Pregnancy outcomes in PCOS patients undergoing IVF with long GnRH agonist protocol versus flexible GnRH antagonist

Introduction: IVF is a good option for Polycystic ovary syndrome patients who not respond to ovulation induction treatment. This study was performed with aim to compare pregnancy outcomes in PCOS patients undergoing IVF with long GnRH agonist versus flexible GnRH antagonist regimens. Methods: This r...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Nayereh Khadem Ghaebi [verfasserIn] Maliheh Amirian [verfasserIn] Seyede Houra Mousavi Vahed [verfasserIn] Yalda Arian [verfasserIn] Vida Vakili [verfasserIn] Yousef Yousefi [verfasserIn] Seyedeh Azam Tashkori Hashemi [verfasserIn]

Format:	E-Artikel
Sprache:	Persisch

Erschienen:	2018

Schlagwörter:	gnrh agonist gnrh antagonist pcos

Übergeordnetes Werk:	In: Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān - Mashhad University of Medical Sciences, 2017, 21(2018), 9, Seite 9
Übergeordnetes Werk:	volume:21 ; year:2018 ; number:9 ; pages:9

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.22038/ijogi.2018.12126

Katalog-ID:	DOAJ027366499

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520			\|a Introduction: IVF is a good option for Polycystic ovary syndrome patients who not respond to ovulation induction treatment. This study was performed with aim to compare pregnancy outcomes in PCOS patients undergoing IVF with long GnRH agonist versus flexible GnRH antagonist regimens. Methods: This randomized clinical trial study was performed on 96 infertile PCOS women candidates for IVF who referred to Milad Infertility Center in 2014. The patients were divided into 2 groups: long GnRH agonist and GnRH antagonist. Oral contraceptive pills were prescribed as pretreatment and recombinant FSH was given for ovarian induction. Data were analyzed by SPSS software (version 20) and Chi-square, Exact Fisher, and Mann-Whitney tests. P<0.05 was considered statistically significant. Results: Two groups of GnRH agonist and GnRH antagonist were not significantly different in terms of pregnancy outcomes like chemical pregnancy (p=0.544), clinical pregnancy (p=0.6), abortion (p=1), and multiple pregnancy (p=0.688). The prevalence of Ovarian hyperstimulation syndrome was less in antagonist group versus agonist group that had statistically significant difference (p=0.0001). Dose of gonadotropins (p=0.344) and the number of days of gonadotropins consumption (p=0.236) were not significantly different between two groups. Conclusion: GnRH antagonist can be used in PCOS patient's candidates for IVF. The use of GnRH antagonist is not different in pregnancy outcome compared to GnRH agonist and only decreases the complications of infertility treatment.
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allfields	10.22038/ijogi.2018.12126 doi (DE-627)DOAJ027366499 (DE-599)DOAJe1c4e522fc9d408c92f1b288ea926278 DE-627 ger DE-627 rakwb per RG1-991 Nayereh Khadem Ghaebi verfasserin aut Pregnancy outcomes in PCOS patients undergoing IVF with long GnRH agonist protocol versus flexible GnRH antagonist 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: IVF is a good option for Polycystic ovary syndrome patients who not respond to ovulation induction treatment. This study was performed with aim to compare pregnancy outcomes in PCOS patients undergoing IVF with long GnRH agonist versus flexible GnRH antagonist regimens. Methods: This randomized clinical trial study was performed on 96 infertile PCOS women candidates for IVF who referred to Milad Infertility Center in 2014. The patients were divided into 2 groups: long GnRH agonist and GnRH antagonist. Oral contraceptive pills were prescribed as pretreatment and recombinant FSH was given for ovarian induction. Data