Association study of genetic variations of inflammatory biomarkers with susceptibility and severity of obstructive sleep apnea

Abstract Background Obstructive sleep apnea (OSA) increases health risks of cardiovascular disease and stroke. Both genetic factors and environmental exposures contribute to the occurrence of OSA. The purpose of this study was to determine the role of four functional inflammatory single nucleotide p...
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Autor*in:	Zeming Zhang [verfasserIn] Qiubo Wang [verfasserIn] Baoyuan Chen [verfasserIn] Yancun Wang [verfasserIn] Yafang Miao [verfasserIn] Li Han [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	genetic IL‐6 inflammatory biomarkers obstructive sleep apnea VWF

Übergeordnetes Werk:	In: Molecular Genetics & Genomic Medicine - Wiley, 2014, 7(2019), 8, Seite n/a-n/a
Übergeordnetes Werk:	volume:7 ; year:2019 ; number:8 ; pages:n/a-n/a

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1002/mgg3.801

Katalog-ID:	DOAJ026821575

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520			\|a Abstract Background Obstructive sleep apnea (OSA) increases health risks of cardiovascular disease and stroke. Both genetic factors and environmental exposures contribute to the occurrence of OSA. The purpose of this study was to determine the role of four functional inflammatory single nucleotide polymorphisms (SNPs) (VWF rs1063856, IL‐6 rs1800796, TNF rs1800629, and CRP rs2794521) in the susceptibility and severity of OSA. Methods A case–control study of OSA among Chinese population was conducted. Genotyping was performed using ABI TaqMan SNP genotyping technique. Results We found VWF rs1063856 (OR = 1.50, 95% CIs = 1.10–2.04; p = 0.010), IL‐6 rs1800796 (OR = 1.32, 95% CIs = 1.11–1.56; p = 0.002), TNF rs1800629 (OR = 1.44, 95% CIs = 1.13–1.83; p = 0.003), and CRP rs2794521 (OR = 1.27, 95% CIs = 1.04–1.55; p = 0.021) were all significantly associated with increased susceptibility of OSA, while VWF rs1063856 (OR = 1.75, 95% CIs = 1.18–2.62; p = 0.006), IL‐6 rs1800796 (OR = 1.39, 95% CIs = 1.10–1.76; p = 0.006) were associated with the severity of OSA. Conclusions Our study indicated that functional variants of inflammatory biomarkers could cause the occurrence of OSA and influence the severity of OSA. These findings further support that inflammatory cytokines were closely related to the occurrence and development of OSA.
650		4	\|a genetic
650		4	\|a IL‐6
650		4	\|a inflammatory biomarkers
650		4	\|a obstructive sleep apnea
650		4	\|a VWF
653		0	\|a Genetics
700	0		\|a Qiubo Wang \|e verfasserin \|4 aut
700	0		\|a Baoyuan Chen \|e verfasserin \|4 aut
700	0		\|a Yancun Wang \|e verfasserin \|4 aut
700	0		\|a Yafang Miao \|e verfasserin \|4 aut
700	0		\|a Li Han \|e verfasserin \|4 aut
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912			\|a GBV_ILN_293
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912			\|a GBV_ILN_636
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allfields	10.1002/mgg3.801 doi (DE-627)DOAJ026821575 (DE-599)DOAJa1bd975c5594493799fcd11389da1e89 DE-627 ger DE-627 rakwb eng QH426-470 Zeming Zhang verfasserin aut Association study of genetic variations of inflammatory biomarkers with susceptibility and severity of obstructive sleep apnea 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Obstructive sleep apnea (OSA) increases health risks of cardiovascular disease and stroke. Both genetic factors and environmental exposures contribute to the occurrence of OSA. The purpose of this study was to determine the role of four functional inflammatory single nucleotide polymorphisms (SNPs) (VWF rs1063856, IL‐6 