A Changing Paradigm for the Treatment of Intermediate-Stage Hepatocellular Carcinoma: Asia-Pacific Primary Liver Cancer Expert Consensus Statements

The Asia-Pacific Primary Liver Cancer Expert (APPLE) Consensus Statement on the treatment strategy for patients with intermediate-stage hepatocellular carcinoma (HCC) was established on August 31, 2019, in Sapporo, Hokkaido during the 10th Annual APPLE Meeting. This manuscript summarizes the interna...
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Autor*in:	Masatoshi Kudo [verfasserIn] Kwang-Hyub Han [verfasserIn] Sheng-Long Ye [verfasserIn] Jian Zhou [verfasserIn] Yi-Hsiang Huang [verfasserIn] Shi-Ming Lin [verfasserIn] Chung-Kwe Wang [verfasserIn] Masafumi Ikeda [verfasserIn] Stephen Lam Chan [verfasserIn] Su Pin Choo [verfasserIn] Shiro Miyayama [verfasserIn] Ann Lii Cheng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	asia-pacific primary liver cancer expert hepatocellular carcinoma intermediate stage systemic therapy transarterial chemoembolization

Übergeordnetes Werk:	In: Liver Cancer - Karger Publishers, 2020, 9(2020), 3, Seite 245-260
Übergeordnetes Werk:	volume:9 ; year:2020 ; number:3 ; pages:245-260

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1159/000507370

Katalog-ID:	DOAJ027135012

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allfields	10.1159/000507370 doi (DE-627)DOAJ027135012 (DE-599)DOAJ10dc796a200244dc9411f022c236f9fa DE-627 ger DE-627 rakwb eng RC254-282 Masatoshi Kudo verfasserin aut A Changing Paradigm for the Treatment of Intermediate-Stage Hepatocellular Carcinoma: Asia-Pacific Primary Liver Cancer Expert Consensus Statements 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Asia-Pacific Primary Liver Cancer Expert (APPLE) Consensus Statement on the treatment strategy for patients with intermediate-stage hepatocellular carcinoma (HCC) was established on August 31, 2019, in Sapporo, Hokkaido during the 10th Annual APPLE Meeting. This manuscript summarizes the international consensus statements developed at APPLE 2019. Transarterial chemoembolization (TACE) is the only guideline-recommended global standard of care for intermediate-stage HCC. However, not all patients benefit from TACE because intermediate-stage HCC is a heterogeneous disease in terms of tumor burden and liver function. Ten important clinical questions regarding this stage of HCC were raised, and consensus statements were generated based on high-quality evidence. In intermediate-stage HCC, preservation of liver function is as important as achieving a high objective response (OR) because the treatment goal is to prolong overall survival. Superselective conventional TACE (cTACE) is recommended as the first choice of treatment in patients eligible for effective (curative) TACE, whereas in patients who are not eligible, systemic therapy is recommended as the first choice of treatment. TACE is not indicated as the first-line therapy in TACE-unsuitable patients. Another important statement is that TACE should not be continued in patients who develop TACE failure/refractoriness in order to preserve liver function. Targeted therapy is the recommended first-line treatment for TACE-unsuitable patients. Especially, the drug, which can have higher OR rate, is preferred. Immunotherapy, transarterial radioembolization, TACE + targeted therapy or other modalities may be considered alternative options in TACE-unsuitable patients who are not candidates for targeted therapy. Better liver function, such as albumin-bilirubin grade 1, is an important factor for maximizing the therapeutic effect of systemic therapy. asia-pacific primary liver cancer expert hepatocellular carcinoma intermediate stage systemic therapy transarterial chemoembolization Neoplasms. Tumors. Oncology. Including cancer and carcinogens Kwang-Hyub Han verfasserin aut Sheng-Long Ye verfasserin aut Jian Zhou verfasserin aut Yi-Hsiang Huang verfasserin aut Shi-Ming Lin verfasserin aut Chung-Kwe Wang verfasserin aut Masafumi Ikeda verfasserin aut Stephen Lam Chan verfasserin aut Su Pin Choo verfasserin aut Shiro Miyayama verfasserin aut Ann Lii Cheng verfasserin aut In Liver Cancer Karger Publishers, 2020 9(2020), 3, Seite 245-260 (DE-627)71871766X (DE-600)2666925-0 16645553 nnns volume:9 year:2020 number:3 pages:245-260 https://doi.org/10.1159/000507370 kostenfrei https://doaj.org/article/10dc796a200244dc9411f022c236f9fa kostenfrei https://www.karger.com/Article/FullText/507370 kostenfrei https://doaj.org/toc/2235-1795 Journal toc kostenfrei https://doaj.org/toc/1664-5553 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 3 245-260
