Antibody Responses after Two Doses of COVID-19 mRNA Vaccine in Dialysis and Kidney Transplantation Patients Recovered from SARS-CoV-2 Infection

<i<Background and Objectives:</i< Hemodialysis patients (HD) and kidney transplant recipients (KTRs) have been heavily impacted by COVID-19, showing increased risk of infection, worse clinical outcomes, and higher mortality rates than the general population. Although mass vaccination rem...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Maria Cappuccilli [verfasserIn] Simona Semprini [verfasserIn] Elisabetta Fabbri [verfasserIn] Michela Fantini [verfasserIn] Paolo Ferdinando Bruno [verfasserIn] Alessandra Spazzoli [verfasserIn] Matteo Righini [verfasserIn] Marta Flachi [verfasserIn] Gaetano La Manna [verfasserIn] Vittorio Sambri [verfasserIn] Giovanni Mosconi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	COVID-19 COVID-19 vaccination hemodialysis immunodepressed patients kidney transplantation mRNA vaccines

Übergeordnetes Werk:	In: Medicina - MDPI AG, 2016, 58(2022), 7, p 893
Übergeordnetes Werk:	volume:58 ; year:2022 ; number:7, p 893

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/medicina58070893

Katalog-ID:	DOAJ02619399X

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520			\|a <i<Background and Objectives:</i< Hemodialysis patients (HD) and kidney transplant recipients (KTRs) have been heavily impacted by COVID-19, showing increased risk of infection, worse clinical outcomes, and higher mortality rates than the general population. Although mass vaccination remains the most successful measure in counteracting the pandemic, less evidence is available on vaccine effectiveness in immunodepressed subjects previously infected and recovered from COVID-19. <i<Materials and Methods</i<: This study aimed at investigating the ability to develop an adequate antibody response after vaccination in a 2-dose series against SARS-CoV-2 in HD patients and KTR that was administered after laboratory and clinical recovery from COVID-19. <i<Results:</i< Comparing SARS-CoV-2 S1/S2 IgG levels measured before and after 2 doses of mRNA vaccine (BNT162b2 vaccine, Comirnaty, Pfizer–BioNTech or mRNA-1273 vaccine, Spikevax, Moderna), highly significant increases of antibody titers were observed. The antibody peak level was reached at 3 months following second dose administration, regardless of the underlying cause of immune depression and the time of pre-vaccine serology assessment after negativization. <i<Conclusions:</i< Our data indicate that HD patients and KTR exhibit a satisfying antibody response to a 2-dose series of mRNA vaccine, even in cases when infection-induced humoral immunity was poor or rapidly fading. Further studies are needed to evaluate the role of booster doses in conferring effective and durable protection in weak patient categories.
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allfields	10.3390/medicina58070893 doi (DE-627)DOAJ02619399X (DE-599)DOAJ8e4ddadd709e4883824cc45cce08c692 DE-627 ger DE-627 rakwb eng R5-920 Maria Cappuccilli verfasserin aut Antibody Responses after Two Doses of COVID-19 mRNA Vaccine in Dialysis and Kidney Transplantation Patients Recovered from SARS-CoV-2 Infection 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background and Objectives:</i< Hemodialysis patients (HD) and kidney transplant recipients (KTRs) have been heavily impacted by COVID-19, showing increased risk of infection, worse clinical outcomes, and higher mortality rates than the general population. Although mass vaccination remains the most successful measure in counteracting the pandemic, less evidence is available on vaccine effectiveness in immunodepressed subjects previously infected and recovered from COVID-19. <i<Materials and Methods</i<: This study aimed at investigating the ability to develop an adequate antibody response after vaccination in a 2-dose series against SARS-CoV-2 in HD patients and KTR that was administered after laboratory and clinical recovery from COVID-19. <i<Results:</i< Comparing SARS-CoV-2 S1/S2 IgG levels measured before and after 2 doses of mRNA vaccine (BNT162b2 vaccine, Comirnaty, Pfizer–BioNTech or mRNA-1273 vaccine, Spikevax, Moderna), highly significant increases of antibody titers were observed. The