Serotonin 2a Receptor and serotonin 1a receptor interact within the medial prefrontal cortex during recognition memory in mice

Episodic memory, can be defined as the memory for unique events. The serotonergic system one of the main neuromodulatory systems in the brain appears to play a role in it. The serotonin 2a receptor (5-HT2aR) one of the principal post-synaptic receptors for 5-HT in the brain, is involved in neuropsyc...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Juan Facundo Morici [verfasserIn] Lucia eCiccia [verfasserIn] Gaël eMalleret [verfasserIn] Jay eGingrich [verfasserIn] Pedro eBekinschtein [verfasserIn] Noelia eWeisstaub [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Serotonin recognition memory interference control 5-HT1A receptor 5-HT2A receptor

Übergeordnetes Werk:	In: Frontiers in Pharmacology - Frontiers Media S.A., 2010, 6(2015)
Übergeordnetes Werk:	volume:6 ; year:2015

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphar.2015.00298

Katalog-ID:	DOAJ026300354

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allfieldsSound	10.3389/fphar.2015.00298 doi (DE-627)DOAJ026300354 (DE-599)DOAJ14058f7a22604b6ba75b69772c601e3e DE-627 ger DE-627 rakwb eng RM1-950 Juan Facundo Morici verfasserin aut Serotonin 2a Receptor and serotonin 1a receptor interact within the medial prefrontal cortex during recognition memory in mice 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Episodic memory, can be defined as the memory for unique events. The serotonergic system one of the main neuromodulatory systems in the brain appears to play a role in it. The serotonin 2a receptor (5-HT2aR) one of the principal post-synaptic receptors for 5-HT in the brain, is involved in neuropsychiatric and neurological disorders associated with memory deficits. Recognition memory can be defined as the ability to recognize if a particular event or item was previously encountered and is thus considered, under certain conditions, a form of episodic memory. As human data suggest that a constitutively decrease of 5-HT2A signaling might affect episodic memory performance we decided to compare the performance of mice with disrupted 5-HT2aR signaling (htr2a -/-) with wild type (htr2a+/+) littermates in different recognition memory and working memory tasks that differed in the level of proactive interference. We found that ablation of 5-HT2aR signaling throughout development produces a deficit in tasks that cannot be solved by single item strategy suggesting that 5-HT2aR signaling is involved in interference resolution. We also found that in the absence of 5-HT2aR signaling serotonin has a deleterious effect on recognition memory retrieval through the activation of 5-HT1aR in the medial prefrontal cortex. Serotonin recognition memory interference control 5-HT1A receptor 5-HT2A receptor Therapeutics. Pharmacology Lucia eCiccia verfasserin aut Gaël eMalleret verfasserin aut Jay eGingrich verfasserin aut Jay eGingrich verfasserin aut Pedro eBekinschtein verfasserin aut Noelia eWeisstaub verfasserin aut In Frontiers in Pharmacology Frontiers Media S.A., 2010 6(2015) (DE-627)642889392 (DE-600)2587355-6 16639812 nnns volume:6 year:2015 https://doi.org/10.3389/fphar.2015.00298 kostenfrei https://doaj.org/article/14058f7a22604b6ba75b69772c601e3e kostenfrei http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00298/full kostenfrei https://doaj.org/toc/1663-9812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2015
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authorswithroles_txt_mv	Juan Facundo Morici @@aut@@ Lucia eCiccia @@aut@@ Gaël eMalleret @@aut@@ Jay eGingrich @@aut@@ Pedro eBekinschtein @@aut@@ Noelia eWeisstaub @@aut@@
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callnumber-first	R - Medicine
author	Juan Facundo Morici
spellingShingle	Juan Facundo Morici misc RM1-950 misc Serotonin misc recognition memory misc interference control misc 5-HT1A receptor misc 5-HT2A receptor misc Therapeutics. Pharmacology Serotonin 2a Receptor and serotonin 1a receptor interact within the medial prefrontal cortex during recognition memory in mice
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topic_title	RM1-950 Serotonin 2a Receptor and serotonin 1a receptor interact within the medial prefrontal cortex during recognition memory in mice Serotonin recognition memory interference control 5-HT1A receptor 5-HT2A receptor
topic	misc RM1-950 misc Serotonin misc recognition memory misc interference control misc 5-HT1A receptor misc 5-HT2A receptor misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc Serotonin misc recognition memory misc interference control misc 5-HT1A receptor misc 5-HT2A receptor misc Therapeutics. Pharmacology
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title	Serotonin 2a Receptor and serotonin 1a receptor interact within the medial prefrontal cortex during recognition memory in mice
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title_full	Serotonin 2a Receptor and serotonin 1a receptor interact within the medial prefrontal cortex during recognition memory in mice
