Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms

Transcriptional enhancers are known to regulate transcript production. Here, the authors show that transcription factors that bind to enhancers also regulate polyadenylation site cleavage activity, thus changing expression of alternative 3’ UTRs.

Gespeichert in:

Autor*in:	Buki Kwon [verfasserIn] Mervin M. Fansler [verfasserIn] Neil D. Patel [verfasserIn] Jihye Lee [verfasserIn] Weirui Ma [verfasserIn] Christine Mayr [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 13(2022), 1, Seite 14
Übergeordnetes Werk:	volume:13 ; year:2022 ; number:1 ; pages:14

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-022-30525-y

Katalog-ID:	DOAJ028067134

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topic_title	Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms
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title	Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms
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title_full	Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms
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title_sort	enhancers regulate 3′ end processing activity to control expression of alternative 3′utr isoforms
title_auth	Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms
abstract	Transcriptional enhancers are known to regulate transcript production. Here, the authors show that transcription factors that bind to enhancers also regulate polyadenylation site cleavage activity, thus changing expression of alternative 3’ UTRs.
abstractGer	Transcriptional enhancers are known to regulate transcript production. Here, the authors show that transcription factors that bind to enhancers also regulate polyadenylation site cleavage activity, thus changing expression of alternative 3’ UTRs.
abstract_unstemmed	Transcriptional enhancers are known to regulate transcript production. Here, the authors show that transcription factors that bind to enhancers also regulate polyadenylation site cleavage activity, thus changing expression of alternative 3’ UTRs.
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title_short	Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms
url	https://doi.org/10.1038/s41467-022-30525-y https://doaj.org/article/c243a4bae9f044088d21f66806728608 https://doaj.org/toc/2041-1723
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