antibody peak level was reached at 3 months following second dose administration, regardless of the underlying cause of immune depression and the time of pre-vaccine serology assessment after negativization. <i<Conclusions:</i< Our data indicate that HD patients and KTR exhibit a satisfying antibody response to a 2-dose series of mRNA vaccine, even in cases when infection-induced humoral immunity was poor or rapidly fading. Further studies are needed to evaluate the role of booster doses in conferring effective and durable protection in weak patient categories. COVID-19 COVID-19 vaccination hemodialysis immunodepressed patients kidney transplantation mRNA vaccines Medicine (General) Simona Semprini verfasserin aut Elisabetta Fabbri verfasserin aut Michela Fantini verfasserin aut Paolo Ferdinando Bruno verfasserin aut Alessandra Spazzoli verfasserin aut Matteo Righini verfasserin aut Marta Flachi verfasserin aut Gaetano La Manna verfasserin aut Vittorio Sambri verfasserin aut Giovanni Mosconi verfasserin aut In Medicina MDPI AG, 2016 58(2022), 7, p 893 (DE-627)354543296 (DE-600)2088820-X 16489144 nnns volume:58 year:2022 number:7, p 893 https://doi.org/10.3390/medicina58070893 kostenfrei https://doaj.org/article/8e4ddadd709e4883824cc45cce08c692 kostenfrei https://www.mdpi.com/1648-9144/58/7/893 kostenfrei https://doaj.org/toc/1010-660X Journal toc kostenfrei https://doaj.org/toc/1648-9144 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 58 2022 7, p 893
spelling	10.3390/medicina58070893 doi (DE-627)DOAJ02619399X (DE-599)DOAJ8e4ddadd709e4883824cc45cce08c692 DE-627 ger DE-627 rakwb eng R5-920 Maria Cappuccilli verfasserin aut Antibody Responses after Two Doses of COVID-19 mRNA Vaccine in Dialysis and Kidney Transplantation Patients Recovered from SARS-CoV-2 Infection 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background and Objectives:</i< Hemodialysis patients (HD) and kidney transplant recipients (KTRs) have been heavily impacted by COVID-19, showing increased risk of infection, worse clinical outcomes, and higher mortality rates than the general population. Although mass vaccination remains the most successful measure in counteracting the pandemic, less evidence is available on vaccine effectiveness in immunodepressed subjects previously infected and recovered from COVID-19. <i<Materials and Methods</i<: This study aimed at investigating the ability to develop an adequate antibody response after vaccination in a 2-dose series against SARS-CoV-2 in HD patients and KTR that was administered after laboratory and clinical recovery from COVID-19. <i<Results:</i< Comparing SARS-CoV-2 S1/S2 IgG levels measured before and after 2 doses of mRNA vaccine (BNT162b2 vaccine, Comirnaty, Pfizer–BioNTech or mRNA-1273 vaccine, Spikevax, Moderna), highly significant increases of antibody titers were observed. The antibody peak level was reached at 3 months following second dose administration, regardless of the underlying cause of immune depression and the time of pre-vaccine serology assessment after negativization. <i<Conclusions:</i< Our data indicate that HD patients and KTR exhibit a satisfying antibody response to a 2-dose series of mRNA vaccine, even in cases when infection-induced humoral immunity was poor or rapidly fading. Further studies are needed to evaluate the role of booster doses in conferring effective and durable protection in weak patient categories. COVID-19 COVID-19 vaccination hemodialysis immunodepressed patients kidney transplantation mRNA vaccines Medicine (General) Simona Semprini verfasserin aut Elisabetta Fabbri verfasserin aut Michela Fantini verfasserin aut Paolo Ferdinando Bruno verfasserin aut Alessandra Spazzoli verfasserin aut Matteo Righini verfasserin aut Marta Flachi verfasserin aut Gaetano La Manna verfasserin aut Vittorio Sambri verfasserin aut Giovanni Mosconi verfasserin aut In Medicina MDPI AG, 2016 58(2022), 7, p 893 (DE-627)354543296 (DE-600)2088820-X 16489144 nnns volume:58 year:2022 number:7, p 893 https://doi.org/10.3390/medicina58070893 kostenfrei https://doaj.org/article/8e4ddadd709e4883824cc45cce08c692 kostenfrei https://www.mdpi.com/1648-9144/58/7/893 kostenfrei https://doaj.org/toc/1010-660X Journal toc kostenfrei https://doaj.org/toc/1648-9144 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 58 2022 7, p 893
