Association between an 8q24 locus and the risk of colorectal cancer in Japanese

<p<Abstract</p< <p<Background</p< <p<A genome-wide association study (GWAS), which assessed multiple ethnicities, reported an association between single nucleotide polymorphisms in the 8q24 region and colorectal cancer risk. Although the association with the identified...
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Autor*in:	Kanemitsu Yukihide [verfasserIn] Komori Koji [verfasserIn] Shitara Kohei [verfasserIn] Watanabe Miki [verfasserIn] Kawase Takakazu [verfasserIn] Hosono Satoyo [verfasserIn] Ito Hidemi [verfasserIn] Suzuki Takeshi [verfasserIn] Matsuo Keitaro [verfasserIn] Hirai Takashi [verfasserIn] Yatabe Yasushi [verfasserIn] Tanaka Hideo [verfasserIn] Tajima Kazuo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Übergeordnetes Werk:	In: BMC Cancer - BMC, 2003, 9(2009), 1, p 379
Übergeordnetes Werk:	volume:9 ; year:2009 ; number:1, p 379

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1471-2407-9-379

Katalog-ID:	DOAJ026787334

Internformat


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allfields	10.1186/1471-2407-9-379 doi (DE-627)DOAJ026787334 (DE-599)DOAJ94bd1403643c480b991146648fc4f674 DE-627 ger DE-627 rakwb eng RC254-282 Kanemitsu Yukihide verfasserin aut Association between an 8q24 locus and the risk of colorectal cancer in Japanese 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<A genome-wide association study (GWAS), which assessed multiple ethnicities, reported an association between single nucleotide polymorphisms in the 8q24 region and colorectal cancer risk. Although the association with the identified loci was strong, information on its impact in combination with lifestyle factors is limited.</p< <p<Methods</p< <p<We conducted a case-control study in 481 patients with colorectal cancer (CRC) and 962 sex-age matched non-cancer controls. Data on lifestyle factors, including diet, were obtained by self-administered questionnaire. Two 8q24 loci, rs6983267 and rs10090154, were assessed by the TaqMan method. Associations were then assessed by multivariate logistic regression models that considered potential confounders.</p< <p<Results</p< <p<We found an increased risk of CRC with rs6983267 but not with rs10090154. An allelic OR was 1.22 (1.04-1.44, p for trend = 0.014), which remained significant after adjustment for confounders (OR = 1.25). No statistically significant interaction with potential confounding factors was observed.</p< <p<Conclusion</p< <p<The polymorphism rs6983267 showed a significant association with CRC in a Japanese population. Further investigation of the biological mechanism of this association is warranted.</p< Neoplasms. Tumors. Oncology. Including cancer and carcinogens Komori Koji verfasserin aut Shitara Kohei verfasserin aut Watanabe Miki verfasserin aut Kawase Takakazu verfasserin aut Hosono Satoyo verfasserin aut Ito Hidemi verfasserin aut Suzuki Takeshi verfasserin aut Matsuo Keitaro verfasserin aut Hirai Takashi verfasserin aut Yatabe Yasushi verfasserin aut Tanaka Hideo verfasserin aut Tajima Kazuo verfasserin aut In BMC Cancer BMC, 2003 9(2009), 1, p 379 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:9 year:2009 number:1, p 379 https://doi.org/10.1186/1471-2407-9-379 kostenfrei https://doaj.org/article/94bd1403643c480b991146648fc4f674 kostenfrei http://www.biomedcentral.com/1471-2407/9/379 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1, p 379
spelling	10.1186/1471-2407-9-379 doi (DE-627)DOAJ026787334 (DE-599)DOAJ94bd1403643c480b991146648fc4f674 DE-627 ger DE-627 rakwb eng RC254-282 Kanemitsu Yukihide verfasserin aut Association between an 8q24 locus and the risk of colorectal cancer in Japanese 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<A genome-wide association study (GWAS), which assessed multiple ethnicities, reported an association between single nucleotide polymorphisms in the 8q24 region and colorectal cancer risk. Although the association with the identified loci was strong, information on its impact in combination with lifestyle factors is limited.</p< <p<Methods</p< <p<We conducted a case-control study in 481 patients with colorectal cancer (CRC) and 962 sex-age matched non-cancer controls. Data on lifestyle factors, including diet, were obtained by self-administered questionnaire. Two 8q24 loci, rs6983267 and rs10090154, were assessed by the TaqMan method. Associations were then assessed by multivariate logistic regression models that considered potential confounders.</p< <p<Results</p< <p<We found an increased risk of CRC with rs6983267 but not with rs10090154. An allelic OR was 1.22 (1.04-1.44, p for trend = 0.014), which remained significant after adjustment for confounders (OR = 1.25). No statistically significant interaction with potential confounding factors was observed.