Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID
In the COVID-19 pandemic, caused by SARS-CoV-2, many individuals experience prolonged symptoms, termed long-lasting COVID-19 symptoms (long COVID). Long COVID is thought to be linked to immune dysregulation due to harmful inflammation, with the exact causes being unknown. Given the role of the micro...
Ausführliche Beschreibung
Autor*in: |
John P. Haran [verfasserIn] Evan Bradley [verfasserIn] Abigail L. Zeamer [verfasserIn] Lindsey Cincotta [verfasserIn] Marie-Claire Salive [verfasserIn] Protiva Dutta [verfasserIn] Shafik Mutaawe [verfasserIn] Otuwe Anya [verfasserIn] Mario Meza-Segura [verfasserIn] Ann M. Moormann [verfasserIn] Doyle V. Ward [verfasserIn] Beth A. McCormick [verfasserIn] Vanni Bucci [verfasserIn] |
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E-Artikel |
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Englisch |
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2021 |
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In: JCI Insight - American Society for Clinical investigation, 2020, 6(2021), 20 |
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Übergeordnetes Werk: |
volume:6 ; year:2021 ; number:20 |
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DOAJ027381773 |
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(DE-627)DOAJ027381773 (DE-599)DOAJ193c7559a3794fd88d29155faf3cb51b DE-627 ger DE-627 rakwb eng John P. Haran verfasserin aut Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the COVID-19 pandemic, caused by SARS-CoV-2, many individuals experience prolonged symptoms, termed long-lasting COVID-19 symptoms (long COVID). Long COVID is thought to be linked to immune dysregulation due to harmful inflammation, with the exact causes being unknown. Given the role of the microbiome in mediating inflammation, we aimed to examine the relationship between the oral microbiome and the duration of long COVID symptoms. Tongue swabs were collected from patients presenting with COVID-19 symptoms. Confirmed infections were followed until resolution of all symptoms. Bacterial composition was determined by metagenomic sequencing. We used random forest modeling to identify microbiota and clinical covariates that are associated with long COVID symptoms. Of the patients followed, 63% developed ongoing symptomatic COVID-19 and 37% went on to long COVID. Patients with prolonged symptoms had significantly higher abundances of microbiota that induced inflammation, such as members of the genera Prevotella and Veillonella, which, of note, are species that produce LPS. The oral microbiome of patients with long COVID was similar to that of patients with chronic fatigue syndrome. Altogether, our findings suggest an association with the oral microbiome and long COVID, revealing the possibility that dysfunction of the oral microbiome may have contributed to this draining disease. COVID-19 Inflammation Medicine R Evan Bradley verfasserin aut Abigail L. Zeamer verfasserin aut Lindsey Cincotta verfasserin aut Marie-Claire Salive verfasserin aut Protiva Dutta verfasserin aut Shafik Mutaawe verfasserin aut Otuwe Anya verfasserin aut Mario Meza-Segura verfasserin aut Ann M. Moormann verfasserin aut Doyle V. Ward verfasserin aut Beth A. McCormick verfasserin aut Vanni Bucci verfasserin aut In JCI Insight American Society for Clinical investigation, 2020 6(2021), 20 (DE-627)872610594 (DE-600)2874757-4 23793708 nnns volume:6 year:2021 number:20 https://doaj.org/article/193c7559a3794fd88d29155faf3cb51b kostenfrei https://doi.org/10.1172/jci.insight.152346 kostenfrei https://doaj.org/toc/2379-3708 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2021 20 |
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(DE-627)DOAJ027381773 (DE-599)DOAJ193c7559a3794fd88d29155faf3cb51b DE-627 ger DE-627 rakwb eng John P. Haran verfasserin aut Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the COVID-19 pandemic, caused by SARS-CoV-2, many individuals experience prolonged symptoms, termed long-lasting COVID-19 symptoms (long COVID). Long COVID is thought to be linked to immune dysregulation due to harmful inflammation, with the exact causes being unknown. Given the role of the microbiome in mediating inflammation, we aimed to examine the relationship between the oral microbiome and the duration of long COVID symptoms. Tongue swabs were collected from patients presenting with COVID-19 symptoms. Confirmed infections were