allfields_unstemmed	10.3390/medicina58070893 doi (DE-627)DOAJ02619399X (DE-599)DOAJ8e4ddadd709e4883824cc45cce08c692 DE-627 ger DE-627 rakwb eng R5-920 Maria Cappuccilli verfasserin aut Antibody Responses after Two Doses of COVID-19 mRNA Vaccine in Dialysis and Kidney Transplantation Patients Recovered from SARS-CoV-2 Infection 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background and Objectives:</i< Hemodialysis patients (HD) and kidney transplant recipients (KTRs) have been heavily impacted by COVID-19, showing increased risk of infection, worse clinical outcomes, and higher mortality rates than the general population. Although mass vaccination remains the most successful measure in counteracting the pandemic, less evidence is available on vaccine effectiveness in immunodepressed subjects previously infected and recovered from COVID-19. <i<Materials and Methods</i<: This study aimed at investigating the ability to develop an adequate antibody response after vaccination in a 2-dose series against SARS-CoV-2 in HD patients and KTR that was administered after laboratory and clinical recovery from COVID-19. <i<Results:</i< Comparing SARS-CoV-2 S1/S2 IgG levels measured before and after 2 doses of mRNA vaccine (BNT162b2 vaccine, Comirnaty, Pfizer–BioNTech or mRNA-1273 vaccine, Spikevax, Moderna), highly significant increases of antibody titers were observed. The antibody peak level was reached at 3 months following second dose administration, regardless of the underlying cause of immune depression and the time of pre-vaccine serology assessment after negativization. <i<Conclusions:</i< Our data indicate that HD patients and KTR exhibit a satisfying antibody response to a 2-dose series of mRNA vaccine, even in cases when infection-induced humoral immunity was poor or rapidly fading. Further studies are needed to evaluate the role of booster doses in conferring effective and durable protection in weak patient categories. COVID-19 COVID-19 vaccination hemodialysis immunodepressed patients kidney transplantation mRNA vaccines Medicine (General) Simona Semprini verfasserin aut Elisabetta Fabbri verfasserin aut Michela Fantini verfasserin aut Paolo Ferdinando Bruno verfasserin aut Alessandra Spazzoli verfasserin aut Matteo Righini verfasserin aut Marta Flachi verfasserin aut Gaetano La Manna verfasserin aut Vittorio Sambri verfasserin aut Giovanni Mosconi verfasserin aut In Medicina MDPI AG, 2016 58(2022), 7, p 893 (DE-627)354543296 (DE-600)2088820-X 16489144 nnns volume:58 year:2022 number:7, p 893 https://doi.org/10.3390/medicina58070893 kostenfrei https://doaj.org/article/8e4ddadd709e4883824cc45cce08c692 kostenfrei https://www.mdpi.com/1648-9144/58/7/893 kostenfrei https://doaj.org/toc/1010-660X Journal toc kostenfrei https://doaj.org/toc/1648-9144 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 58 2022 7, p 893
allfieldsGer	10.3390/medicina58070893 doi (DE-627)DOAJ02619399X (DE-599)DOAJ8e4ddadd709e4883824cc45cce08c692 DE-627 ger DE-627 rakwb eng R5-920 Maria Cappuccilli verfasserin aut Antibody Responses after Two Doses of COVID-19 mRNA Vaccine in Dialysis and Kidney Transplantation Patients Recovered from SARS-CoV-2 Infection 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background and Objectives:</i< Hemodialysis patients (HD) and kidney transplant recipients (KTRs) have been heavily impacted by COVID-19, showing increased risk of infection, worse clinical outcomes, and higher mortality rates than the general population. Although mass vaccination remains the most successful measure in counteracting the pandemic, less evidence is available on vaccine effectiveness in immunodepressed subjects previously infected and recovered from COVID-19. <i<Materials and Methods</i<: This study aimed at investigating the ability to develop an adequate antibody response after vaccination in a 2-dose series against SARS-CoV-2 in HD patients and KTR that was administered after laboratory and clinical recovery from COVID-19. <i<Results:</i< Comparing SARS-CoV-2 S1/S2 IgG levels measured before and after 2 doses of mRNA vaccine (BNT162b2 vaccine, Comirnaty, Pfizer–BioNTech or mRNA-1273 vaccine, Spikevax, Moderna), highly significant