Fludrocortisone Induces Aortic Pathologies in Mice

Background and Objective: In an experiment designed to explore the mechanisms of fludrocortisone-induced high blood pressure, we serendipitously observed aortic aneurysms in mice infused with fludrocortisone. The purpose of this study was to investigate whether fludrocortisone induces aortic pathologies in both normocholesterolemic and hypercholesterolemic mice. Methods and Results: Male adult C57BL/6J mice were infused with either vehicle (85% polyethylene glycol 400 (PEG-400) and 15% dimethyl sulfoxide (DMSO); <i<n</i< = 5) or fludrocortisone (12 mg/kg/day dissolved in 85% PEG-400 and 15% DMSO; <i<n</i< = 15) for 28 days. Fludrocortisone-infused mice had higher systolic blood pressure, compared to mice infused with vehicle. Fludrocortisone induced aortic pathologies in 4 of 15 mice with 3 having pathologies in the ascending and aortic arch regions and 1 having pathology in both the ascending and descending thoracic aorta. No pathologies were noted in abdominal aortas. Subsequently, we infused either vehicle (<i<n</i< = 5/group) or fludrocortisone (<i<n</i< = 15/group) into male ApoE <sup<−/−</sup< mice fed a normal laboratory diet or LDL receptor <sup<−/−</sup< mice fed either normal or Western diet. Fludrocortisone increased systolic blood pressure, irrespective of mouse strain or diet. In ApoE <sup<−/−</sup< mice infused with fludrocortisone, 2 of 15 mice had ascending aortic pathologies, but no mice had abdominal aortic pathologies. In LDL receptor <sup<−/−</sup< mice fed normal diet, 5 had ascending/arch pathologies and 1 had pathologies in the ascending, arch, and suprarenal aortic regions. In LDL receptor <sup<−/−</sup< mice fed Western diet, 2 died of aortic rupture in either the descending thoracic or abdominal region, and 2 of the 13 survived mice had ascending/arch aortic pathologies. Aortic pathologies included hemorrhage, wall thickening or thinning, or dilation. Only ascending aortic diameter in LDLR <sup<−/−</sup< mice fed Western diet reached statistical significance, compared to their vehicle. Conclusion: Fludrocortisone induces aortic pathologies independent of hypercholesterolemia. As indicated by the findings in mouse studies, people who are taking or have taken fludrocortisone might have an increased risk of aortic pathologies. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Dien Ye [verfasserIn] Congqing Wu [verfasserIn] Hui Chen [verfasserIn] Ching-Ling Liang [verfasserIn] Deborah A. Howatt [verfasserIn] Michael K. Franklin [verfasserIn] Jessica J. Moorleghen [verfasserIn] Samuel C. Tyagi [verfasserIn] Estrellita Uijl [verfasserIn] A. H. Jan Danser [verfasserIn] Hisashi Sawada [verfasserIn] Alan Daugherty [verfasserIn] Hong S. Lu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	aortic aneurysms aortic dissection fludrocortisone angiotensin hypercholesterolemia mouse

Übergeordnetes Werk:	In: Biomolecules - MDPI AG, 2013, 12(2022), 6, p 825
Übergeordnetes Werk:	volume:12 ; year:2022 ; number:6, p 825

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biom12060825

Katalog-ID:	DOAJ028224256

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520			\|a Background and Objective: In an experiment designed to explore the mechanisms of fludrocortisone-induced high blood pressure, we serendipitously observed aortic aneurysms in mice infused with fludrocortisone. The purpose of this study was to investigate whether fludrocortisone induces aortic pathologies in both normocholesterolemic and hypercholesterolemic mice. Methods and Results: Male adult C57BL/6J mice were infused with either vehicle (85% polyethylene glycol 400 (PEG-400) and 15% dimethyl sulfoxide (DMSO); <i<n</i< = 5) or fludrocortisone (12 mg/kg/day dissolved in 85% PEG-400 and 15% DMSO; <i<n</i< = 15) for 28 days. Fludrocortisone-infused mice had higher systolic blood pressure, compared to mice infused with vehicle. Fludrocortisone induced aortic pathologies in 4 of 15 mice with 3 having pathologies in the ascending and aortic arch regions and 1 having pathology in both the ascending and descending thoracic aorta. No pathologies were noted in abdominal aortas. Subsequently, we infused either vehicle (<i<n</i< = 5/group) or fludrocortisone (<i<n</i< = 15/group) into male ApoE <sup<−/−</sup< mice fed a normal laboratory diet or LDL receptor <sup<−/−</sup< mice fed either normal or Western diet. Fludrocortisone increased systolic blood pressure, irrespective of mouse strain or diet. In ApoE <sup<−/−</sup< mice infused with fludrocortisone, 2 of 15 mice had ascending aortic pathologies, but no mice had abdominal aortic pathologies. In LDL receptor <sup<−/−</sup< mice fed normal diet, 5 had ascending/arch pathologies and 1 had pathologies in the ascending, arch, and suprarenal aortic regions. In LDL receptor <sup<−/−</sup< mice fed Western diet, 2 died of aortic rupture in either the descending thoracic or abdominal region, and 2 of the 13 survived mice had ascending/arch aortic pathologies. Aortic pathologies included hemorrhage, wall thickening or thinning, or dilation. Only ascending aortic diameter in LDLR <sup<−/−</sup< mice fed Western diet reached statistical significance, compared to their vehicle. Conclusion: Fludrocortisone induces aortic pathologies independent of hypercholesterolemia. As indicated by the findings in mouse studies, people who are taking or have taken fludrocortisone might have an increased risk of aortic pathologies.