were analyzed by SPSS software (version 20) and Chi-square, Exact Fisher, and Mann-Whitney tests. P<0.05 was considered statistically significant. Results: Two groups of GnRH agonist and GnRH antagonist were not significantly different in terms of pregnancy outcomes like chemical pregnancy (p=0.544), clinical pregnancy (p=0.6), abortion (p=1), and multiple pregnancy (p=0.688). The prevalence of Ovarian hyperstimulation syndrome was less in antagonist group versus agonist group that had statistically significant difference (p=0.0001). Dose of gonadotropins (p=0.344) and the number of days of gonadotropins consumption (p=0.236) were not significantly different between two groups. Conclusion: GnRH antagonist can be used in PCOS patient's candidates for IVF. The use of GnRH antagonist is not different in pregnancy outcome compared to GnRH agonist and only decreases the complications of infertility treatment. gnrh agonist gnrh antagonist pcos Gynecology and obstetrics Maliheh Amirian verfasserin aut Seyede Houra Mousavi Vahed verfasserin aut Yalda Arian verfasserin aut Vida Vakili verfasserin aut Yousef Yousefi verfasserin aut Seyedeh Azam Tashkori Hashemi verfasserin aut In Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān Mashhad University of Medical Sciences, 2017 21(2018), 9, Seite 9 (DE-627)686947827 (DE-600)2651625-1 20082363 nnns volume:21 year:2018 number:9 pages:9 https://doi.org/10.22038/ijogi.2018.12126 kostenfrei https://doaj.org/article/e1c4e522fc9d408c92f1b288ea926278 kostenfrei https://ijogi.mums.ac.ir/article_12126_536b4b2c5024b5cc3c92b7c678605c1a.pdf kostenfrei https://doaj.org/toc/1680-2993 Journal toc kostenfrei https://doaj.org/toc/2008-2363 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2018 9 9
spelling	10.22038/ijogi.2018.12126 doi (DE-627)DOAJ027366499 (DE-599)DOAJe1c4e522fc9d408c92f1b288ea926278 DE-627 ger DE-627 rakwb per RG1-991 Nayereh Khadem Ghaebi verfasserin aut Pregnancy outcomes in PCOS patients undergoing IVF with long GnRH agonist protocol versus flexible GnRH antagonist 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: IVF is a good option for Polycystic ovary syndrome patients who not respond to ovulation induction treatment. This study was performed with aim to compare pregnancy outcomes in PCOS patients undergoing IVF with long GnRH agonist versus flexible GnRH antagonist regimens. Methods: This randomized clinical trial study was performed on 96 infertile PCOS women candidates for IVF who referred to Milad Infertility Center in 2014. The patients were divided into 2 groups: long GnRH agonist and GnRH antagonist. Oral contraceptive pills were prescribed as pretreatment and recombinant FSH was given for ovarian induction. Data were analyzed by SPSS software (version 20) and Chi-square, Exact Fisher, and Mann-Whitney tests. P<0.05 was considered statistically significant. Results: Two groups of GnRH agonist and GnRH antagonist were not significantly different in terms of pregnancy outcomes like chemical pregnancy (p=0.544), clinical pregnancy (p=0.6), abortion (p=1), and multiple pregnancy (p=0.688). The prevalence of Ovarian hyperstimulation syndrome was less in antagonist group versus agonist group that had statistically significant difference (p=0.0001). Dose of gonadotropins (p=0.344) and the number of days of gonadotropins consumption (p=0.236) were not significantly different between two groups. Conclusion: GnRH antagonist can be used in PCOS patient's candidates for IVF. The use of GnRH antagonist is not different in pregnancy outcome compared to GnRH agonist and only decreases the complications of infertility treatment. gnrh agonist gnrh antagonist pcos Gynecology and obstetrics Maliheh Amirian verfasserin aut Seyede Houra Mousavi Vahed verfasserin