Dose optimisation and scarce resource allocation: two sides of the same coin

Objective A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines.Summary of key data The vast majority of drug development and repurposing during the COVID-19 pandemic – an...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Govind Persad [verfasserIn] Srinivas Murthy [verfasserIn] William F Parker [verfasserIn] Garth Strohbehn [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Übergeordnetes Werk:	In: BMJ Open - BMJ Publishing Group, 2011, 12(2022), 10
Übergeordnetes Werk:	volume:12 ; year:2022 ; number:10

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1136/bmjopen-2022-063436

Katalog-ID:	DOAJ027877086

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allfields	10.1136/bmjopen-2022-063436 doi (DE-627)DOAJ027877086 (DE-599)DOAJefc698172f9e418c83d1fc2af685bc73 DE-627 ger DE-627 rakwb eng Govind Persad verfasserin aut Dose optimisation and scarce resource allocation: two sides of the same coin 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines.Summary of key data The vast majority of drug development and repurposing during the COVID-19 pandemic – an event that has made clear the ever-present scarcity in healthcare systems –has been ignorant of scarcity and dose optimisation's ability to help address it.Conclusions Future pandemic clinical trials systems should obtain dose optimisation data, as these appear necessary to enable appropriate scarce resource allocation according to societal values. Medicine R Srinivas Murthy verfasserin aut William F Parker verfasserin aut Garth Strohbehn verfasserin aut In BMJ Open BMJ Publishing Group, 2011 12(2022), 10 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:12 year:2022 number:10 https://doi.org/10.1136/bmjopen-2022-063436 kostenfrei https://doaj.org/article/efc698172f9e418c83d1fc2af685bc73 kostenfrei https://bmjopen.bmj.com/content/12/10/e063436.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 10
spelling	10.1136/bmjopen-2022-063436 doi (DE-627)DOAJ027877086 (DE-599)DOAJefc698172f9e418c83d1fc2af685bc73 DE-627 ger DE-627 rakwb eng Govind Persad verfasserin aut Dose optimisation and scarce resource allocation: two sides of the same coin 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines.Summary of key data The vast majority of drug development and repurposing during the COVID-19 pandemic – an event that has made clear the ever-present scarcity in healthcare systems –has been ignorant of scarcity and dose optimisation's ability to help address it.Conclusions Future pandemic clinical trials systems should obtain dose optimisation data, as these appear necessary to enable appropriate scarce resource allocation according to societal values. Medicine R Srinivas Murthy verfasserin aut William F Parker verfasserin aut Garth Strohbehn verfasserin aut In BMJ Open BMJ Publishing Group, 2011 12(2022), 10 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:12 year:2022 number:10 https://doi.org/10.1136/bmjopen-2022-063436 kostenfrei https://doaj.org/article/efc698172f9e418c83d1fc2af685bc73 kostenfrei https://bmjopen.bmj.com/content/12/10/e063436.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 10
allfields_unstemmed	10.1136/bmjopen-2022-063436 doi (DE-627)DOAJ027877086 (DE-599)DOAJefc698172f9e418c83d1fc2af685bc73 DE-627 ger DE-627 rakwb eng Govind Persad verfasserin aut Dose optimisation and scarce resource allocation: two sides of the same coin 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines.Summary of key data The vast majority of drug development and repurposing during the COVID-19 pandemic – an event that has made clear the ever-present scarcity in healthcare systems –has been ignorant of scarcity and dose optimisation's ability to help address it.Conclusions Future pandemic clinical trials systems should obtain dose optimisation data, as these appear necessary to enable appropriate scarce resource allocation according to societal values. Medicine R Srinivas Murthy verfasserin aut William F Parker verfasserin aut Garth Strohbehn verfasserin aut In BMJ Open BMJ Publishing Group, 2011 12(2022), 10 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:12 year:2022 number:10 https://doi.org/10.1136/bmjopen-2022-063436 kostenfrei https://doaj.org/article/efc698172f9e418c83d1fc2af685bc73 kostenfrei https://bmjopen.bmj.com/content/12/10/e063436.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 10