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allfields	10.3390/biom12060825 doi (DE-627)DOAJ028224256 (DE-599)DOAJ38c5d62cb2f04a0b91bea96eb2f18cb4 DE-627 ger DE-627 rakwb eng QR1-502 Dien Ye verfasserin aut Fludrocortisone Induces Aortic Pathologies in Mice 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objective: In an experiment designed to explore the mechanisms of fludrocortisone-induced high blood pressure, we serendipitously observed aortic aneurysms in mice infused with fludrocortisone. The purpose of this study was to investigate whether fludrocortisone induces aortic pathologies in both normocholesterolemic and hypercholesterolemic mice. Methods and Results: Male adult C57BL/6J mice were infused with either vehicle (85% polyethylene glycol 400 (PEG-400) and 15% dimethyl sulfoxide (DMSO); <i<n</i< = 5) or fludrocortisone (12 mg/kg/day dissolved in 85% PEG-400 and 15% DMSO; <i<n</i< = 15) for 28 days. Fludrocortisone-infused mice had higher systolic blood pressure, compared to mice infused with vehicle. Fludrocortisone induced aortic pathologies in 4 of 15 mice with 3 having pathologies in the ascending and aortic arch regions and 1 having pathology in both the ascending and descending thoracic aorta. No pathologies were noted in abdominal aortas. Subsequently, we infused either vehicle (<i<n</i< = 5/group) or fludrocortisone (<i<n</i< = 15/group) into male ApoE <sup<−/−</sup< mice fed a normal laboratory diet or LDL receptor <sup<−/−</sup< mice fed either normal or Western diet. Fludrocortisone increased systolic blood pressure, irrespective of mouse strain or diet. In ApoE <sup<−/−</sup< mice infused with fludrocortisone, 2 of 15 mice had ascending aortic pathologies, but no mice had abdominal aortic pathologies. In LDL receptor <sup<−/−</sup< mice fed normal diet, 5 had ascending/arch pathologies and 1 had pathologies in the ascending, arch, and suprarenal aortic regions. In LDL receptor <sup<−/−</sup< mice fed Western diet, 2 died of aortic rupture in either the descending thoracic or abdominal region, and 2 of the 13 survived mice had ascending/arch aortic pathologies. Aortic pathologies included hemorrhage, wall thickening or thinning, or dilation. Only ascending aortic diameter in LDLR <sup<−/−</sup< mice fed Western diet reached statistical significance, compared to their vehicle. Conclusion: Fludrocortisone induces aortic pathologies independent of hypercholesterolemia. As indicated by the findings in mouse studies, people who are taking or have taken fludrocortisone might have an increased risk of aortic pathologies. aortic aneurysms aortic dissection fludrocortisone angiotensin hypercholesterolemia mouse Microbiology Congqing Wu verfasserin aut Hui Chen verfasserin aut Ching-Ling Liang verfasserin aut Deborah A. Howatt verfasserin aut Michael K. Franklin verfasserin aut Jessica J. Moorleghen verfasserin aut Samuel C. Tyagi verfasserin aut Estrellita Uijl verfasserin aut A. H. Jan Danser verfasserin aut Hisashi Sawada verfasserin aut Alan Daugherty verfasserin aut Hong S. Lu verfasserin aut In Biomolecules MDPI AG, 2013 12(2022), 6, p 825 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:12 year:2022 number:6, p 825 https://doi.org/10.3390/biom12060825 kostenfrei https://doaj.org/article/38c5d62cb2f04a0b91bea96eb2f18cb4 kostenfrei https://www.mdpi.com/2218-273X/12/6/825 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 6, p 825
spelling	10.3390/biom12060825 doi (DE-627)DOAJ028224256 (DE-599)DOAJ38c5d62cb2f04a0b91bea96eb2f18cb4 DE-627 ger DE-627 rakwb eng QR1-502 Dien Ye verfasserin aut Fludrocortisone Induces Aortic Pathologies in Mice 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objective: In an experiment designed to explore the mechanisms of fludrocortisone-induced high blood pressure, we serendipitously observed aortic aneurysms in mice infused with fludrocortisone. The purpose of this study was to investigate whether fludrocortisone induces aortic pathologies in both normocholesterolemic and hypercholesterolemic mice. Methods and