rs1800796, TNF rs1800629, and CRP rs2794521) in the susceptibility and severity of OSA. Methods A case–control study of OSA among Chinese population was conducted. Genotyping was performed using ABI TaqMan SNP genotyping technique. Results We found VWF rs1063856 (OR = 1.50, 95% CIs = 1.10–2.04; p = 0.010), IL‐6 rs1800796 (OR = 1.32, 95% CIs = 1.11–1.56; p = 0.002), TNF rs1800629 (OR = 1.44, 95% CIs = 1.13–1.83; p = 0.003), and CRP rs2794521 (OR = 1.27, 95% CIs = 1.04–1.55; p = 0.021) were all significantly associated with increased susceptibility of OSA, while VWF rs1063856 (OR = 1.75, 95% CIs = 1.18–2.62; p = 0.006), IL‐6 rs1800796 (OR = 1.39, 95% CIs = 1.10–1.76; p = 0.006) were associated with the severity of OSA. Conclusions Our study indicated that functional variants of inflammatory biomarkers could cause the occurrence of OSA and influence the severity of OSA. These findings further support that inflammatory cytokines were closely related to the occurrence and development of OSA. genetic IL‐6 inflammatory biomarkers obstructive sleep apnea VWF Genetics Qiubo Wang verfasserin aut Baoyuan Chen verfasserin aut Yancun Wang verfasserin aut Yafang Miao verfasserin aut Li Han verfasserin aut In Molecular Genetics & Genomic Medicine Wiley, 2014 7(2019), 8, Seite n/a-n/a (DE-627)769222234 (DE-600)2734884-2 23249269 nnns volume:7 year:2019 number:8 pages:n/a-n/a https://doi.org/10.1002/mgg3.801 kostenfrei https://doaj.org/article/a1bd975c5594493799fcd11389da1e89 kostenfrei https://doi.org/10.1002/mgg3.801 kostenfrei https://doaj.org/toc/2324-9269 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 8 n/a-n/a
spelling	10.1002/mgg3.801 doi (DE-627)DOAJ026821575 (DE-599)DOAJa1bd975c5594493799fcd11389da1e89 DE-627 ger DE-627 rakwb eng QH426-470 Zeming Zhang verfasserin aut Association study of genetic variations of inflammatory biomarkers with susceptibility and severity of obstructive sleep apnea 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Obstructive sleep apnea (OSA) increases health risks of cardiovascular disease and stroke. Both genetic factors and environmental exposures contribute to the occurrence of OSA. The purpose of this study was to determine the role of four functional inflammatory single nucleotide polymorphisms (SNPs) (VWF rs1063856, IL‐6 rs1800796, TNF rs1800629, and CRP rs2794521) in the susceptibility and severity of OSA. Methods A case–control study of OSA among Chinese population was conducted. Genotyping was performed using ABI TaqMan SNP genotyping technique. Results We found VWF rs1063856 (OR = 1.50, 95% CIs = 1.10–2.04; p = 0.010), IL‐6 rs1800796 (OR = 1.32, 95% CIs = 1.11–1.56; p = 0.002), TNF rs1800629 (OR = 1.44, 95% CIs = 1.13–1.83; p = 0.003), and CRP rs2794521 (OR = 1.27, 95% CIs = 1.04–1.55; p = 0.021) were all significantly associated with increased susceptibility of OSA, while VWF rs1063856 (OR = 1.75, 95% CIs = 1.18–2.62; p = 0.006), IL‐6 rs1800796 (OR = 1.39, 95% CIs = 1.10–1.76; p = 0.006) were associated with the severity of OSA. Conclusions Our study indicated that functional variants of inflammatory biomarkers could cause the occurrence of OSA and influence the severity of OSA. These findings further support that inflammatory cytokines were closely related to the occurrence and development of OSA. genetic IL‐6 inflammatory biomarkers obstructive sleep apnea VWF Genetics Qiubo Wang verfasserin aut Baoyuan Chen verfasserin aut Yancun Wang verfasserin aut Yafang Miao verfasserin aut Li Han verfasserin aut In Molecular Genetics & Genomic Medicine Wiley, 2014 7(2019), 8, Seite n/a-n/a (DE-627)769222234 (DE-600)2734884-2 23249269 nnns volume:7 year:2019 number:8 pages:n/a-n/a https://doi.org/10.1002/mgg3.801 kostenfrei https://doaj.org/article/a1bd975c5594493799fcd11389da1e89 kostenfrei https://doi.org/10.1002/mgg3.801 kostenfrei https://doaj.org/toc/2324-9269 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 8 n/a-n/a