</p< <p<Conclusion</p< <p<The polymorphism rs6983267 showed a significant association with CRC in a Japanese population. Further investigation of the biological mechanism of this association is warranted.</p< Neoplasms. Tumors. Oncology. Including cancer and carcinogens Komori Koji verfasserin aut Shitara Kohei verfasserin aut Watanabe Miki verfasserin aut Kawase Takakazu verfasserin aut Hosono Satoyo verfasserin aut Ito Hidemi verfasserin aut Suzuki Takeshi verfasserin aut Matsuo Keitaro verfasserin aut Hirai Takashi verfasserin aut Yatabe Yasushi verfasserin aut Tanaka Hideo verfasserin aut Tajima Kazuo verfasserin aut In BMC Cancer BMC, 2003 9(2009), 1, p 379 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:9 year:2009 number:1, p 379 https://doi.org/10.1186/1471-2407-9-379 kostenfrei https://doaj.org/article/94bd1403643c480b991146648fc4f674 kostenfrei http://www.biomedcentral.com/1471-2407/9/379 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1, p 379
allfields_unstemmed	10.1186/1471-2407-9-379 doi (DE-627)DOAJ026787334 (DE-599)DOAJ94bd1403643c480b991146648fc4f674 DE-627 ger DE-627 rakwb eng RC254-282 Kanemitsu Yukihide verfasserin aut Association between an 8q24 locus and the risk of colorectal cancer in Japanese 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<A genome-wide association study (GWAS), which assessed multiple ethnicities, reported an association between single nucleotide polymorphisms in the 8q24 region and colorectal cancer risk. Although the association with the identified loci was strong, information on its impact in combination with lifestyle factors is limited.</p< <p<Methods</p< <p<We conducted a case-control study in 481 patients with colorectal cancer (CRC) and 962 sex-age matched non-cancer controls. Data on lifestyle factors, including diet, were obtained by self-administered questionnaire. Two 8q24 loci, rs6983267 and rs10090154, were assessed by the TaqMan method. Associations were then assessed by multivariate logistic regression models that considered potential confounders.</p< <p<Results</p< <p<We found an increased risk of CRC with rs6983267 but not with rs10090154. An allelic OR was 1.22 (1.04-1.44, p for trend = 0.014), which remained significant after adjustment for confounders (OR = 1.25). No statistically significant interaction with potential confounding factors was observed.</p< <p<Conclusion</p< <p<The polymorphism rs6983267 showed a significant association with CRC in a Japanese population. Further investigation of the biological mechanism of this association is warranted.</p< Neoplasms. Tumors. Oncology. Including cancer and carcinogens Komori Koji verfasserin aut Shitara Kohei verfasserin aut Watanabe Miki verfasserin aut Kawase Takakazu verfasserin aut Hosono Satoyo verfasserin aut Ito Hidemi verfasserin aut Suzuki Takeshi verfasserin aut Matsuo Keitaro verfasserin aut Hirai Takashi verfasserin aut Yatabe Yasushi verfasserin aut Tanaka Hideo verfasserin aut Tajima Kazuo verfasserin aut In BMC Cancer BMC, 2003 9(2009), 1, p 379 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:9 year:2009 number:1, p 379 https://doi.org/10.1186/1471-2407-9-379 kostenfrei https://doaj.org/article/94bd1403643c480b991146648fc4f674 kostenfrei http://www.biomedcentral.com/1471-2407/9/379 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1, p 379
allfieldsGer	10.1186/1471-2407-9-379 doi (DE-627)DOAJ026787334 (DE-599)DOAJ94bd1403643c480b991146648fc4f674 DE-627 ger DE-627 rakwb eng RC254-282 Kanemitsu Yukihide verfasserin aut Association between an 8q24 locus and the risk of colorectal cancer in Japanese 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<A genome-wide association study (GWAS), which assessed multiple ethnicities, reported an association between single nucleotide polymorphisms in the 8q24 region and colorectal cancer risk. Although the association with the identified loci was strong, information on its impact in combination with lifestyle factors is limited.</p< <p<Methods</p< <p<We conducted a case-control study in 481 patients with colorectal cancer (CRC) and 962 sex-age matched non-cancer controls. Data on lifestyle factors, including diet, were obtained by self-administered questionnaire. Two 8q24 loci, rs6983267 and rs10090154, were assessed by the TaqMan method. Associations were then assessed by multivariate logistic regression models that considered potential confounders.</p< <p<Results</p< <p<We found an increased risk of CRC with rs6983267 but not with rs10090154. An allelic OR was 1.22 (1.04-1.44, p for trend = 0.014), which remained significant after adjustment for confounders (OR = 1.25). No statistically significant interaction with potential confounding factors was observed.</p< <p<Conclusion</p< <p<The polymorphism rs6983267 showed a significant association with CRC in a Japanese population. Further investigation of the biological mechanism of this association is warranted.