Results: Male adult C57BL/6J mice were infused with either vehicle (85% polyethylene glycol 400 (PEG-400) and 15% dimethyl sulfoxide (DMSO); <i<n</i< = 5) or fludrocortisone (12 mg/kg/day dissolved in 85% PEG-400 and 15% DMSO; <i<n</i< = 15) for 28 days. Fludrocortisone-infused mice had higher systolic blood pressure, compared to mice infused with vehicle. Fludrocortisone induced aortic pathologies in 4 of 15 mice with 3 having pathologies in the ascending and aortic arch regions and 1 having pathology in both the ascending and descending thoracic aorta. No pathologies were noted in abdominal aortas. Subsequently, we infused either vehicle (<i<n</i< = 5/group) or fludrocortisone (<i<n</i< = 15/group) into male ApoE <sup<−/−</sup< mice fed a normal laboratory diet or LDL receptor <sup<−/−</sup< mice fed either normal or Western diet. Fludrocortisone increased systolic blood pressure, irrespective of mouse strain or diet. In ApoE <sup<−/−</sup< mice infused with fludrocortisone, 2 of 15 mice had ascending aortic pathologies, but no mice had abdominal aortic pathologies. In LDL receptor <sup<−/−</sup< mice fed normal diet, 5 had ascending/arch pathologies and 1 had pathologies in the ascending, arch, and suprarenal aortic regions. In LDL receptor <sup<−/−</sup< mice fed Western diet, 2 died of aortic rupture in either the descending thoracic or abdominal region, and 2 of the 13 survived mice had ascending/arch aortic pathologies. Aortic pathologies included hemorrhage, wall thickening or thinning, or dilation. Only ascending aortic diameter in LDLR <sup<−/−</sup< mice fed Western diet reached statistical significance, compared to their vehicle. Conclusion: Fludrocortisone induces aortic pathologies independent of hypercholesterolemia. As indicated by the findings in mouse studies, people who are taking or have taken fludrocortisone might have an increased risk of aortic pathologies. aortic aneurysms aortic dissection fludrocortisone angiotensin hypercholesterolemia mouse Microbiology Congqing Wu verfasserin aut Hui Chen verfasserin aut Ching-Ling Liang verfasserin aut Deborah A. Howatt verfasserin aut Michael K. Franklin verfasserin aut Jessica J. Moorleghen verfasserin aut Samuel C. Tyagi verfasserin aut Estrellita Uijl verfasserin aut A. H. Jan Danser verfasserin aut Hisashi Sawada verfasserin aut Alan Daugherty verfasserin aut Hong S. Lu verfasserin aut In Biomolecules MDPI AG, 2013 12(2022), 6, p 825 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:12 year:2022 number:6, p 825 https://doi.org/10.3390/biom12060825 kostenfrei https://doaj.org/article/38c5d62cb2f04a0b91bea96eb2f18cb4 kostenfrei https://www.mdpi.com/2218-273X/12/6/825 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 6, p 825
allfields_unstemmed	10.3390/biom12060825 doi (DE-627)DOAJ028224256 (DE-599)DOAJ38c5d62cb2f04a0b91bea96eb2f18cb4 DE-627 ger DE-627 rakwb eng QR1-502 Dien Ye verfasserin aut Fludrocortisone Induces Aortic Pathologies in Mice 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objective: In an experiment designed to explore the mechanisms of fludrocortisone-induced high blood pressure, we serendipitously observed aortic aneurysms in mice infused with fludrocortisone. The purpose of this study was to investigate whether fludrocortisone induces aortic pathologies in both normocholesterolemic and hypercholesterolemic mice. Methods and Results: Male adult C57BL/6J mice were infused with either vehicle (85% polyethylene glycol 400 (PEG-400) and 15% dimethyl sulfoxide (DMSO); <i<n</i< = 5) or fludrocortisone (12 mg/kg/day dissolved in 85% PEG-400 and 15% DMSO; <i<n</i< = 15) for 28 days. Fludrocortisone-infused mice had higher systolic blood pressure, compared to mice infused with vehicle. Fludrocortisone induced aortic pathologies in 4 of 15 mice with 3 having pathologies in the ascending and aortic arch regions and 1 having pathology in both the ascending and descending thoracic aorta. No pathologies were noted in abdominal aortas. Subsequently, we infused either vehicle (<i<n</i< = 5/group) or