Combination of dasabuvir and PSI-6206 for the treatment of coxsackievirus B3 infection

Coxsackievirus B3 (CVB3) infections may cause life-threatening diseases and have no approved specific treatment. Some promising approaches to treat viral diseases include drug repurposing and combination therapy. We have selected in this study dasabuvir, an approved antiviral drug, and PSI-6206, an...
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Gespeichert in:

Autor*in:	Oluwatayo Israel Olasunkanmi [verfasserIn] Zhao-Hua Zhong [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Coxsackievirus B3 Dasabuvir PSI-6206 Drug repurposing Drug combination

Übergeordnetes Werk:	In: Journal of Virus Eradication - Elsevier, 2021, 8(2022), 2, Seite 100074-
Übergeordnetes Werk:	volume:8 ; year:2022 ; number:2 ; pages:100074-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jve.2022.100074

Katalog-ID:	DOAJ027141055

Internformat


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allfields	10.1016/j.jve.2022.100074 doi (DE-627)DOAJ027141055 (DE-599)DOAJff14578c21684ebab826fa9868ffeef7 DE-627 ger DE-627 rakwb eng QR1-502 RA1-1270 Oluwatayo Israel Olasunkanmi verfasserin aut Combination of dasabuvir and PSI-6206 for the treatment of coxsackievirus B3 infection 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Coxsackievirus B3 (CVB3) infections may cause life-threatening diseases and have no approved specific treatment. Some promising approaches to treat viral diseases include drug repurposing and combination therapy. We have selected in this study dasabuvir, an approved antiviral drug, and PSI-6206, an experimental drug and determined their individual and combined antiviral activity against CVB3 replication in vitro. Our results show that the individual drugs inhibited CVB3 infection in a dose-dependent manner, at a selective index <10 with a strong synergetic antiviral effect of the two compounds. Given that dasabuvir has already been approved for the treatment of hepatitis C virus infection, treatment of CVB3-related disease with this drug may represent a promising treatment strategy. Coxsackievirus B3 Dasabuvir PSI-6206 Drug repurposing Drug combination Microbiology Public aspects of medicine Zhao-Hua Zhong verfasserin aut In Journal of Virus Eradication Elsevier, 2021 8(2022), 2, Seite 100074- (DE-627)867995882 (DE-600)2868549-0 20556659 nnns volume:8 year:2022 number:2 pages:100074- https://doi.org/10.1016/j.jve.2022.100074 kostenfrei https://doaj.org/article/ff14578c21684ebab826fa9868ffeef7 kostenfrei http://www.sciencedirect.com/science/article/pii/S2055664022000127 kostenfrei https://doaj.org/toc/2055-6640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 8 2022 2 100074-
spelling	10.1016/j.jve.2022.100074 doi (DE-627)DOAJ027141055 (DE-599)DOAJff14578c21684ebab826fa9868ffeef7 DE-627 ger DE-627 rakwb eng QR1-502 RA1-1270 Oluwatayo Israel Olasunkanmi verfasserin aut Combination of dasabuvir and PSI-6206 for the treatment of coxsackievirus B3 infection 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Coxsackievirus B3 (CVB3) infections may cause life-threatening diseases and have no approved specific treatment. Some promising approaches to treat viral diseases include drug repurposing and combination therapy. We have selected in this study dasabuvir, an approved antiviral drug, and PSI-6206, an experimental drug and determined their individual and combined antiviral activity against CVB3 replication in vitro. Our results show that the individual drugs inhibited CVB3 infection in a dose-dependent manner, at a selective index <10 with a strong synergetic antiviral effect of the two compounds. Given that dasabuvir has already been approved for the treatment of hepatitis C virus infection, treatment of CVB3-related disease with this drug may represent a promising treatment strategy. Coxsackievirus B3 Dasabuvir PSI-6206 Drug repurposing Drug combination Microbiology Public aspects of medicine Zhao-Hua Zhong verfasserin aut In Journal of Virus Eradication Elsevier, 2021 8(2022), 2, Seite 100074- (DE-627)867995882 (DE-600)2868549-0 20556659 nnns volume:8 year:2022 number:2 pages:100074- https://doi.org/10.1016/j.jve.2022.100074 kostenfrei https://doaj.org/article/ff14578c21684ebab826fa9868ffeef7 kostenfrei http://www.sciencedirect.com/science/article/pii/S2055664022000127 kostenfrei https://doaj.org/toc/2055-6640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 8 2022 2 100074-