spelling	10.1159/000507370 doi (DE-627)DOAJ027135012 (DE-599)DOAJ10dc796a200244dc9411f022c236f9fa DE-627 ger DE-627 rakwb eng RC254-282 Masatoshi Kudo verfasserin aut A Changing Paradigm for the Treatment of Intermediate-Stage Hepatocellular Carcinoma: Asia-Pacific Primary Liver Cancer Expert Consensus Statements 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Asia-Pacific Primary Liver Cancer Expert (APPLE) Consensus Statement on the treatment strategy for patients with intermediate-stage hepatocellular carcinoma (HCC) was established on August 31, 2019, in Sapporo, Hokkaido during the 10th Annual APPLE Meeting. This manuscript summarizes the international consensus statements developed at APPLE 2019. Transarterial chemoembolization (TACE) is the only guideline-recommended global standard of care for intermediate-stage HCC. However, not all patients benefit from TACE because intermediate-stage HCC is a heterogeneous disease in terms of tumor burden and liver function. Ten important clinical questions regarding this stage of HCC were raised, and consensus statements were generated based on high-quality evidence. In intermediate-stage HCC, preservation of liver function is as important as achieving a high objective response (OR) because the treatment goal is to prolong overall survival. Superselective conventional TACE (cTACE) is recommended as the first choice of treatment in patients eligible for effective (curative) TACE, whereas in patients who are not eligible, systemic therapy is recommended as the first choice of treatment. TACE is not indicated as the first-line therapy in TACE-unsuitable patients. Another important statement is that TACE should not be continued in patients who develop TACE failure/refractoriness in order to preserve liver function. Targeted therapy is the recommended first-line treatment for TACE-unsuitable patients. Especially, the drug, which can have higher OR rate, is preferred. Immunotherapy, transarterial radioembolization, TACE + targeted therapy or other modalities may be considered alternative options in TACE-unsuitable patients who are not candidates for targeted therapy. Better liver function, such as albumin-bilirubin grade 1, is an important factor for maximizing the therapeutic effect of systemic therapy. asia-pacific primary liver cancer expert hepatocellular carcinoma intermediate stage systemic therapy transarterial chemoembolization Neoplasms. Tumors. Oncology. Including cancer and carcinogens Kwang-Hyub Han verfasserin aut Sheng-Long Ye verfasserin aut Jian Zhou verfasserin aut Yi-Hsiang Huang verfasserin aut Shi-Ming Lin verfasserin aut Chung-Kwe Wang verfasserin aut Masafumi Ikeda verfasserin aut Stephen Lam Chan verfasserin aut Su Pin Choo verfasserin aut Shiro Miyayama verfasserin aut Ann Lii Cheng verfasserin aut In Liver Cancer Karger Publishers, 2020 9(2020), 3, Seite 245-260 (DE-627)71871766X (DE-600)2666925-0 16645553 nnns volume:9 year:2020 number:3 pages:245-260 https://doi.org/10.1159/000507370 kostenfrei https://doaj.org/article/10dc796a200244dc9411f022c236f9fa kostenfrei https://www.karger.com/Article/FullText/507370 kostenfrei https://doaj.org/toc/2235-1795 Journal toc kostenfrei https://doaj.org/toc/1664-5553 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 3 245-260
allfields_unstemmed	10.1159/000507370 doi (DE-627)DOAJ027135012 (DE-599)DOAJ10dc796a200244dc9411f022c236f9fa DE-627 ger DE-627 rakwb eng RC254-282 Masatoshi Kudo verfasserin aut A Changing Paradigm for the Treatment of Intermediate-Stage Hepatocellular Carcinoma: Asia-Pacific Primary Liver Cancer Expert Consensus Statements 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Asia-Pacific Primary Liver Cancer Expert (APPLE) Consensus Statement on the treatment strategy for patients with intermediate-stage hepatocellular carcinoma (HCC) was established on August 31, 2019, in Sapporo, Hokkaido during the 10th Annual APPLE Meeting. This manuscript summarizes the international consensus statements developed at APPLE 2019. Transarterial chemoembolization (TACE) is the only guideline-recommended global standard of care for intermediate-stage HCC. However, not all patients benefit from TACE because intermediate-stage HCC is a heterogeneous disease in terms of tumor burden and liver function. Ten important clinical questions regarding this stage of HCC were raised, and consensus statements were generated based on high-quality evidence. In intermediate-stage HCC, preservation of liver function is as important as achieving a high