negative prognostic value when evaluated on both biopsies and surgical specimens (HR = 8.808, <i<p</i< = 0.0003 and HR = 11.207, <i<p</i< = 0.0002). CPS ≥ 1 appeared to be a favorable prognostic factor (HR = 0.100, <i<p</i< = 0.0265). The association between bioptic and surgical specimen TSR and PD-L1 expression should be further investigated for a potential impact on targeted treatments, also with regard to immunotherapeutic protocols. laryngeal squamous cell carcinoma tumor-stroma ratio programmed cell death ligand 1 PD-L1 biopsy prognosis Biology (General) Chemistry Leonardo Franz verfasserin aut Marta Sbaraglia verfasserin aut Tommaso Saccardo verfasserin aut Filippo Cappello verfasserin aut Alessandro Drigo verfasserin aut Anna Chiara Frigo verfasserin aut Gino Marioni verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 14, p 8053 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:14, p 8053 https://doi.org/10.3390/ijms23148053 kostenfrei https://doaj.org/article/f812b6f8e1af4f15bdfe4577e3ab919a kostenfrei https://www.mdpi.com/1422-0067/23/14/8053 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 14, p 8053
allfields_unstemmed	10.3390/ijms23148053 doi (DE-627)DOAJ02615739X (DE-599)DOAJf812b6f8e1af4f15bdfe4577e3ab919a DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Lara Alessandrini verfasserin aut Tumor-Stroma Ratio and Programmed Cell Death Ligand 1 Expression in Preoperative Biopsy and Matched Laryngeal Carcinoma Surgical Specimen 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Programmed cell death ligand 1 (PD-L1) seems to rely on close relations between neoplastic and immune cells in the tumor microenvironment. Tumor to stroma ratio (TSR) has been associated with prognosis in different malignancies. The aims of this exploratory investigation were to analyze for the first time the: (i) association between TSR, PD-L1 expression and other clinical–pathological features in laryngeal squamous cell carcinoma (LSCC) biopsies and paired surgical specimens; (ii) prognostic and predictive role of TSR and PD-L1. TSR, PD-L1 expression (in terms of combined positive score [CPS]), and other clinical–pathological features were analyzed in biopsies and surgical specimens of 43 consecutive LSCC cases. A CPS < 1 evaluated on surgical specimens was associated with a low TSR (stroma rich) on both biopsies and surgical specimens (<i<p</i< = 0.0143 and <i<p</i< = 0.0063). Low TSR showed a significant negative prognostic value when evaluated on both biopsies and surgical specimens (HR = 8.808, <i<p</i< = 0.0003 and HR = 11.207, <i<p</i< = 0.0002). CPS ≥ 1 appeared to be a favorable prognostic factor (HR = 0.100, <i<p</i< = 0.0265). The association between bioptic and surgical specimen TSR and PD-L1 expression should be further investigated for a potential impact on targeted treatments, also with regard to immunotherapeutic protocols. laryngeal squamous cell carcinoma tumor-stroma ratio programmed cell death ligand 1 PD-L1 biopsy prognosis Biology (General) Chemistry Leonardo Franz verfasserin aut Marta Sbaraglia verfasserin aut Tommaso Saccardo verfasserin aut Filippo Cappello verfasserin aut Alessandro Drigo verfasserin aut Anna Chiara Frigo verfasserin aut Gino Marioni verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 14, p 8053 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:14, p 8053 https://doi.org/10.3390/ijms23148053 kostenfrei https://doaj.org/article/f812b6f8e1af4f15bdfe4577e3ab919a kostenfrei https://www.mdpi.com/1422-0067/23/14/8053 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 14, p 8053
allfieldsGer	10.3390/ijms23148053 doi (DE-627)DOAJ02615739X (DE-599)DOAJf812b6f8e1af4f15bdfe4577e3ab919a DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Lara Alessandrini verfasserin aut Tumor-Stroma Ratio and Programmed Cell Death Ligand 1 Expression in Preoperative Biopsy and Matched Laryngeal Carcinoma Surgical Specimen 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Programmed cell death ligand 1 (PD-L1) seems to rely on close relations between neoplastic and immune cells in the tumor microenvironment. Tumor to stroma ratio (TSR) has been associated with prognosis in different malignancies. The aims of this exploratory investigation were to analyze for the first time the: (i) association between TSR, PD-L1 expression and other clinical–pathological features in laryngeal squamous cell carcinoma (LSCC) biopsies