Young people at ultra high risk for psychosis: research from the PACE clinic Jovens em risco ultra alto de psicose: pesquisa na clínica PACE

Over the last fifteen years, attempts have been made to prospectively identify individuals in the prodromal phase of schizophrenia and other psychotic disorders. The ultra high risk approach, based on a combination of known trait and state risk factors, has been the main strategy used. The validation of the ultra high risk criteria allowed for predictive research in this population in an attempt to identify clinical, neurocognitive and neurobiological risk factors for psychosis onset. It also led to a series of intervention studies in this population, which have included the use of low dose antipsychotic medication, cognitive therapy, and omega-3 fatty acids. Although there is moderate evidence for the effectiveness of specific intervention strategies in this population, the most effective type and duration of intervention is yet to be determined. A current controversy in the field is whether to include an adaption of the ultra high risk criteria (the attenuated psychosis syndrome) in the next version of the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition).<br<Nos últimos quinze anos, foram feitas tentativas para identificar prospectivamente indivíduos na fase prodrômica de esquizofrenia e outros transtornos psicóticos. A abordagem de risco ultra alto, baseada na combinação de fatores conhecidos de risco de traço e estado, tem sido a principal estratégia utilizada. A validação dos critérios de risco ultra alto levou em conta a pesquisa preditiva nessa população, em uma tentativa de identificar fatores de risco clínicos, neurocognitivos e neurobiológicos para o início de psicose. Também levou a uma série de estudos de intervenção nessa população, que incluíram o uso de medicação antipsicótica em baixa dose, terapia cognitiva e ácidos graxos ômega-3. Ainda que existam evidências razoáveis sobre a eficácia de estratégias de intervenção específicas nessa população, o tipo mais efetivo e sua duração ainda têm que ser determinados. Uma controvérsia atual no campo refere-se à inclusão de uma adaptação dos critérios de risco ultra alto (a síndrome de psicose atenuada) na próxima versão do Manual Diagnóstico e Estatístico de Transtornos Mentais (Quinta Edição). Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Alison R. Yung [verfasserIn] Barnaby Nelson [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch ; Portugiesisch

Erschienen:	2011

Schlagwörter:	Diagnóstico Transtornos psicóticos Esquizofrenia Pesquisa biomédica Terapia cognitiva Diagnosis Psychotic disorders Schizophrenia Biomedical research Cognitive therapy

Übergeordnetes Werk:	In: Brazilian Journal of Psychiatry - Associação Brasileira de Psiquiatria (ABP), 2004, 33(2011), Seite s143-s160
Übergeordnetes Werk:	volume:33 ; year:2011 ; pages:s143-s160

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1590/S1516-44462011000600003

