Effects of Fructus Psoraleae Extract on the Intestinal Absorption Kinetics of Geniposide and Geniposidic Acid in Rat

Cortex Eucommia has been used as a kidney-tonifying herbal medicine with a long history of compatibility with Fructus Psoraleae. Geniposide (GP) and geniposidic acid (GPA) are the two main chemical components in Cortex Eucommia. In the present study, the effects of Fructus Psoraleae extract (FPE) on...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Yan Huo [verfasserIn] Yuxing Huang [verfasserIn] Xiangmei Hou [verfasserIn] Lifeng Han [verfasserIn] Lei Wang [verfasserIn] Erwei Liu [verfasserIn] Xiumei Gao [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Fructus Psoraleae Cortex Eucommia compatibility geniposide (GP) geniposidic acid (GPA) in situ intestinal perfusion

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 19(2014), 6, Seite 7557-7567
Übergeordnetes Werk:	volume:19 ; year:2014 ; number:6 ; pages:7557-7567

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules19067557

Katalog-ID:	DOAJ026952424

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allfieldsSound	10.3390/molecules19067557 doi (DE-627)DOAJ026952424 (DE-599)DOAJ84dbeb5dfeb149a88026ae6bf7a755a4 DE-627 ger DE-627 rakwb eng QD241-441 Yan Huo verfasserin aut Effects of Fructus Psoraleae Extract on the Intestinal Absorption Kinetics of Geniposide and Geniposidic Acid in Rat 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cortex Eucommia has been used as a kidney-tonifying herbal medicine with a long history of compatibility with Fructus Psoraleae. Geniposide (GP) and geniposidic acid (GPA) are the two main chemical components in Cortex Eucommia. In the present study, the effects of Fructus Psoraleae extract (FPE) on intestinal absorption kinetics of GP and GPA in rat were investigated. Twenty four male Sprague-Dawley rats were randomly assigned into four groups which were treated with GP, GPA, GP mixed with FPE and GPA mixed with FPE, respectively, by in situ intestinal perfusion for 3 h. The samples of intestinal perfusion solutions were collected every 30 min, and analyzed by ultra high performance liquid chromatography (UPLC). The curves of time and residual quantities of GP and GPA (lnx) in the intestinal perfusion solution and the cumulative absorption rate were obtained. The results showed that FPE exhibited different effects on the intestinal absorption of GP and GPA in rat: it increased the intestinal absorption of GP (p < 0.05), while demonstrated no significant effect on the absorption of GPA. Fructus Psoraleae Cortex Eucommia compatibility geniposide (GP) geniposidic acid (GPA) in situ intestinal perfusion Organic chemistry Yuxing Huang verfasserin aut Xiangmei Hou verfasserin aut Lifeng Han verfasserin aut Lei Wang verfasserin aut Erwei Liu verfasserin aut Xiumei Gao verfasserin aut In Molecules MDPI AG, 2003 19(2014), 6, Seite 7557-7567 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:19 year:2014 number:6 pages:7557-7567 https://doi.org/10.3390/molecules19067557 kostenfrei https://doaj.org/article/84dbeb5dfeb149a88026ae6bf7a755a4 kostenfrei http://www.mdpi.com/1420-3049/19/6/7557 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2014 6 7557-7567
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authorswithroles_txt_mv	Yan Huo @@aut@@ Yuxing Huang @@aut@@ Xiangmei Hou @@aut@@ Lifeng Han @@aut@@ Lei Wang @@aut@@ Erwei Liu @@aut@@ Xiumei Gao @@aut@@
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callnumber-first	Q - Science
author	Yan Huo
spellingShingle	Yan Huo misc QD241-441 misc Fructus Psoraleae misc Cortex Eucommia misc compatibility misc geniposide (GP) misc geniposidic acid (GPA) misc in situ intestinal perfusion misc Organic chemistry Effects of Fructus Psoraleae Extract on the Intestinal Absorption Kinetics of Geniposide and Geniposidic Acid in Rat
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topic_title	QD241-441 Effects of Fructus Psoraleae Extract on the Intestinal Absorption Kinetics of Geniposide and Geniposidic Acid in Rat Fructus Psoraleae Cortex Eucommia compatibility geniposide (GP) geniposidic acid (GPA) in situ intestinal perfusion
topic	misc QD241-441 misc Fructus Psoraleae misc Cortex Eucommia misc compatibility misc geniposide (GP) misc geniposidic acid (GPA) misc in situ intestinal perfusion misc Organic chemistry
topic_unstemmed	misc QD241-441 misc Fructus Psoraleae misc Cortex Eucommia misc compatibility misc geniposide (GP) misc geniposidic acid (GPA) misc in situ intestinal perfusion misc Organic chemistry
topic_browse	misc QD241-441 misc Fructus Psoraleae misc Cortex Eucommia misc compatibility misc geniposide (GP) misc geniposidic acid (GPA) misc in situ intestinal perfusion misc Organic chemistry
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title	Effects of Fructus Psoraleae Extract on the Intestinal Absorption Kinetics of Geniposide and Geniposidic Acid in Rat