author_sort	Juan Facundo Morici
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title_sort	serotonin 2a receptor and serotonin 1a receptor interact within the medial prefrontal cortex during recognition memory in mice
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title_auth	Serotonin 2a Receptor and serotonin 1a receptor interact within the medial prefrontal cortex during recognition memory in mice
abstract	Episodic memory, can be defined as the memory for unique events. The serotonergic system one of the main neuromodulatory systems in the brain appears to play a role in it. The serotonin 2a receptor (5-HT2aR) one of the principal post-synaptic receptors for 5-HT in the brain, is involved in neuropsychiatric and neurological disorders associated with memory deficits. Recognition memory can be defined as the ability to recognize if a particular event or item was previously encountered and is thus considered, under certain conditions, a form of episodic memory. As human data suggest that a constitutively decrease of 5-HT2A signaling might affect episodic memory performance we decided to compare the performance of mice with disrupted 5-HT2aR signaling (htr2a -/-) with wild type (htr2a+/+) littermates in different recognition memory and working memory tasks that differed in the level of proactive interference. We found that ablation of 5-HT2aR signaling throughout development produces a deficit in tasks that cannot be solved by single item strategy suggesting that 5-HT2aR signaling is involved in interference resolution. We also found that in the absence of 5-HT2aR signaling serotonin has a deleterious effect on recognition memory retrieval through the activation of 5-HT1aR in the medial prefrontal cortex.
abstractGer	Episodic memory, can be defined as the memory for unique events. The serotonergic system one of the main neuromodulatory systems in the brain appears to play a role in it. The serotonin 2a receptor (5-HT2aR) one of the principal post-synaptic receptors for 5-HT in the brain, is involved in neuropsychiatric and neurological disorders associated with memory deficits. Recognition memory can be defined as the ability to recognize if a particular event or item was previously encountered and is thus considered, under certain conditions, a form of episodic memory. As human data suggest that a constitutively decrease of 5-HT2A signaling might affect episodic memory performance we decided to compare the performance of mice with disrupted 5-HT2aR signaling (htr2a -/-) with wild type (htr2a+/+) littermates in different recognition memory and working memory tasks that differed in the level of proactive interference. We found that ablation of 5-HT2aR signaling throughout development produces a deficit in tasks that cannot be solved by single item strategy suggesting that 5-HT2aR signaling is involved in interference resolution. We also found that in the absence of 5-HT2aR signaling serotonin has a deleterious effect on recognition memory retrieval through the activation of 5-HT1aR in the medial prefrontal cortex.
abstract_unstemmed	Episodic memory, can be defined as the memory for unique events. The serotonergic system one of the main neuromodulatory systems in the brain appears to play a role in it. The serotonin 2a receptor (5-HT2aR) one of the principal post-synaptic receptors for 5-HT in the brain, is involved in neuropsychiatric and neurological disorders associated with memory deficits. Recognition memory can be defined as the ability to recognize if a particular event or item was previously encountered and is thus considered, under certain conditions, a form of episodic memory. As human data suggest that a constitutively decrease of 5-HT2A signaling might affect episodic memory performance we decided to compare the performance of mice with disrupted 5-HT2aR signaling (htr2a -/-) with wild type (htr2a+/+) littermates in different recognition memory and working memory tasks that differed in the level of proactive interference. We found that ablation of 5-HT2aR signaling throughout development produces a deficit in tasks that cannot be solved by single item strategy suggesting that 5-HT2aR signaling is involved in interference resolution. We also found that in the absence of 5-HT2aR signaling serotonin has a deleterious effect on recognition memory retrieval through the activation of 5-HT1aR in the medial prefrontal cortex.
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title_short	Serotonin 2a Receptor and serotonin 1a receptor interact within the medial prefrontal cortex during recognition memory in mice
url	https://doi.org/10.3389/fphar.2015.00298 https://doaj.org/article/14058f7a22604b6ba75b69772c601e3e http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00298/full https://doaj.org/toc/1663-9812
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up_date	2024-07-03T20:12:30.294Z
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Serotonin 2a Receptor and serotonin 1a receptor interact within the medial prefrontal cortex during recognition memory in mice

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