fludrocortisone (<i<n</i< = 15/group) into male ApoE <sup<−/−</sup< mice fed a normal laboratory diet or LDL receptor <sup<−/−</sup< mice fed either normal or Western diet. Fludrocortisone increased systolic blood pressure, irrespective of mouse strain or diet. In ApoE <sup<−/−</sup< mice infused with fludrocortisone, 2 of 15 mice had ascending aortic pathologies, but no mice had abdominal aortic pathologies. In LDL receptor <sup<−/−</sup< mice fed normal diet, 5 had ascending/arch pathologies and 1 had pathologies in the ascending, arch, and suprarenal aortic regions. In LDL receptor <sup<−/−</sup< mice fed Western diet, 2 died of aortic rupture in either the descending thoracic or abdominal region, and 2 of the 13 survived mice had ascending/arch aortic pathologies. Aortic pathologies included hemorrhage, wall thickening or thinning, or dilation. Only ascending aortic diameter in LDLR <sup<−/−</sup< mice fed Western diet reached statistical significance, compared to their vehicle. Conclusion: Fludrocortisone induces aortic pathologies independent of hypercholesterolemia. As indicated by the findings in mouse studies, people who are taking or have taken fludrocortisone might have an increased risk of aortic pathologies. aortic aneurysms aortic dissection fludrocortisone angiotensin hypercholesterolemia mouse Microbiology Congqing Wu verfasserin aut Hui Chen verfasserin aut Ching-Ling Liang verfasserin aut Deborah A. Howatt verfasserin aut Michael K. Franklin verfasserin aut Jessica J. Moorleghen verfasserin aut Samuel C. Tyagi verfasserin aut Estrellita Uijl verfasserin aut A. H. Jan Danser verfasserin aut Hisashi Sawada verfasserin aut Alan Daugherty verfasserin aut Hong S. Lu verfasserin aut In Biomolecules MDPI AG, 2013 12(2022), 6, p 825 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:12 year:2022 number:6, p 825 https://doi.org/10.3390/biom12060825 kostenfrei https://doaj.org/article/38c5d62cb2f04a0b91bea96eb2f18cb4 kostenfrei https://www.mdpi.com/2218-273X/12/6/825 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 6, p 825
allfieldsGer	10.3390/biom12060825 doi (DE-627)DOAJ028224256 (DE-599)DOAJ38c5d62cb2f04a0b91bea96eb2f18cb4 DE-627 ger DE-627 rakwb eng QR1-502 Dien Ye verfasserin aut Fludrocortisone Induces Aortic Pathologies in Mice 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objective: In an experiment designed to explore the mechanisms of fludrocortisone-induced high blood pressure, we serendipitously observed aortic aneurysms in mice infused with fludrocortisone. The purpose of this study was to investigate whether fludrocortisone induces aortic pathologies in both normocholesterolemic and hypercholesterolemic mice. Methods and Results: Male adult C57BL/6J mice were infused with either vehicle (85% polyethylene glycol 400 (PEG-400) and 15% dimethyl sulfoxide (DMSO); <i<n</i< = 5) or fludrocortisone (12 mg/kg/day dissolved in 85% PEG-400 and 15% DMSO; <i<n</i< = 15) for 28 days. Fludrocortisone-infused mice had higher systolic blood pressure, compared to mice infused with vehicle. Fludrocortisone induced aortic pathologies in 4 of 15 mice with 3 having pathologies in the ascending and aortic arch regions and 1 having pathology in both the ascending and descending thoracic aorta. No pathologies were noted in abdominal aortas. Subsequently, we infused either vehicle (<i<n</i< = 5/group) or fludrocortisone (<i<n</i< = 15/group) into male ApoE <sup<−/−</sup< mice fed a normal laboratory diet or LDL receptor <sup<−/−</sup< mice fed either normal or Western diet. Fludrocortisone increased systolic blood pressure, irrespective of mouse strain or diet. In ApoE <sup<−/−</sup< mice infused with fludrocortisone, 2 of 15 mice had ascending aortic pathologies, but no mice had abdominal aortic pathologies. In LDL receptor <sup<−/−</sup< mice fed normal diet, 5 had ascending/arch pathologies and 1 had pathologies in the ascending, arch, and suprarenal aortic regions. In LDL receptor <sup<−/−</sup< mice fed Western diet, 2 died of aortic rupture in either the