Excess Risk of Major Adverse Cardiovascular and Kidney Events after Acute Kidney Injury following Living Donor Liver Transplantation

Acute kidney injury (AKI) is a well-known risk factor for major adverse kidney events (MAKE) and major adverse cardiovascular events (MACE) in nontransplant settings. However, the association between AKI after liver transplantation (LT) and MACE/MAKE is not established. A retrospective cohort analys...
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Autor*in:	Yi-Chia Chan [verfasserIn] Cheng-Hsi Yeh [verfasserIn] Lung-Chih Li [verfasserIn] Chao-Long Chen [verfasserIn] Chih-Chi Wang [verfasserIn] Chih-Chi Lin [verfasserIn] Aldwin D. Ong [verfasserIn] Ting-Yu Chiou [verfasserIn] Chee-Chien Yong [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	acute kidney injury liver transplantation major adverse cardiovascular events major adverse kidney event cardiovascular disease

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 11(2022), 11, p 3100
Übergeordnetes Werk:	volume:11 ; year:2022 ; number:11, p 3100

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm11113100

Katalog-ID:	DOAJ028390725

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520			\|a Acute kidney injury (AKI) is a well-known risk factor for major adverse kidney events (MAKE) and major adverse cardiovascular events (MACE) in nontransplant settings. However, the association between AKI after liver transplantation (LT) and MACE/MAKE is not established. A retrospective cohort analysis including 512 LT recipients was conducted. The incidence of post-LT AKI was 35.0% (<i<n</i< = 179). In total, 13 patients (2.5%) developed de novo coronary artery disease (CAD), 3 patients (0.6%) diagnosed with heart failure (HF), and 11 patients (2.1%) had stroke. The post-LT AKI group showed a higher incidence of CAD and HF than the no post-LT AKI group (4.5% versus 1.5%, <i<p</i< = 0.042; 1.7% versus 0%, <i<p</i< = 0.018; respectively), while there was no significant difference in the stroke events (2.8% versus 1.8%, <i<p</i< = 0.461). Through Cox regression analysis, history of cardiovascular disease (HR 6.51, 95% CI 2.43–17.46), post-LT AKI (HR 3.06, 95% CI 1.39–6.75), and pre-LT diabetes (HR 2.37, 95% CI 1.09–5.17) were identified as independent predictors of MACE; pre-LT chronic kidney disease (HR 9.54, 95% CI 3.49–26.10), pre-LT diabetes (HR 3.51, 95% CI 1.25–9.86), and post-LT AKI (HR 6.76, 95% CI 2.19–20.91) were risk factors for end-stage renal disease. Post-LT AKI is predictive for the development of MACE and MAKE.
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allfields	10.3390/jcm11113100 doi (DE-627)DOAJ028390725 (DE-599)DOAJa8264161d43a41d792bb0276ef48e9ae DE-627 ger DE-627 rakwb eng Yi-Chia Chan verfasserin aut Excess Risk of Major Adverse Cardiovascular and Kidney Events after Acute Kidney Injury following Living Donor Liver Transplantation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Acute kidney injury (AKI) is a well-known risk factor for major adverse kidney events (MAKE) and major adverse cardiovascular events (MACE) in nontransplant settings. However, the association between AKI after liver transplantation (LT) and MACE/MAKE is not established. A retrospective cohort analysis including 512 LT recipients was conducted. The incidence of post-LT AKI was 35.0% (<i<n</i< = 179). In total, 13 patients (2.5%) developed de novo coronary artery disease (CAD), 3 patients (0.6%) diagnosed with heart failure (HF), and 11 patients (2.1%) had stroke. The post-LT AKI group showed a higher incidence of CAD and HF than the no post-LT AKI group (4.5% versus 1.5%, <i<p</i< = 0.042; 1.7% versus 0%, <i<p</i< = 0.018; respectively), while there was no significant difference in the stroke events (2.8% versus 1.8%, <i<p</i< = 0.461). Through Cox regression