increases of antibody titers were observed. The antibody peak level was reached at 3 months following second dose administration, regardless of the underlying cause of immune depression and the time of pre-vaccine serology assessment after negativization. <i<Conclusions:</i< Our data indicate that HD patients and KTR exhibit a satisfying antibody response to a 2-dose series of mRNA vaccine, even in cases when infection-induced humoral immunity was poor or rapidly fading. Further studies are needed to evaluate the role of booster doses in conferring effective and durable protection in weak patient categories. COVID-19 COVID-19 vaccination hemodialysis immunodepressed patients kidney transplantation mRNA vaccines Medicine (General) Simona Semprini verfasserin aut Elisabetta Fabbri verfasserin aut Michela Fantini verfasserin aut Paolo Ferdinando Bruno verfasserin aut Alessandra Spazzoli verfasserin aut Matteo Righini verfasserin aut Marta Flachi verfasserin aut Gaetano La Manna verfasserin aut Vittorio Sambri verfasserin aut Giovanni Mosconi verfasserin aut In Medicina MDPI AG, 2016 58(2022), 7, p 893 (DE-627)354543296 (DE-600)2088820-X 16489144 nnns volume:58 year:2022 number:7, p 893 https://doi.org/10.3390/medicina58070893 kostenfrei https://doaj.org/article/8e4ddadd709e4883824cc45cce08c692 kostenfrei https://www.mdpi.com/1648-9144/58/7/893 kostenfrei https://doaj.org/toc/1010-660X Journal toc kostenfrei https://doaj.org/toc/1648-9144 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 58 2022 7, p 893
allfieldsSound	10.3390/medicina58070893 doi (DE-627)DOAJ02619399X (DE-599)DOAJ8e4ddadd709e4883824cc45cce08c692 DE-627 ger DE-627 rakwb eng R5-920 Maria Cappuccilli verfasserin aut Antibody Responses after Two Doses of COVID-19 mRNA Vaccine in Dialysis and Kidney Transplantation Patients Recovered from SARS-CoV-2 Infection 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background and Objectives:</i< Hemodialysis patients (HD) and kidney transplant recipients (KTRs) have been heavily impacted by COVID-19, showing increased risk of infection, worse clinical outcomes, and higher mortality rates than the general population. Although mass vaccination remains the most successful measure in counteracting the pandemic, less evidence is available on vaccine effectiveness in immunodepressed subjects previously infected and recovered from COVID-19. <i<Materials and Methods</i<: This study aimed at investigating the ability to develop an adequate antibody response after vaccination in a 2-dose series against SARS-CoV-2 in HD patients and KTR that was administered after laboratory and clinical recovery from COVID-19. <i<Results:</i< Comparing SARS-CoV-2 S1/S2 IgG levels measured before and after 2 doses of mRNA vaccine (BNT162b2 vaccine, Comirnaty, Pfizer–BioNTech or mRNA-1273 vaccine, Spikevax, Moderna), highly significant increases of antibody titers were observed. The antibody peak level was reached at 3 months following second dose administration, regardless of the underlying cause of immune depression and the time of pre-vaccine serology assessment after negativization. <i<Conclusions:</i< Our data indicate that HD patients and KTR exhibit a satisfying antibody response to a 2-dose series of mRNA vaccine, even in cases when infection-induced humoral immunity was poor or rapidly fading. Further studies are needed to evaluate the role of booster doses in conferring effective and durable protection in weak patient categories. COVID-19 COVID-19 vaccination hemodialysis immunodepressed patients kidney transplantation mRNA vaccines Medicine (General) Simona Semprini verfasserin aut Elisabetta Fabbri verfasserin aut Michela Fantini verfasserin aut Paolo Ferdinando Bruno verfasserin aut Alessandra Spazzoli verfasserin aut Matteo Righini verfasserin aut Marta Flachi verfasserin aut Gaetano La Manna verfasserin aut Vittorio Sambri verfasserin aut Giovanni Mosconi verfasserin aut In Medicina MDPI AG, 2016 58(2022), 7, p 893 (DE-627)354543296 (DE-600)2088820-X 16489144 nnns volume:58 year:2022 number:7, p 893 https://doi.org/10.3390/medicina58070893 kostenfrei https://doaj.org/article/8e4ddadd709e4883824cc45cce08c692 kostenfrei https://www.mdpi.com/1648-9144/58/7/893 kostenfrei https://doaj.org/toc/1010-660X Journal toc kostenfrei https://doaj.org/toc/1648-9144 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 58 2022 7, p 893