allfields_unstemmed	10.1002/mgg3.801 doi (DE-627)DOAJ026821575 (DE-599)DOAJa1bd975c5594493799fcd11389da1e89 DE-627 ger DE-627 rakwb eng QH426-470 Zeming Zhang verfasserin aut Association study of genetic variations of inflammatory biomarkers with susceptibility and severity of obstructive sleep apnea 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Obstructive sleep apnea (OSA) increases health risks of cardiovascular disease and stroke. Both genetic factors and environmental exposures contribute to the occurrence of OSA. The purpose of this study was to determine the role of four functional inflammatory single nucleotide polymorphisms (SNPs) (VWF rs1063856, IL‐6 rs1800796, TNF rs1800629, and CRP rs2794521) in the susceptibility and severity of OSA. Methods A case–control study of OSA among Chinese population was conducted. Genotyping was performed using ABI TaqMan SNP genotyping technique. Results We found VWF rs1063856 (OR = 1.50, 95% CIs = 1.10–2.04; p = 0.010), IL‐6 rs1800796 (OR = 1.32, 95% CIs = 1.11–1.56; p = 0.002), TNF rs1800629 (OR = 1.44, 95% CIs = 1.13–1.83; p = 0.003), and CRP rs2794521 (OR = 1.27, 95% CIs = 1.04–1.55; p = 0.021) were all significantly associated with increased susceptibility of OSA, while VWF rs1063856 (OR = 1.75, 95% CIs = 1.18–2.62; p = 0.006), IL‐6 rs1800796 (OR = 1.39, 95% CIs = 1.10–1.76; p = 0.006) were associated with the severity of OSA. Conclusions Our study indicated that functional variants of inflammatory biomarkers could cause the occurrence of OSA and influence the severity of OSA. These findings further support that inflammatory cytokines were closely related to the occurrence and development of OSA. genetic IL‐6 inflammatory biomarkers obstructive sleep apnea VWF Genetics Qiubo Wang verfasserin aut Baoyuan Chen verfasserin aut Yancun Wang verfasserin aut Yafang Miao verfasserin aut Li Han verfasserin aut In Molecular Genetics & Genomic Medicine Wiley, 2014 7(2019), 8, Seite n/a-n/a (DE-627)769222234 (DE-600)2734884-2 23249269 nnns volume:7 year:2019 number:8 pages:n/a-n/a https://doi.org/10.1002/mgg3.801 kostenfrei https://doaj.org/article/a1bd975c5594493799fcd11389da1e89 kostenfrei https://doi.org/10.1002/mgg3.801 kostenfrei https://doaj.org/toc/2324-9269 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 8 n/a-n/a
allfieldsGer	10.1002/mgg3.801 doi (DE-627)DOAJ026821575 (DE-599)DOAJa1bd975c5594493799fcd11389da1e89 DE-627 ger DE-627 rakwb eng QH426-470 Zeming Zhang verfasserin aut Association study of genetic variations of inflammatory biomarkers with susceptibility and severity of obstructive sleep apnea 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Obstructive sleep apnea (OSA) increases health risks of cardiovascular disease and stroke. Both genetic factors and environmental exposures contribute to the occurrence of OSA. The purpose of this study was to determine the role of four functional inflammatory single nucleotide polymorphisms (SNPs) (VWF rs1063856, IL‐6 rs1800796, TNF rs1800629, and CRP rs2794521) in the susceptibility and severity of OSA. Methods A case–control study of OSA among Chinese population was conducted. Genotyping was performed using ABI TaqMan SNP genotyping technique. Results We found VWF rs1063856 (OR = 1.50, 95% CIs = 1.10–2.04; p = 0.010), IL‐6 rs1800796 (OR = 1.32, 95% CIs = 1.11–1.56; p = 0.002), TNF rs1800629 (OR = 1.44, 95% CIs = 1.13–1.83; p = 0.003), and CRP rs2794521 (OR = 1.27, 95% CIs = 1.04–1.55; p = 0.021) were all significantly associated with increased susceptibility of OSA, while VWF rs1063856 (OR = 1.75, 95% CIs = 1.18–2.62; p = 0.006), IL‐6 rs1800796 (OR = 1.39, 95% CIs = 1.10–1.76; p = 0.006) were associated with the severity of OSA. Conclusions Our study indicated that functional variants of inflammatory biomarkers could cause the occurrence of OSA and influence the severity of OSA. These findings further support that inflammatory cytokines were closely related to the occurrence and development of OSA. genetic IL‐6 inflammatory biomarkers obstructive sleep apnea VWF Genetics Qiubo Wang verfasserin aut Baoyuan Chen verfasserin aut Yancun Wang verfasserin aut Yafang Miao verfasserin aut Li Han verfasserin aut In Molecular Genetics & Genomic Medicine Wiley, 2014 7(2019), 8, Seite n/a-n/a (DE-627)769222234 (DE-600)2734884-2 23249269 nnns volume:7 year:2019 number:8 pages:n/a-n/a https://doi.org/10.1002/mgg3.801 kostenfrei https://doaj.org/article/a1bd975c5594493799fcd11389da1e89 kostenfrei https://doi.org/10.1002/mgg3.801 kostenfrei https://doaj.org/toc/2324-9269 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 8 n/a-n/a
allfieldsSound	10.1002/mgg3.801 doi (DE-627)DOAJ026821575 (DE-599)DOAJa1bd975c5594493799fcd11389da1e89 DE-627 ger DE-627 rakwb eng QH426-470 Zeming Zhang verfasserin aut Association study of genetic variations of inflammatory biomarkers with susceptibility and severity of obstructive sleep apnea 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Obstructive sleep apnea (OSA) increases health risks of cardiovascular disease and stroke. Both genetic factors and environmental exposures contribute to the occurrence of OSA. The purpose of this study was to determine the role of four functional inflammatory single nucleotide polymorphisms (SNPs) (VWF rs1063856, IL‐6 rs1800796, TNF rs1800629, and CRP rs2794521) in the susceptibility and severity of OSA. Methods A case–control study of OSA among Chinese population was conducted. Genotyping was performed using ABI TaqMan SNP genotyping technique. Results We found VWF rs1063856 (OR = 1.50, 95% CIs = 1.10–2.04; p = 0.010), IL‐6 rs1800796 (OR = 1.32, 95% CIs = 1.11–1.56; p = 0.002), TNF rs1800629 (OR = 1.44, 95% CIs = 1.13–1.83; p = 0.003), and CRP rs2794521 (OR = 1.27, 95% CIs = 1.04–1.55; p = 0.021) were all significantly associated with increased susceptibility of OSA, while VWF rs1063856 (OR = 1.75, 95% CIs = 1.18–2.62; p = 0.006), IL‐6 rs1800796 (OR = 1.39, 95% CIs = 1.10–1.76; p = 0.006) were associated with the severity of OSA. Conclusions Our study indicated that functional variants of inflammatory biomarkers could cause the occurrence of OSA and influence the severity of OSA. These findings further support that inflammatory cytokines were closely related to the occurrence and development of OSA. genetic IL‐6 inflammatory biomarkers obstructive sleep apnea VWF Genetics Qiubo Wang verfasserin aut Baoyuan Chen verfasserin aut Yancun Wang verfasserin aut Yafang Miao verfasserin aut Li Han verfasserin aut In Molecular Genetics & Genomic Medicine Wiley, 2014 7(2019), 8, Seite n/a-n/a (DE-627)769222234 (DE-600)2734884-2 23249269 nnns volume:7 year:2019 number:8 pages:n/a-n/a https://doi.org/10.1002/mgg3.801 kostenfrei https://doaj.org/article/a1bd975c5594493799fcd11389da1e89 kostenfrei https://doi.org/10.1002/mgg3.801 kostenfrei https://doaj.org/toc/2324-9269 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 8 n/a-n/a
language	English
source	In Molecular Genetics & Genomic Medicine 7(2019), 8, Seite n/a-n/a volume:7 year:2019 number:8 pages:n/a-n/a
