Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults

Motivated by the frontal- and white matter (WM) retrogenesis hypotheses and the as- sumptions that fronto-striatal circuits are especially vulnerable in normal aging, the goal of the present study was to identify fiber bundles connecting subcortical nuclei and frontal ar- eas and obtain site-specifi...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Alexandra eVik [verfasserIn] Erlend eHodneland [verfasserIn] Judit eHaász [verfasserIn] Martin eYstad [verfasserIn] Astri Johansen Lundervold [verfasserIn] Arvid eLundervold [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	tractography Diffusion Weighted Imaging fractional anisotropy healthy aging longitudinal study 3D MRI

Übergeordnetes Werk:	In: Frontiers in Aging Neuroscience - Frontiers Media S.A., 2010, 7(2015)
Übergeordnetes Werk:	volume:7 ; year:2015

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnagi.2015.00081

Katalog-ID:	DOAJ028279123

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callnumber-first	R - Medicine
author	Alexandra eVik
spellingShingle	Alexandra eVik misc RC321-571 misc tractography misc Diffusion Weighted Imaging misc fractional anisotropy misc healthy aging misc longitudinal study misc 3D MRI misc Neurosciences. Biological psychiatry. Neuropsychiatry Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults
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topic_title	RC321-571 Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults tractography Diffusion Weighted Imaging fractional anisotropy healthy aging longitudinal study 3D MRI
topic	misc RC321-571 misc tractography misc Diffusion Weighted Imaging misc fractional anisotropy misc healthy aging misc longitudinal study misc 3D MRI misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc tractography misc Diffusion Weighted Imaging misc fractional anisotropy misc healthy aging misc longitudinal study misc 3D MRI misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults
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title_full	Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults
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title_sort	fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - a longitudinal mri study of 76 middle-aged and older adults
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title_auth	Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults
abstract	Motivated by the frontal- and white matter (WM) retrogenesis hypotheses and the as- sumptions that fronto-striatal circuits are especially vulnerable in normal aging, the goal of the present study was to identify fiber bundles connecting subcortical nuclei and frontal ar- eas and obtain site-specific information about age related fractional anisotropy (FA) changes. Multimodal magnetic resonance image acquisitions (3D T1-weighted and diffusion weighted imaging (DWI)) were obtained from healthy older adults (N=76, range 49-80 years at inclusion) at two time points, three years apart. A subset of the participants (N=24) was included at a third time-point. In addition to the frontal-subcortical fibers, the anterior callosal fiber (ACF) and the corticospinal tract (CST) was investigated by its mean FA together with tract parameterization analysis. Our results demonstrated fronto-striatal structural connec- tivity decline (reduced FA) in normal aging with substantial inter-individual differences. The tract parameterization analysis showed that the along tract FA profiles were characterized by piece-wise differential changes along their extension rather than being uniformly affected. To the best of our knowledge, this is the first longitudinal study detecting age-related changes in frontal-subcortical WM connections in normal aging.
abstractGer	Motivated by the frontal- and white matter (WM) retrogenesis hypotheses and the as- sumptions that fronto-striatal circuits are especially vulnerable in normal aging, the goal of the present study was to identify fiber bundles connecting subcortical nuclei and frontal ar- eas and obtain site-specific information about age related fractional anisotropy (FA) changes. Multimodal magnetic resonance image acquisitions (3D T1-weighted and diffusion weighted imaging (DWI)) were obtained from healthy older adults (N=76, range 49-80 years at inclusion) at two time points, three years apart. A subset of the participants (N=24) was included at a third time-point. In addition to the frontal-subcortical fibers, the anterior callosal fiber (ACF) and the corticospinal tract (CST) was investigated by its mean FA together with tract parameterization analysis. Our results demonstrated fronto-striatal structural connec- tivity decline (reduced FA) in normal aging with substantial inter-individual differences. The tract parameterization analysis showed that the along tract FA profiles were characterized by piece-wise differential changes along their extension rather than being uniformly affected. To the best of our knowledge, this is the first longitudinal study detecting age-related changes in frontal-subcortical WM connections in normal aging.
abstract_unstemmed	Motivated by the frontal- and white matter (WM) retrogenesis hypotheses and the as- sumptions that fronto-striatal circuits are especially vulnerable in normal aging, the goal of the present study was to identify fiber bundles connecting subcortical nuclei and frontal ar- eas and obtain site-specific information about age related fractional anisotropy (FA) changes. Multimodal magnetic resonance image acquisitions (3D T1-weighted and diffusion weighted imaging (DWI)) were obtained from healthy older adults (N=76, range 49-80 years at inclusion) at two time points, three years apart. A subset of the participants (N=24) was included at a third time-point. In addition to the frontal-subcortical fibers, the anterior callosal fiber (ACF) and the corticospinal tract (CST) was investigated by its mean FA together with tract parameterization analysis. Our results demonstrated fronto-striatal structural connec- tivity decline (reduced FA) in normal aging with substantial inter-individual differences. The tract parameterization analysis showed that the along tract FA profiles were characterized by piece-wise differential changes along their extension rather than being uniformly affected. To the best of our knowledge, this is the first longitudinal study detecting age-related changes in frontal-subcortical WM connections in normal aging.
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title_short	Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults
url	https://doi.org/10.3389/fnagi.2015.00081 https://doaj.org/article/b7ab1a1e063a4fd08de4da8102a6d96c http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00081/full https://doaj.org/toc/1663-4365
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up_date	2024-07-03T16:42:48.066Z
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Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults

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