analysis, history of cardiovascular disease (HR 6.51, 95% CI 2.43–17.46), post-LT AKI (HR 3.06, 95% CI 1.39–6.75), and pre-LT diabetes (HR 2.37, 95% CI 1.09–5.17) were identified as independent predictors of MACE; pre-LT chronic kidney disease (HR 9.54, 95% CI 3.49–26.10), pre-LT diabetes (HR 3.51, 95% CI 1.25–9.86), and post-LT AKI (HR 6.76, 95% CI 2.19–20.91) were risk factors for end-stage renal disease. Post-LT AKI is predictive for the development of MACE and MAKE. acute kidney injury liver transplantation major adverse cardiovascular events major adverse kidney event cardiovascular disease Medicine R Cheng-Hsi Yeh verfasserin aut Lung-Chih Li verfasserin aut Chao-Long Chen verfasserin aut Chih-Chi Wang verfasserin aut Chih-Chi Lin verfasserin aut Aldwin D. Ong verfasserin aut Ting-Yu Chiou verfasserin aut Chee-Chien Yong verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 11, p 3100 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:11, p 3100 https://doi.org/10.3390/jcm11113100 kostenfrei https://doaj.org/article/a8264161d43a41d792bb0276ef48e9ae kostenfrei https://www.mdpi.com/2077-0383/11/11/3100 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 11, p 3100
spelling	10.3390/jcm11113100 doi (DE-627)DOAJ028390725 (DE-599)DOAJa8264161d43a41d792bb0276ef48e9ae DE-627 ger DE-627 rakwb eng Yi-Chia Chan verfasserin aut Excess Risk of Major Adverse Cardiovascular and Kidney Events after Acute Kidney Injury following Living Donor Liver Transplantation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Acute kidney injury (AKI) is a well-known risk factor for major adverse kidney events (MAKE) and major adverse cardiovascular events (MACE) in nontransplant settings. However, the association between AKI after liver transplantation (LT) and MACE/MAKE is not established. A retrospective cohort analysis including 512 LT recipients was conducted. The incidence of post-LT AKI was 35.0% (<i<n</i< = 179). In total, 13 patients (2.5%) developed de novo coronary artery disease (CAD), 3 patients (0.6%) diagnosed with heart failure (HF), and 11 patients (2.1%) had stroke. The post-LT AKI group showed a higher incidence of CAD and HF than the no post-LT AKI group (4.5% versus 1.5%, <i<p</i< = 0.042; 1.7% versus 0%, <i<p</i< = 0.018; respectively), while there was no significant difference in the stroke events (2.8% versus 1.8%, <i<p</i< = 0.461). Through Cox regression analysis, history of cardiovascular disease (HR 6.51, 95% CI 2.43–17.46), post-LT AKI (HR 3.06, 95% CI 1.39–6.75), and pre-LT diabetes (HR 2.37, 95% CI 1.09–5.17) were identified as independent predictors of MACE; pre-LT chronic kidney disease (HR 9.54, 95% CI 3.49–26.10), pre-LT diabetes (HR 3.51, 95% CI 1.25–9.86), and post-LT AKI (HR 6.76, 95% CI 2.19–20.91) were risk factors for end-stage renal disease. Post-LT AKI is predictive for the development of MACE and MAKE. acute kidney injury liver transplantation major adverse cardiovascular events major adverse kidney event cardiovascular disease Medicine R Cheng-Hsi Yeh verfasserin aut Lung-Chih Li verfasserin aut Chao-Long Chen verfasserin aut Chih-Chi Wang verfasserin aut Chih-Chi Lin verfasserin aut Aldwin D. Ong verfasserin aut Ting-Yu Chiou verfasserin aut Chee-Chien Yong verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 11, p 3100 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:11, p 3100 https://doi.org/10.3390/jcm11113100 kostenfrei https://doaj.org/article/a8264161d43a41d792bb0276ef48e9ae kostenfrei https://www.mdpi.com/2077-0383/11/11/3100 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 11, p 3100