aut Yalda Arian verfasserin aut Vida Vakili verfasserin aut Yousef Yousefi verfasserin aut Seyedeh Azam Tashkori Hashemi verfasserin aut In Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān Mashhad University of Medical Sciences, 2017 21(2018), 9, Seite 9 (DE-627)686947827 (DE-600)2651625-1 20082363 nnns volume:21 year:2018 number:9 pages:9 https://doi.org/10.22038/ijogi.2018.12126 kostenfrei https://doaj.org/article/e1c4e522fc9d408c92f1b288ea926278 kostenfrei https://ijogi.mums.ac.ir/article_12126_536b4b2c5024b5cc3c92b7c678605c1a.pdf kostenfrei https://doaj.org/toc/1680-2993 Journal toc kostenfrei https://doaj.org/toc/2008-2363 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2018 9 9
allfields_unstemmed	10.22038/ijogi.2018.12126 doi (DE-627)DOAJ027366499 (DE-599)DOAJe1c4e522fc9d408c92f1b288ea926278 DE-627 ger DE-627 rakwb per RG1-991 Nayereh Khadem Ghaebi verfasserin aut Pregnancy outcomes in PCOS patients undergoing IVF with long GnRH agonist protocol versus flexible GnRH antagonist 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: IVF is a good option for Polycystic ovary syndrome patients who not respond to ovulation induction treatment. This study was performed with aim to compare pregnancy outcomes in PCOS patients undergoing IVF with long GnRH agonist versus flexible GnRH antagonist regimens. Methods: This randomized clinical trial study was performed on 96 infertile PCOS women candidates for IVF who referred to Milad Infertility Center in 2014. The patients were divided into 2 groups: long GnRH agonist and GnRH antagonist. Oral contraceptive pills were prescribed as pretreatment and recombinant FSH was given for ovarian induction. Data were analyzed by SPSS software (version 20) and Chi-square, Exact Fisher, and Mann-Whitney tests. P<0.05 was considered statistically significant. Results: Two groups of GnRH agonist and GnRH antagonist were not significantly different in terms of pregnancy outcomes like chemical pregnancy (p=0.544), clinical pregnancy (p=0.6), abortion (p=1), and multiple pregnancy (p=0.688). The prevalence of Ovarian hyperstimulation syndrome was less in antagonist group versus agonist group that had statistically significant difference (p=0.0001). Dose of gonadotropins (p=0.344) and the number of days of gonadotropins consumption (p=0.236) were not significantly different between two groups. Conclusion: GnRH antagonist can be used in PCOS patient's candidates for IVF. The use of GnRH antagonist is not different in pregnancy outcome compared to GnRH agonist and only decreases the complications of infertility treatment. gnrh agonist gnrh antagonist pcos Gynecology and obstetrics Maliheh Amirian verfasserin aut Seyede Houra Mousavi Vahed verfasserin aut Yalda Arian verfasserin aut Vida Vakili verfasserin aut Yousef Yousefi verfasserin aut Seyedeh Azam Tashkori Hashemi verfasserin aut In Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān Mashhad University of Medical Sciences, 2017 21(2018), 9, Seite 9 (DE-627)686947827 (DE-600)2651625-1 20082363 nnns volume:21 year:2018 number:9 pages:9 https://doi.org/10.22038/ijogi.2018.12126 kostenfrei https://doaj.org/article/e1c4e522fc9d408c92f1b288ea926278 kostenfrei https://ijogi.mums.ac.ir/article_12126_536b4b2c5024b5cc3c92b7c678605c1a.pdf kostenfrei https://doaj.org/toc/1680-2993 Journal toc kostenfrei https://doaj.org/toc/2008-2363 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2018 9 9
