Epicardial Adipose Tissue and Cardiac Arrhythmias: Focus on Atrial Fibrillation

Atrial Fibrillation (AF) is the most frequent cardiac arrhythmia and its prevalence increases with age. AF is strongly associated with an increased risk of stroke, heart failure and cardiovascular mortality. Among the risk factors associated with AF onset and severity, obesity and inflammation play...
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Gespeichert in:

Autor*in:	Maddalena Conte [verfasserIn] Laura Petraglia [verfasserIn] Serena Cabaro [verfasserIn] Vincenza Valerio [verfasserIn] Paolo Poggio [verfasserIn] Emanuele Pilato [verfasserIn] Emilio Attena [verfasserIn] Vincenzo Russo [verfasserIn] Adele Ferro [verfasserIn] Pietro Formisano [verfasserIn] Dario Leosco [verfasserIn] Valentina Parisi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	epicardial adipose tissue visceral fat inflammation atrial fibrillation fibrosis atrial remodeling

Übergeordnetes Werk:	In: Frontiers in Cardiovascular Medicine - Frontiers Media S.A., 2015, 9(2022)
Übergeordnetes Werk:	volume:9 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fcvm.2022.932262

Katalog-ID:	DOAJ027438783

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author	Maddalena Conte
spellingShingle	Maddalena Conte misc RC666-701 misc epicardial adipose tissue misc visceral fat misc inflammation misc atrial fibrillation misc fibrosis misc atrial remodeling misc Diseases of the circulatory (Cardiovascular) system Epicardial Adipose Tissue and Cardiac Arrhythmias: Focus on Atrial Fibrillation
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topic_title	RC666-701 Epicardial Adipose Tissue and Cardiac Arrhythmias: Focus on Atrial Fibrillation epicardial adipose tissue visceral fat inflammation atrial fibrillation fibrosis atrial remodeling
topic	misc RC666-701 misc epicardial adipose tissue misc visceral fat misc inflammation misc atrial fibrillation misc fibrosis misc atrial remodeling misc Diseases of the circulatory (Cardiovascular) system
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title	Epicardial Adipose Tissue and Cardiac Arrhythmias: Focus on Atrial Fibrillation
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title_sort	epicardial adipose tissue and cardiac arrhythmias: focus on atrial fibrillation
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title_auth	Epicardial Adipose Tissue and Cardiac Arrhythmias: Focus on Atrial Fibrillation
abstract	Atrial Fibrillation (AF) is the most frequent cardiac arrhythmia and its prevalence increases with age. AF is strongly associated with an increased risk of stroke, heart failure and cardiovascular mortality. Among the risk factors associated with AF onset and severity, obesity and inflammation play a prominent role. Numerous recent evidence suggested a role of epicardial adipose tissue (EAT), the visceral fat depot of the heart, in the development of AF. Several potential arrhythmogenic mechanisms have been attributed to EAT, including myocardial inflammation, fibrosis, oxidative stress, and fat infiltration. EAT is a local source of inflammatory mediators which potentially contribute to atrial collagen deposition and fibrosis, the anatomical substrate for AF. Moreover, the close proximity between EAT and myocardium allows the EAT to penetrate and generate atrial myocardium fat infiltrates that can alter atrial electrophysiological properties. These observations support the hypothesis of a strong implication of EAT in structural and electrical atrial remodeling, which underlies AF onset and burden. The measure of EAT, through different imaging methods, such as echocardiography, computed tomography and cardiac magnetic resonance, has been proposed as a useful prognostic tool to predict the presence, severity and recurrence of AF. Furthermore, EAT is increasingly emerging as a promising potential therapeutic target. This review aims to summarize the recent evidence exploring the potential role of EAT in the pathogenesis of AF, the main mechanisms by which EAT can promote structural and electrical atrial remodeling and the potential therapeutic strategies targeting the cardiac visceral fat.
abstractGer	Atrial Fibrillation (AF) is the most frequent cardiac arrhythmia and its prevalence increases with age. AF is strongly associated with an increased risk of stroke, heart failure and cardiovascular mortality. Among the risk factors associated with AF onset and severity, obesity and inflammation play a prominent role. Numerous recent evidence suggested a role of epicardial adipose tissue (EAT), the visceral fat depot of the heart, in the development of AF. Several potential arrhythmogenic mechanisms have been attributed to EAT, including myocardial inflammation, fibrosis, oxidative stress, and fat infiltration. EAT is a local source of inflammatory mediators which potentially contribute to atrial collagen deposition and fibrosis, the anatomical substrate for AF. Moreover, the close proximity between EAT and myocardium allows the EAT to penetrate and generate atrial myocardium fat infiltrates that can alter atrial electrophysiological properties. These observations support the hypothesis of a strong implication of EAT in structural and electrical atrial remodeling, which underlies AF onset and burden. The measure of EAT, through different imaging methods, such as echocardiography, computed tomography and cardiac magnetic resonance, has been proposed as a useful prognostic tool to predict the presence, severity and recurrence of AF. Furthermore, EAT is increasingly emerging as a promising potential therapeutic target. This review aims to summarize the recent evidence exploring the potential role of EAT in the pathogenesis of AF, the main mechanisms by which EAT can promote structural and electrical atrial remodeling and the potential therapeutic strategies targeting the cardiac visceral fat.
abstract_unstemmed	Atrial Fibrillation (AF) is the most frequent cardiac arrhythmia and its prevalence increases with age. AF is strongly associated with an increased risk of stroke, heart failure and cardiovascular mortality. Among the risk factors associated with AF onset and severity, obesity and inflammation play a prominent role. Numerous recent evidence suggested a role of epicardial adipose tissue (EAT), the visceral fat depot of the heart, in the development of AF. Several potential arrhythmogenic mechanisms have been attributed to EAT, including myocardial inflammation, fibrosis, oxidative stress, and fat infiltration. EAT is a local source of inflammatory mediators which potentially contribute to atrial collagen deposition and fibrosis, the anatomical substrate for AF. Moreover, the close proximity between EAT and myocardium allows the EAT to penetrate and generate atrial myocardium fat infiltrates that can alter atrial electrophysiological properties. These observations support the hypothesis of a strong implication of EAT in structural and electrical atrial remodeling, which underlies AF onset and burden. The measure of EAT, through different imaging methods, such as echocardiography, computed tomography and cardiac magnetic resonance, has been proposed as a useful prognostic tool to predict the presence, severity and recurrence of AF. Furthermore, EAT is increasingly emerging as a promising potential therapeutic target. This review aims to summarize the recent evidence exploring the potential role of EAT in the pathogenesis of AF, the main mechanisms by which EAT can promote structural and electrical atrial remodeling and the potential therapeutic strategies targeting the cardiac visceral fat.
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title_short	Epicardial Adipose Tissue and Cardiac Arrhythmias: Focus on Atrial Fibrillation
url	https://doi.org/10.3389/fcvm.2022.932262 https://doaj.org/article/68d47a9b12bf4555b5d82b3450849124 https://www.frontiersin.org/articles/10.3389/fcvm.2022.932262/full https://doaj.org/toc/2297-055X
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