followed until resolution of all symptoms. Bacterial composition was determined by metagenomic sequencing. We used random forest modeling to identify microbiota and clinical covariates that are associated with long COVID symptoms. Of the patients followed, 63% developed ongoing symptomatic COVID-19 and 37% went on to long COVID. Patients with prolonged symptoms had significantly higher abundances of microbiota that induced inflammation, such as members of the genera Prevotella and Veillonella, which, of note, are species that produce LPS. The oral microbiome of patients with long COVID was similar to that of patients with chronic fatigue syndrome. Altogether, our findings suggest an association with the oral microbiome and long COVID, revealing the possibility that dysfunction of the oral microbiome may have contributed to this draining disease. COVID-19 Inflammation Medicine R Evan Bradley verfasserin aut Abigail L. Zeamer verfasserin aut Lindsey Cincotta verfasserin aut Marie-Claire Salive verfasserin aut Protiva Dutta verfasserin aut Shafik Mutaawe verfasserin aut Otuwe Anya verfasserin aut Mario Meza-Segura verfasserin aut Ann M. Moormann verfasserin aut Doyle V. Ward verfasserin aut Beth A. McCormick verfasserin aut Vanni Bucci verfasserin aut In JCI Insight American Society for Clinical investigation, 2020 6(2021), 20 (DE-627)872610594 (DE-600)2874757-4 23793708 nnns volume:6 year:2021 number:20 https://doaj.org/article/193c7559a3794fd88d29155faf3cb51b kostenfrei https://doi.org/10.1172/jci.insight.152346 kostenfrei https://doaj.org/toc/2379-3708 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2021 20 |
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(DE-627)DOAJ027381773 (DE-599)DOAJ193c7559a3794fd88d29155faf3cb51b DE-627 ger DE-627 rakwb eng John P. Haran verfasserin aut Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the COVID-19 pandemic, caused by SARS-CoV-2, many individuals experience prolonged symptoms, termed long-lasting COVID-19 symptoms (long COVID). Long COVID is thought to be linked to immune dysregulation due to harmful inflammation, with the exact causes being unknown. Given the role of the microbiome in mediating inflammation, we aimed to examine the relationship between the oral microbiome and the duration of long COVID symptoms. Tongue swabs were collected from patients presenting with COVID-19 symptoms. Confirmed infections were followed until resolution of all symptoms. Bacterial composition was determined by metagenomic sequencing. We used random forest modeling to identify microbiota and clinical covariates that are associated with long COVID symptoms. Of the patients followed, 63% developed ongoing symptomatic COVID-19 and 37% went on to long COVID. Patients with prolonged symptoms had significantly higher abundances of microbiota that induced inflammation, such as members of the genera Prevotella and Veillonella, which, of note, are species that produce LPS. The oral microbiome of patients with long COVID was similar to that of patients with chronic fatigue syndrome. Altogether, our findings suggest an association with the oral microbiome and long COVID, revealing the possibility that dysfunction of the oral microbiome may have contributed to this draining disease. COVID-19 Inflammation Medicine R Evan Bradley verfasserin aut Abigail L. Zeamer verfasserin aut Lindsey Cincotta verfasserin aut Marie-Claire Salive verfasserin aut Protiva Dutta verfasserin aut Shafik Mutaawe verfasserin aut Otuwe Anya verfasserin aut Mario Meza-Segura verfasserin aut Ann M. Moormann verfasserin aut Doyle V. Ward verfasserin aut Beth A. McCormick verfasserin aut Vanni Bucci verfasserin aut In JCI Insight American Society for Clinical investigation, 2020 6(2021), 20 (DE-627)872610594 (DE-600)2874757-4 23793708 nnns volume:6 year:2021 number:20 https://doaj.org/article/193c7559a3794fd88d29155faf3cb51b kostenfrei https://doi.org/10.1172/jci.insight.152346 kostenfrei https://doaj.org/toc/2379-3708 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2021 20 |
