Vitamin D and VDR in Gynecological Cancers—A Systematic Review

In recent years, a vast amount of studies have centered on the role of vitamin D in the pathogenesis of certain types of cancers such as breast, colorectal and lung cancer. Increasing evidence suggests that vitamin D and its receptor play a crucial role in the development of gynecological cancers. I...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Eileen Deuster [verfasserIn] Udo Jeschke [verfasserIn] Yao Ye [verfasserIn] Sven Mahner [verfasserIn] Bastian Czogalla [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	vitamin D vitamin D receptor VDR gynecological cancers ovarian endometrial cervical vulvar vaginal cancer

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 18(2017), 11, p 2328
Übergeordnetes Werk:	volume:18 ; year:2017 ; number:11, p 2328

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ijms18112328

Katalog-ID:	DOAJ027647102

Internformat


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author_variant	e d ed u j uj y y yy s m sm b c bc
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allfields	10.3390/ijms18112328 doi (DE-627)DOAJ027647102 (DE-599)DOAJcd8d4c28be154470af0f41b44ceff888 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Eileen Deuster verfasserin aut Vitamin D and VDR in Gynecological Cancers—A Systematic Review 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In recent years, a vast amount of studies have centered on the role of vitamin D in the pathogenesis of certain types of cancers such as breast, colorectal and lung cancer. Increasing evidence suggests that vitamin D and its receptor play a crucial role in the development of gynecological cancers. In this review, we systematically analyzed the effect of vitamin D and the vitamin D receptor on endometrial, ovarian, cervical, vulvar and vaginal cancer. Our literature research shows that vitamin D levels and vitamin-D-related pathways affect the risk of gynecological cancers. Numerous ecological studies give evidence on the inverse relationship between UVB exposure and gynecological cancer risk. However, epidemiologic research is still inconclusive for endometrial and ovarian cancer and insufficient for rarer types of gynecological cancers. The vitamin D receptor (VDR) is upregulated in all gynecological cancers, indicating its influence on cancer etiology. The VDR polymorphism FokI (rs2228570) seems to increase the risk of ovarian cancer. Other nuclear receptors, such as the RXR, also influence gynecological cancers. Although there is limited knowledge on the role of the VDR/RXR on the survival of endometrial, cervical, vulvar or vaginal cancer patients, some studies showed that both receptors influence survival. Therefore, we suggest that further studies should focus on the vitamin D- and its hetero dimer receptor RXR in gynecological cancers. vitamin D vitamin D receptor VDR gynecological cancers ovarian endometrial cervical vulvar vaginal cancer Biology (General) Chemistry Udo Jeschke verfasserin aut Yao Ye verfasserin aut Sven Mahner verfasserin aut Bastian Czogalla verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 18(2017), 11, p 2328 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:18 year:2017 number:11, p 2328 https://doi.org/10.3390/ijms18112328 kostenfrei https://doaj.org/article/cd8d4c28be154470af0f41b44ceff888 kostenfrei https://www.mdpi.com/1422-0067/18/11/2328 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 11, p 2328
spelling	10.3390/ijms18112328 doi (DE-627)DOAJ027647102 (DE-599)DOAJcd8d4c28be154470af0f41b44ceff888 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Eileen Deuster verfasserin aut Vitamin D and VDR in Gynecological Cancers—A Systematic Review 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In recent years, a vast amount of studies have centered on the role of vitamin D in the pathogenesis of certain types of cancers such as breast, colorectal and lung cancer. Increasing evidence suggests that vitamin D and its receptor play a crucial role in the development of gynecological cancers. In this review, we systematically analyzed the effect of vitamin D and the vitamin D receptor on endometrial, ovarian, cervical, vulvar and vaginal cancer. Our literature research shows that vitamin D levels and vitamin-D-related pathways affect the risk of gynecological cancers. Numerous ecological studies give evidence on the inverse relationship between UVB exposure and gynecological cancer risk. However, epidemiologic research is still inconclusive for endometrial and ovarian cancer and insufficient for rarer types of gynecological cancers. The vitamin D receptor (VDR) is upregulated in all gynecological cancers, indicating its influence on cancer etiology. The VDR polymorphism FokI (rs2228570) seems to increase the risk of ovarian cancer. Other nuclear receptors, such as the RXR, also influence gynecological cancers. Although there is limited knowledge on the role of the VDR/RXR on the survival of endometrial, cervical, vulvar or vaginal cancer patients, some studies showed that both receptors influence survival. Therefore, we suggest that further studies should focus on the vitamin D- and its hetero dimer receptor RXR in gynecological cancers. vitamin D vitamin D receptor VDR gynecological cancers ovarian endometrial cervical vulvar vaginal cancer Biology (General) Chemistry Udo Jeschke verfasserin aut Yao Ye verfasserin aut Sven Mahner verfasserin aut Bastian Czogalla verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 18(2017), 11, p 2328 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:18 year:2017 number:11, p 2328 https://doi.org/10.3390/ijms18112328 kostenfrei https://doaj.org/article/cd8d4c28be154470af0f41b44ceff888 kostenfrei https://www.mdpi.com/1422-0067/18/11/2328 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 11, p 2328