sourceStr	In Molecular Genetics & Genomic Medicine 7(2019), 8, Seite n/a-n/a volume:7 year:2019 number:8 pages:n/a-n/a
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	genetic IL‐6 inflammatory biomarkers obstructive sleep apnea VWF Genetics
isfreeaccess_bool	true
container_title	Molecular Genetics & Genomic Medicine
authorswithroles_txt_mv	Zeming Zhang @@aut@@ Qiubo Wang @@aut@@ Baoyuan Chen @@aut@@ Yancun Wang @@aut@@ Yafang Miao @@aut@@ Li Han @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	769222234
id	DOAJ026821575
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ026821575</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230307104623.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230226s2019 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1002/mgg3.801</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ026821575</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJa1bd975c5594493799fcd11389da1e89</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH426-470</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Zeming Zhang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Association study of genetic variations of inflammatory biomarkers with susceptibility and severity of obstructive sleep apnea</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background Obstructive sleep apnea (OSA) increases health risks of cardiovascular disease and stroke. Both genetic factors and environmental exposures contribute to the occurrence of OSA. The purpose of this study was to determine the role of four functional inflammatory single nucleotide polymorphisms (SNPs) (VWF rs1063856, IL‐6 rs1800796, TNF rs1800629, and CRP rs2794521) in the susceptibility and severity of OSA. Methods A case–control study of OSA among Chinese population was conducted. Genotyping was performed using ABI TaqMan SNP genotyping technique. Results We found VWF rs1063856 (OR = 1.50, 95% CIs = 1.10–2.04; p = 0.010), IL‐6 rs1800796 (OR = 1.32, 95% CIs = 1.11–1.56; p = 0.002), TNF rs1800629 (OR = 1.44, 95% CIs = 1.13–1.83; p = 0.003), and CRP rs2794521 (OR = 1.27, 95% CIs = 1.04–1.55; p = 0.021) were all significantly associated with increased susceptibility of OSA, while VWF rs1063856 (OR = 1.75, 95% CIs = 1.18–2.62; p = 0.006), IL‐6 rs1800796 (OR = 1.39, 95% CIs = 1.10–1.76; p = 0.006) were associated with the severity of OSA. Conclusions Our study indicated that functional variants of inflammatory biomarkers could cause the occurrence of OSA and influence the severity of OSA. 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callnumber-first	Q - Science
author	Zeming Zhang
spellingShingle	Zeming Zhang misc QH426-470 misc genetic misc IL‐6 misc inflammatory biomarkers misc obstructive sleep apnea misc VWF misc Genetics Association study of genetic variations of inflammatory biomarkers with susceptibility and severity of obstructive sleep apnea
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topic_title	QH426-470 Association study of genetic variations of inflammatory biomarkers with susceptibility and severity of obstructive sleep apnea genetic IL‐6 inflammatory biomarkers obstructive sleep apnea VWF
topic	misc QH426-470 misc genetic misc IL‐6 misc inflammatory biomarkers misc obstructive sleep apnea misc VWF misc Genetics
topic_unstemmed	misc QH426-470 misc genetic misc IL‐6 misc inflammatory biomarkers misc obstructive sleep apnea misc VWF misc Genetics
topic_browse	misc QH426-470 misc genetic misc IL‐6 misc inflammatory biomarkers misc obstructive sleep apnea misc VWF misc Genetics
