The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples

Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5–PPP1CB fusion is not specific fo...
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Gespeichert in:

Autor*in:	Karl Vandepoele [verfasserIn] Jan Philippé [verfasserIn] Barbara Denys [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Chronic lymphocytic leukemia YPEL5–PPP1CB Trans-splicing

Übergeordnetes Werk:	In: Leukemia Research Reports - Elsevier, 2015, 4(2015), 2, Seite 51-54
Übergeordnetes Werk:	volume:4 ; year:2015 ; number:2 ; pages:51-54

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.lrr.2015.07.001

Katalog-ID:	DOAJ028067983

Internformat


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author_variant	k v kv j p jp b d bd
matchkey_str	article:22130489:2015----::hye5p1buinrncitseetdnifrnhmtlgclai
hierarchy_sort_str	2015
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publishDate	2015
allfields	10.1016/j.lrr.2015.07.001 doi (DE-627)DOAJ028067983 (DE-599)DOAJ2aaeeb72f1ab4895aac36a2581ccd197 DE-627 ger DE-627 rakwb eng RC254-282 Karl Vandepoele verfasserin aut The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5–PPP1CB fusion is not specific for CLL but is also detected in other hematological malignancies such as chronic myeloid leukemia, monoclonal B cell lymphocytosis or acute leukemia and also in normal samples. As such, it is unlikely that the YPEL5–PPP1CB fusion is a good drug target in CLL or a suitable target to monitor disease. Chronic lymphocytic leukemia YPEL5–PPP1CB Trans-splicing Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jan Philippé verfasserin aut Barbara Denys verfasserin aut In Leukemia Research Reports Elsevier, 2015 4(2015), 2, Seite 51-54 (DE-627)738404586 (DE-600)2706248-X 22130489 nnns volume:4 year:2015 number:2 pages:51-54 https://doi.org/10.1016/j.lrr.2015.07.001 kostenfrei https://doaj.org/article/2aaeeb72f1ab4895aac36a2581ccd197 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213048914200239 kostenfrei https://doaj.org/toc/2213-0489 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 4 2015 2 51-54
spelling	10.1016/j.lrr.2015.07.001 doi (DE-627)DOAJ028067983 (DE-599)DOAJ2aaeeb72f1ab4895aac36a2581ccd197 DE-627 ger DE-627 rakwb eng RC254-282 Karl Vandepoele verfasserin aut The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5–PPP1CB fusion is not specific for CLL but is also detected in other hematological malignancies such as chronic myeloid leukemia, monoclonal B cell lymphocytosis or acute leukemia and also in normal samples. As such, it is unlikely that the YPEL5–PPP1CB fusion is a good drug target in CLL or a suitable target to monitor disease. Chronic lymphocytic leukemia YPEL5–PPP1CB Trans-splicing Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jan Philippé verfasserin aut Barbara Denys verfasserin aut In Leukemia Research Reports Elsevier, 2015 4(2015), 2, Seite 51-54 (DE-627)738404586 (DE-600)2706248-X 22130489 nnns volume:4 year:2015 number:2 pages:51-54 https://doi.org/10.1016/j.lrr.2015.07.001 kostenfrei https://doaj.org/article/2aaeeb72f1ab4895aac36a2581ccd197 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213048914200239 kostenfrei https://doaj.org/toc/2213-0489 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 4 2015 2 51-54
allfields_unstemmed	10.1016/j.lrr.2015.07.001 doi (DE-627)DOAJ028067983 (DE-599)DOAJ2aaeeb72f1ab4895aac36a2581ccd197 DE-627 ger DE-627 rakwb eng RC254-282 Karl Vandepoele verfasserin aut The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5–PPP1CB fusion is not specific for CLL but is also detected in other hematological malignancies such as chronic myeloid leukemia, monoclonal B cell lymphocytosis or acute leukemia and also in normal samples. As such, it is unlikely that the YPEL5–PPP1CB fusion is a good drug target in CLL or a suitable target to monitor disease. Chronic lymphocytic leukemia YPEL5–PPP1CB Trans-splicing Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jan Philippé verfasserin aut Barbara Denys verfasserin aut In Leukemia Research Reports Elsevier, 2015 4(2015), 2, Seite 51-54 (DE-627)738404586 (DE-600)2706248-X 22130489 nnns volume:4 year:2015 number:2 pages:51-54 https://doi.org/10.1016/j.lrr.2015.07.001 kostenfrei https://doaj.org/article/2aaeeb72f1ab4895aac36a2581ccd197 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213048914200239 kostenfrei https://doaj.org/toc/2213-0489 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 4 2015 2 51-54
allfieldsGer	10.1016/j.lrr.2015.07.001 doi (DE-627)DOAJ028067983 (DE-599)DOAJ2aaeeb72f1ab4895aac36a2581ccd197 DE-627 ger DE-627 rakwb eng RC254-282 Karl Vandepoele verfasserin aut The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5–PPP1CB fusion is not specific for CLL but is also detected in other hematological malignancies such as chronic myeloid leukemia, monoclonal B cell lymphocytosis or acute leukemia and also in normal samples. As such, it is unlikely that the YPEL5–PPP1CB fusion is a good drug target in CLL or a suitable target to monitor disease. Chronic lymphocytic leukemia YPEL5–PPP1CB Trans-splicing Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jan Philippé verfasserin aut Barbara Denys verfasserin aut In Leukemia Research Reports Elsevier, 2015 4(2015), 2, Seite 51-54 (DE-627)738404586 (DE-600)2706248-X 22130489 nnns volume:4 year:2015 number:2 pages:51-54 https://doi.org/10.1016/j.lrr.2015.07.001 kostenfrei https://doaj.org/article/2aaeeb72f1ab4895aac36a2581ccd197 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213048914200239 kostenfrei https://doaj.org/toc/2213-0489 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 4 2015 2 51-54