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authorswithroles_txt_mv	Maria Cappuccilli @@aut@@ Simona Semprini @@aut@@ Elisabetta Fabbri @@aut@@ Michela Fantini @@aut@@ Paolo Ferdinando Bruno @@aut@@ Alessandra Spazzoli @@aut@@ Matteo Righini @@aut@@ Marta Flachi @@aut@@ Gaetano La Manna @@aut@@ Vittorio Sambri @@aut@@ Giovanni Mosconi @@aut@@
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callnumber-first	R - Medicine
author	Maria Cappuccilli
spellingShingle	Maria Cappuccilli misc R5-920 misc COVID-19 misc COVID-19 vaccination misc hemodialysis misc immunodepressed patients misc kidney transplantation misc mRNA vaccines misc Medicine (General) Antibody Responses after Two Doses of COVID-19 mRNA Vaccine in Dialysis and Kidney Transplantation Patients Recovered from SARS-CoV-2 Infection
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topic_title	R5-920 Antibody Responses after Two Doses of COVID-19 mRNA Vaccine in Dialysis and Kidney Transplantation Patients Recovered from SARS-CoV-2 Infection COVID-19 COVID-19 vaccination hemodialysis immunodepressed patients kidney transplantation mRNA vaccines
topic	misc R5-920 misc COVID-19 misc COVID-19 vaccination misc hemodialysis misc immunodepressed patients misc kidney transplantation misc mRNA vaccines misc Medicine (General)
topic_unstemmed	misc R5-920 misc COVID-19 misc COVID-19 vaccination misc hemodialysis misc immunodepressed patients misc kidney transplantation misc mRNA vaccines misc Medicine (General)
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title	Antibody Responses after Two Doses of COVID-19 mRNA Vaccine in Dialysis and Kidney Transplantation Patients Recovered from SARS-CoV-2 Infection
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title_full	Antibody Responses after Two Doses of COVID-19 mRNA Vaccine in Dialysis and Kidney Transplantation Patients Recovered from SARS-CoV-2 Infection
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author_browse	Maria Cappuccilli Simona Semprini Elisabetta Fabbri Michela Fantini Paolo Ferdinando Bruno Alessandra Spazzoli Matteo Righini Marta Flachi Gaetano La Manna Vittorio Sambri Giovanni Mosconi
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title_sort	antibody responses after two doses of covid-19 mrna vaccine in dialysis and kidney transplantation patients recovered from sars-cov-2 infection
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title_auth	Antibody Responses after Two Doses of COVID-19 mRNA Vaccine in Dialysis and Kidney Transplantation Patients Recovered from SARS-CoV-2 Infection
abstract	<i<Background and Objectives:</i< Hemodialysis patients (HD) and kidney transplant recipients (KTRs) have been heavily impacted by COVID-19, showing increased risk of infection, worse clinical outcomes, and higher mortality rates than the general population. Although mass vaccination remains the most successful measure in counteracting the pandemic, less evidence is available on vaccine effectiveness in immunodepressed subjects previously infected and recovered from COVID-19. <i<Materials and Methods</i<: This study aimed at investigating the ability to develop an adequate antibody response after vaccination in a 2-dose series against SARS-CoV-2 in HD patients and KTR that was administered after laboratory and clinical recovery from COVID-19. <i<Results:</i< Comparing SARS-CoV-2 S1/S2 IgG levels measured before and after 2 doses of mRNA vaccine (BNT162b2 vaccine, Comirnaty, Pfizer–BioNTech or mRNA-1273 vaccine, Spikevax, Moderna), highly significant increases of antibody titers were observed. The antibody peak level was reached at 3 months following second dose administration, regardless of the underlying cause of immune depression and the time of pre-vaccine serology assessment after negativization. <i<Conclusions:</i< Our data indicate that HD patients and KTR exhibit a satisfying antibody response to a 2-dose series of mRNA vaccine, even in cases when infection-induced humoral immunity was poor or rapidly fading. Further studies are needed to evaluate the role of booster doses in conferring effective and durable protection in weak patient categories.