objective response (OR) because the treatment goal is to prolong overall survival. Superselective conventional TACE (cTACE) is recommended as the first choice of treatment in patients eligible for effective (curative) TACE, whereas in patients who are not eligible, systemic therapy is recommended as the first choice of treatment. TACE is not indicated as the first-line therapy in TACE-unsuitable patients. Another important statement is that TACE should not be continued in patients who develop TACE failure/refractoriness in order to preserve liver function. Targeted therapy is the recommended first-line treatment for TACE-unsuitable patients. Especially, the drug, which can have higher OR rate, is preferred. Immunotherapy, transarterial radioembolization, TACE + targeted therapy or other modalities may be considered alternative options in TACE-unsuitable patients who are not candidates for targeted therapy. Better liver function, such as albumin-bilirubin grade 1, is an important factor for maximizing the therapeutic effect of systemic therapy. asia-pacific primary liver cancer expert hepatocellular carcinoma intermediate stage systemic therapy transarterial chemoembolization Neoplasms. Tumors. Oncology. Including cancer and carcinogens Kwang-Hyub Han verfasserin aut Sheng-Long Ye verfasserin aut Jian Zhou verfasserin aut Yi-Hsiang Huang verfasserin aut Shi-Ming Lin verfasserin aut Chung-Kwe Wang verfasserin aut Masafumi Ikeda verfasserin aut Stephen Lam Chan verfasserin aut Su Pin Choo verfasserin aut Shiro Miyayama verfasserin aut Ann Lii Cheng verfasserin aut In Liver Cancer Karger Publishers, 2020 9(2020), 3, Seite 245-260 (DE-627)71871766X (DE-600)2666925-0 16645553 nnns volume:9 year:2020 number:3 pages:245-260 https://doi.org/10.1159/000507370 kostenfrei https://doaj.org/article/10dc796a200244dc9411f022c236f9fa kostenfrei https://www.karger.com/Article/FullText/507370 kostenfrei https://doaj.org/toc/2235-1795 Journal toc kostenfrei https://doaj.org/toc/1664-5553 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 3 245-260
allfieldsGer	10.1159/000507370 doi (DE-627)DOAJ027135012 (DE-599)DOAJ10dc796a200244dc9411f022c236f9fa DE-627 ger DE-627 rakwb eng RC254-282 Masatoshi Kudo verfasserin aut A Changing Paradigm for the Treatment of Intermediate-Stage Hepatocellular Carcinoma: Asia-Pacific Primary Liver Cancer Expert Consensus Statements 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Asia-Pacific Primary Liver Cancer Expert (APPLE) Consensus Statement on the treatment strategy for patients with intermediate-stage hepatocellular carcinoma (HCC) was established on August 31, 2019, in Sapporo, Hokkaido during the 10th Annual APPLE Meeting. This manuscript summarizes the international consensus statements developed at APPLE 2019. Transarterial chemoembolization (TACE) is the only guideline-recommended global standard of care for intermediate-stage HCC. However, not all patients benefit from TACE because intermediate-stage HCC is a heterogeneous disease in terms of tumor burden and liver function. Ten important clinical questions regarding this stage of HCC were raised, and consensus statements were generated based on high-quality evidence. In intermediate-stage HCC, preservation of liver function is as important as achieving a high objective response (OR) because the treatment goal is to prolong overall survival. Superselective conventional TACE (cTACE) is recommended as the first choice of treatment in patients eligible for effective (curative) TACE, whereas in patients who are not eligible, systemic therapy is recommended as the first choice of treatment. TACE is not indicated as the first-line therapy in TACE-unsuitable patients. Another important statement is that TACE should not be continued in patients who develop TACE failure/refractoriness in order to preserve liver function. Targeted therapy is the recommended first-line treatment for TACE-unsuitable patients. Especially, the drug, which can have higher OR rate, is preferred. Immunotherapy, transarterial radioembolization, TACE + targeted therapy or other modalities may be considered alternative options in TACE-unsuitable patients who are not candidates for targeted therapy. Better liver function, such as albumin-bilirubin grade 1, is an important factor for maximizing the therapeutic effect of systemic therapy. asia-pacific primary liver cancer expert hepatocellular carcinoma intermediate stage systemic therapy transarterial chemoembolization Neoplasms. Tumors. Oncology. Including cancer and carcinogens Kwang-Hyub Han verfasserin