Treatment of Refractory Metastatic Renal Cell Carcinoma

First-line treatment for metastatic renal cell carcinoma (mRCC) rapidly shifted in recent years with the advent of combination therapies, including immune checkpoint inhibitor (ICI) doublets and combinations of an ICI with a vascular endothelial growth factor receptor (VEGFR) targeted tyrosine kinas...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Joseph A. Vento [verfasserIn] Brian I. Rini [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	metastatic renal cell carcinoma refractory therapies immune checkpoint inhibition VEGFR tyrosine kinase inhibitors new RCC agents

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 14(2022), 20, p 5005
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:20, p 5005

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers14205005

Katalog-ID:	DOAJ027987914

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language	English
source	In Cancers 14(2022), 20, p 5005 volume:14 year:2022 number:20, p 5005
sourceStr	In Cancers 14(2022), 20, p 5005 volume:14 year:2022 number:20, p 5005
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	metastatic renal cell carcinoma refractory therapies immune checkpoint inhibition VEGFR tyrosine kinase inhibitors new RCC agents Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Cancers
authorswithroles_txt_mv	Joseph A. Vento @@aut@@ Brian I. Rini @@aut@@
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callnumber-first	R - Medicine
author	Joseph A. Vento
spellingShingle	Joseph A. Vento misc RC254-282 misc metastatic renal cell carcinoma misc refractory therapies misc immune checkpoint inhibition misc VEGFR tyrosine kinase inhibitors misc new RCC agents misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Treatment of Refractory Metastatic Renal Cell Carcinoma
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topic_title	RC254-282 Treatment of Refractory Metastatic Renal Cell Carcinoma metastatic renal cell carcinoma refractory therapies immune checkpoint inhibition VEGFR tyrosine kinase inhibitors new RCC agents
topic	misc RC254-282 misc metastatic renal cell carcinoma misc refractory therapies misc immune checkpoint inhibition misc VEGFR tyrosine kinase inhibitors misc new RCC agents misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc metastatic renal cell carcinoma misc refractory therapies misc immune checkpoint inhibition misc VEGFR tyrosine kinase inhibitors misc new RCC agents misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Treatment of Refractory Metastatic Renal Cell Carcinoma
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title_auth	Treatment of Refractory Metastatic Renal Cell Carcinoma
abstract	First-line treatment for metastatic renal cell carcinoma (mRCC) rapidly shifted in recent years with the advent of combination therapies, including immune checkpoint inhibitor (ICI) doublets and combinations of an ICI with a vascular endothelial growth factor receptor (VEGFR) targeted tyrosine kinase inhibitor (TKI). Despite improvements in overall survival and many durable responses, there exists a significant number of patients who fail to respond to these agents, and many patients eventually progress. Given the rapid changes in the front-line setting, it is essential to understand treatment options in refractory mRCC. Here, we review the evidence behind current options for later-line therapies, often involving additional VEGFR-TKIs alone or in combination with mammalian target of rapamycin (mTOR) targeted agents, as well as situations where consideration of immunotherapy rechallenge may be appropriate. Additionally, we describe ongoing clinical trials examining concurrent ICI and TKI in the refractory setting, as well as those studying novel agents, such as targeted drug–antibody conjugates and hypoxia inducible factor 2α (HIF-2α) inhibitors. Finally, we review considerations for non-clear cell histologies in the refractory setting and mechanisms of resistance in mRCC.
abstractGer	First-line treatment for metastatic renal cell carcinoma (mRCC) rapidly shifted in recent years with the advent of combination therapies, including immune checkpoint inhibitor (ICI) doublets and combinations of an ICI with a vascular endothelial growth factor receptor (VEGFR) targeted tyrosine kinase inhibitor (TKI). Despite improvements in overall survival and many durable responses, there exists a significant number of patients who fail to respond to these agents, and many patients eventually progress. Given the rapid changes in the front-line setting, it is essential to understand treatment options in refractory mRCC. Here, we review the evidence behind current options for later-line therapies, often involving additional VEGFR-TKIs alone or in combination with mammalian target of rapamycin (mTOR) targeted agents, as well as situations where consideration of immunotherapy rechallenge may be appropriate. Additionally, we describe ongoing clinical trials examining concurrent ICI and TKI in the refractory setting, as well as those studying novel agents, such as targeted drug–antibody conjugates and hypoxia inducible factor 2α (HIF-2α) inhibitors. Finally, we review considerations for non-clear cell histologies in the refractory setting and mechanisms of resistance in mRCC.
abstract_unstemmed	First-line treatment for metastatic renal cell carcinoma (mRCC) rapidly shifted in recent years with the advent of combination therapies, including immune checkpoint inhibitor (ICI) doublets and combinations of an ICI with a vascular endothelial growth factor receptor (VEGFR) targeted tyrosine kinase inhibitor (TKI). Despite improvements in overall survival and many durable responses, there exists a significant number of patients who fail to respond to these agents, and many patients eventually progress. Given the rapid changes in the front-line setting, it is essential to understand treatment options in refractory mRCC. Here, we review the evidence behind current options for later-line therapies, often involving additional VEGFR-TKIs alone or in combination with mammalian target of rapamycin (mTOR) targeted agents, as well as situations where consideration of immunotherapy rechallenge may be appropriate. Additionally, we describe ongoing clinical trials examining concurrent ICI and TKI in the refractory setting, as well as those studying novel agents, such as targeted drug–antibody conjugates and hypoxia inducible factor 2α (HIF-2α) inhibitors. Finally, we review considerations for non-clear cell histologies in the refractory setting and mechanisms of resistance in mRCC.
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title_short	Treatment of Refractory Metastatic Renal Cell Carcinoma
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