allfieldsGer	10.22038/ijogi.2018.12126 doi (DE-627)DOAJ027366499 (DE-599)DOAJe1c4e522fc9d408c92f1b288ea926278 DE-627 ger DE-627 rakwb per RG1-991 Nayereh Khadem Ghaebi verfasserin aut Pregnancy outcomes in PCOS patients undergoing IVF with long GnRH agonist protocol versus flexible GnRH antagonist 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: IVF is a good option for Polycystic ovary syndrome patients who not respond to ovulation induction treatment. This study was performed with aim to compare pregnancy outcomes in PCOS patients undergoing IVF with long GnRH agonist versus flexible GnRH antagonist regimens. Methods: This randomized clinical trial study was performed on 96 infertile PCOS women candidates for IVF who referred to Milad Infertility Center in 2014. The patients were divided into 2 groups: long GnRH agonist and GnRH antagonist. Oral contraceptive pills were prescribed as pretreatment and recombinant FSH was given for ovarian induction. Data were analyzed by SPSS software (version 20) and Chi-square, Exact Fisher, and Mann-Whitney tests. P<0.05 was considered statistically significant. Results: Two groups of GnRH agonist and GnRH antagonist were not significantly different in terms of pregnancy outcomes like chemical pregnancy (p=0.544), clinical pregnancy (p=0.6), abortion (p=1), and multiple pregnancy (p=0.688). The prevalence of Ovarian hyperstimulation syndrome was less in antagonist group versus agonist group that had statistically significant difference (p=0.0001). Dose of gonadotropins (p=0.344) and the number of days of gonadotropins consumption (p=0.236) were not significantly different between two groups. Conclusion: GnRH antagonist can be used in PCOS patient's candidates for IVF. The use of GnRH antagonist is not different in pregnancy outcome compared to GnRH agonist and only decreases the complications of infertility treatment. gnrh agonist gnrh antagonist pcos Gynecology and obstetrics Maliheh Amirian verfasserin aut Seyede Houra Mousavi Vahed verfasserin aut Yalda Arian verfasserin aut Vida Vakili verfasserin aut Yousef Yousefi verfasserin aut Seyedeh Azam Tashkori Hashemi verfasserin aut In Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān Mashhad University of Medical Sciences, 2017 21(2018), 9, Seite 9 (DE-627)686947827 (DE-600)2651625-1 20082363 nnns volume:21 year:2018 number:9 pages:9 https://doi.org/10.22038/ijogi.2018.12126 kostenfrei https://doaj.org/article/e1c4e522fc9d408c92f1b288ea926278 kostenfrei https://ijogi.mums.ac.ir/article_12126_536b4b2c5024b5cc3c92b7c678605c1a.pdf kostenfrei https://doaj.org/toc/1680-2993 Journal toc kostenfrei https://doaj.org/toc/2008-2363 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2018 9 9
allfieldsSound	10.22038/ijogi.2018.12126 doi (DE-627)DOAJ027366499 (DE-599)DOAJe1c4e522fc9d408c92f1b288ea926278 DE-627 ger DE-627 rakwb per RG1-991 Nayereh Khadem Ghaebi verfasserin aut Pregnancy outcomes in PCOS patients undergoing IVF with long GnRH agonist protocol versus flexible GnRH antagonist 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: IVF is a good option for Polycystic ovary syndrome patients who not respond to ovulation induction treatment. This study was performed with aim to compare pregnancy outcomes in PCOS patients undergoing IVF with long GnRH agonist versus flexible GnRH antagonist regimens. Methods: This randomized clinical trial study was performed on 96 infertile PCOS women candidates for IVF who referred to Milad Infertility Center in 2014. The patients were divided into 2 groups: long GnRH agonist and GnRH antagonist. Oral contraceptive pills were prescribed as pretreatment and recombinant FSH was given for ovarian induction. Data were analyzed by SPSS software (version 20) and Chi-square, Exact Fisher, and Mann-Whitney tests. P<0.05 was considered statistically significant. Results: Two groups of GnRH agonist and GnRH antagonist were not significantly different in terms of pregnancy outcomes like chemical pregnancy (p=0.544), clinical pregnancy (p=0.6), abortion (p=1), and multiple pregnancy (p=0.688). The prevalence