descending thoracic or abdominal region, and 2 of the 13 survived mice had ascending/arch aortic pathologies. Aortic pathologies included hemorrhage, wall thickening or thinning, or dilation. Only ascending aortic diameter in LDLR <sup<−/−</sup< mice fed Western diet reached statistical significance, compared to their vehicle. Conclusion: Fludrocortisone induces aortic pathologies independent of hypercholesterolemia. As indicated by the findings in mouse studies, people who are taking or have taken fludrocortisone might have an increased risk of aortic pathologies. aortic aneurysms aortic dissection fludrocortisone angiotensin hypercholesterolemia mouse Microbiology Congqing Wu verfasserin aut Hui Chen verfasserin aut Ching-Ling Liang verfasserin aut Deborah A. Howatt verfasserin aut Michael K. Franklin verfasserin aut Jessica J. Moorleghen verfasserin aut Samuel C. Tyagi verfasserin aut Estrellita Uijl verfasserin aut A. H. Jan Danser verfasserin aut Hisashi Sawada verfasserin aut Alan Daugherty verfasserin aut Hong S. Lu verfasserin aut In Biomolecules MDPI AG, 2013 12(2022), 6, p 825 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:12 year:2022 number:6, p 825 https://doi.org/10.3390/biom12060825 kostenfrei https://doaj.org/article/38c5d62cb2f04a0b91bea96eb2f18cb4 kostenfrei https://www.mdpi.com/2218-273X/12/6/825 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 6, p 825
allfieldsSound	10.3390/biom12060825 doi (DE-627)DOAJ028224256 (DE-599)DOAJ38c5d62cb2f04a0b91bea96eb2f18cb4 DE-627 ger DE-627 rakwb eng QR1-502 Dien Ye verfasserin aut Fludrocortisone Induces Aortic Pathologies in Mice 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objective: In an experiment designed to explore the mechanisms of fludrocortisone-induced high blood pressure, we serendipitously observed aortic aneurysms in mice infused with fludrocortisone. The purpose of this study was to investigate whether fludrocortisone induces aortic pathologies in both normocholesterolemic and hypercholesterolemic mice. Methods and Results: Male adult C57BL/6J mice were infused with either vehicle (85% polyethylene glycol 400 (PEG-400) and 15% dimethyl sulfoxide (DMSO); <i<n</i< = 5) or fludrocortisone (12 mg/kg/day dissolved in 85% PEG-400 and 15% DMSO; <i<n</i< = 15) for 28 days. Fludrocortisone-infused mice had higher systolic blood pressure, compared to mice infused with vehicle. Fludrocortisone induced aortic pathologies in 4 of 15 mice with 3 having pathologies in the ascending and aortic arch regions and 1 having pathology in both the ascending and descending thoracic aorta. No pathologies were noted in abdominal aortas. Subsequently, we infused either vehicle (<i<n</i< = 5/group) or fludrocortisone (<i<n</i< = 15/group) into male ApoE <sup<−/−</sup< mice fed a normal laboratory diet or LDL receptor <sup<−/−</sup< mice fed either normal or Western diet. Fludrocortisone increased systolic blood pressure, irrespective of mouse strain or diet. In ApoE <sup<−/−</sup< mice infused with fludrocortisone, 2 of 15 mice had ascending aortic pathologies, but no mice had abdominal aortic pathologies. In LDL receptor <sup<−/−</sup< mice fed normal diet, 5 had ascending/arch pathologies and 1 had pathologies in the ascending, arch, and suprarenal aortic regions. In LDL receptor <sup<−/−</sup< mice fed Western diet, 2 died of aortic rupture in either the descending thoracic or abdominal region, and 2 of the 13 survived mice had ascending/arch aortic pathologies. Aortic pathologies included hemorrhage, wall thickening or thinning, or dilation. Only ascending aortic diameter in LDLR <sup<−/−</sup< mice fed Western diet reached statistical significance, compared to their vehicle. Conclusion: Fludrocortisone induces aortic pathologies independent of hypercholesterolemia. As indicated by the findings in mouse studies, people who are taking or have taken fludrocortisone might have an increased risk of aortic pathologies. aortic aneurysms aortic dissection fludrocortisone angiotensin hypercholesterolemia mouse Microbiology