allfields_unstemmed	10.3390/jcm11113100 doi (DE-627)DOAJ028390725 (DE-599)DOAJa8264161d43a41d792bb0276ef48e9ae DE-627 ger DE-627 rakwb eng Yi-Chia Chan verfasserin aut Excess Risk of Major Adverse Cardiovascular and Kidney Events after Acute Kidney Injury following Living Donor Liver Transplantation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Acute kidney injury (AKI) is a well-known risk factor for major adverse kidney events (MAKE) and major adverse cardiovascular events (MACE) in nontransplant settings. However, the association between AKI after liver transplantation (LT) and MACE/MAKE is not established. A retrospective cohort analysis including 512 LT recipients was conducted. The incidence of post-LT AKI was 35.0% (<i<n</i< = 179). In total, 13 patients (2.5%) developed de novo coronary artery disease (CAD), 3 patients (0.6%) diagnosed with heart failure (HF), and 11 patients (2.1%) had stroke. The post-LT AKI group showed a higher incidence of CAD and HF than the no post-LT AKI group (4.5% versus 1.5%, <i<p</i< = 0.042; 1.7% versus 0%, <i<p</i< = 0.018; respectively), while there was no significant difference in the stroke events (2.8% versus 1.8%, <i<p</i< = 0.461). Through Cox regression analysis, history of cardiovascular disease (HR 6.51, 95% CI 2.43–17.46), post-LT AKI (HR 3.06, 95% CI 1.39–6.75), and pre-LT diabetes (HR 2.37, 95% CI 1.09–5.17) were identified as independent predictors of MACE; pre-LT chronic kidney disease (HR 9.54, 95% CI 3.49–26.10), pre-LT diabetes (HR 3.51, 95% CI 1.25–9.86), and post-LT AKI (HR 6.76, 95% CI 2.19–20.91) were risk factors for end-stage renal disease. Post-LT AKI is predictive for the development of MACE and MAKE. acute kidney injury liver transplantation major adverse cardiovascular events major adverse kidney event cardiovascular disease Medicine R Cheng-Hsi Yeh verfasserin aut Lung-Chih Li verfasserin aut Chao-Long Chen verfasserin aut Chih-Chi Wang verfasserin aut Chih-Chi Lin verfasserin aut Aldwin D. Ong verfasserin aut Ting-Yu Chiou verfasserin aut Chee-Chien Yong verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 11, p 3100 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:11, p 3100 https://doi.org/10.3390/jcm11113100 kostenfrei https://doaj.org/article/a8264161d43a41d792bb0276ef48e9ae kostenfrei https://www.mdpi.com/2077-0383/11/11/3100 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 11, p 3100
allfieldsGer	10.3390/jcm11113100 doi (DE-627)DOAJ028390725 (DE-599)DOAJa8264161d43a41d792bb0276ef48e9ae DE-627 ger DE-627 rakwb eng Yi-Chia Chan verfasserin aut Excess Risk of Major Adverse Cardiovascular and Kidney Events after Acute Kidney Injury following Living Donor Liver Transplantation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Acute kidney injury (AKI) is a well-known risk factor for major adverse kidney events (MAKE) and major adverse cardiovascular events (MACE) in nontransplant settings. However, the association between AKI after liver transplantation (LT) and MACE/MAKE is not established. A retrospective cohort analysis including 512 LT recipients was conducted. The incidence of post-LT AKI was 35.0% (<i<n</i< = 179). In total, 13 patients (2.5%) developed de novo coronary artery disease (CAD), 3 patients (0.6%) diagnosed with heart failure (HF), and 11 patients (2.1%) had stroke. The post-LT AKI group showed a higher incidence of CAD and HF than the no post-LT AKI group (4.5% versus 1.5%, <i<p</i< = 0.042; 1.7% versus 0%, <i<p</i< = 0.018; respectively), while there was no significant difference in the stroke events (2.8% versus 1.8%, <i<p</i< = 0.461). Through Cox regression analysis, history of cardiovascular disease (HR 6.51, 95% CI 2.43–17.46), post-LT AKI (HR 3.06, 95% CI 1.39–6.75), and pre-LT diabetes (HR 2.37, 95% CI 1.09–5.17) were identified as independent predictors of MACE; pre-LT chronic kidney disease (HR 9.54, 95% CI 3.49–26.10), pre-LT diabetes (HR 3.51, 95% CI 1.25–9.86), and post-LT AKI (HR 6.76, 95% CI 2.19–20.91) were risk factors for end-stage renal disease. Post-LT AKI is predictive