Effect of thymoquinone on cyclophosphamide-induced oxidative and inflammatory ovarian damage in rat

This study intends to investigate the effect of thymoquinone against possible ovarian damage and infertility caused by cyclophosphamide in female rats. The rats in the experiment (n=36) were separated into three groups; cyclophosphamide administered, thymoquinone plus cyclophosphamide administered a...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Cagdas Colluoglu [verfasserIn] Serdar Balci [verfasserIn] Betul Gundogdu [verfasserIn] Taha Abdulkadir Coban [verfasserIn] Seval Bulut [verfasserIn] Halis Suleyman [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Cyclophosphamide Ovarian damage Thymoquinone Rat

Übergeordnetes Werk:	In: Bangladesh Journal of Pharmacology - Bangladesh Pharmacological Society, 2016, 17(2022), 3
Übergeordnetes Werk:	volume:17 ; year:2022 ; number:3

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3329/bjp.v17i3.59418

Katalog-ID:	DOAJ028148185

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authorswithroles_txt_mv	Cagdas Colluoglu @@aut@@ Serdar Balci @@aut@@ Betul Gundogdu @@aut@@ Taha Abdulkadir Coban @@aut@@ Seval Bulut @@aut@@ Halis Suleyman @@aut@@
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callnumber-first	R - Medicine
author	Cagdas Colluoglu
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topic_title	RM1-950 Effect of thymoquinone on cyclophosphamide-induced oxidative and inflammatory ovarian damage in rat Cyclophosphamide Ovarian damage Thymoquinone Rat
topic	misc RM1-950 misc Cyclophosphamide misc Ovarian damage misc Thymoquinone misc Rat misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc Cyclophosphamide misc Ovarian damage misc Thymoquinone misc Rat misc Therapeutics. Pharmacology
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title	Effect of thymoquinone on cyclophosphamide-induced oxidative and inflammatory ovarian damage in rat
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title_full	Effect of thymoquinone on cyclophosphamide-induced oxidative and inflammatory ovarian damage in rat
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title_sort	effect of thymoquinone on cyclophosphamide-induced oxidative and inflammatory ovarian damage in rat
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title_auth	Effect of thymoquinone on cyclophosphamide-induced oxidative and inflammatory ovarian damage in rat
abstract	This study intends to investigate the effect of thymoquinone against possible ovarian damage and infertility caused by cyclophosphamide in female rats. The rats in the experiment (n=36) were separated into three groups; cyclophosphamide administered, thymoquinone plus cyclophosphamide administered and healthy control. At the end of 30 days of administration, 6 rats from each group were killed and the biochemical and histopathological examina-tions were performed on the ovarian tissues. The remaining animals were kept in the same cage with mature male rats for two months. Infertility developed in 83% of cyclophosphamide group animals. Thymoquinone attenuated cyclophosphamide-related oxidative and inflammatory ovarian damage and reduced the development of infertility. The outcomes suggest that thymoquinone may be useful in treating infertility due to oxidative and inflammatory ovarian damage.
abstractGer	This study intends to investigate the effect of thymoquinone against possible ovarian damage and infertility caused by cyclophosphamide in female rats. The rats in the experiment (n=36) were separated into three groups; cyclophosphamide administered, thymoquinone plus cyclophosphamide administered and healthy control. At the end of 30 days of administration, 6 rats from each group were killed and the biochemical and histopathological examina-tions were performed on the ovarian tissues. The remaining animals were kept in the same cage with mature male rats for two months. Infertility developed in 83% of cyclophosphamide group animals. Thymoquinone attenuated cyclophosphamide-related oxidative and inflammatory ovarian damage and reduced the development of infertility. The outcomes suggest that thymoquinone may be useful in treating infertility due to oxidative and inflammatory ovarian damage.
abstract_unstemmed	This study intends to investigate the effect of thymoquinone against possible ovarian damage and infertility caused by cyclophosphamide in female rats. The rats in the experiment (n=36) were separated into three groups; cyclophosphamide administered, thymoquinone plus cyclophosphamide administered and healthy control. At the end of 30 days of administration, 6 rats from each group were killed and the biochemical and histopathological examina-tions were performed on the ovarian tissues. The remaining animals were kept in the same cage with mature male rats for two months. Infertility developed in 83% of cyclophosphamide group animals. Thymoquinone attenuated cyclophosphamide-related oxidative and inflammatory ovarian damage and reduced the development of infertility. The outcomes suggest that thymoquinone may be useful in treating infertility due to oxidative and inflammatory ovarian damage.
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title_short	Effect of thymoquinone on cyclophosphamide-induced oxidative and inflammatory ovarian damage in rat
url	https://doi.org/10.3329/bjp.v17i3.59418 https://doaj.org/article/29bf39646e204e418e2d9b7f0d5e2eff https://www.banglajol.info/index.php/BJP/article/view/59418 https://doaj.org/toc/1991-0088
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Effect of thymoquinone on cyclophosphamide-induced oxidative and inflammatory ovarian damage in rat

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