and paired surgical specimens; (ii) prognostic and predictive role of TSR and PD-L1. TSR, PD-L1 expression (in terms of combined positive score [CPS]), and other clinical–pathological features were analyzed in biopsies and surgical specimens of 43 consecutive LSCC cases. A CPS < 1 evaluated on surgical specimens was associated with a low TSR (stroma rich) on both biopsies and surgical specimens (<i<p</i< = 0.0143 and <i<p</i< = 0.0063). Low TSR showed a significant negative prognostic value when evaluated on both biopsies and surgical specimens (HR = 8.808, <i<p</i< = 0.0003 and HR = 11.207, <i<p</i< = 0.0002). CPS ≥ 1 appeared to be a favorable prognostic factor (HR = 0.100, <i<p</i< = 0.0265). The association between bioptic and surgical specimen TSR and PD-L1 expression should be further investigated for a potential impact on targeted treatments, also with regard to immunotherapeutic protocols. laryngeal squamous cell carcinoma tumor-stroma ratio programmed cell death ligand 1 PD-L1 biopsy prognosis Biology (General) Chemistry Leonardo Franz verfasserin aut Marta Sbaraglia verfasserin aut Tommaso Saccardo verfasserin aut Filippo Cappello verfasserin aut Alessandro Drigo verfasserin aut Anna Chiara Frigo verfasserin aut Gino Marioni verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 14, p 8053 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:14, p 8053 https://doi.org/10.3390/ijms23148053 kostenfrei https://doaj.org/article/f812b6f8e1af4f15bdfe4577e3ab919a kostenfrei https://www.mdpi.com/1422-0067/23/14/8053 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 14, p 8053
allfieldsSound	10.3390/ijms23148053 doi (DE-627)DOAJ02615739X (DE-599)DOAJf812b6f8e1af4f15bdfe4577e3ab919a DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Lara Alessandrini verfasserin aut Tumor-Stroma Ratio and Programmed Cell Death Ligand 1 Expression in Preoperative Biopsy and Matched Laryngeal Carcinoma Surgical Specimen 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Programmed cell death ligand 1 (PD-L1) seems to rely on close relations between neoplastic and immune cells in the tumor microenvironment. Tumor to stroma ratio (TSR) has been associated with prognosis in different malignancies. The aims of this exploratory investigation were to analyze for the first time the: (i) association between TSR, PD-L1 expression and other clinical–pathological features in laryngeal squamous cell carcinoma (LSCC) biopsies and paired surgical specimens; (ii) prognostic and predictive role of TSR and PD-L1. TSR, PD-L1 expression (in terms of combined positive score [CPS]), and other clinical–pathological features were analyzed in biopsies and surgical specimens of 43 consecutive LSCC cases. A CPS < 1 evaluated on surgical specimens was associated with a low TSR (stroma rich) on both biopsies and surgical specimens (<i<p</i< = 0.0143 and <i<p</i< = 0.0063). Low TSR showed a significant negative prognostic value when evaluated on both biopsies and surgical specimens (HR = 8.808, <i<p</i< = 0.0003 and HR = 11.207, <i<p</i< = 0.0002). CPS ≥ 1 appeared to be a favorable prognostic factor (HR = 0.100, <i<p</i< = 0.0265). The association between bioptic and surgical specimen TSR and PD-L1 expression should be further investigated for a potential impact on targeted treatments, also with regard to immunotherapeutic protocols. laryngeal squamous cell carcinoma tumor-stroma ratio programmed cell death ligand 1 PD-L1 biopsy prognosis Biology (General) Chemistry Leonardo Franz verfasserin aut Marta Sbaraglia verfasserin aut Tommaso Saccardo verfasserin aut Filippo Cappello verfasserin aut Alessandro Drigo verfasserin aut Anna Chiara Frigo verfasserin aut Gino Marioni verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 14, p 8053 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:14, p 8053 https://doi.org/10.3390/ijms23148053 kostenfrei https://doaj.org/article/f812b6f8e1af4f15bdfe4577e3ab919a kostenfrei https://www.mdpi.com/1422-0067/23/14/8053 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 14, p 8053
language	English
source	In International Journal of Molecular Sciences 23(2022), 14, p 8053 volume:23 year:2022 number:14, p 8053
sourceStr	In International Journal of Molecular Sciences 23(2022), 14, p 8053 volume:23 year:2022 number:14, p 8053
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	laryngeal squamous cell carcinoma tumor-stroma ratio programmed cell death ligand 1 PD-L1 biopsy prognosis Biology (General) Chemistry