</p< Neoplasms. Tumors. Oncology. Including cancer and carcinogens Komori Koji verfasserin aut Shitara Kohei verfasserin aut Watanabe Miki verfasserin aut Kawase Takakazu verfasserin aut Hosono Satoyo verfasserin aut Ito Hidemi verfasserin aut Suzuki Takeshi verfasserin aut Matsuo Keitaro verfasserin aut Hirai Takashi verfasserin aut Yatabe Yasushi verfasserin aut Tanaka Hideo verfasserin aut Tajima Kazuo verfasserin aut In BMC Cancer BMC, 2003 9(2009), 1, p 379 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:9 year:2009 number:1, p 379 https://doi.org/10.1186/1471-2407-9-379 kostenfrei https://doaj.org/article/94bd1403643c480b991146648fc4f674 kostenfrei http://www.biomedcentral.com/1471-2407/9/379 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1, p 379
allfieldsSound	10.1186/1471-2407-9-379 doi (DE-627)DOAJ026787334 (DE-599)DOAJ94bd1403643c480b991146648fc4f674 DE-627 ger DE-627 rakwb eng RC254-282 Kanemitsu Yukihide verfasserin aut Association between an 8q24 locus and the risk of colorectal cancer in Japanese 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<A genome-wide association study (GWAS), which assessed multiple ethnicities, reported an association between single nucleotide polymorphisms in the 8q24 region and colorectal cancer risk. Although the association with the identified loci was strong, information on its impact in combination with lifestyle factors is limited.</p< <p<Methods</p< <p<We conducted a case-control study in 481 patients with colorectal cancer (CRC) and 962 sex-age matched non-cancer controls. Data on lifestyle factors, including diet, were obtained by self-administered questionnaire. Two 8q24 loci, rs6983267 and rs10090154, were assessed by the TaqMan method. Associations were then assessed by multivariate logistic regression models that considered potential confounders.</p< <p<Results</p< <p<We found an increased risk of CRC with rs6983267 but not with rs10090154. An allelic OR was 1.22 (1.04-1.44, p for trend = 0.014), which remained significant after adjustment for confounders (OR = 1.25). No statistically significant interaction with potential confounding factors was observed.</p< <p<Conclusion</p< <p<The polymorphism rs6983267 showed a significant association with CRC in a Japanese population. Further investigation of the biological mechanism of this association is warranted.</p< Neoplasms. Tumors. Oncology. Including cancer and carcinogens Komori Koji verfasserin aut Shitara Kohei verfasserin aut Watanabe Miki verfasserin aut Kawase Takakazu verfasserin aut Hosono Satoyo verfasserin aut Ito Hidemi verfasserin aut Suzuki Takeshi verfasserin aut Matsuo Keitaro verfasserin aut Hirai Takashi verfasserin aut Yatabe Yasushi verfasserin aut Tanaka Hideo verfasserin aut Tajima Kazuo verfasserin aut In BMC Cancer BMC, 2003 9(2009), 1, p 379 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:9 year:2009 number:1, p 379 https://doi.org/10.1186/1471-2407-9-379 kostenfrei https://doaj.org/article/94bd1403643c480b991146648fc4f674 kostenfrei http://www.biomedcentral.com/1471-2407/9/379 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1, p 379
language	English
source	In BMC Cancer 9(2009), 1, p 379 volume:9 year:2009 number:1, p 379
sourceStr	In BMC Cancer 9(2009), 1, p 379 volume:9 year:2009 number:1, p 379
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	BMC Cancer
authorswithroles_txt_mv	Kanemitsu Yukihide @@aut@@ Komori Koji @@aut@@ Shitara Kohei @@aut@@ Watanabe Miki @@aut@@ Kawase Takakazu @@aut@@ Hosono Satoyo @@aut@@ Ito Hidemi @@aut@@ Suzuki Takeshi @@aut@@ Matsuo Keitaro @@aut@@ Hirai Takashi @@aut@@ Yatabe Yasushi @@aut@@ Tanaka Hideo @@aut@@ Tajima Kazuo @@aut@@
publishDateDaySort_date	2009-01-01T00:00:00Z
hierarchy_top_id	326643710
id	DOAJ026787334
language_de	englisch
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callnumber-first	R - Medicine
author	Kanemitsu Yukihide
spellingShingle	Kanemitsu Yukihide misc RC254-282 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Association between an 8q24 locus and the risk of colorectal cancer in Japanese
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topic_title	RC254-282 Association between an 8q24 locus and the risk of colorectal cancer in Japanese
topic	misc RC254-282 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Association between an 8q24 locus and the risk of colorectal cancer in Japanese
ctrlnum	(DE-627)DOAJ026787334 (DE-599)DOAJ94bd1403643c480b991146648fc4f674
title_full	Association between an 8q24 locus and the risk of colorectal cancer in Japanese
author_sort	Kanemitsu Yukihide
journal	BMC Cancer
journalStr	BMC Cancer
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author_browse	Kanemitsu Yukihide Komori Koji Shitara Kohei Watanabe Miki Kawase Takakazu Hosono Satoyo Ito Hidemi Suzuki Takeshi Matsuo Keitaro Hirai Takashi Yatabe Yasushi Tanaka Hideo Tajima Kazuo
container_volume	9
class	RC254-282
format_se	Elektronische Aufsätze