for the development of MACE and MAKE. acute kidney injury liver transplantation major adverse cardiovascular events major adverse kidney event cardiovascular disease Medicine R Cheng-Hsi Yeh verfasserin aut Lung-Chih Li verfasserin aut Chao-Long Chen verfasserin aut Chih-Chi Wang verfasserin aut Chih-Chi Lin verfasserin aut Aldwin D. Ong verfasserin aut Ting-Yu Chiou verfasserin aut Chee-Chien Yong verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 11, p 3100 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:11, p 3100 https://doi.org/10.3390/jcm11113100 kostenfrei https://doaj.org/article/a8264161d43a41d792bb0276ef48e9ae kostenfrei https://www.mdpi.com/2077-0383/11/11/3100 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 11, p 3100
allfieldsSound	10.3390/jcm11113100 doi (DE-627)DOAJ028390725 (DE-599)DOAJa8264161d43a41d792bb0276ef48e9ae DE-627 ger DE-627 rakwb eng Yi-Chia Chan verfasserin aut Excess Risk of Major Adverse Cardiovascular and Kidney Events after Acute Kidney Injury following Living Donor Liver Transplantation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Acute kidney injury (AKI) is a well-known risk factor for major adverse kidney events (MAKE) and major adverse cardiovascular events (MACE) in nontransplant settings. However, the association between AKI after liver transplantation (LT) and MACE/MAKE is not established. A retrospective cohort analysis including 512 LT recipients was conducted. The incidence of post-LT AKI was 35.0% (<i<n</i< = 179). In total, 13 patients (2.5%) developed de novo coronary artery disease (CAD), 3 patients (0.6%) diagnosed with heart failure (HF), and 11 patients (2.1%) had stroke. The post-LT AKI group showed a higher incidence of CAD and HF than the no post-LT AKI group (4.5% versus 1.5%, <i<p</i< = 0.042; 1.7% versus 0%, <i<p</i< = 0.018; respectively), while there was no significant difference in the stroke events (2.8% versus 1.8%, <i<p</i< = 0.461). Through Cox regression analysis, history of cardiovascular disease (HR 6.51, 95% CI 2.43–17.46), post-LT AKI (HR 3.06, 95% CI 1.39–6.75), and pre-LT diabetes (HR 2.37, 95% CI 1.09–5.17) were identified as independent predictors of MACE; pre-LT chronic kidney disease (HR 9.54, 95% CI 3.49–26.10), pre-LT diabetes (HR 3.51, 95% CI 1.25–9.86), and post-LT AKI (HR 6.76, 95% CI 2.19–20.91) were risk factors for end-stage renal disease. Post-LT AKI is predictive for the development of MACE and MAKE. acute kidney injury liver transplantation major adverse cardiovascular events major adverse kidney event cardiovascular disease Medicine R Cheng-Hsi Yeh verfasserin aut Lung-Chih Li verfasserin aut Chao-Long Chen verfasserin aut Chih-Chi Wang verfasserin aut Chih-Chi Lin verfasserin aut Aldwin D. Ong verfasserin aut Ting-Yu Chiou verfasserin aut Chee-Chien Yong verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 11, p 3100 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:11, p 3100 https://doi.org/10.3390/jcm11113100 kostenfrei https://doaj.org/article/a8264161d43a41d792bb0276ef48e9ae kostenfrei https://www.mdpi.com/2077-0383/11/11/3100 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 11, p 3100
language	English
source	In Journal of Clinical Medicine 11(2022), 11, p 3100 volume:11 year:2022 number:11, p 3100
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publishDateDaySort_date	2022-01-01T00:00:00Z
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author	Yi-Chia Chan
spellingShingle	Yi-Chia Chan misc acute kidney injury misc liver transplantation misc major adverse cardiovascular events misc major adverse kidney event misc cardiovascular disease misc Medicine misc R Excess Risk of Major Adverse Cardiovascular and Kidney Events after Acute Kidney Injury following Living Donor Liver Transplantation
authorStr	Yi-Chia Chan