allfieldsSound	10.1016/j.lrr.2015.07.001 doi (DE-627)DOAJ028067983 (DE-599)DOAJ2aaeeb72f1ab4895aac36a2581ccd197 DE-627 ger DE-627 rakwb eng RC254-282 Karl Vandepoele verfasserin aut The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5–PPP1CB fusion is not specific for CLL but is also detected in other hematological malignancies such as chronic myeloid leukemia, monoclonal B cell lymphocytosis or acute leukemia and also in normal samples. As such, it is unlikely that the YPEL5–PPP1CB fusion is a good drug target in CLL or a suitable target to monitor disease. Chronic lymphocytic leukemia YPEL5–PPP1CB Trans-splicing Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jan Philippé verfasserin aut Barbara Denys verfasserin aut In Leukemia Research Reports Elsevier, 2015 4(2015), 2, Seite 51-54 (DE-627)738404586 (DE-600)2706248-X 22130489 nnns volume:4 year:2015 number:2 pages:51-54 https://doi.org/10.1016/j.lrr.2015.07.001 kostenfrei https://doaj.org/article/2aaeeb72f1ab4895aac36a2581ccd197 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213048914200239 kostenfrei https://doaj.org/toc/2213-0489 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 4 2015 2 51-54
language	English
source	In Leukemia Research Reports 4(2015), 2, Seite 51-54 volume:4 year:2015 number:2 pages:51-54
sourceStr	In Leukemia Research Reports 4(2015), 2, Seite 51-54 volume:4 year:2015 number:2 pages:51-54
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Chronic lymphocytic leukemia YPEL5–PPP1CB Trans-splicing Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Leukemia Research Reports
authorswithroles_txt_mv	Karl Vandepoele @@aut@@ Jan Philippé @@aut@@ Barbara Denys @@aut@@
publishDateDaySort_date	2015-01-01T00:00:00Z
hierarchy_top_id	738404586
id	DOAJ028067983
language_de	englisch
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callnumber-first	R - Medicine
author	Karl Vandepoele
spellingShingle	Karl Vandepoele misc RC254-282 misc Chronic lymphocytic leukemia misc YPEL5–PPP1CB misc Trans-splicing misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples
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topic_title	RC254-282 The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples Chronic lymphocytic leukemia YPEL5–PPP1CB Trans-splicing
topic	misc RC254-282 misc Chronic lymphocytic leukemia misc YPEL5–PPP1CB misc Trans-splicing misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Chronic lymphocytic leukemia misc YPEL5–PPP1CB misc Trans-splicing misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples
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title_full	The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples
author_sort	Karl Vandepoele
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author_browse	Karl Vandepoele Jan Philippé Barbara Denys
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title_sort	ypel5–ppp1cb fusion transcript is detected in different hematological malignancies and in normal samples
callnumber	RC254-282
title_auth	The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples
abstract	Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5–PPP1CB fusion is not specific for CLL but is also detected in other hematological malignancies such as chronic myeloid leukemia, monoclonal B cell lymphocytosis or acute leukemia and also in normal samples. As such, it is unlikely that the YPEL5–PPP1CB fusion is a good drug target in CLL or a suitable target to monitor disease.
abstractGer	Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5–PPP1CB fusion is not specific for CLL but is also detected in other hematological malignancies such as chronic myeloid leukemia, monoclonal B cell lymphocytosis or acute leukemia and also in normal samples. As such, it is unlikely that the YPEL5–PPP1CB fusion is a good drug target in CLL or a suitable target to monitor disease.
abstract_unstemmed	Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5–PPP1CB fusion is not specific for CLL but is also detected in other hematological malignancies such as chronic myeloid leukemia, monoclonal B cell lymphocytosis or acute leukemia and also in normal samples. As such, it is unlikely that the YPEL5–PPP1CB fusion is a good drug target in CLL or a suitable target to monitor disease.
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title_short	The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples
url	https://doi.org/10.1016/j.lrr.2015.07.001 https://doaj.org/article/2aaeeb72f1ab4895aac36a2581ccd197 http://www.sciencedirect.com/science/article/pii/S2213048914200239 https://doaj.org/toc/2213-0489
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up_date	2024-07-03T15:33:29.365Z
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The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples

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