aut Sheng-Long Ye verfasserin aut Jian Zhou verfasserin aut Yi-Hsiang Huang verfasserin aut Shi-Ming Lin verfasserin aut Chung-Kwe Wang verfasserin aut Masafumi Ikeda verfasserin aut Stephen Lam Chan verfasserin aut Su Pin Choo verfasserin aut Shiro Miyayama verfasserin aut Ann Lii Cheng verfasserin aut In Liver Cancer Karger Publishers, 2020 9(2020), 3, Seite 245-260 (DE-627)71871766X (DE-600)2666925-0 16645553 nnns volume:9 year:2020 number:3 pages:245-260 https://doi.org/10.1159/000507370 kostenfrei https://doaj.org/article/10dc796a200244dc9411f022c236f9fa kostenfrei https://www.karger.com/Article/FullText/507370 kostenfrei https://doaj.org/toc/2235-1795 Journal toc kostenfrei https://doaj.org/toc/1664-5553 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 3 245-260
allfieldsSound	10.1159/000507370 doi (DE-627)DOAJ027135012 (DE-599)DOAJ10dc796a200244dc9411f022c236f9fa DE-627 ger DE-627 rakwb eng RC254-282 Masatoshi Kudo verfasserin aut A Changing Paradigm for the Treatment of Intermediate-Stage Hepatocellular Carcinoma: Asia-Pacific Primary Liver Cancer Expert Consensus Statements 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Asia-Pacific Primary Liver Cancer Expert (APPLE) Consensus Statement on the treatment strategy for patients with intermediate-stage hepatocellular carcinoma (HCC) was established on August 31, 2019, in Sapporo, Hokkaido during the 10th Annual APPLE Meeting. This manuscript summarizes the international consensus statements developed at APPLE 2019. Transarterial chemoembolization (TACE) is the only guideline-recommended global standard of care for intermediate-stage HCC. However, not all patients benefit from TACE because intermediate-stage HCC is a heterogeneous disease in terms of tumor burden and liver function. Ten important clinical questions regarding this stage of HCC were raised, and consensus statements were generated based on high-quality evidence. In intermediate-stage HCC, preservation of liver function is as important as achieving a high objective response (OR) because the treatment goal is to prolong overall survival. Superselective conventional TACE (cTACE) is recommended as the first choice of treatment in patients eligible for effective (curative) TACE, whereas in patients who are not eligible, systemic therapy is recommended as the first choice of treatment. TACE is not indicated as the first-line therapy in TACE-unsuitable patients. Another important statement is that TACE should not be continued in patients who develop TACE failure/refractoriness in order to preserve liver function. Targeted therapy is the recommended first-line treatment for TACE-unsuitable patients. Especially, the drug, which can have higher OR rate, is preferred. Immunotherapy, transarterial radioembolization, TACE + targeted therapy or other modalities may be considered alternative options in TACE-unsuitable patients who are not candidates for targeted therapy. Better liver function, such as albumin-bilirubin grade 1, is an important factor for maximizing the therapeutic effect of systemic therapy. asia-pacific primary liver cancer expert hepatocellular carcinoma intermediate stage systemic therapy transarterial chemoembolization Neoplasms. Tumors. Oncology. Including cancer and carcinogens Kwang-Hyub Han verfasserin aut Sheng-Long Ye verfasserin aut Jian Zhou verfasserin aut Yi-Hsiang Huang verfasserin aut Shi-Ming Lin verfasserin aut Chung-Kwe Wang verfasserin aut Masafumi Ikeda verfasserin aut Stephen Lam Chan verfasserin aut Su Pin Choo verfasserin aut Shiro Miyayama verfasserin aut Ann Lii Cheng verfasserin aut In Liver Cancer Karger Publishers, 2020 9(2020), 3, Seite 245-260 (DE-627)71871766X (DE-600)2666925-0 16645553 nnns volume:9 year:2020 number:3 pages:245-260 https://doi.org/10.1159/000507370 kostenfrei https://doaj.org/article/10dc796a200244dc9411f022c236f9fa kostenfrei https://www.karger.com/Article/FullText/507370 kostenfrei https://doaj.org/toc/2235-1795 Journal toc kostenfrei https://doaj.org/toc/1664-5553 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 3 245-260
language	English
source	In Liver Cancer 9(2020), 3, Seite 245-260 volume:9 year:2020 number:3 pages:245-260
sourceStr	In Liver Cancer 9(2020), 3, Seite 245-260 volume:9 year:2020 number:3 pages:245-260
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	asia-pacific primary liver cancer expert hepatocellular carcinoma intermediate stage systemic therapy transarterial chemoembolization Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Liver Cancer