of Ovarian hyperstimulation syndrome was less in antagonist group versus agonist group that had statistically significant difference (p=0.0001). Dose of gonadotropins (p=0.344) and the number of days of gonadotropins consumption (p=0.236) were not significantly different between two groups. Conclusion: GnRH antagonist can be used in PCOS patient's candidates for IVF. The use of GnRH antagonist is not different in pregnancy outcome compared to GnRH agonist and only decreases the complications of infertility treatment. gnrh agonist gnrh antagonist pcos Gynecology and obstetrics Maliheh Amirian verfasserin aut Seyede Houra Mousavi Vahed verfasserin aut Yalda Arian verfasserin aut Vida Vakili verfasserin aut Yousef Yousefi verfasserin aut Seyedeh Azam Tashkori Hashemi verfasserin aut In Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān Mashhad University of Medical Sciences, 2017 21(2018), 9, Seite 9 (DE-627)686947827 (DE-600)2651625-1 20082363 nnns volume:21 year:2018 number:9 pages:9 https://doi.org/10.22038/ijogi.2018.12126 kostenfrei https://doaj.org/article/e1c4e522fc9d408c92f1b288ea926278 kostenfrei https://ijogi.mums.ac.ir/article_12126_536b4b2c5024b5cc3c92b7c678605c1a.pdf kostenfrei https://doaj.org/toc/1680-2993 Journal toc kostenfrei https://doaj.org/toc/2008-2363 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2018 9 9
language	Persian
source	In Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān 21(2018), 9, Seite 9 volume:21 year:2018 number:9 pages:9
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title	Pregnancy outcomes in PCOS patients undergoing IVF with long GnRH agonist protocol versus flexible GnRH antagonist
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title_full	Pregnancy outcomes in PCOS patients undergoing IVF with long GnRH agonist protocol versus flexible GnRH antagonist
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title_sort	pregnancy outcomes in pcos patients undergoing ivf with long gnrh agonist protocol versus flexible gnrh antagonist
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title_auth	Pregnancy outcomes in PCOS patients undergoing IVF with long GnRH agonist protocol versus flexible GnRH antagonist
abstract	Introduction: IVF is a good option for Polycystic ovary syndrome patients who not respond to ovulation induction treatment. This study was performed with aim to compare pregnancy outcomes in PCOS patients undergoing IVF with long GnRH agonist versus flexible GnRH antagonist regimens. Methods: This randomized clinical trial study was performed on 96 infertile PCOS women candidates for IVF who referred to Milad Infertility Center in 2014. The patients were divided into 2 groups: long GnRH agonist and GnRH antagonist. Oral contraceptive pills were prescribed as pretreatment and recombinant FSH was given for ovarian induction. Data were analyzed by SPSS software (version 20) and Chi-square, Exact Fisher, and Mann-Whitney tests. P<0.05 was considered statistically significant. Results: Two groups of GnRH agonist and GnRH antagonist were not significantly different in terms of pregnancy outcomes like chemical pregnancy (p=0.544), clinical pregnancy (p=0.6), abortion (p=1), and multiple pregnancy (p=0.688). The prevalence of Ovarian hyperstimulation syndrome was less in antagonist group versus agonist group that had statistically significant difference (p=0.0001). Dose of gonadotropins (p=0.344) and the number of days of gonadotropins consumption (p=0.236) were not significantly different between two groups. Conclusion: GnRH antagonist can be used in PCOS patient's candidates for IVF. The use of GnRH antagonist is not different in pregnancy outcome compared to GnRH agonist and only decreases the complications of infertility treatment.