Congqing Wu verfasserin aut Hui Chen verfasserin aut Ching-Ling Liang verfasserin aut Deborah A. Howatt verfasserin aut Michael K. Franklin verfasserin aut Jessica J. Moorleghen verfasserin aut Samuel C. Tyagi verfasserin aut Estrellita Uijl verfasserin aut A. H. Jan Danser verfasserin aut Hisashi Sawada verfasserin aut Alan Daugherty verfasserin aut Hong S. Lu verfasserin aut In Biomolecules MDPI AG, 2013 12(2022), 6, p 825 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:12 year:2022 number:6, p 825 https://doi.org/10.3390/biom12060825 kostenfrei https://doaj.org/article/38c5d62cb2f04a0b91bea96eb2f18cb4 kostenfrei https://www.mdpi.com/2218-273X/12/6/825 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 6, p 825
language	English
source	In Biomolecules 12(2022), 6, p 825 volume:12 year:2022 number:6, p 825
sourceStr	In Biomolecules 12(2022), 6, p 825 volume:12 year:2022 number:6, p 825
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	aortic aneurysms aortic dissection fludrocortisone angiotensin hypercholesterolemia mouse Microbiology
isfreeaccess_bool	true
container_title	Biomolecules
authorswithroles_txt_mv	Dien Ye @@aut@@ Congqing Wu @@aut@@ Hui Chen @@aut@@ Ching-Ling Liang @@aut@@ Deborah A. Howatt @@aut@@ Michael K. Franklin @@aut@@ Jessica J. Moorleghen @@aut@@ Samuel C. Tyagi @@aut@@ Estrellita Uijl @@aut@@ A. H. Jan Danser @@aut@@ Hisashi Sawada @@aut@@ Alan Daugherty @@aut@@ Hong S. Lu @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	735688915
id	DOAJ028224256
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ028224256</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240414205244.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230226s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/biom12060825</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ028224256</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ38c5d62cb2f04a0b91bea96eb2f18cb4</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QR1-502</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Dien Ye</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Fludrocortisone Induces Aortic Pathologies in Mice</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background and Objective: In an experiment designed to explore the mechanisms of fludrocortisone-induced high blood pressure, we serendipitously observed aortic aneurysms in mice infused with fludrocortisone. The purpose of this study was to investigate whether fludrocortisone induces aortic pathologies in both normocholesterolemic and hypercholesterolemic mice. Methods and Results: Male adult C57BL/6J mice were infused with either vehicle (85% polyethylene glycol 400 (PEG-400) and 15% dimethyl sulfoxide (DMSO); <i<n</i< = 5) or fludrocortisone (12 mg/kg/day dissolved in 85% PEG-400 and 15% DMSO; <i<n</i< = 15) for 28 days. Fludrocortisone-infused mice had higher systolic blood pressure, compared to mice infused with vehicle. Fludrocortisone induced aortic pathologies in 4 of 15 mice with 3 having pathologies in the ascending and aortic arch regions and 1 having pathology in both the ascending and descending thoracic aorta. No pathologies were noted in abdominal aortas. Subsequently, we infused either vehicle (<i<n</i< = 5/group) or fludrocortisone (<i<n</i< = 15/group) into male ApoE <sup<−/−</sup< mice fed a normal laboratory diet or LDL receptor <sup<−/−</sup< mice fed either normal or Western diet. Fludrocortisone increased systolic blood pressure, irrespective of mouse strain or diet. In ApoE <sup<−/−</sup< mice infused with fludrocortisone, 2 of 15 mice had ascending aortic pathologies, but no mice had abdominal aortic pathologies. In LDL receptor <sup<−/−</sup< mice fed normal diet, 5 had ascending/arch pathologies and 1 had pathologies in the ascending, arch, and suprarenal aortic regions. In LDL receptor <sup<−/−</sup< mice fed Western diet, 2 died of aortic rupture in either the descending thoracic or abdominal region, and 2 of the 13 survived mice had ascending/arch aortic pathologies. Aortic pathologies included hemorrhage, wall thickening or thinning, or dilation. Only ascending aortic diameter in LDLR <sup<−/−</sup< mice fed Western diet reached statistical significance, compared to their vehicle. Conclusion: Fludrocortisone induces aortic pathologies independent of hypercholesterolemia. 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callnumber-first	Q - Science