abstractGer	<i<Background and Objectives:</i< Hemodialysis patients (HD) and kidney transplant recipients (KTRs) have been heavily impacted by COVID-19, showing increased risk of infection, worse clinical outcomes, and higher mortality rates than the general population. Although mass vaccination remains the most successful measure in counteracting the pandemic, less evidence is available on vaccine effectiveness in immunodepressed subjects previously infected and recovered from COVID-19. <i<Materials and Methods</i<: This study aimed at investigating the ability to develop an adequate antibody response after vaccination in a 2-dose series against SARS-CoV-2 in HD patients and KTR that was administered after laboratory and clinical recovery from COVID-19. <i<Results:</i< Comparing SARS-CoV-2 S1/S2 IgG levels measured before and after 2 doses of mRNA vaccine (BNT162b2 vaccine, Comirnaty, Pfizer–BioNTech or mRNA-1273 vaccine, Spikevax, Moderna), highly significant increases of antibody titers were observed. The antibody peak level was reached at 3 months following second dose administration, regardless of the underlying cause of immune depression and the time of pre-vaccine serology assessment after negativization. <i<Conclusions:</i< Our data indicate that HD patients and KTR exhibit a satisfying antibody response to a 2-dose series of mRNA vaccine, even in cases when infection-induced humoral immunity was poor or rapidly fading. Further studies are needed to evaluate the role of booster doses in conferring effective and durable protection in weak patient categories.
abstract_unstemmed	<i<Background and Objectives:</i< Hemodialysis patients (HD) and kidney transplant recipients (KTRs) have been heavily impacted by COVID-19, showing increased risk of infection, worse clinical outcomes, and higher mortality rates than the general population. Although mass vaccination remains the most successful measure in counteracting the pandemic, less evidence is available on vaccine effectiveness in immunodepressed subjects previously infected and recovered from COVID-19. <i<Materials and Methods</i<: This study aimed at investigating the ability to develop an adequate antibody response after vaccination in a 2-dose series against SARS-CoV-2 in HD patients and KTR that was administered after laboratory and clinical recovery from COVID-19. <i<Results:</i< Comparing SARS-CoV-2 S1/S2 IgG levels measured before and after 2 doses of mRNA vaccine (BNT162b2 vaccine, Comirnaty, Pfizer–BioNTech or mRNA-1273 vaccine, Spikevax, Moderna), highly significant increases of antibody titers were observed. The antibody peak level was reached at 3 months following second dose administration, regardless of the underlying cause of immune depression and the time of pre-vaccine serology assessment after negativization. <i<Conclusions:</i< Our data indicate that HD patients and KTR exhibit a satisfying antibody response to a 2-dose series of mRNA vaccine, even in cases when infection-induced humoral immunity was poor or rapidly fading. Further studies are needed to evaluate the role of booster doses in conferring effective and durable protection in weak patient categories.
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title_short	Antibody Responses after Two Doses of COVID-19 mRNA Vaccine in Dialysis and Kidney Transplantation Patients Recovered from SARS-CoV-2 Infection
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Although mass vaccination remains the most successful measure in counteracting the pandemic, less evidence is available on vaccine effectiveness in immunodepressed subjects previously infected and recovered from COVID-19. <i<Materials and Methods</i<: This study aimed at investigating the ability to develop an adequate antibody response after vaccination in a 2-dose series against SARS-CoV-2 in HD patients and KTR that was administered after laboratory and clinical recovery from COVID-19. <i<Results:</i< Comparing SARS-CoV-2 S1/S2 IgG levels measured before and after 2 doses of mRNA vaccine (BNT162b2 vaccine, Comirnaty, Pfizer–BioNTech or mRNA-1273 vaccine, Spikevax, Moderna), highly significant increases of antibody titers were observed. The antibody peak level was reached at 3 months following second dose administration, regardless of the underlying cause of immune depression and the time of pre-vaccine serology assessment after negativization. <i<Conclusions:</i< Our data indicate that HD patients and KTR exhibit a satisfying antibody response to a 2-dose series of mRNA vaccine, even in cases when infection-induced humoral immunity was poor or rapidly fading. 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