Immunogenic Properties Studyoffusion Recombinant Proteins Based on VP6 and VP8 of Human Rotavirus A
Rotavirus infection is the leading cause of severe acute diarrhea among young children worldwide. Contagion with these viruses often leads to severe dehydration of organism. Rotaviral gastroenteritis cases may repeat intra vitam. Because of the absence of drugs with direct action on rotavirus, a tim...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
I. V. Dukhovlinov [verfasserIn] E. G. Bogomolova [verfasserIn] E. A. Fedorova [verfasserIn] A. S. Simbirtsev [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Russisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Эпидемиология и вакцинопрофилактика - Numikom LLC, 2019, 14(2015), 2, Seite 96-101 |
|---|---|
| Übergeordnetes Werk: |
volume:14 ; year:2015 ; number:2 ; pages:96-101 |
| Links: |
Link aufrufen |
|---|
| DOI / URN: |
10.31631/2073-3046-2015-14-2-96-101 |
|---|
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DOAJ027579697 |
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| 520 | |a Rotavirus infection is the leading cause of severe acute diarrhea among young children worldwide. Contagion with these viruses often leads to severe dehydration of organism. Rotaviral gastroenteritis cases may repeat intra vitam. Because of the absence of drugs with direct action on rotavirus, a timely vaccination is considered the most effective way of this disease's control. Nowadays vaccines based on attenuated alive rotaviral strains are used for this purpose, which can result in different complications. In this work the immunogenicity of recombinant fusion proteins VP6VP8 and FliCVP6VP8 - the crucial active agents of the candidate vaccine against rotaviruses - was studied. As part of the study highly purified proteins preparationsin native state were obtained, their high antigenic activity in experiments with laboratory Balb/c mice was demonstrated. | ||
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Immunogenic Properties Studyoffusion Recombinant Proteins Based on VP6 and VP8 of Human Rotavirus A |
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I. V. Dukhovlinov |
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Эпидемиология и вакцинопрофилактика |
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Эпидемиология и вакцинопрофилактика |
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rus |
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2015 |
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96 |
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I. V. Dukhovlinov E. G. Bogomolova E. A. Fedorova A. S. Simbirtsev |
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14 |
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BD143-237 |
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Elektronische Aufsätze |
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I. V. Dukhovlinov |
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10.31631/2073-3046-2015-14-2-96-101 |
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verfasserin |
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immunogenic properties studyoffusion recombinant proteins based on vp6 and vp8 of human rotavirus a |
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BD143-237 |
| title_auth |
Immunogenic Properties Studyoffusion Recombinant Proteins Based on VP6 and VP8 of Human Rotavirus A |
| abstract |
Rotavirus infection is the leading cause of severe acute diarrhea among young children worldwide. Contagion with these viruses often leads to severe dehydration of organism. Rotaviral gastroenteritis cases may repeat intra vitam. Because of the absence of drugs with direct action on rotavirus, a timely vaccination is considered the most effective way of this disease's control. Nowadays vaccines based on attenuated alive rotaviral strains are used for this purpose, which can result in different complications. In this work the immunogenicity of recombinant fusion proteins VP6VP8 and FliCVP6VP8 - the crucial active agents of the candidate vaccine against rotaviruses - was studied. As part of the study highly purified proteins preparationsin native state were obtained, their high antigenic activity in experiments with laboratory Balb/c mice was demonstrated. |
| abstractGer |
Rotavirus infection is the leading cause of severe acute diarrhea among young children worldwide. Contagion with these viruses often leads to severe dehydration of organism. Rotaviral gastroenteritis cases may repeat intra vitam. Because of the absence of drugs with direct action on rotavirus, a timely vaccination is considered the most effective way of this disease's control. Nowadays vaccines based on attenuated alive rotaviral strains are used for this purpose, which can result in different complications. In this work the immunogenicity of recombinant fusion proteins VP6VP8 and FliCVP6VP8 - the crucial active agents of the candidate vaccine against rotaviruses - was studied. As part of the study highly purified proteins preparationsin native state were obtained, their high antigenic activity in experiments with laboratory Balb/c mice was demonstrated. |
| abstract_unstemmed |
Rotavirus infection is the leading cause of severe acute diarrhea among young children worldwide. Contagion with these viruses often leads to severe dehydration of organism. Rotaviral gastroenteritis cases may repeat intra vitam. Because of the absence of drugs with direct action on rotavirus, a timely vaccination is considered the most effective way of this disease's control. Nowadays vaccines based on attenuated alive rotaviral strains are used for this purpose, which can result in different complications. In this work the immunogenicity of recombinant fusion proteins VP6VP8 and FliCVP6VP8 - the crucial active agents of the candidate vaccine against rotaviruses - was studied. As part of the study highly purified proteins preparationsin native state were obtained, their high antigenic activity in experiments with laboratory Balb/c mice was demonstrated. |
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Immunogenic Properties Studyoffusion Recombinant Proteins Based on VP6 and VP8 of Human Rotavirus A |
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https://doi.org/10.31631/2073-3046-2015-14-2-96-101 https://doaj.org/article/14af003a238f4cdcae7289a1d64a7adb https://www.epidemvac.ru/jour/article/view/45 https://doaj.org/toc/2073-3046 https://doaj.org/toc/2619-0494 |
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E. G. Bogomolova E. A. Fedorova A. S. Simbirtsev |
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E. G. Bogomolova E. A. Fedorova A. S. Simbirtsev |
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1760606634 |
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BD - Speculative Philosophy |
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10.31631/2073-3046-2015-14-2-96-101 |
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| up_date |
2024-07-04T02:13:16.998Z |
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