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(DE-627)DOAJ027381773 (DE-599)DOAJ193c7559a3794fd88d29155faf3cb51b DE-627 ger DE-627 rakwb eng John P. Haran verfasserin aut Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the COVID-19 pandemic, caused by SARS-CoV-2, many individuals experience prolonged symptoms, termed long-lasting COVID-19 symptoms (long COVID). Long COVID is thought to be linked to immune dysregulation due to harmful inflammation, with the exact causes being unknown. Given the role of the microbiome in mediating inflammation, we aimed to examine the relationship between the oral microbiome and the duration of long COVID symptoms. Tongue swabs were collected from patients presenting with COVID-19 symptoms. Confirmed infections were followed until resolution of all symptoms. Bacterial composition was determined by metagenomic sequencing. We used random forest modeling to identify microbiota and clinical covariates that are associated with long COVID symptoms. Of the patients followed, 63% developed ongoing symptomatic COVID-19 and 37% went on to long COVID. Patients with prolonged symptoms had significantly higher abundances of microbiota that induced inflammation, such as members of the genera Prevotella and Veillonella, which, of note, are species that produce LPS. The oral microbiome of patients with long COVID was similar to that of patients with chronic fatigue syndrome. Altogether, our findings suggest an association with the oral microbiome and long COVID, revealing the possibility that dysfunction of the oral microbiome may have contributed to this draining disease. COVID-19 Inflammation Medicine R Evan Bradley verfasserin aut Abigail L. Zeamer verfasserin aut Lindsey Cincotta verfasserin aut Marie-Claire Salive verfasserin aut Protiva Dutta verfasserin aut Shafik Mutaawe verfasserin aut Otuwe Anya verfasserin aut Mario Meza-Segura verfasserin aut Ann M. Moormann verfasserin aut Doyle V. Ward verfasserin aut Beth A. McCormick verfasserin aut Vanni Bucci verfasserin aut In JCI Insight American Society for Clinical investigation, 2020 6(2021), 20 (DE-627)872610594 (DE-600)2874757-4 23793708 nnns volume:6 year:2021 number:20 https://doaj.org/article/193c7559a3794fd88d29155faf3cb51b kostenfrei https://doi.org/10.1172/jci.insight.152346 kostenfrei https://doaj.org/toc/2379-3708 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2021 20 |
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(DE-627)DOAJ027381773 (DE-599)DOAJ193c7559a3794fd88d29155faf3cb51b DE-627 ger DE-627 rakwb eng John P. Haran verfasserin aut Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the COVID-19 pandemic, caused by SARS-CoV-2, many individuals experience prolonged symptoms, termed long-lasting COVID-19 symptoms (long COVID). Long COVID is thought to be linked to immune dysregulation due to harmful inflammation, with the exact causes being unknown. Given the role of the microbiome in mediating inflammation, we aimed to examine the relationship between the oral microbiome and the duration of long COVID symptoms. Tongue swabs were collected from patients presenting with COVID-19 symptoms. Confirmed infections were followed until resolution of all symptoms. Bacterial composition was determined by metagenomic sequencing. We used random forest modeling to identify microbiota and clinical covariates that are associated with long COVID symptoms. Of the patients followed, 63% developed ongoing symptomatic COVID-19 and 37% went on to long COVID. Patients with prolonged symptoms had significantly higher abundances of microbiota that induced inflammation, such as members of the genera Prevotella and Veillonella, which, of note, are species that produce LPS. The oral microbiome of patients with long COVID was similar to that of patients with chronic fatigue syndrome. Altogether, our findings suggest an association with the oral microbiome and long COVID, revealing the possibility that dysfunction of the oral microbiome may have contributed to this draining disease. COVID-19 Inflammation Medicine R Evan Bradley verfasserin aut Abigail L. Zeamer verfasserin aut Lindsey Cincotta verfasserin aut Marie-Claire Salive verfasserin aut Protiva Dutta verfasserin aut Shafik Mutaawe verfasserin aut Otuwe Anya verfasserin aut Mario Meza-Segura verfasserin aut Ann M. Moormann verfasserin aut Doyle V. Ward verfasserin aut Beth A. McCormick verfasserin aut Vanni Bucci verfasserin aut In JCI Insight American Society for Clinical investigation, 2020 6(2021), 20 (DE-627)872610594 (DE-600)2874757-4 23793708 nnns volume:6 year:2021 number:20 https://doaj.org/article/193c7559a3794fd88d29155faf3cb51b kostenfrei https://doi.org/10.1172/jci.insight.152346 kostenfrei https://doaj.org/toc/2379-3708 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2021 20 |
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Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID |
abstract |
In the COVID-19 pandemic, caused by SARS-CoV-2, many individuals experience prolonged symptoms, termed long-lasting COVID-19 symptoms (long COVID). Long COVID is thought to be linked to immune dysregulation due to harmful inflammation, with the exact causes being unknown. Given the role of the microbiome in mediating inflammation, we aimed to examine the relationship between the oral microbiome and the duration of long COVID symptoms. Tongue swabs were collected from patients presenting with COVID-19 symptoms. Confirmed infections were followed until resolution of all symptoms. Bacterial composition was determined by metagenomic sequencing. We used random forest modeling to identify microbiota and clinical covariates that are associated with long COVID symptoms. Of the patients followed, 63% developed ongoing symptomatic COVID-19 and 37% went on to long COVID. Patients with prolonged symptoms had significantly higher abundances of microbiota that induced inflammation, such as members of the genera Prevotella and Veillonella, which, of note, are species that produce LPS. The oral microbiome of patients with long COVID was similar to that of patients with chronic fatigue syndrome. Altogether, our findings suggest an association with the oral microbiome and long COVID, revealing the possibility that dysfunction of the oral microbiome may have contributed to this draining disease. |
abstractGer |
In the COVID-19 pandemic, caused by SARS-CoV-2, many individuals experience prolonged symptoms, termed long-lasting COVID-19 symptoms (long COVID). Long COVID is thought to be linked to immune dysregulation due to harmful inflammation, with the exact causes being unknown. Given the role of the microbiome in mediating inflammation, we aimed to examine the relationship between the oral microbiome and the duration of long COVID symptoms. Tongue swabs were collected from patients presenting with COVID-19 symptoms. Confirmed infections were followed until resolution of all symptoms. Bacterial composition was determined by metagenomic sequencing. We used random forest modeling to identify microbiota and clinical covariates that are associated with long COVID symptoms. Of the patients followed, 63% developed ongoing symptomatic COVID-19 and 37% went on to long COVID. Patients with prolonged symptoms had significantly higher abundances of microbiota that induced inflammation, such as members of the genera Prevotella and Veillonella, which, of note, are species that produce LPS. The oral microbiome of patients with long COVID was similar to that of patients with chronic fatigue syndrome. Altogether, our findings suggest an association with the oral microbiome and long COVID, revealing the possibility that dysfunction of the oral microbiome may have contributed to this draining disease. |
abstract_unstemmed |
In the COVID-19 pandemic, caused by SARS-CoV-2, many individuals experience prolonged symptoms, termed long-lasting COVID-19 symptoms (long COVID). Long COVID is thought to be linked to immune dysregulation due to harmful inflammation, with the exact causes being unknown. Given the role of the microbiome in mediating inflammation, we aimed to examine the relationship between the oral microbiome and the duration of long COVID symptoms. Tongue swabs were collected from patients presenting with COVID-19 symptoms. Confirmed infections were followed until resolution of all symptoms. Bacterial composition was determined by metagenomic sequencing. We used random forest modeling to identify microbiota and clinical covariates that are associated with long COVID symptoms. Of the patients followed, 63% developed ongoing symptomatic COVID-19 and 37% went on to long COVID. Patients with prolonged symptoms had significantly higher abundances of microbiota that induced inflammation, such as members of the genera Prevotella and Veillonella, which, of note, are species that produce LPS. The oral microbiome of patients with long COVID was similar to that of patients with chronic fatigue syndrome. Altogether, our findings suggest an association with the oral microbiome and long COVID, revealing the possibility that dysfunction of the oral microbiome may have contributed to this draining disease. |
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Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID |
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