authorswithroles_txt_mv	Masatoshi Kudo @@aut@@ Kwang-Hyub Han @@aut@@ Sheng-Long Ye @@aut@@ Jian Zhou @@aut@@ Yi-Hsiang Huang @@aut@@ Shi-Ming Lin @@aut@@ Chung-Kwe Wang @@aut@@ Masafumi Ikeda @@aut@@ Stephen Lam Chan @@aut@@ Su Pin Choo @@aut@@ Shiro Miyayama @@aut@@ Ann Lii Cheng @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	71871766X
id	DOAJ027135012
language_de	englisch
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callnumber-first	R - Medicine
author	Masatoshi Kudo
spellingShingle	Masatoshi Kudo misc RC254-282 misc asia-pacific primary liver cancer expert misc hepatocellular carcinoma misc intermediate stage misc systemic therapy misc transarterial chemoembolization misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens A Changing Paradigm for the Treatment of Intermediate-Stage Hepatocellular Carcinoma: Asia-Pacific Primary Liver Cancer Expert Consensus Statements
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topic_title	RC254-282 A Changing Paradigm for the Treatment of Intermediate-Stage Hepatocellular Carcinoma: Asia-Pacific Primary Liver Cancer Expert Consensus Statements asia-pacific primary liver cancer expert hepatocellular carcinoma intermediate stage systemic therapy transarterial chemoembolization
topic	misc RC254-282 misc asia-pacific primary liver cancer expert misc hepatocellular carcinoma misc intermediate stage misc systemic therapy misc transarterial chemoembolization misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc asia-pacific primary liver cancer expert misc hepatocellular carcinoma misc intermediate stage misc systemic therapy misc transarterial chemoembolization misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	A Changing Paradigm for the Treatment of Intermediate-Stage Hepatocellular Carcinoma: Asia-Pacific Primary Liver Cancer Expert Consensus Statements
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title_full	A Changing Paradigm for the Treatment of Intermediate-Stage Hepatocellular Carcinoma: Asia-Pacific Primary Liver Cancer Expert Consensus Statements
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author_browse	Masatoshi Kudo Kwang-Hyub Han Sheng-Long Ye Jian Zhou Yi-Hsiang Huang Shi-Ming Lin Chung-Kwe Wang Masafumi Ikeda Stephen Lam Chan Su Pin Choo Shiro Miyayama Ann Lii Cheng
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title_sort	changing paradigm for the treatment of intermediate-stage hepatocellular carcinoma: asia-pacific primary liver cancer expert consensus statements
callnumber	RC254-282
title_auth	A Changing Paradigm for the Treatment of Intermediate-Stage Hepatocellular Carcinoma: Asia-Pacific Primary Liver Cancer Expert Consensus Statements
abstract	The Asia-Pacific Primary Liver Cancer Expert (APPLE) Consensus Statement on the treatment strategy for patients with intermediate-stage hepatocellular carcinoma (HCC) was established on August 31, 2019, in Sapporo, Hokkaido during the 10th Annual APPLE Meeting. This manuscript summarizes the international consensus statements developed at APPLE 2019. Transarterial chemoembolization (TACE) is the only guideline-recommended global standard of care for intermediate-stage HCC. However, not all patients benefit from TACE because intermediate-stage HCC is a heterogeneous disease in terms of tumor burden and liver function. Ten important clinical questions regarding this stage of HCC were raised, and consensus statements were generated based on high-quality evidence. In intermediate-stage HCC, preservation of liver function is as important as achieving a high objective response (OR) because the treatment goal is to prolong overall survival. Superselective conventional TACE (cTACE) is recommended as the first choice of treatment in patients eligible for effective (curative) TACE, whereas in patients who are not eligible, systemic therapy is recommended as the first choice of treatment. TACE is not indicated as the first-line therapy in TACE-unsuitable patients. Another important statement is that TACE should not be continued in patients who develop TACE failure/refractoriness in order to preserve liver function. Targeted therapy is the recommended first-line treatment for TACE-unsuitable patients. Especially, the drug, which can have higher OR rate, is preferred. Immunotherapy, transarterial radioembolization, TACE + targeted therapy or other modalities may be considered alternative options in TACE-unsuitable patients who are not candidates for targeted therapy. Better liver function, such as albumin-bilirubin grade 1, is an important factor for maximizing the therapeutic effect of systemic therapy.