author	Dien Ye
spellingShingle	Dien Ye misc QR1-502 misc aortic aneurysms misc aortic dissection misc fludrocortisone misc angiotensin misc hypercholesterolemia misc mouse misc Microbiology Fludrocortisone Induces Aortic Pathologies in Mice
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topic_title	QR1-502 Fludrocortisone Induces Aortic Pathologies in Mice aortic aneurysms aortic dissection fludrocortisone angiotensin hypercholesterolemia mouse
topic	misc QR1-502 misc aortic aneurysms misc aortic dissection misc fludrocortisone misc angiotensin misc hypercholesterolemia misc mouse misc Microbiology
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title	Fludrocortisone Induces Aortic Pathologies in Mice
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title_full	Fludrocortisone Induces Aortic Pathologies in Mice
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author_browse	Dien Ye Congqing Wu Hui Chen Ching-Ling Liang Deborah A. Howatt Michael K. Franklin Jessica J. Moorleghen Samuel C. Tyagi Estrellita Uijl A. H. Jan Danser Hisashi Sawada Alan Daugherty Hong S. Lu
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doi_str_mv	10.3390/biom12060825
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title_sort	fludrocortisone induces aortic pathologies in mice
callnumber	QR1-502
title_auth	Fludrocortisone Induces Aortic Pathologies in Mice
abstract	Background and Objective: In an experiment designed to explore the mechanisms of fludrocortisone-induced high blood pressure, we serendipitously observed aortic aneurysms in mice infused with fludrocortisone. The purpose of this study was to investigate whether fludrocortisone induces aortic pathologies in both normocholesterolemic and hypercholesterolemic mice. Methods and Results: Male adult C57BL/6J mice were infused with either vehicle (85% polyethylene glycol 400 (PEG-400) and 15% dimethyl sulfoxide (DMSO); <i<n</i< = 5) or fludrocortisone (12 mg/kg/day dissolved in 85% PEG-400 and 15% DMSO; <i<n</i< = 15) for 28 days. Fludrocortisone-infused mice had higher systolic blood pressure, compared to mice infused with vehicle. Fludrocortisone induced aortic pathologies in 4 of 15 mice with 3 having pathologies in the ascending and aortic arch regions and 1 having pathology in both the ascending and descending thoracic aorta. No pathologies were noted in abdominal aortas. Subsequently, we infused either vehicle (<i<n</i< = 5/group) or fludrocortisone (<i<n</i< = 15/group) into male ApoE <sup<−/−</sup< mice fed a normal laboratory diet or LDL receptor <sup<−/−</sup< mice fed either normal or Western diet. Fludrocortisone increased systolic blood pressure, irrespective of mouse strain or diet. In ApoE <sup<−/−</sup< mice infused with fludrocortisone, 2 of 15 mice had ascending aortic pathologies, but no mice had abdominal aortic pathologies. In LDL receptor <sup<−/−</sup< mice fed normal diet, 5 had ascending/arch pathologies and 1 had pathologies in the ascending, arch, and suprarenal aortic regions. In LDL receptor <sup<−/−</sup< mice fed Western diet, 2 died of aortic rupture in either the descending thoracic or abdominal region, and 2 of the 13 survived mice had ascending/arch aortic pathologies. Aortic pathologies included hemorrhage, wall thickening or thinning, or dilation. Only ascending aortic diameter in LDLR <sup<−/−</sup< mice fed Western diet reached statistical significance, compared to their vehicle. Conclusion: Fludrocortisone induces aortic pathologies independent of hypercholesterolemia. As indicated by the findings in mouse studies, people who are taking or have taken fludrocortisone might have an increased risk of aortic pathologies.