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title	Association study of genetic variations of inflammatory biomarkers with susceptibility and severity of obstructive sleep apnea
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title_full	Association study of genetic variations of inflammatory biomarkers with susceptibility and severity of obstructive sleep apnea
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journal	Molecular Genetics & Genomic Medicine
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author_browse	Zeming Zhang Qiubo Wang Baoyuan Chen Yancun Wang Yafang Miao Li Han
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doi_str_mv	10.1002/mgg3.801
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title_sort	association study of genetic variations of inflammatory biomarkers with susceptibility and severity of obstructive sleep apnea
callnumber	QH426-470
title_auth	Association study of genetic variations of inflammatory biomarkers with susceptibility and severity of obstructive sleep apnea
abstract	Abstract Background Obstructive sleep apnea (OSA) increases health risks of cardiovascular disease and stroke. Both genetic factors and environmental exposures contribute to the occurrence of OSA. The purpose of this study was to determine the role of four functional inflammatory single nucleotide polymorphisms (SNPs) (VWF rs1063856, IL‐6 rs1800796, TNF rs1800629, and CRP rs2794521) in the susceptibility and severity of OSA. Methods A case–control study of OSA among Chinese population was conducted. Genotyping was performed using ABI TaqMan SNP genotyping technique. Results We found VWF rs1063856 (OR = 1.50, 95% CIs = 1.10–2.04; p = 0.010), IL‐6 rs1800796 (OR = 1.32, 95% CIs = 1.11–1.56; p = 0.002), TNF rs1800629 (OR = 1.44, 95% CIs = 1.13–1.83; p = 0.003), and CRP rs2794521 (OR = 1.27, 95% CIs = 1.04–1.55; p = 0.021) were all significantly associated with increased susceptibility of OSA, while VWF rs1063856 (OR = 1.75, 95% CIs = 1.18–2.62; p = 0.006), IL‐6 rs1800796 (OR = 1.39, 95% CIs = 1.10–1.76; p = 0.006) were associated with the severity of OSA. Conclusions Our study indicated that functional variants of inflammatory biomarkers could cause the occurrence of OSA and influence the severity of OSA. These findings further support that inflammatory cytokines were closely related to the occurrence and development of OSA.
abstractGer	Abstract Background Obstructive sleep apnea (OSA) increases health risks of cardiovascular disease and stroke. Both genetic factors and environmental exposures contribute to the occurrence of OSA. The purpose of this study was to determine the role of four functional inflammatory single nucleotide polymorphisms (SNPs) (VWF rs1063856, IL‐6 rs1800796, TNF rs1800629, and CRP rs2794521) in the susceptibility and severity of OSA. Methods A case–control study of OSA among Chinese population was conducted. Genotyping was performed using ABI TaqMan SNP genotyping technique. Results We found VWF rs1063856 (OR = 1.50, 95% CIs = 1.10–2.04; p = 0.010), IL‐6 rs1800796 (OR = 1.32, 95% CIs = 1.11–1.56; p = 0.002), TNF rs1800629 (OR = 1.44, 95% CIs = 1.13–1.83; p = 0.003), and CRP rs2794521 (OR = 1.27, 95% CIs = 1.04–1.55; p = 0.021) were all significantly associated with increased susceptibility of OSA, while VWF rs1063856 (OR = 1.75, 95% CIs = 1.18–2.62; p = 0.006), IL‐6 rs1800796 (OR = 1.39, 95% CIs = 1.10–1.76; p = 0.006) were associated with the severity of OSA. Conclusions Our study indicated that functional variants of inflammatory biomarkers could cause the occurrence of OSA and influence the severity of OSA. These findings further support that inflammatory cytokines were closely related to the occurrence and development of OSA.