allfields_unstemmed	10.1016/j.jve.2022.100074 doi (DE-627)DOAJ027141055 (DE-599)DOAJff14578c21684ebab826fa9868ffeef7 DE-627 ger DE-627 rakwb eng QR1-502 RA1-1270 Oluwatayo Israel Olasunkanmi verfasserin aut Combination of dasabuvir and PSI-6206 for the treatment of coxsackievirus B3 infection 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Coxsackievirus B3 (CVB3) infections may cause life-threatening diseases and have no approved specific treatment. Some promising approaches to treat viral diseases include drug repurposing and combination therapy. We have selected in this study dasabuvir, an approved antiviral drug, and PSI-6206, an experimental drug and determined their individual and combined antiviral activity against CVB3 replication in vitro. Our results show that the individual drugs inhibited CVB3 infection in a dose-dependent manner, at a selective index <10 with a strong synergetic antiviral effect of the two compounds. Given that dasabuvir has already been approved for the treatment of hepatitis C virus infection, treatment of CVB3-related disease with this drug may represent a promising treatment strategy. Coxsackievirus B3 Dasabuvir PSI-6206 Drug repurposing Drug combination Microbiology Public aspects of medicine Zhao-Hua Zhong verfasserin aut In Journal of Virus Eradication Elsevier, 2021 8(2022), 2, Seite 100074- (DE-627)867995882 (DE-600)2868549-0 20556659 nnns volume:8 year:2022 number:2 pages:100074- https://doi.org/10.1016/j.jve.2022.100074 kostenfrei https://doaj.org/article/ff14578c21684ebab826fa9868ffeef7 kostenfrei http://www.sciencedirect.com/science/article/pii/S2055664022000127 kostenfrei https://doaj.org/toc/2055-6640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 8 2022 2 100074-
allfieldsGer	10.1016/j.jve.2022.100074 doi (DE-627)DOAJ027141055 (DE-599)DOAJff14578c21684ebab826fa9868ffeef7 DE-627 ger DE-627 rakwb eng QR1-502 RA1-1270 Oluwatayo Israel Olasunkanmi verfasserin aut Combination of dasabuvir and PSI-6206 for the treatment of coxsackievirus B3 infection 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Coxsackievirus B3 (CVB3) infections may cause life-threatening diseases and have no approved specific treatment. Some promising approaches to treat viral diseases include drug repurposing and combination therapy. We have selected in this study dasabuvir, an approved antiviral drug, and PSI-6206, an experimental drug and determined their individual and combined antiviral activity against CVB3 replication in vitro. Our results show that the individual drugs inhibited CVB3 infection in a dose-dependent manner, at a selective index <10 with a strong synergetic antiviral effect of the two compounds. Given that dasabuvir has already been approved for the treatment of hepatitis C virus infection, treatment of CVB3-related disease with this drug may represent a promising treatment strategy. Coxsackievirus B3 Dasabuvir PSI-6206 Drug repurposing Drug combination Microbiology Public aspects of medicine Zhao-Hua Zhong verfasserin aut In Journal of Virus Eradication Elsevier, 2021 8(2022), 2, Seite 100074- (DE-627)867995882 (DE-600)2868549-0 20556659 nnns volume:8 year:2022 number:2 pages:100074- https://doi.org/10.1016/j.jve.2022.100074 kostenfrei https://doaj.org/article/ff14578c21684ebab826fa9868ffeef7 kostenfrei http://www.sciencedirect.com/science/article/pii/S2055664022000127 kostenfrei https://doaj.org/toc/2055-6640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 8 2022 2 100074-
allfieldsSound	10.1016/j.jve.2022.100074 doi (DE-627)DOAJ027141055 (DE-599)DOAJff14578c21684ebab826fa9868ffeef7 DE-627 ger DE-627 rakwb eng QR1-502 RA1-1270 Oluwatayo Israel Olasunkanmi verfasserin aut Combination of dasabuvir and PSI-6206 for the treatment of coxsackievirus B3 infection 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Coxsackievirus B3 (CVB3) infections may cause life-threatening diseases and have no approved specific treatment. Some promising approaches to treat viral diseases include drug repurposing and combination therapy. We have selected in this study dasabuvir, an approved antiviral drug, and PSI-6206, an experimental drug and determined their individual and combined antiviral activity against CVB3 replication in vitro. Our results show that the individual drugs inhibited CVB3 infection in a dose-dependent manner, at a selective index <10 with a strong synergetic antiviral effect of the two compounds. Given that dasabuvir has already been approved for the treatment of hepatitis C virus infection, treatment of CVB3-related disease with this drug may represent a promising treatment strategy. Coxsackievirus B3 Dasabuvir PSI-6206 Drug repurposing Drug combination Microbiology Public aspects of medicine Zhao-Hua Zhong verfasserin aut In Journal of Virus Eradication Elsevier, 2021 8(2022), 2, Seite 100074- (DE-627)867995882 (DE-600)2868549-0 20556659 nnns volume:8 year:2022 number:2 pages:100074- https://doi.org/10.1016/j.jve.2022.100074 kostenfrei https://doaj.org/article/ff14578c21684ebab826fa9868ffeef7 kostenfrei http://www.sciencedirect.com/science/article/pii/S2055664022000127 kostenfrei https://doaj.org/toc/2055-6640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 8 2022 2 100074-
language	English
source	In Journal of Virus Eradication 8(2022), 2, Seite 100074- volume:8 year:2022 number:2 pages:100074-