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allfieldsGer	10.3390/ijms18112328 doi (DE-627)DOAJ027647102 (DE-599)DOAJcd8d4c28be154470af0f41b44ceff888 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Eileen Deuster verfasserin aut Vitamin D and VDR in Gynecological Cancers—A Systematic Review 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In recent years, a vast amount of studies have centered on the role of vitamin D in the pathogenesis of certain types of cancers such as breast, colorectal and lung cancer. Increasing evidence suggests that vitamin D and its receptor play a crucial role in the development of gynecological cancers. In this review, we systematically analyzed the effect of vitamin D and the vitamin D receptor on endometrial, ovarian, cervical, vulvar and vaginal cancer. Our literature research shows that vitamin D levels and vitamin-D-related pathways affect the risk of gynecological cancers. Numerous ecological studies give evidence on the inverse relationship between UVB exposure and gynecological cancer risk. However, epidemiologic research is still inconclusive for endometrial and ovarian cancer and insufficient for rarer types of gynecological cancers. The vitamin D receptor (VDR) is upregulated in all gynecological cancers, indicating its influence on cancer etiology. The VDR polymorphism FokI (rs2228570) seems to increase the risk of ovarian cancer. Other nuclear receptors, such as the RXR, also influence gynecological cancers. Although there is limited knowledge on the role of the VDR/RXR on the survival of endometrial, cervical, vulvar or vaginal cancer patients, some studies showed that both receptors influence survival. Therefore, we suggest that further studies should focus on the vitamin D- and its hetero dimer receptor RXR in gynecological cancers. vitamin D vitamin D receptor VDR gynecological cancers ovarian endometrial cervical vulvar vaginal cancer Biology (General) Chemistry Udo Jeschke verfasserin aut Yao Ye verfasserin aut Sven Mahner verfasserin aut Bastian Czogalla verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 18(2017), 11, p 2328 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:18 year:2017 number:11, p 2328 https://doi.org/10.3390/ijms18112328 kostenfrei https://doaj.org/article/cd8d4c28be154470af0f41b44ceff888 kostenfrei https://www.mdpi.com/1422-0067/18/11/2328 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 11, p 2328
allfieldsSound	10.3390/ijms18112328 doi (DE-627)DOAJ027647102 (DE-599)DOAJcd8d4c28be154470af0f41b44ceff888 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Eileen Deuster verfasserin aut Vitamin D and VDR in Gynecological Cancers—A Systematic Review 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In recent years, a vast amount of studies have centered on the role of vitamin D in the pathogenesis of certain types of cancers such as breast, colorectal and lung cancer. Increasing evidence suggests that vitamin D and its receptor play a crucial role in the development of gynecological cancers. In this review, we systematically analyzed the effect of vitamin D and the vitamin D receptor on endometrial, ovarian, cervical, vulvar and vaginal cancer. Our literature research shows that vitamin D levels and vitamin-D-related pathways affect the risk of gynecological cancers. Numerous ecological studies give evidence on the inverse relationship between UVB exposure and gynecological cancer risk. However, epidemiologic research is still inconclusive for endometrial and ovarian cancer and insufficient for rarer types of gynecological cancers. The vitamin D receptor (VDR) is upregulated in all gynecological cancers, indicating its influence on cancer etiology. The VDR polymorphism FokI (rs2228570) seems to increase the risk of ovarian cancer. Other nuclear receptors, such as the RXR, also influence gynecological cancers. Although there is limited knowledge on the role of the VDR/RXR on the survival of endometrial, cervical, vulvar or vaginal cancer patients, some studies showed that both receptors influence survival. Therefore, we suggest that further studies should focus on the vitamin D- and its hetero dimer receptor RXR in gynecological cancers. vitamin D vitamin D receptor VDR gynecological cancers ovarian endometrial cervical vulvar vaginal cancer Biology (General) Chemistry Udo Jeschke verfasserin aut Yao Ye verfasserin aut Sven Mahner verfasserin aut Bastian Czogalla verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 18(2017), 11, p 2328 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:18 year:2017 number:11, p 2328 https://doi.org/10.3390/ijms18112328 kostenfrei https://doaj.org/article/cd8d4c28be154470af0f41b44ceff888 kostenfrei https://www.mdpi.com/1422-0067/18/11/2328 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 11, p 2328
language	English
source	In International Journal of Molecular Sciences 18(2017), 11, p 2328 volume:18 year:2017 number:11, p 2328
sourceStr	In International Journal of Molecular Sciences 18(2017), 11, p 2328 volume:18 year:2017 number:11, p 2328
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topic_facet	vitamin D vitamin D receptor VDR gynecological cancers ovarian endometrial cervical vulvar vaginal cancer Biology (General) Chemistry
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container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Eileen Deuster @@aut@@ Udo Jeschke @@aut@@ Yao Ye @@aut@@ Sven Mahner @@aut@@ Bastian Czogalla @@aut@@
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callnumber-first	Q - Science
author	Eileen Deuster
spellingShingle	Eileen Deuster misc QH301-705.5 misc QD1-999 misc vitamin D misc vitamin D receptor misc VDR misc gynecological cancers misc ovarian misc endometrial misc cervical misc vulvar misc vaginal misc cancer misc Biology (General) misc Chemistry Vitamin D and VDR in Gynecological Cancers—A Systematic Review