Katalog-ID:	DOAJ028042433

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allfieldsGer	10.1590/S1516-44462011000600003 doi (DE-627)DOAJ028042433 (DE-599)DOAJa380804bc8b14f16afef603fae528528 DE-627 ger DE-627 rakwb eng por RC435-571 Alison R. Yung verfasserin aut Young people at ultra high risk for psychosis: research from the PACE clinic Jovens em risco ultra alto de psicose: pesquisa na clínica PACE 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Over the last fifteen years, attempts have been made to prospectively identify individuals in the prodromal phase of schizophrenia and other psychotic disorders. The ultra high risk approach, based on a combination of known trait and state risk factors, has been the main strategy used. The validation of the ultra high risk criteria allowed for predictive research in this population in an attempt to identify clinical, neurocognitive and neurobiological risk factors for psychosis onset. It also led to a series of intervention studies in this population, which have included the use of low dose antipsychotic medication, cognitive therapy, and omega-3 fatty acids. Although there is moderate evidence for the effectiveness of specific intervention strategies in this population, the most effective type and duration of intervention is yet to be determined. A current controversy in the field is whether to include an adaption of the ultra high risk criteria (the attenuated psychosis syndrome) in the next version of the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition).<br<Nos últimos quinze anos, foram feitas tentativas para identificar prospectivamente indivíduos na fase prodrômica de esquizofrenia e outros transtornos psicóticos. A abordagem de risco ultra alto, baseada na combinação de fatores conhecidos de risco de traço e estado, tem sido a principal estratégia utilizada. A validação dos critérios de risco ultra alto levou em conta a pesquisa preditiva nessa população, em uma tentativa de identificar fatores de risco clínicos, neurocognitivos e neurobiológicos para o início de psicose. Também levou a uma série de estudos de intervenção nessa população, que incluíram o uso de medicação antipsicótica em baixa dose, terapia cognitiva e ácidos graxos ômega-3. Ainda que existam evidências razoáveis sobre a eficácia de estratégias de intervenção específicas nessa população, o tipo mais efetivo e sua duração ainda têm que ser determinados. Uma controvérsia atual no campo refere-se à inclusão de uma adaptação dos critérios de risco ultra alto (a síndrome de psicose atenuada) na próxima versão do Manual Diagnóstico e Estatístico de Transtornos Mentais (Quinta Edição). Diagnóstico Transtornos psicóticos Esquizofrenia Pesquisa biomédica Terapia cognitiva Diagnosis Psychotic disorders Schizophrenia Biomedical research Cognitive therapy Psychiatry Barnaby Nelson verfasserin aut In Brazilian Journal of Psychiatry Associação Brasileira de Psiquiatria (ABP), 2004 33(2011), Seite s143-s160 (DE-627)320632717 (DE-600)2024119-7 1809452X nnns volume:33 year:2011 pages:s143-s160 https://doi.org/10.1590/S1516-44462011000600003 kostenfrei https://doaj.org/article/a380804bc8b14f16afef603fae528528 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462011000600003 kostenfrei https://doaj.org/toc/1516-4446 Journal toc kostenfrei https://doaj.org/toc/1809-452X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 33 2011 s143-s160
allfieldsSound	10.1590/S1516-44462011000600003 doi (DE-627)DOAJ028042433 (DE-599)DOAJa380804bc8b14f16afef603fae528528 DE-627 ger DE-627 rakwb eng por RC435-571 Alison R. Yung verfasserin aut Young people at ultra high risk for psychosis: research from the PACE clinic Jovens em risco ultra alto de psicose: pesquisa na clínica PACE 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Over the last fifteen years, attempts have been made to prospectively identify individuals in the prodromal phase of schizophrenia and other psychotic disorders. The ultra high risk approach, based on a combination of known trait and state risk factors, has been the main strategy used. The validation of the ultra high risk criteria allowed for predictive research in this population in an attempt to identify clinical, neurocognitive and neurobiological risk factors for psychosis onset. It also led to a series of intervention studies in this population, which have included the use of low dose antipsychotic medication, cognitive therapy, and omega-3 fatty acids. Although there is moderate evidence for the effectiveness of specific intervention strategies in this population, the most effective type and duration of intervention is yet to be determined. A current controversy in the field is whether to include an adaption of the ultra high risk criteria (the attenuated psychosis syndrome) in the next version of the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition).<br<Nos últimos quinze anos, foram feitas tentativas para identificar prospectivamente indivíduos na fase prodrômica de esquizofrenia e outros transtornos psicóticos. A abordagem de risco ultra alto, baseada na combinação de fatores conhecidos de risco de traço e estado, tem sido a principal estratégia utilizada. A validação dos critérios de risco ultra alto levou em conta a pesquisa preditiva nessa população, em uma tentativa de identificar fatores de risco clínicos, neurocognitivos e neurobiológicos para o início de psicose. Também levou a uma série de estudos de intervenção nessa população, que incluíram o uso de medicação antipsicótica em baixa dose, terapia cognitiva e ácidos graxos ômega-3. Ainda que existam evidências razoáveis sobre a eficácia de estratégias de intervenção específicas nessa população, o tipo mais efetivo e sua duração ainda têm que ser determinados. Uma controvérsia atual no campo refere-se à inclusão de uma adaptação dos critérios de risco ultra alto (a síndrome de psicose atenuada) na próxima versão do Manual Diagnóstico e Estatístico de Transtornos Mentais (Quinta Edição). Diagnóstico Transtornos psicóticos Esquizofrenia Pesquisa biomédica Terapia cognitiva Diagnosis Psychotic disorders Schizophrenia Biomedical research Cognitive therapy Psychiatry Barnaby Nelson verfasserin aut In Brazilian Journal of Psychiatry Associação Brasileira de Psiquiatria (ABP), 2004 33(2011), Seite s143-s160 (DE-627)320632717 (DE-600)2024119-7 1809452X nnns volume:33 year:2011 pages:s143-s160 https://doi.org/10.1590/S1516-44462011000600003 kostenfrei https://doaj.org/article/a380804bc8b14f16afef603fae528528 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462011000600003 kostenfrei https://doaj.org/toc/1516-4446 Journal toc kostenfrei https://doaj.org/toc/1809-452X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 33 2011 s143-s160
language	English Portuguese
source	In Brazilian Journal of Psychiatry 33(2011), Seite s143-s160 volume:33 year:2011 pages:s143-s160
sourceStr	In Brazilian Journal of Psychiatry 33(2011), Seite s143-s160 volume:33 year:2011 pages:s143-s160
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topic_facet	Diagnóstico Transtornos psicóticos Esquizofrenia Pesquisa biomédica Terapia cognitiva Diagnosis Psychotic disorders Schizophrenia Biomedical research Cognitive therapy Psychiatry
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container_title	Brazilian Journal of Psychiatry
authorswithroles_txt_mv	Alison R. Yung @@aut@@ Barnaby Nelson @@aut@@
publishDateDaySort_date	2011-01-01T00:00:00Z
hierarchy_top_id	320632717
id	DOAJ028042433
language_de	englisch portugiesisch
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callnumber-first	R - Medicine
author	Alison R. Yung
spellingShingle	Alison R. Yung misc RC435-571 misc Diagnóstico misc Transtornos psicóticos misc Esquizofrenia misc Pesquisa biomédica misc Terapia cognitiva misc Diagnosis misc Psychotic disorders misc Schizophrenia misc Biomedical research misc Cognitive therapy misc Psychiatry Young people at ultra high risk for psychosis: research from the PACE clinic Jovens em risco ultra alto de psicose: pesquisa na clínica PACE
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topic_title	RC435-571 Young people at ultra high risk for psychosis: research from the PACE clinic Jovens em risco ultra alto de psicose: pesquisa na clínica PACE Diagnóstico Transtornos psicóticos Esquizofrenia Pesquisa biomédica Terapia cognitiva Diagnosis Psychotic disorders Schizophrenia Biomedical research Cognitive therapy
topic	misc RC435-571 misc Diagnóstico misc Transtornos psicóticos misc Esquizofrenia misc Pesquisa biomédica misc Terapia cognitiva misc Diagnosis misc Psychotic disorders misc Schizophrenia misc Biomedical research misc Cognitive therapy misc Psychiatry
topic_unstemmed	misc RC435-571 misc Diagnóstico misc Transtornos psicóticos misc Esquizofrenia misc Pesquisa biomédica misc Terapia cognitiva misc Diagnosis misc Psychotic disorders misc Schizophrenia misc Biomedical research misc Cognitive therapy misc Psychiatry
topic_browse	misc RC435-571 misc Diagnóstico misc Transtornos psicóticos misc Esquizofrenia misc Pesquisa biomédica misc Terapia cognitiva misc Diagnosis misc Psychotic disorders misc Schizophrenia misc Biomedical research misc Cognitive therapy misc Psychiatry
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title	Young people at ultra high risk for psychosis: research from the PACE clinic Jovens em risco ultra alto de psicose: pesquisa na clínica PACE
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title_full	Young people at ultra high risk for psychosis: research from the PACE clinic Jovens em risco ultra alto de psicose: pesquisa na clínica PACE
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title_sort	young people at ultra high risk for psychosis: research from the pace clinic jovens em risco ultra alto de psicose: pesquisa na clínica pace
callnumber	RC435-571
title_auth	Young people at ultra high risk for psychosis: research from the PACE clinic Jovens em risco ultra alto de psicose: pesquisa na clínica PACE
abstract	Over the last fifteen years, attempts have been made to prospectively identify individuals in the prodromal phase of schizophrenia and other psychotic disorders. The ultra high risk approach, based on a combination of known trait and state risk factors, has been the main strategy used. The validation of the ultra high risk criteria allowed for predictive research in this population in an attempt to identify clinical, neurocognitive and neurobiological risk factors for psychosis onset. It also led to a series of intervention studies in this population, which have included the use of low dose antipsychotic medication, cognitive therapy, and omega-3 fatty acids. Although there is moderate evidence for the effectiveness of specific intervention strategies in this population, the most effective type and duration of intervention is yet to be determined. A current controversy in the field is whether to include an adaption of the ultra high risk criteria (the attenuated psychosis syndrome) in the next version of the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition).<br<Nos últimos quinze anos, foram feitas tentativas para identificar prospectivamente indivíduos na fase prodrômica de esquizofrenia e outros transtornos psicóticos. A abordagem de risco ultra alto, baseada na combinação de fatores conhecidos de risco de traço e estado, tem sido a principal estratégia utilizada. A validação dos critérios de risco ultra alto levou em conta a pesquisa preditiva nessa população, em uma tentativa de identificar fatores de risco clínicos, neurocognitivos e neurobiológicos para o início de psicose. Também levou a uma série de estudos de intervenção nessa população, que incluíram o uso de medicação antipsicótica em baixa dose, terapia cognitiva e ácidos graxos ômega-3. Ainda que existam evidências razoáveis sobre a eficácia de estratégias de intervenção específicas nessa população, o tipo mais efetivo e sua duração ainda têm que ser determinados. Uma controvérsia atual no campo refere-se à inclusão de uma adaptação dos critérios de risco ultra alto (a síndrome de psicose atenuada) na próxima versão do Manual Diagnóstico e Estatístico de Transtornos Mentais (Quinta Edição).
abstractGer	Over the last fifteen years, attempts have been made to prospectively identify individuals in the prodromal phase of schizophrenia and other psychotic disorders. The ultra high risk approach, based on a combination of known trait and state risk factors, has been the main strategy used. The validation of the ultra high risk criteria allowed for predictive research in this population in an attempt to identify clinical, neurocognitive and neurobiological risk factors for psychosis onset. It also led to a series of intervention studies in this population, which have included the use of low dose antipsychotic medication, cognitive therapy, and omega-3 fatty acids. Although there is moderate evidence for the effectiveness of specific intervention strategies in this population, the most effective type and duration of intervention is yet to be determined. A current controversy in the field is whether to include an adaption of the ultra high risk criteria (the attenuated psychosis syndrome) in the next version of the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition).<br<Nos últimos quinze anos, foram feitas tentativas para identificar prospectivamente indivíduos na fase prodrômica de esquizofrenia e outros transtornos psicóticos. A abordagem de risco ultra alto, baseada na combinação de fatores conhecidos de risco de traço e estado, tem sido a principal estratégia utilizada. A validação dos critérios de risco ultra alto levou em conta a pesquisa preditiva nessa população, em uma tentativa de identificar fatores de risco clínicos, neurocognitivos e neurobiológicos para o início de psicose. Também levou a uma série de estudos de intervenção nessa população, que incluíram o uso de medicação antipsicótica em baixa dose, terapia cognitiva e ácidos graxos ômega-3. Ainda que existam evidências razoáveis sobre a eficácia de estratégias de intervenção específicas nessa população, o tipo mais efetivo e sua duração ainda têm que ser determinados. Uma controvérsia atual no campo refere-se à inclusão de uma adaptação dos critérios de risco ultra alto (a síndrome de psicose atenuada) na próxima versão do Manual Diagnóstico e Estatístico de Transtornos Mentais (Quinta Edição).
abstract_unstemmed	Over the last fifteen years, attempts have been made to prospectively identify individuals in the prodromal phase of schizophrenia and other psychotic disorders. The ultra high risk approach, based on a combination of known trait and state risk factors, has been the main strategy used. The validation of the ultra high risk criteria allowed for predictive research in this population in an attempt to identify clinical, neurocognitive and neurobiological risk factors for psychosis onset. It also led to a series of intervention studies in this population, which have included the use of low dose antipsychotic medication, cognitive therapy, and omega-3 fatty acids. Although there is moderate evidence for the effectiveness of specific intervention strategies in this population, the most effective type and duration of intervention is yet to be determined. A current controversy in the field is whether to include an adaption of the ultra high risk criteria (the attenuated psychosis syndrome) in the next version of the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition).<br<Nos últimos quinze anos, foram feitas tentativas para identificar prospectivamente indivíduos na fase prodrômica de esquizofrenia e outros transtornos psicóticos. A abordagem de risco ultra alto, baseada na combinação de fatores conhecidos de risco de traço e estado, tem sido a principal estratégia utilizada. A validação dos critérios de risco ultra alto levou em conta a pesquisa preditiva nessa população, em uma tentativa de identificar fatores de risco clínicos, neurocognitivos e neurobiológicos para o início de psicose. Também levou a uma série de estudos de intervenção nessa população, que incluíram o uso de medicação antipsicótica em baixa dose, terapia cognitiva e ácidos graxos ômega-3. Ainda que existam evidências razoáveis sobre a eficácia de estratégias de intervenção específicas nessa população, o tipo mais efetivo e sua duração ainda têm que ser determinados. Uma controvérsia atual no campo refere-se à inclusão de uma adaptação dos critérios de risco ultra alto (a síndrome de psicose atenuada) na próxima versão do Manual Diagnóstico e Estatístico de Transtornos Mentais (Quinta Edição).
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title_short	Young people at ultra high risk for psychosis: research from the PACE clinic Jovens em risco ultra alto de psicose: pesquisa na clínica PACE
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