From bench to bedside: Calprotectin (S100A8/S100A9) as a biomarker in rheumatoid arthritis

S100A9/S100A8 (calprotectin), a member of the S100 protein family, has been shown to play a pivotal role in innate immunity activation. Calprotectin plays a critical role in the pathogenesis of rheumatoid arthritis (RA), as it triggers chemotaxis, phagocyte migration and modulation of neutrophils an...
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Autor*in:	José Inciarte-Mundo [verfasserIn] Beatriz Frade-Sosa [verfasserIn] Raimon Sanmartí [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	calprotectin rheumatoid arthritis biomarker acute phase reactants CRP - C-reactive protein

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 13(2022)
Übergeordnetes Werk:	volume:13 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2022.1001025

Katalog-ID:	DOAJ027734080

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allfieldsSound	10.3389/fimmu.2022.1001025 doi (DE-627)DOAJ027734080 (DE-599)DOAJ889b142dd7ae4b59bd85198cb9e20198 DE-627 ger DE-627 rakwb eng RC581-607 José Inciarte-Mundo verfasserin aut From bench to bedside: Calprotectin (S100A8/S100A9) as a biomarker in rheumatoid arthritis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier S100A9/S100A8 (calprotectin), a member of the S100 protein family, has been shown to play a pivotal role in innate immunity activation. Calprotectin plays a critical role in the pathogenesis of rheumatoid arthritis (RA), as it triggers chemotaxis, phagocyte migration and modulation of neutrophils and macrophages. Higher calprotectin levels have been found in synovial fluid, plasma, and serum from RA patients. Recent studies have demonstrated better correlations between serum or plasma calprotectin and composite inflammatory disease activity indexes than c-reactive protein (CRP) or the erythrocyte sedimentation rate (ESR). Calprotectin serum levels decreased after treatment, independently of the DMARD type or strategy. Calprotectin has shown the strongest correlations with other sensitive techniques to detect inflammation, such as ultrasound. Calprotectin independently predicts radiographic progression. However, its value as a biomarker of treatment response and flare after tapering is unclear. This update reviews the current understanding of calprotectin in RA and discusses possible applications as a biomarker in clinical practice. calprotectin rheumatoid arthritis biomarker acute phase reactants CRP - C-reactive protein Immunologic diseases. Allergy Beatriz Frade-Sosa verfasserin aut Raimon Sanmartí verfasserin aut Raimon Sanmartí verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.1001025 kostenfrei https://doaj.org/article/889b142dd7ae4b59bd85198cb9e20198 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.1001025/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
language	English
source	In Frontiers in Immunology 13(2022) volume:13 year:2022
sourceStr	In Frontiers in Immunology 13(2022) volume:13 year:2022
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topic_facet	calprotectin rheumatoid arthritis biomarker acute phase reactants CRP - C-reactive protein Immunologic diseases. Allergy
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container_title	Frontiers in Immunology
authorswithroles_txt_mv	José Inciarte-Mundo @@aut@@ Beatriz Frade-Sosa @@aut@@ Raimon Sanmartí @@aut@@
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callnumber-first	R - Medicine
author	José Inciarte-Mundo
spellingShingle	José Inciarte-Mundo misc RC581-607 misc calprotectin misc rheumatoid arthritis misc biomarker misc acute phase reactants misc CRP - C-reactive protein misc Immunologic diseases. Allergy From bench to bedside: Calprotectin (S100A8/S100A9) as a biomarker in rheumatoid arthritis
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topic_title	RC581-607 From bench to bedside: Calprotectin (S100A8/S100A9) as a biomarker in rheumatoid arthritis calprotectin rheumatoid arthritis biomarker acute phase reactants CRP - C-reactive protein
topic	misc RC581-607 misc calprotectin misc rheumatoid arthritis misc biomarker misc acute phase reactants misc CRP - C-reactive protein misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc calprotectin misc rheumatoid arthritis misc biomarker misc acute phase reactants misc CRP - C-reactive protein misc Immunologic diseases. Allergy
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title	From bench to bedside: Calprotectin (S100A8/S100A9) as a biomarker in rheumatoid arthritis
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title_full	From bench to bedside: Calprotectin (S100A8/S100A9) as a biomarker in rheumatoid arthritis
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title_sort	from bench to bedside: calprotectin (s100a8/s100a9) as a biomarker in rheumatoid arthritis
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title_auth	From bench to bedside: Calprotectin (S100A8/S100A9) as a biomarker in rheumatoid arthritis
abstract	S100A9/S100A8 (calprotectin), a member of the S100 protein family, has been shown to play a pivotal role in innate immunity activation. Calprotectin plays a critical role in the pathogenesis of rheumatoid arthritis (RA), as it triggers chemotaxis, phagocyte migration and modulation of neutrophils and macrophages. Higher calprotectin levels have been found in synovial fluid, plasma, and serum from RA patients. Recent studies have demonstrated better correlations between serum or plasma calprotectin and composite inflammatory disease activity indexes than c-reactive protein (CRP) or the erythrocyte sedimentation rate (ESR). Calprotectin serum levels decreased after treatment, independently of the DMARD type or strategy. Calprotectin has shown the strongest correlations with other sensitive techniques to detect inflammation, such as ultrasound. Calprotectin independently predicts radiographic progression. However, its value as a biomarker of treatment response and flare after tapering is unclear. This update reviews the current understanding of calprotectin in RA and discusses possible applications as a biomarker in clinical practice.
abstractGer	S100A9/S100A8 (calprotectin), a member of the S100 protein family, has been shown to play a pivotal role in innate immunity activation. Calprotectin plays a critical role in the pathogenesis of rheumatoid arthritis (RA), as it triggers chemotaxis, phagocyte migration and modulation of neutrophils and macrophages. Higher calprotectin levels have been found in synovial fluid, plasma, and serum from RA patients. Recent studies have demonstrated better correlations between serum or plasma calprotectin and composite inflammatory disease activity indexes than c-reactive protein (CRP) or the erythrocyte sedimentation rate (ESR). Calprotectin serum levels decreased after treatment, independently of the DMARD type or strategy. Calprotectin has shown the strongest correlations with other sensitive techniques to detect inflammation, such as ultrasound. Calprotectin independently predicts radiographic progression. However, its value as a biomarker of treatment response and flare after tapering is unclear. This update reviews the current understanding of calprotectin in RA and discusses possible applications as a biomarker in clinical practice.
abstract_unstemmed	S100A9/S100A8 (calprotectin), a member of the S100 protein family, has been shown to play a pivotal role in innate immunity activation. Calprotectin plays a critical role in the pathogenesis of rheumatoid arthritis (RA), as it triggers chemotaxis, phagocyte migration and modulation of neutrophils and macrophages. Higher calprotectin levels have been found in synovial fluid, plasma, and serum from RA patients. Recent studies have demonstrated better correlations between serum or plasma calprotectin and composite inflammatory disease activity indexes than c-reactive protein (CRP) or the erythrocyte sedimentation rate (ESR). Calprotectin serum levels decreased after treatment, independently of the DMARD type or strategy. Calprotectin has shown the strongest correlations with other sensitive techniques to detect inflammation, such as ultrasound. Calprotectin independently predicts radiographic progression. However, its value as a biomarker of treatment response and flare after tapering is unclear. This update reviews the current understanding of calprotectin in RA and discusses possible applications as a biomarker in clinical practice.
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title_short	From bench to bedside: Calprotectin (S100A8/S100A9) as a biomarker in rheumatoid arthritis
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