isfreeaccess_bool	true
container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Lara Alessandrini @@aut@@ Leonardo Franz @@aut@@ Marta Sbaraglia @@aut@@ Tommaso Saccardo @@aut@@ Filippo Cappello @@aut@@ Alessandro Drigo @@aut@@ Anna Chiara Frigo @@aut@@ Gino Marioni @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	316340715
id	DOAJ02615739X
language_de	englisch
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callnumber-first	Q - Science
author	Lara Alessandrini
spellingShingle	Lara Alessandrini misc QH301-705.5 misc QD1-999 misc laryngeal squamous cell carcinoma misc tumor-stroma ratio misc programmed cell death ligand 1 misc PD-L1 misc biopsy misc prognosis misc Biology (General) misc Chemistry Tumor-Stroma Ratio and Programmed Cell Death Ligand 1 Expression in Preoperative Biopsy and Matched Laryngeal Carcinoma Surgical Specimen
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topic_title	QH301-705.5 QD1-999 Tumor-Stroma Ratio and Programmed Cell Death Ligand 1 Expression in Preoperative Biopsy and Matched Laryngeal Carcinoma Surgical Specimen laryngeal squamous cell carcinoma tumor-stroma ratio programmed cell death ligand 1 PD-L1 biopsy prognosis
topic	misc QH301-705.5 misc QD1-999 misc laryngeal squamous cell carcinoma misc tumor-stroma ratio misc programmed cell death ligand 1 misc PD-L1 misc biopsy misc prognosis misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc laryngeal squamous cell carcinoma misc tumor-stroma ratio misc programmed cell death ligand 1 misc PD-L1 misc biopsy misc prognosis misc Biology (General) misc Chemistry
topic_browse	misc QH301-705.5 misc QD1-999 misc laryngeal squamous cell carcinoma misc tumor-stroma ratio misc programmed cell death ligand 1 misc PD-L1 misc biopsy misc prognosis misc Biology (General) misc Chemistry
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title	Tumor-Stroma Ratio and Programmed Cell Death Ligand 1 Expression in Preoperative Biopsy and Matched Laryngeal Carcinoma Surgical Specimen
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title_full	Tumor-Stroma Ratio and Programmed Cell Death Ligand 1 Expression in Preoperative Biopsy and Matched Laryngeal Carcinoma Surgical Specimen
author_sort	Lara Alessandrini
journal	International Journal of Molecular Sciences
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author_browse	Lara Alessandrini Leonardo Franz Marta Sbaraglia Tommaso Saccardo Filippo Cappello Alessandro Drigo Anna Chiara Frigo Gino Marioni
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author-letter	Lara Alessandrini
doi_str_mv	10.3390/ijms23148053
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title_sort	tumor-stroma ratio and programmed cell death ligand 1 expression in preoperative biopsy and matched laryngeal carcinoma surgical specimen
callnumber	QH301-705.5
title_auth	Tumor-Stroma Ratio and Programmed Cell Death Ligand 1 Expression in Preoperative Biopsy and Matched Laryngeal Carcinoma Surgical Specimen
abstract	Programmed cell death ligand 1 (PD-L1) seems to rely on close relations between neoplastic and immune cells in the tumor microenvironment. Tumor to stroma ratio (TSR) has been associated with prognosis in different malignancies. The aims of this exploratory investigation were to analyze for the first time the: (i) association between TSR, PD-L1 expression and other clinical–pathological features in laryngeal squamous cell carcinoma (LSCC) biopsies and paired surgical specimens; (ii) prognostic and predictive role of TSR and PD-L1. TSR, PD-L1 expression (in terms of combined positive score [CPS]), and other clinical–pathological features were analyzed in biopsies and surgical specimens of 43 consecutive LSCC cases. A CPS < 1 evaluated on surgical specimens was associated with a low TSR (stroma rich) on both biopsies and surgical specimens (<i<p</i< = 0.0143 and <i<p</i< = 0.0063). Low TSR showed a significant negative prognostic value when evaluated on both biopsies and surgical specimens (HR = 8.808, <i<p</i< = 0.0003 and HR = 11.207, <i<p</i< = 0.0002). CPS ≥ 1 appeared to be a favorable prognostic factor (HR = 0.100, <i<p</i< = 0.0265). The association between bioptic and surgical specimen TSR and PD-L1 expression should be further investigated for a potential impact on targeted treatments, also with regard to immunotherapeutic protocols.