author-letter	Kanemitsu Yukihide
doi_str_mv	10.1186/1471-2407-9-379
author2-role	verfasserin
title_sort	association between an 8q24 locus and the risk of colorectal cancer in japanese
callnumber	RC254-282
title_auth	Association between an 8q24 locus and the risk of colorectal cancer in Japanese
abstract	<p<Abstract</p< <p<Background</p< <p<A genome-wide association study (GWAS), which assessed multiple ethnicities, reported an association between single nucleotide polymorphisms in the 8q24 region and colorectal cancer risk. Although the association with the identified loci was strong, information on its impact in combination with lifestyle factors is limited.</p< <p<Methods</p< <p<We conducted a case-control study in 481 patients with colorectal cancer (CRC) and 962 sex-age matched non-cancer controls. Data on lifestyle factors, including diet, were obtained by self-administered questionnaire. Two 8q24 loci, rs6983267 and rs10090154, were assessed by the TaqMan method. Associations were then assessed by multivariate logistic regression models that considered potential confounders.</p< <p<Results</p< <p<We found an increased risk of CRC with rs6983267 but not with rs10090154. An allelic OR was 1.22 (1.04-1.44, p for trend = 0.014), which remained significant after adjustment for confounders (OR = 1.25). No statistically significant interaction with potential confounding factors was observed.</p< <p<Conclusion</p< <p<The polymorphism rs6983267 showed a significant association with CRC in a Japanese population. Further investigation of the biological mechanism of this association is warranted.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<A genome-wide association study (GWAS), which assessed multiple ethnicities, reported an association between single nucleotide polymorphisms in the 8q24 region and colorectal cancer risk. Although the association with the identified loci was strong, information on its impact in combination with lifestyle factors is limited.</p< <p<Methods</p< <p<We conducted a case-control study in 481 patients with colorectal cancer (CRC) and 962 sex-age matched non-cancer controls. Data on lifestyle factors, including diet, were obtained by self-administered questionnaire. Two 8q24 loci, rs6983267 and rs10090154, were assessed by the TaqMan method. Associations were then assessed by multivariate logistic regression models that considered potential confounders.</p< <p<Results</p< <p<We found an increased risk of CRC with rs6983267 but not with rs10090154. An allelic OR was 1.22 (1.04-1.44, p for trend = 0.014), which remained significant after adjustment for confounders (OR = 1.25). No statistically significant interaction with potential confounding factors was observed.</p< <p<Conclusion</p< <p<The polymorphism rs6983267 showed a significant association with CRC in a Japanese population. Further investigation of the biological mechanism of this association is warranted.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<A genome-wide association study (GWAS), which assessed multiple ethnicities, reported an association between single nucleotide polymorphisms in the 8q24 region and colorectal cancer risk. Although the association with the identified loci was strong, information on its impact in combination with lifestyle factors is limited.</p< <p<Methods</p< <p<We conducted a case-control study in 481 patients with colorectal cancer (CRC) and 962 sex-age matched non-cancer controls. Data on lifestyle factors, including diet, were obtained by self-administered questionnaire. Two 8q24 loci, rs6983267 and rs10090154, were assessed by the TaqMan method. Associations were then assessed by multivariate logistic regression models that considered potential confounders.</p< <p<Results</p< <p<We found an increased risk of CRC with rs6983267 but not with rs10090154. An allelic OR was 1.22 (1.04-1.44, p for trend = 0.014), which remained significant after adjustment for confounders (OR = 1.25). No statistically significant interaction with potential confounding factors was observed.</p< <p<Conclusion</p< <p<The polymorphism rs6983267 showed a significant association with CRC in a Japanese population. Further investigation of the biological mechanism of this association is warranted.</p<
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container_issue	1, p 379
title_short	Association between an 8q24 locus and the risk of colorectal cancer in Japanese
url	https://doi.org/10.1186/1471-2407-9-379 https://doaj.org/article/94bd1403643c480b991146648fc4f674 http://www.biomedcentral.com/1471-2407/9/379 https://doaj.org/toc/1471-2407
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up_date	2024-07-03T22:56:14.149Z
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Association between an 8q24 locus and the risk of colorectal cancer in Japanese

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