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topic_title	QH301-705.5 QD1-999 Vitamin D and VDR in Gynecological Cancers—A Systematic Review vitamin D vitamin D receptor VDR gynecological cancers ovarian endometrial cervical vulvar vaginal cancer
topic	misc QH301-705.5 misc QD1-999 misc vitamin D misc vitamin D receptor misc VDR misc gynecological cancers misc ovarian misc endometrial misc cervical misc vulvar misc vaginal misc cancer misc Biology (General) misc Chemistry
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title_sort	vitamin d and vdr in gynecological cancers—a systematic review
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title_auth	Vitamin D and VDR in Gynecological Cancers—A Systematic Review
abstract	In recent years, a vast amount of studies have centered on the role of vitamin D in the pathogenesis of certain types of cancers such as breast, colorectal and lung cancer. Increasing evidence suggests that vitamin D and its receptor play a crucial role in the development of gynecological cancers. In this review, we systematically analyzed the effect of vitamin D and the vitamin D receptor on endometrial, ovarian, cervical, vulvar and vaginal cancer. Our literature research shows that vitamin D levels and vitamin-D-related pathways affect the risk of gynecological cancers. Numerous ecological studies give evidence on the inverse relationship between UVB exposure and gynecological cancer risk. However, epidemiologic research is still inconclusive for endometrial and ovarian cancer and insufficient for rarer types of gynecological cancers. The vitamin D receptor (VDR) is upregulated in all gynecological cancers, indicating its influence on cancer etiology. The VDR polymorphism FokI (rs2228570) seems to increase the risk of ovarian cancer. Other nuclear receptors, such as the RXR, also influence gynecological cancers. Although there is limited knowledge on the role of the VDR/RXR on the survival of endometrial, cervical, vulvar or vaginal cancer patients, some studies showed that both receptors influence survival. Therefore, we suggest that further studies should focus on the vitamin D- and its hetero dimer receptor RXR in gynecological cancers.
abstractGer	In recent years, a vast amount of studies have centered on the role of vitamin D in the pathogenesis of certain types of cancers such as breast, colorectal and lung cancer. Increasing evidence suggests that vitamin D and its receptor play a crucial role in the development of gynecological cancers. In this review, we systematically analyzed the effect of vitamin D and the vitamin D receptor on endometrial, ovarian, cervical, vulvar and vaginal cancer. Our literature research shows that vitamin D levels and vitamin-D-related pathways affect the risk of gynecological cancers. Numerous ecological studies give evidence on the inverse relationship between UVB exposure and gynecological cancer risk. However, epidemiologic research is still inconclusive for endometrial and ovarian cancer and insufficient for rarer types of gynecological cancers. The vitamin D receptor (VDR) is upregulated in all gynecological cancers, indicating its influence on cancer etiology. The VDR polymorphism FokI (rs2228570) seems to increase the risk of ovarian cancer. Other nuclear receptors, such as the RXR, also influence gynecological cancers. Although there is limited knowledge on the role of the VDR/RXR on the survival of endometrial, cervical, vulvar or vaginal cancer patients, some studies showed that both receptors influence survival. Therefore, we suggest that further studies should focus on the vitamin D- and its hetero dimer receptor RXR in gynecological cancers.
abstract_unstemmed	In recent years, a vast amount of studies have centered on the role of vitamin D in the pathogenesis of certain types of cancers such as breast, colorectal and lung cancer. Increasing evidence suggests that vitamin D and its receptor play a crucial role in the development of gynecological cancers. In this review, we systematically analyzed the effect of vitamin D and the vitamin D receptor on endometrial, ovarian, cervical, vulvar and vaginal cancer. Our literature research shows that vitamin D levels and vitamin-D-related pathways affect the risk of gynecological cancers. Numerous ecological studies give evidence on the inverse relationship between UVB exposure and gynecological cancer risk. However, epidemiologic research is still inconclusive for endometrial and ovarian cancer and insufficient for rarer types of gynecological cancers. The vitamin D receptor (VDR) is upregulated in all gynecological cancers, indicating its influence on cancer etiology. The VDR polymorphism FokI (rs2228570) seems to increase the risk of ovarian cancer. Other nuclear receptors, such as the RXR, also influence gynecological cancers. Although there is limited knowledge on the role of the VDR/RXR on the survival of endometrial, cervical, vulvar or vaginal cancer patients, some studies showed that both receptors influence survival. Therefore, we suggest that further studies should focus on the vitamin D- and its hetero dimer receptor RXR in gynecological cancers.
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title_short	Vitamin D and VDR in Gynecological Cancers—A Systematic Review
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Although there is limited knowledge on the role of the VDR/RXR on the survival of endometrial, cervical, vulvar or vaginal cancer patients, some studies showed that both receptors influence survival. 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Vitamin D and VDR in Gynecological Cancers—A Systematic Review

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