Prevalence of Hyperhomocysteinemia in China: A Systematic Review and Meta-Analysis

Hyperhomocysteinemia (HHcy, total homocysteine concentrations > 15 μmol/L) has been associated with increased risk of many diseases. A systematic review was performed to summarize the prevalence of HHcy in China. We searched multiple international and Chinese scientific databases for relevant...
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Autor*in:	Boyi Yang [verfasserIn] Shujun Fan [verfasserIn] Xueyuan Zhi [verfasserIn] Yinuo Wang [verfasserIn] Yanxun Wang [verfasserIn] Quanmei Zheng [verfasserIn] Guifan Sun [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	hyperhomocysteinemia prevalence China meta-analysis

Übergeordnetes Werk:	In: Nutrients - MDPI AG, 2009, 7(2014), 1, Seite 74-90
Übergeordnetes Werk:	volume:7 ; year:2014 ; number:1 ; pages:74-90

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nu7010074

Katalog-ID:	DOAJ026718626

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allfieldsGer	10.3390/nu7010074 doi (DE-627)DOAJ026718626 (DE-599)DOAJ28b316adc6ca4a94855daa008e80726a DE-627 ger DE-627 rakwb eng TX341-641 Boyi Yang verfasserin aut Prevalence of Hyperhomocysteinemia in China: A Systematic Review and Meta-Analysis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hyperhomocysteinemia (HHcy, total homocysteine concentrations > 15 μmol/L) has been associated with increased risk of many diseases. A systematic review was performed to summarize the prevalence of HHcy in China. We searched multiple international and Chinese scientific databases for relevant literature, and further manually screened reference lists and corresponded with original authors. Pooled prevalence of HHcy was calculated using random effects model. Subgroup analysis, meta-regression and sensitivity analysis were also performed. A total of 36 studies consisting 60,754 subjects (57.3% male; age range, 3–97 years) were finally included. The overall pooled prevalence of HHcy was 27.5%. Geographically, the prevalence was high in north areas, intermediate in central areas, and low in south areas, and was higher in inland versus coastal areas. The prevalence increased with age and was significantly higher in men than in women. Rural residents had a slightly higher HHcy prevalence than urban residents, and the studies conducted during 2006 to 2012 presented a higher HHcy prevalence than those during 1990 to 2005. In summary, the prevalence of HHcy in China is high, particularly in northern populations, the inlanders, males, and the elderly. Homocysteine-lowering strategies are necessary to reduce this highly preventable disorder. hyperhomocysteinemia prevalence China meta-analysis Nutrition. Foods and food supply Shujun Fan verfasserin aut Xueyuan Zhi verfasserin aut Yinuo Wang verfasserin aut Yanxun Wang verfasserin aut Quanmei Zheng verfasserin aut Guifan Sun verfasserin aut In Nutrients MDPI AG, 2009 7(2014), 1, Seite 74-90 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:7 year:2014 number:1 pages:74-90 https://doi.org/10.3390/nu7010074 kostenfrei https://doaj.org/article/28b316adc6ca4a94855daa008e80726a kostenfrei http://www.mdpi.com/2072-6643/7/1/74 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2014 1 74-90
allfieldsSound	10.3390/nu7010074 doi (DE-627)DOAJ026718626 (DE-599)DOAJ28b316adc6ca4a94855daa008e80726a DE-627 ger DE-627 rakwb eng TX341-641 Boyi Yang verfasserin aut Prevalence of Hyperhomocysteinemia in China: A Systematic Review and Meta-Analysis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hyperhomocysteinemia (HHcy, total homocysteine concentrations > 15 μmol/L) has been associated with increased risk of many diseases. A systematic review was performed to summarize the prevalence of HHcy in China. We searched multiple international and Chinese scientific databases for relevant literature, and further manually screened reference lists and corresponded with original authors. Pooled prevalence of HHcy was calculated using random effects model. Subgroup analysis, meta-regression and sensitivity analysis were also performed. A total of 36 studies consisting 60,754 subjects (57.3% male; age range, 3–97 years) were finally included. The overall pooled prevalence of HHcy was 27.5%. Geographically, the prevalence was high in north areas, intermediate in central areas, and low in south areas, and was higher in inland versus coastal areas. The prevalence increased with age and was significantly higher in men than in women. Rural residents had a slightly higher HHcy prevalence than urban residents, and the studies conducted during 2006 to 2012 presented a higher HHcy prevalence than those during 1990 to 2005. In summary, the prevalence of HHcy in China is high, particularly in northern populations, the inlanders, males, and the elderly. Homocysteine-lowering strategies are necessary to reduce this highly preventable disorder. hyperhomocysteinemia prevalence China meta-analysis Nutrition. Foods and food supply Shujun Fan verfasserin aut Xueyuan Zhi verfasserin aut Yinuo Wang verfasserin aut Yanxun Wang verfasserin aut Quanmei Zheng verfasserin aut Guifan Sun verfasserin aut In Nutrients MDPI AG, 2009 7(2014), 1, Seite 74-90 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:7 year:2014 number:1 pages:74-90 https://doi.org/10.3390/nu7010074 kostenfrei https://doaj.org/article/28b316adc6ca4a94855daa008e80726a kostenfrei http://www.mdpi.com/2072-6643/7/1/74 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2014 1 74-90
language	English
source	In Nutrients 7(2014), 1, Seite 74-90 volume:7 year:2014 number:1 pages:74-90