abstractGer	Programmed cell death ligand 1 (PD-L1) seems to rely on close relations between neoplastic and immune cells in the tumor microenvironment. Tumor to stroma ratio (TSR) has been associated with prognosis in different malignancies. The aims of this exploratory investigation were to analyze for the first time the: (i) association between TSR, PD-L1 expression and other clinical–pathological features in laryngeal squamous cell carcinoma (LSCC) biopsies and paired surgical specimens; (ii) prognostic and predictive role of TSR and PD-L1. TSR, PD-L1 expression (in terms of combined positive score [CPS]), and other clinical–pathological features were analyzed in biopsies and surgical specimens of 43 consecutive LSCC cases. A CPS < 1 evaluated on surgical specimens was associated with a low TSR (stroma rich) on both biopsies and surgical specimens (<i<p</i< = 0.0143 and <i<p</i< = 0.0063). Low TSR showed a significant negative prognostic value when evaluated on both biopsies and surgical specimens (HR = 8.808, <i<p</i< = 0.0003 and HR = 11.207, <i<p</i< = 0.0002). CPS ≥ 1 appeared to be a favorable prognostic factor (HR = 0.100, <i<p</i< = 0.0265). The association between bioptic and surgical specimen TSR and PD-L1 expression should be further investigated for a potential impact on targeted treatments, also with regard to immunotherapeutic protocols.
abstract_unstemmed	Programmed cell death ligand 1 (PD-L1) seems to rely on close relations between neoplastic and immune cells in the tumor microenvironment. Tumor to stroma ratio (TSR) has been associated with prognosis in different malignancies. The aims of this exploratory investigation were to analyze for the first time the: (i) association between TSR, PD-L1 expression and other clinical–pathological features in laryngeal squamous cell carcinoma (LSCC) biopsies and paired surgical specimens; (ii) prognostic and predictive role of TSR and PD-L1. TSR, PD-L1 expression (in terms of combined positive score [CPS]), and other clinical–pathological features were analyzed in biopsies and surgical specimens of 43 consecutive LSCC cases. A CPS < 1 evaluated on surgical specimens was associated with a low TSR (stroma rich) on both biopsies and surgical specimens (<i<p</i< = 0.0143 and <i<p</i< = 0.0063). Low TSR showed a significant negative prognostic value when evaluated on both biopsies and surgical specimens (HR = 8.808, <i<p</i< = 0.0003 and HR = 11.207, <i<p</i< = 0.0002). CPS ≥ 1 appeared to be a favorable prognostic factor (HR = 0.100, <i<p</i< = 0.0265). The association between bioptic and surgical specimen TSR and PD-L1 expression should be further investigated for a potential impact on targeted treatments, also with regard to immunotherapeutic protocols.
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container_issue	14, p 8053
title_short	Tumor-Stroma Ratio and Programmed Cell Death Ligand 1 Expression in Preoperative Biopsy and Matched Laryngeal Carcinoma Surgical Specimen
url	https://doi.org/10.3390/ijms23148053 https://doaj.org/article/f812b6f8e1af4f15bdfe4577e3ab919a https://www.mdpi.com/1422-0067/23/14/8053 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067
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up_date	2024-07-03T19:21:39.026Z
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