Isomeric lipid signatures reveal compartmentalized fatty acid metabolism in cancer

The cellular energy and biomass demands of cancer drive a complex dynamic between uptake of extracellular FAs and their de novo synthesis. Given that oxidation of de novo synthesized FAs for energy would result in net-energy loss, there is an implication that FAs from these two sources must have dis...
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Autor*in:	Reuben S.E. Young [verfasserIn] Andrew P. Bowman [verfasserIn] Kaylyn D. Tousignant [verfasserIn] Berwyck L.J. Poad [verfasserIn] Jennifer H. Gunter [verfasserIn] Lisa K. Philp [verfasserIn] Colleen C. Nelson [verfasserIn] Shane R. Ellis [verfasserIn] Ron M.A. Heeren [verfasserIn] Martin C. Sadowski [verfasserIn] Stephen J. Blanksby [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	FA/transport lipolysis and FA metabolism lipase phospholipid/metabolism phospholipids/phosphatidylcholine lipid isomers

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 63(2022), 6, Seite 100223-
Übergeordnetes Werk:	volume:63 ; year:2022 ; number:6 ; pages:100223-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jlr.2022.100223

Katalog-ID:	DOAJ027724840

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callnumber-first	Q - Science
author	Reuben S.E. Young
spellingShingle	Reuben S.E. Young misc QD415-436 misc FA/transport misc lipolysis and FA metabolism misc lipase misc phospholipid/metabolism misc phospholipids/phosphatidylcholine misc lipid isomers misc Biochemistry Isomeric lipid signatures reveal compartmentalized fatty acid metabolism in cancer
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topic_title	QD415-436 Isomeric lipid signatures reveal compartmentalized fatty acid metabolism in cancer FA/transport lipolysis and FA metabolism lipase phospholipid/metabolism phospholipids/phosphatidylcholine lipid isomers
topic	misc QD415-436 misc FA/transport misc lipolysis and FA metabolism misc lipase misc phospholipid/metabolism misc phospholipids/phosphatidylcholine misc lipid isomers misc Biochemistry
topic_unstemmed	misc QD415-436 misc FA/transport misc lipolysis and FA metabolism misc lipase misc phospholipid/metabolism misc phospholipids/phosphatidylcholine misc lipid isomers misc Biochemistry
topic_browse	misc QD415-436 misc FA/transport misc lipolysis and FA metabolism misc lipase misc phospholipid/metabolism misc phospholipids/phosphatidylcholine misc lipid isomers misc Biochemistry
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title	Isomeric lipid signatures reveal compartmentalized fatty acid metabolism in cancer
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title_full	Isomeric lipid signatures reveal compartmentalized fatty acid metabolism in cancer
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author_browse	Reuben S.E. Young Andrew P. Bowman Kaylyn D. Tousignant Berwyck L.J. Poad Jennifer H. Gunter Lisa K. Philp Colleen C. Nelson Shane R. Ellis Ron M.A. Heeren Martin C. Sadowski Stephen J. Blanksby
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title_sort	isomeric lipid signatures reveal compartmentalized fatty acid metabolism in cancer
callnumber	QD415-436
title_auth	Isomeric lipid signatures reveal compartmentalized fatty acid metabolism in cancer
abstract	The cellular energy and biomass demands of cancer drive a complex dynamic between uptake of extracellular FAs and their de novo synthesis. Given that oxidation of de novo synthesized FAs for energy would result in net-energy loss, there is an implication that FAs from these two sources must have distinct metabolic fates; however, hitherto, all FAs have been considered part of a common pool. To probe potential metabolic partitioning of cellular FAs, cancer cells were supplemented with stable isotope-labeled FAs. Structural analysis of the resulting glycerophospholipids revealed that labeled FAs from uptake were largely incorporated to canonical (sn-) positions on the glycerol backbone. Surprisingly, labeled FA uptake also disrupted canonical isomer patterns of the unlabeled lipidome and induced repartitioning of n-3 and n-6 PUFAs into glycerophospholipid classes. These structural changes support the existence of differences in the metabolic fates of FAs derived from uptake or de novo sources and demonstrate unique signaling and remodeling behaviors usually hidden from conventional lipidomics.
abstractGer	The cellular energy and biomass demands of cancer drive a complex dynamic between uptake of extracellular FAs and their de novo synthesis. Given that oxidation of de novo synthesized FAs for energy would result in net-energy loss, there is an implication that FAs from these two sources must have distinct metabolic fates; however, hitherto, all FAs have been considered part of a common pool. To probe potential metabolic partitioning of cellular FAs, cancer cells were supplemented with stable isotope-labeled FAs. Structural analysis of the resulting glycerophospholipids revealed that labeled FAs from uptake were largely incorporated to canonical (sn-) positions on the glycerol backbone. Surprisingly, labeled FA uptake also disrupted canonical isomer patterns of the unlabeled lipidome and induced repartitioning of n-3 and n-6 PUFAs into glycerophospholipid classes. These structural changes support the existence of differences in the metabolic fates of FAs derived from uptake or de novo sources and demonstrate unique signaling and remodeling behaviors usually hidden from conventional lipidomics.
abstract_unstemmed	The cellular energy and biomass demands of cancer drive a complex dynamic between uptake of extracellular FAs and their de novo synthesis. Given that oxidation of de novo synthesized FAs for energy would result in net-energy loss, there is an implication that FAs from these two sources must have distinct metabolic fates; however, hitherto, all FAs have been considered part of a common pool. To probe potential metabolic partitioning of cellular FAs, cancer cells were supplemented with stable isotope-labeled FAs. Structural analysis of the resulting glycerophospholipids revealed that labeled FAs from uptake were largely incorporated to canonical (sn-) positions on the glycerol backbone. Surprisingly, labeled FA uptake also disrupted canonical isomer patterns of the unlabeled lipidome and induced repartitioning of n-3 and n-6 PUFAs into glycerophospholipid classes. These structural changes support the existence of differences in the metabolic fates of FAs derived from uptake or de novo sources and demonstrate unique signaling and remodeling behaviors usually hidden from conventional lipidomics.
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title_short	Isomeric lipid signatures reveal compartmentalized fatty acid metabolism in cancer
url	https://doi.org/10.1016/j.jlr.2022.100223 https://doaj.org/article/fee2b5d060ce47b7a34577bf15b24534 http://www.sciencedirect.com/science/article/pii/S0022227522000566 https://doaj.org/toc/0022-2275
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