abstractGer	The Asia-Pacific Primary Liver Cancer Expert (APPLE) Consensus Statement on the treatment strategy for patients with intermediate-stage hepatocellular carcinoma (HCC) was established on August 31, 2019, in Sapporo, Hokkaido during the 10th Annual APPLE Meeting. This manuscript summarizes the international consensus statements developed at APPLE 2019. Transarterial chemoembolization (TACE) is the only guideline-recommended global standard of care for intermediate-stage HCC. However, not all patients benefit from TACE because intermediate-stage HCC is a heterogeneous disease in terms of tumor burden and liver function. Ten important clinical questions regarding this stage of HCC were raised, and consensus statements were generated based on high-quality evidence. In intermediate-stage HCC, preservation of liver function is as important as achieving a high objective response (OR) because the treatment goal is to prolong overall survival. Superselective conventional TACE (cTACE) is recommended as the first choice of treatment in patients eligible for effective (curative) TACE, whereas in patients who are not eligible, systemic therapy is recommended as the first choice of treatment. TACE is not indicated as the first-line therapy in TACE-unsuitable patients. Another important statement is that TACE should not be continued in patients who develop TACE failure/refractoriness in order to preserve liver function. Targeted therapy is the recommended first-line treatment for TACE-unsuitable patients. Especially, the drug, which can have higher OR rate, is preferred. Immunotherapy, transarterial radioembolization, TACE + targeted therapy or other modalities may be considered alternative options in TACE-unsuitable patients who are not candidates for targeted therapy. Better liver function, such as albumin-bilirubin grade 1, is an important factor for maximizing the therapeutic effect of systemic therapy.
abstract_unstemmed	The Asia-Pacific Primary Liver Cancer Expert (APPLE) Consensus Statement on the treatment strategy for patients with intermediate-stage hepatocellular carcinoma (HCC) was established on August 31, 2019, in Sapporo, Hokkaido during the 10th Annual APPLE Meeting. This manuscript summarizes the international consensus statements developed at APPLE 2019. Transarterial chemoembolization (TACE) is the only guideline-recommended global standard of care for intermediate-stage HCC. However, not all patients benefit from TACE because intermediate-stage HCC is a heterogeneous disease in terms of tumor burden and liver function. Ten important clinical questions regarding this stage of HCC were raised, and consensus statements were generated based on high-quality evidence. In intermediate-stage HCC, preservation of liver function is as important as achieving a high objective response (OR) because the treatment goal is to prolong overall survival. Superselective conventional TACE (cTACE) is recommended as the first choice of treatment in patients eligible for effective (curative) TACE, whereas in patients who are not eligible, systemic therapy is recommended as the first choice of treatment. TACE is not indicated as the first-line therapy in TACE-unsuitable patients. Another important statement is that TACE should not be continued in patients who develop TACE failure/refractoriness in order to preserve liver function. Targeted therapy is the recommended first-line treatment for TACE-unsuitable patients. Especially, the drug, which can have higher OR rate, is preferred. Immunotherapy, transarterial radioembolization, TACE + targeted therapy or other modalities may be considered alternative options in TACE-unsuitable patients who are not candidates for targeted therapy. Better liver function, such as albumin-bilirubin grade 1, is an important factor for maximizing the therapeutic effect of systemic therapy.
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title_short	A Changing Paradigm for the Treatment of Intermediate-Stage Hepatocellular Carcinoma: Asia-Pacific Primary Liver Cancer Expert Consensus Statements
url	https://doi.org/10.1159/000507370 https://doaj.org/article/10dc796a200244dc9411f022c236f9fa https://www.karger.com/Article/FullText/507370 https://doaj.org/toc/2235-1795 https://doaj.org/toc/1664-5553
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Nicht das Richtige dabei?