Interplay between path and speed in decision making by high-dimensional stochastic gene regulatory networks.

Induction of a specific transcriptional program by external signaling inputs is a crucial aspect of intracellular network functioning. The theoretical concept of coexisting attractors representing particular genetic programs is reasonably adapted to experimental observations of "genome-wide&quo...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Nuno R Nené [verfasserIn] Alexey Zaikin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Übergeordnetes Werk:	In: PLoS ONE - Public Library of Science (PLoS), 2007, 7(2012), 7, p e40085
Übergeordnetes Werk:	volume:7 ; year:2012 ; number:7, p e40085

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1371/journal.pone.0040085

Katalog-ID:	DOAJ028031296

Internformat


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allfieldsSound	10.1371/journal.pone.0040085 doi (DE-627)DOAJ028031296 (DE-599)DOAJb94dec4afe3640c9bc773d8adce90fae DE-627 ger DE-627 rakwb eng Nuno R Nené verfasserin aut Interplay between path and speed in decision making by high-dimensional stochastic gene regulatory networks. 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Induction of a specific transcriptional program by external signaling inputs is a crucial aspect of intracellular network functioning. The theoretical concept of coexisting attractors representing particular genetic programs is reasonably adapted to experimental observations of "genome-wide" expression profiles or phenotypes. Attractors can be associated either with developmental outcomes such as differentiation into specific types of cells, or maintenance of cell functioning such as proliferation or apoptosis. Here we review a mechanism known as speed-dependent cellular decision making (SdCDM) in a small epigenetic switch and generalize the concept to high-dimensional space. We demonstrate that high-dimensional network clustering capacity is dependent on the level of intrinsic noise and the speed at which external signals operate on the transcriptional landscape. Medicine R Science Q Alexey Zaikin verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 7(2012), 7, p e40085 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:7 year:2012 number:7, p e40085 https://doi.org/10.1371/journal.pone.0040085 kostenfrei https://doaj.org/article/b94dec4afe3640c9bc773d8adce90fae kostenfrei http://europepmc.org/articles/PMC3398018?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2012 7, p e40085
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author	Nuno R Nené
spellingShingle	Nuno R Nené misc Medicine misc R misc Science misc Q Interplay between path and speed in decision making by high-dimensional stochastic gene regulatory networks.
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topic_title	Interplay between path and speed in decision making by high-dimensional stochastic gene regulatory networks
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title	Interplay between path and speed in decision making by high-dimensional stochastic gene regulatory networks.
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title_full	Interplay between path and speed in decision making by high-dimensional stochastic gene regulatory networks
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title_sort	interplay between path and speed in decision making by high-dimensional stochastic gene regulatory networks
title_auth	Interplay between path and speed in decision making by high-dimensional stochastic gene regulatory networks.
abstract	Induction of a specific transcriptional program by external signaling inputs is a crucial aspect of intracellular network functioning. The theoretical concept of coexisting attractors representing particular genetic programs is reasonably adapted to experimental observations of "genome-wide" expression profiles or phenotypes. Attractors can be associated either with developmental outcomes such as differentiation into specific types of cells, or maintenance of cell functioning such as proliferation or apoptosis. Here we review a mechanism known as speed-dependent cellular decision making (SdCDM) in a small epigenetic switch and generalize the concept to high-dimensional space. We demonstrate that high-dimensional network clustering capacity is dependent on the level of intrinsic noise and the speed at which external signals operate on the transcriptional landscape.
abstractGer	Induction of a specific transcriptional program by external signaling inputs is a crucial aspect of intracellular network functioning. The theoretical concept of coexisting attractors representing particular genetic programs is reasonably adapted to experimental observations of "genome-wide" expression profiles or phenotypes. Attractors can be associated either with developmental outcomes such as differentiation into specific types of cells, or maintenance of cell functioning such as proliferation or apoptosis. Here we review a mechanism known as speed-dependent cellular decision making (SdCDM) in a small epigenetic switch and generalize the concept to high-dimensional space. We demonstrate that high-dimensional network clustering capacity is dependent on the level of intrinsic noise and the speed at which external signals operate on the transcriptional landscape.
abstract_unstemmed	Induction of a specific transcriptional program by external signaling inputs is a crucial aspect of intracellular network functioning. The theoretical concept of coexisting attractors representing particular genetic programs is reasonably adapted to experimental observations of "genome-wide" expression profiles or phenotypes. Attractors can be associated either with developmental outcomes such as differentiation into specific types of cells, or maintenance of cell functioning such as proliferation or apoptosis. Here we review a mechanism known as speed-dependent cellular decision making (SdCDM) in a small epigenetic switch and generalize the concept to high-dimensional space. We demonstrate that high-dimensional network clustering capacity is dependent on the level of intrinsic noise and the speed at which external signals operate on the transcriptional landscape.
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title_short	Interplay between path and speed in decision making by high-dimensional stochastic gene regulatory networks.
url	https://doi.org/10.1371/journal.pone.0040085 https://doaj.org/article/b94dec4afe3640c9bc773d8adce90fae http://europepmc.org/articles/PMC3398018?pdf=render https://doaj.org/toc/1932-6203
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up_date	2024-07-03T15:21:16.988Z
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Interplay between path and speed in decision making by high-dimensional stochastic gene regulatory networks.

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