abstractGer	Introduction: IVF is a good option for Polycystic ovary syndrome patients who not respond to ovulation induction treatment. This study was performed with aim to compare pregnancy outcomes in PCOS patients undergoing IVF with long GnRH agonist versus flexible GnRH antagonist regimens. Methods: This randomized clinical trial study was performed on 96 infertile PCOS women candidates for IVF who referred to Milad Infertility Center in 2014. The patients were divided into 2 groups: long GnRH agonist and GnRH antagonist. Oral contraceptive pills were prescribed as pretreatment and recombinant FSH was given for ovarian induction. Data were analyzed by SPSS software (version 20) and Chi-square, Exact Fisher, and Mann-Whitney tests. P<0.05 was considered statistically significant. Results: Two groups of GnRH agonist and GnRH antagonist were not significantly different in terms of pregnancy outcomes like chemical pregnancy (p=0.544), clinical pregnancy (p=0.6), abortion (p=1), and multiple pregnancy (p=0.688). The prevalence of Ovarian hyperstimulation syndrome was less in antagonist group versus agonist group that had statistically significant difference (p=0.0001). Dose of gonadotropins (p=0.344) and the number of days of gonadotropins consumption (p=0.236) were not significantly different between two groups. Conclusion: GnRH antagonist can be used in PCOS patient's candidates for IVF. The use of GnRH antagonist is not different in pregnancy outcome compared to GnRH agonist and only decreases the complications of infertility treatment.
abstract_unstemmed	Introduction: IVF is a good option for Polycystic ovary syndrome patients who not respond to ovulation induction treatment. This study was performed with aim to compare pregnancy outcomes in PCOS patients undergoing IVF with long GnRH agonist versus flexible GnRH antagonist regimens. Methods: This randomized clinical trial study was performed on 96 infertile PCOS women candidates for IVF who referred to Milad Infertility Center in 2014. The patients were divided into 2 groups: long GnRH agonist and GnRH antagonist. Oral contraceptive pills were prescribed as pretreatment and recombinant FSH was given for ovarian induction. Data were analyzed by SPSS software (version 20) and Chi-square, Exact Fisher, and Mann-Whitney tests. P<0.05 was considered statistically significant. Results: Two groups of GnRH agonist and GnRH antagonist were not significantly different in terms of pregnancy outcomes like chemical pregnancy (p=0.544), clinical pregnancy (p=0.6), abortion (p=1), and multiple pregnancy (p=0.688). The prevalence of Ovarian hyperstimulation syndrome was less in antagonist group versus agonist group that had statistically significant difference (p=0.0001). Dose of gonadotropins (p=0.344) and the number of days of gonadotropins consumption (p=0.236) were not significantly different between two groups. Conclusion: GnRH antagonist can be used in PCOS patient's candidates for IVF. The use of GnRH antagonist is not different in pregnancy outcome compared to GnRH agonist and only decreases the complications of infertility treatment.
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doi_str	10.22038/ijogi.2018.12126
callnumber-a	RG1-991
up_date	2024-07-04T01:25:05.970Z
_version_	1803609761090895872
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This study was performed with aim to compare pregnancy outcomes in PCOS patients undergoing IVF with long GnRH agonist versus flexible GnRH antagonist regimens. Methods: This randomized clinical trial study was performed on 96 infertile PCOS women candidates for IVF who referred to Milad Infertility Center in 2014. The patients were divided into 2 groups: long GnRH agonist and GnRH antagonist. Oral contraceptive pills were prescribed as pretreatment and recombinant FSH was given for ovarian induction. Data were analyzed by SPSS software (version 20) and Chi-square, Exact Fisher, and Mann-Whitney tests. P<0.05 was considered statistically significant. Results: Two groups of GnRH agonist and GnRH antagonist were not significantly different in terms of pregnancy outcomes like chemical pregnancy (p=0.544), clinical pregnancy (p=0.6), abortion (p=1), and multiple pregnancy (p=0.688). The prevalence of Ovarian hyperstimulation syndrome was less in antagonist group versus agonist group that had statistically significant difference (p=0.0001). Dose of gonadotropins (p=0.344) and the number of days of gonadotropins consumption (p=0.236) were not significantly different between two groups. Conclusion: GnRH antagonist can be used in PCOS patient's candidates for IVF. 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Pregnancy outcomes in PCOS patients undergoing IVF with long GnRH agonist protocol versus flexible GnRH antagonist

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