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authorswithroles_txt_mv	Boyi Yang @@aut@@ Shujun Fan @@aut@@ Xueyuan Zhi @@aut@@ Yinuo Wang @@aut@@ Yanxun Wang @@aut@@ Quanmei Zheng @@aut@@ Guifan Sun @@aut@@
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callnumber-first	T - Technology
author	Boyi Yang
spellingShingle	Boyi Yang misc TX341-641 misc hyperhomocysteinemia misc prevalence misc China misc meta-analysis misc Nutrition. Foods and food supply Prevalence of Hyperhomocysteinemia in China: A Systematic Review and Meta-Analysis
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topic_title	TX341-641 Prevalence of Hyperhomocysteinemia in China: A Systematic Review and Meta-Analysis hyperhomocysteinemia prevalence China meta-analysis
topic	misc TX341-641 misc hyperhomocysteinemia misc prevalence misc China misc meta-analysis misc Nutrition. Foods and food supply
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title	Prevalence of Hyperhomocysteinemia in China: A Systematic Review and Meta-Analysis
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title_sort	prevalence of hyperhomocysteinemia in china: a systematic review and meta-analysis
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title_auth	Prevalence of Hyperhomocysteinemia in China: A Systematic Review and Meta-Analysis
abstract	Hyperhomocysteinemia (HHcy, total homocysteine concentrations > 15 μmol/L) has been associated with increased risk of many diseases. A systematic review was performed to summarize the prevalence of HHcy in China. We searched multiple international and Chinese scientific databases for relevant literature, and further manually screened reference lists and corresponded with original authors. Pooled prevalence of HHcy was calculated using random effects model. Subgroup analysis, meta-regression and sensitivity analysis were also performed. A total of 36 studies consisting 60,754 subjects (57.3% male; age range, 3–97 years) were finally included. The overall pooled prevalence of HHcy was 27.5%. Geographically, the prevalence was high in north areas, intermediate in central areas, and low in south areas, and was higher in inland versus coastal areas. The prevalence increased with age and was significantly higher in men than in women. Rural residents had a slightly higher HHcy prevalence than urban residents, and the studies conducted during 2006 to 2012 presented a higher HHcy prevalence than those during 1990 to 2005. In summary, the prevalence of HHcy in China is high, particularly in northern populations, the inlanders, males, and the elderly. Homocysteine-lowering strategies are necessary to reduce this highly preventable disorder.
abstractGer	Hyperhomocysteinemia (HHcy, total homocysteine concentrations > 15 μmol/L) has been associated with increased risk of many diseases. A systematic review was performed to summarize the prevalence of HHcy in China. We searched multiple international and Chinese scientific databases for relevant literature, and further manually screened reference lists and corresponded with original authors. Pooled prevalence of HHcy was calculated using random effects model. Subgroup analysis, meta-regression and sensitivity analysis were also performed. A total of 36 studies consisting 60,754 subjects (57.3% male; age range, 3–97 years) were finally included. The overall pooled prevalence of HHcy was 27.5%. Geographically, the prevalence was high in north areas, intermediate in central areas, and low in south areas, and was higher in inland versus coastal areas. The prevalence increased with age and was significantly higher in men than in women. Rural residents had a slightly higher HHcy prevalence than urban residents, and the studies conducted during 2006 to 2012 presented a higher HHcy prevalence than those during 1990 to 2005. In summary, the prevalence of HHcy in China is high, particularly in northern populations, the inlanders, males, and the elderly. Homocysteine-lowering strategies are necessary to reduce this highly preventable disorder.
abstract_unstemmed	Hyperhomocysteinemia (HHcy, total homocysteine concentrations > 15 μmol/L) has been associated with increased risk of many diseases. A systematic review was performed to summarize the prevalence of HHcy in China. We searched multiple international and Chinese scientific databases for relevant literature, and further manually screened reference lists and corresponded with original authors. Pooled prevalence of HHcy was calculated using random effects model. Subgroup analysis, meta-regression and sensitivity analysis were also performed. A total of 36 studies consisting 60,754 subjects (57.3% male; age range, 3–97 years) were finally included. The overall pooled prevalence of HHcy was 27.5%. Geographically, the prevalence was high in north areas, intermediate in central areas, and low in south areas, and was higher in inland versus coastal areas. The prevalence increased with age and was significantly higher in men than in women. Rural residents had a slightly higher HHcy prevalence than urban residents, and the studies conducted during 2006 to 2012 presented a higher HHcy prevalence than those during 1990 to 2005. In summary, the prevalence of HHcy in China is high, particularly in northern populations, the inlanders, males, and the elderly. Homocysteine-lowering strategies are necessary to reduce this highly preventable disorder.
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title_short	Prevalence of Hyperhomocysteinemia in China: A Systematic Review and Meta-Analysis
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