allfieldsGer	10.1136/bmjopen-2022-063436 doi (DE-627)DOAJ027877086 (DE-599)DOAJefc698172f9e418c83d1fc2af685bc73 DE-627 ger DE-627 rakwb eng Govind Persad verfasserin aut Dose optimisation and scarce resource allocation: two sides of the same coin 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines.Summary of key data The vast majority of drug development and repurposing during the COVID-19 pandemic – an event that has made clear the ever-present scarcity in healthcare systems –has been ignorant of scarcity and dose optimisation's ability to help address it.Conclusions Future pandemic clinical trials systems should obtain dose optimisation data, as these appear necessary to enable appropriate scarce resource allocation according to societal values. Medicine R Srinivas Murthy verfasserin aut William F Parker verfasserin aut Garth Strohbehn verfasserin aut In BMJ Open BMJ Publishing Group, 2011 12(2022), 10 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:12 year:2022 number:10 https://doi.org/10.1136/bmjopen-2022-063436 kostenfrei https://doaj.org/article/efc698172f9e418c83d1fc2af685bc73 kostenfrei https://bmjopen.bmj.com/content/12/10/e063436.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 10
allfieldsSound	10.1136/bmjopen-2022-063436 doi (DE-627)DOAJ027877086 (DE-599)DOAJefc698172f9e418c83d1fc2af685bc73 DE-627 ger DE-627 rakwb eng Govind Persad verfasserin aut Dose optimisation and scarce resource allocation: two sides of the same coin 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines.Summary of key data The vast majority of drug development and repurposing during the COVID-19 pandemic – an event that has made clear the ever-present scarcity in healthcare systems –has been ignorant of scarcity and dose optimisation's ability to help address it.Conclusions Future pandemic clinical trials systems should obtain dose optimisation data, as these appear necessary to enable appropriate scarce resource allocation according to societal values. Medicine R Srinivas Murthy verfasserin aut William F Parker verfasserin aut Garth Strohbehn verfasserin aut In BMJ Open BMJ Publishing Group, 2011 12(2022), 10 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:12 year:2022 number:10 https://doi.org/10.1136/bmjopen-2022-063436 kostenfrei https://doaj.org/article/efc698172f9e418c83d1fc2af685bc73 kostenfrei https://bmjopen.bmj.com/content/12/10/e063436.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 10
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author	Govind Persad
spellingShingle	Govind Persad misc Medicine misc R Dose optimisation and scarce resource allocation: two sides of the same coin
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topic_title	Dose optimisation and scarce resource allocation: two sides of the same coin
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title	Dose optimisation and scarce resource allocation: two sides of the same coin
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title_full	Dose optimisation and scarce resource allocation: two sides of the same coin
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author_browse	Govind Persad Srinivas Murthy William F Parker Garth Strohbehn
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title_sort	dose optimisation and scarce resource allocation: two sides of the same coin
title_auth	Dose optimisation and scarce resource allocation: two sides of the same coin
abstract	Objective A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines.Summary of key data The vast majority of drug development and repurposing during the COVID-19 pandemic – an event that has made clear the ever-present scarcity in healthcare systems –has been ignorant of scarcity and dose optimisation's ability to help address it.Conclusions Future pandemic clinical trials systems should obtain dose optimisation data, as these appear necessary to enable appropriate scarce resource allocation according to societal values.
abstractGer	Objective A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines.Summary of key data The vast majority of drug development and repurposing during the COVID-19 pandemic – an event that has made clear the ever-present scarcity in healthcare systems –has been ignorant of scarcity and dose optimisation's ability to help address it.Conclusions Future pandemic clinical trials systems should obtain dose optimisation data, as these appear necessary to enable appropriate scarce resource allocation according to societal values.
abstract_unstemmed	Objective A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines.Summary of key data The vast majority of drug development and repurposing during the COVID-19 pandemic – an event that has made clear the ever-present scarcity in healthcare systems –has been ignorant of scarcity and dose optimisation's ability to help address it.Conclusions Future pandemic clinical trials systems should obtain dose optimisation data, as these appear necessary to enable appropriate scarce resource allocation according to societal values.
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title_short	Dose optimisation and scarce resource allocation: two sides of the same coin
url	https://doi.org/10.1136/bmjopen-2022-063436 https://doaj.org/article/efc698172f9e418c83d1fc2af685bc73 https://bmjopen.bmj.com/content/12/10/e063436.full https://doaj.org/toc/2044-6055
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doi_str	10.1136/bmjopen-2022-063436
up_date	2024-07-03T14:31:17.235Z
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