sourceStr	In Journal of Virus Eradication 8(2022), 2, Seite 100074- volume:8 year:2022 number:2 pages:100074-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Coxsackievirus B3 Dasabuvir PSI-6206 Drug repurposing Drug combination Microbiology Public aspects of medicine
isfreeaccess_bool	true
container_title	Journal of Virus Eradication
authorswithroles_txt_mv	Oluwatayo Israel Olasunkanmi @@aut@@ Zhao-Hua Zhong @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	867995882
id	DOAJ027141055
language_de	englisch
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callnumber-first	Q - Science
author	Oluwatayo Israel Olasunkanmi
spellingShingle	Oluwatayo Israel Olasunkanmi misc QR1-502 misc RA1-1270 misc Coxsackievirus B3 misc Dasabuvir misc PSI-6206 misc Drug repurposing misc Drug combination misc Microbiology misc Public aspects of medicine Combination of dasabuvir and PSI-6206 for the treatment of coxsackievirus B3 infection
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topic_title	QR1-502 RA1-1270 Combination of dasabuvir and PSI-6206 for the treatment of coxsackievirus B3 infection Coxsackievirus B3 Dasabuvir PSI-6206 Drug repurposing Drug combination
topic	misc QR1-502 misc RA1-1270 misc Coxsackievirus B3 misc Dasabuvir misc PSI-6206 misc Drug repurposing misc Drug combination misc Microbiology misc Public aspects of medicine
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title	Combination of dasabuvir and PSI-6206 for the treatment of coxsackievirus B3 infection
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title_full	Combination of dasabuvir and PSI-6206 for the treatment of coxsackievirus B3 infection
author_sort	Oluwatayo Israel Olasunkanmi
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author_browse	Oluwatayo Israel Olasunkanmi Zhao-Hua Zhong
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title_sort	combination of dasabuvir and psi-6206 for the treatment of coxsackievirus b3 infection
callnumber	QR1-502
title_auth	Combination of dasabuvir and PSI-6206 for the treatment of coxsackievirus B3 infection
abstract	Coxsackievirus B3 (CVB3) infections may cause life-threatening diseases and have no approved specific treatment. Some promising approaches to treat viral diseases include drug repurposing and combination therapy. We have selected in this study dasabuvir, an approved antiviral drug, and PSI-6206, an experimental drug and determined their individual and combined antiviral activity against CVB3 replication in vitro. Our results show that the individual drugs inhibited CVB3 infection in a dose-dependent manner, at a selective index <10 with a strong synergetic antiviral effect of the two compounds. Given that dasabuvir has already been approved for the treatment of hepatitis C virus infection, treatment of CVB3-related disease with this drug may represent a promising treatment strategy.
abstractGer	Coxsackievirus B3 (CVB3) infections may cause life-threatening diseases and have no approved specific treatment. Some promising approaches to treat viral diseases include drug repurposing and combination therapy. We have selected in this study dasabuvir, an approved antiviral drug, and PSI-6206, an experimental drug and determined their individual and combined antiviral activity against CVB3 replication in vitro. Our results show that the individual drugs inhibited CVB3 infection in a dose-dependent manner, at a selective index <10 with a strong synergetic antiviral effect of the two compounds. Given that dasabuvir has already been approved for the treatment of hepatitis C virus infection, treatment of CVB3-related disease with this drug may represent a promising treatment strategy.
abstract_unstemmed	Coxsackievirus B3 (CVB3) infections may cause life-threatening diseases and have no approved specific treatment. Some promising approaches to treat viral diseases include drug repurposing and combination therapy. We have selected in this study dasabuvir, an approved antiviral drug, and PSI-6206, an experimental drug and determined their individual and combined antiviral activity against CVB3 replication in vitro. Our results show that the individual drugs inhibited CVB3 infection in a dose-dependent manner, at a selective index <10 with a strong synergetic antiviral effect of the two compounds. Given that dasabuvir has already been approved for the treatment of hepatitis C virus infection, treatment of CVB3-related disease with this drug may represent a promising treatment strategy.
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title_short	Combination of dasabuvir and PSI-6206 for the treatment of coxsackievirus B3 infection
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Combination of dasabuvir and PSI-6206 for the treatment of coxsackievirus B3 infection

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