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title_full	Effects of Fructus Psoraleae Extract on the Intestinal Absorption Kinetics of Geniposide and Geniposidic Acid in Rat
author_sort	Yan Huo
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author_browse	Yan Huo Yuxing Huang Xiangmei Hou Lifeng Han Lei Wang Erwei Liu Xiumei Gao
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title_sort	effects of fructus psoraleae extract on the intestinal absorption kinetics of geniposide and geniposidic acid in rat
callnumber	QD241-441
title_auth	Effects of Fructus Psoraleae Extract on the Intestinal Absorption Kinetics of Geniposide and Geniposidic Acid in Rat
abstract	Cortex Eucommia has been used as a kidney-tonifying herbal medicine with a long history of compatibility with Fructus Psoraleae. Geniposide (GP) and geniposidic acid (GPA) are the two main chemical components in Cortex Eucommia. In the present study, the effects of Fructus Psoraleae extract (FPE) on intestinal absorption kinetics of GP and GPA in rat were investigated. Twenty four male Sprague-Dawley rats were randomly assigned into four groups which were treated with GP, GPA, GP mixed with FPE and GPA mixed with FPE, respectively, by in situ intestinal perfusion for 3 h. The samples of intestinal perfusion solutions were collected every 30 min, and analyzed by ultra high performance liquid chromatography (UPLC). The curves of time and residual quantities of GP and GPA (lnx) in the intestinal perfusion solution and the cumulative absorption rate were obtained. The results showed that FPE exhibited different effects on the intestinal absorption of GP and GPA in rat: it increased the intestinal absorption of GP (p < 0.05), while demonstrated no significant effect on the absorption of GPA.
abstractGer	Cortex Eucommia has been used as a kidney-tonifying herbal medicine with a long history of compatibility with Fructus Psoraleae. Geniposide (GP) and geniposidic acid (GPA) are the two main chemical components in Cortex Eucommia. In the present study, the effects of Fructus Psoraleae extract (FPE) on intestinal absorption kinetics of GP and GPA in rat were investigated. Twenty four male Sprague-Dawley rats were randomly assigned into four groups which were treated with GP, GPA, GP mixed with FPE and GPA mixed with FPE, respectively, by in situ intestinal perfusion for 3 h. The samples of intestinal perfusion solutions were collected every 30 min, and analyzed by ultra high performance liquid chromatography (UPLC). The curves of time and residual quantities of GP and GPA (lnx) in the intestinal perfusion solution and the cumulative absorption rate were obtained. The results showed that FPE exhibited different effects on the intestinal absorption of GP and GPA in rat: it increased the intestinal absorption of GP (p < 0.05), while demonstrated no significant effect on the absorption of GPA.
abstract_unstemmed	Cortex Eucommia has been used as a kidney-tonifying herbal medicine with a long history of compatibility with Fructus Psoraleae. Geniposide (GP) and geniposidic acid (GPA) are the two main chemical components in Cortex Eucommia. In the present study, the effects of Fructus Psoraleae extract (FPE) on intestinal absorption kinetics of GP and GPA in rat were investigated. Twenty four male Sprague-Dawley rats were randomly assigned into four groups which were treated with GP, GPA, GP mixed with FPE and GPA mixed with FPE, respectively, by in situ intestinal perfusion for 3 h. The samples of intestinal perfusion solutions were collected every 30 min, and analyzed by ultra high performance liquid chromatography (UPLC). The curves of time and residual quantities of GP and GPA (lnx) in the intestinal perfusion solution and the cumulative absorption rate were obtained. The results showed that FPE exhibited different effects on the intestinal absorption of GP and GPA in rat: it increased the intestinal absorption of GP (p < 0.05), while demonstrated no significant effect on the absorption of GPA.
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title_short	Effects of Fructus Psoraleae Extract on the Intestinal Absorption Kinetics of Geniposide and Geniposidic Acid in Rat
url	https://doi.org/10.3390/molecules19067557 https://doaj.org/article/84dbeb5dfeb149a88026ae6bf7a755a4 http://www.mdpi.com/1420-3049/19/6/7557 https://doaj.org/toc/1420-3049
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author2	Yuxing Huang Xiangmei Hou Lifeng Han Lei Wang Erwei Liu Xiumei Gao
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up_date	2024-07-03T23:45:20.927Z
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Effects of Fructus Psoraleae Extract on the Intestinal Absorption Kinetics of Geniposide and Geniposidic Acid in Rat

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