abstract_unstemmed	Abstract Background Obstructive sleep apnea (OSA) increases health risks of cardiovascular disease and stroke. Both genetic factors and environmental exposures contribute to the occurrence of OSA. The purpose of this study was to determine the role of four functional inflammatory single nucleotide polymorphisms (SNPs) (VWF rs1063856, IL‐6 rs1800796, TNF rs1800629, and CRP rs2794521) in the susceptibility and severity of OSA. Methods A case–control study of OSA among Chinese population was conducted. Genotyping was performed using ABI TaqMan SNP genotyping technique. Results We found VWF rs1063856 (OR = 1.50, 95% CIs = 1.10–2.04; p = 0.010), IL‐6 rs1800796 (OR = 1.32, 95% CIs = 1.11–1.56; p = 0.002), TNF rs1800629 (OR = 1.44, 95% CIs = 1.13–1.83; p = 0.003), and CRP rs2794521 (OR = 1.27, 95% CIs = 1.04–1.55; p = 0.021) were all significantly associated with increased susceptibility of OSA, while VWF rs1063856 (OR = 1.75, 95% CIs = 1.18–2.62; p = 0.006), IL‐6 rs1800796 (OR = 1.39, 95% CIs = 1.10–1.76; p = 0.006) were associated with the severity of OSA. Conclusions Our study indicated that functional variants of inflammatory biomarkers could cause the occurrence of OSA and influence the severity of OSA. These findings further support that inflammatory cytokines were closely related to the occurrence and development of OSA.
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title_short	Association study of genetic variations of inflammatory biomarkers with susceptibility and severity of obstructive sleep apnea
url	https://doi.org/10.1002/mgg3.801 https://doaj.org/article/a1bd975c5594493799fcd11389da1e89 https://doaj.org/toc/2324-9269
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up_date	2024-07-03T23:07:23.177Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ026821575</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230307104623.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230226s2019 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1002/mgg3.801</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ026821575</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJa1bd975c5594493799fcd11389da1e89</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH426-470</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Zeming Zhang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Association study of genetic variations of inflammatory biomarkers with susceptibility and severity of obstructive sleep apnea</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background Obstructive sleep apnea (OSA) increases health risks of cardiovascular disease and stroke. Both genetic factors and environmental exposures contribute to the occurrence of OSA. The purpose of this study was to determine the role of four functional inflammatory single nucleotide polymorphisms (SNPs) (VWF rs1063856, IL‐6 rs1800796, TNF rs1800629, and CRP rs2794521) in the susceptibility and severity of OSA. Methods A case–control study of OSA among Chinese population was conducted. Genotyping was performed using ABI TaqMan SNP genotyping technique. Results We found VWF rs1063856 (OR = 1.50, 95% CIs = 1.10–2.04; p = 0.010), IL‐6 rs1800796 (OR = 1.32, 95% CIs = 1.11–1.56; p = 0.002), TNF rs1800629 (OR = 1.44, 95% CIs = 1.13–1.83; p = 0.003), and CRP rs2794521 (OR = 1.27, 95% CIs = 1.04–1.55; p = 0.021) were all significantly associated with increased susceptibility of OSA, while VWF rs1063856 (OR = 1.75, 95% CIs = 1.18–2.62; p = 0.006), IL‐6 rs1800796 (OR = 1.39, 95% CIs = 1.10–1.76; p = 0.006) were associated with the severity of OSA. Conclusions Our study indicated that functional variants of inflammatory biomarkers could cause the occurrence of OSA and influence the severity of OSA. 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Association study of genetic variations of inflammatory biomarkers with susceptibility and severity of obstructive sleep apnea

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