abstractGer	Background and Objective: In an experiment designed to explore the mechanisms of fludrocortisone-induced high blood pressure, we serendipitously observed aortic aneurysms in mice infused with fludrocortisone. The purpose of this study was to investigate whether fludrocortisone induces aortic pathologies in both normocholesterolemic and hypercholesterolemic mice. Methods and Results: Male adult C57BL/6J mice were infused with either vehicle (85% polyethylene glycol 400 (PEG-400) and 15% dimethyl sulfoxide (DMSO); <i<n</i< = 5) or fludrocortisone (12 mg/kg/day dissolved in 85% PEG-400 and 15% DMSO; <i<n</i< = 15) for 28 days. Fludrocortisone-infused mice had higher systolic blood pressure, compared to mice infused with vehicle. Fludrocortisone induced aortic pathologies in 4 of 15 mice with 3 having pathologies in the ascending and aortic arch regions and 1 having pathology in both the ascending and descending thoracic aorta. No pathologies were noted in abdominal aortas. Subsequently, we infused either vehicle (<i<n</i< = 5/group) or fludrocortisone (<i<n</i< = 15/group) into male ApoE <sup<−/−</sup< mice fed a normal laboratory diet or LDL receptor <sup<−/−</sup< mice fed either normal or Western diet. Fludrocortisone increased systolic blood pressure, irrespective of mouse strain or diet. In ApoE <sup<−/−</sup< mice infused with fludrocortisone, 2 of 15 mice had ascending aortic pathologies, but no mice had abdominal aortic pathologies. In LDL receptor <sup<−/−</sup< mice fed normal diet, 5 had ascending/arch pathologies and 1 had pathologies in the ascending, arch, and suprarenal aortic regions. In LDL receptor <sup<−/−</sup< mice fed Western diet, 2 died of aortic rupture in either the descending thoracic or abdominal region, and 2 of the 13 survived mice had ascending/arch aortic pathologies. Aortic pathologies included hemorrhage, wall thickening or thinning, or dilation. Only ascending aortic diameter in LDLR <sup<−/−</sup< mice fed Western diet reached statistical significance, compared to their vehicle. Conclusion: Fludrocortisone induces aortic pathologies independent of hypercholesterolemia. As indicated by the findings in mouse studies, people who are taking or have taken fludrocortisone might have an increased risk of aortic pathologies.
abstract_unstemmed	Background and Objective: In an experiment designed to explore the mechanisms of fludrocortisone-induced high blood pressure, we serendipitously observed aortic aneurysms in mice infused with fludrocortisone. The purpose of this study was to investigate whether fludrocortisone induces aortic pathologies in both normocholesterolemic and hypercholesterolemic mice. Methods and Results: Male adult C57BL/6J mice were infused with either vehicle (85% polyethylene glycol 400 (PEG-400) and 15% dimethyl sulfoxide (DMSO); <i<n</i< = 5) or fludrocortisone (12 mg/kg/day dissolved in 85% PEG-400 and 15% DMSO; <i<n</i< = 15) for 28 days. Fludrocortisone-infused mice had higher systolic blood pressure, compared to mice infused with vehicle. Fludrocortisone induced aortic pathologies in 4 of 15 mice with 3 having pathologies in the ascending and aortic arch regions and 1 having pathology in both the ascending and descending thoracic aorta. No pathologies were noted in abdominal aortas. Subsequently, we infused either vehicle (<i<n</i< = 5/group) or fludrocortisone (<i<n</i< = 15/group) into male ApoE <sup<−/−</sup< mice fed a normal laboratory diet or LDL receptor <sup<−/−</sup< mice fed either normal or Western diet. Fludrocortisone increased systolic blood pressure, irrespective of mouse strain or diet. In ApoE <sup<−/−</sup< mice infused with fludrocortisone, 2 of 15 mice had ascending aortic pathologies, but no mice had abdominal aortic pathologies. In LDL receptor <sup<−/−</sup< mice fed normal diet, 5 had ascending/arch pathologies and 1 had pathologies in the ascending, arch, and suprarenal aortic regions. In LDL receptor <sup<−/−</sup< mice fed Western diet, 2 died of aortic rupture in either the descending thoracic or abdominal region, and 2 of the 13 survived mice had ascending/arch aortic pathologies. Aortic pathologies included hemorrhage, wall thickening or thinning, or dilation. Only ascending aortic diameter in LDLR <sup<−/−</sup< mice fed Western diet reached statistical significance, compared to their vehicle. Conclusion: Fludrocortisone induces aortic pathologies independent of hypercholesterolemia. As indicated by the findings in mouse studies, people who are taking or have taken fludrocortisone might have an increased risk of aortic pathologies.
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title_short	Fludrocortisone Induces Aortic Pathologies in Mice
url	https://doi.org/10.3390/biom12060825 https://doaj.org/article/38c5d62cb2f04a0b91bea96eb2f18cb4 https://www.mdpi.com/2218-273X/12/6/825 https://doaj.org/toc/2218-273X
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Fludrocortisone Induces Aortic Pathologies in Mice

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