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topic_title	Excess Risk of Major Adverse Cardiovascular and Kidney Events after Acute Kidney Injury following Living Donor Liver Transplantation acute kidney injury liver transplantation major adverse cardiovascular events major adverse kidney event cardiovascular disease
topic	misc acute kidney injury misc liver transplantation misc major adverse cardiovascular events misc major adverse kidney event misc cardiovascular disease misc Medicine misc R
topic_unstemmed	misc acute kidney injury misc liver transplantation misc major adverse cardiovascular events misc major adverse kidney event misc cardiovascular disease misc Medicine misc R
topic_browse	misc acute kidney injury misc liver transplantation misc major adverse cardiovascular events misc major adverse kidney event misc cardiovascular disease misc Medicine misc R
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title	Excess Risk of Major Adverse Cardiovascular and Kidney Events after Acute Kidney Injury following Living Donor Liver Transplantation
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title_full	Excess Risk of Major Adverse Cardiovascular and Kidney Events after Acute Kidney Injury following Living Donor Liver Transplantation
author_sort	Yi-Chia Chan
journal	Journal of Clinical Medicine
journalStr	Journal of Clinical Medicine
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author_browse	Yi-Chia Chan Cheng-Hsi Yeh Lung-Chih Li Chao-Long Chen Chih-Chi Wang Chih-Chi Lin Aldwin D. Ong Ting-Yu Chiou Chee-Chien Yong
container_volume	11
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author-letter	Yi-Chia Chan
doi_str_mv	10.3390/jcm11113100
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title_sort	excess risk of major adverse cardiovascular and kidney events after acute kidney injury following living donor liver transplantation
title_auth	Excess Risk of Major Adverse Cardiovascular and Kidney Events after Acute Kidney Injury following Living Donor Liver Transplantation
abstract	Acute kidney injury (AKI) is a well-known risk factor for major adverse kidney events (MAKE) and major adverse cardiovascular events (MACE) in nontransplant settings. However, the association between AKI after liver transplantation (LT) and MACE/MAKE is not established. A retrospective cohort analysis including 512 LT recipients was conducted. The incidence of post-LT AKI was 35.0% (<i<n</i< = 179). In total, 13 patients (2.5%) developed de novo coronary artery disease (CAD), 3 patients (0.6%) diagnosed with heart failure (HF), and 11 patients (2.1%) had stroke. The post-LT AKI group showed a higher incidence of CAD and HF than the no post-LT AKI group (4.5% versus 1.5%, <i<p</i< = 0.042; 1.7% versus 0%, <i<p</i< = 0.018; respectively), while there was no significant difference in the stroke events (2.8% versus 1.8%, <i<p</i< = 0.461). Through Cox regression analysis, history of cardiovascular disease (HR 6.51, 95% CI 2.43–17.46), post-LT AKI (HR 3.06, 95% CI 1.39–6.75), and pre-LT diabetes (HR 2.37, 95% CI 1.09–5.17) were identified as independent predictors of MACE; pre-LT chronic kidney disease (HR 9.54, 95% CI 3.49–26.10), pre-LT diabetes (HR 3.51, 95% CI 1.25–9.86), and post-LT AKI (HR 6.76, 95% CI 2.19–20.91) were risk factors for end-stage renal disease. Post-LT AKI is predictive for the development of MACE and MAKE.
abstractGer	Acute kidney injury (AKI) is a well-known risk factor for major adverse kidney events (MAKE) and major adverse cardiovascular events (MACE) in nontransplant settings. However, the association between AKI after liver transplantation (LT) and MACE/MAKE is not established. A retrospective cohort analysis including 512 LT recipients was conducted. The incidence of post-LT AKI was 35.0% (<i<n</i< = 179). In total, 13 patients (2.5%) developed de novo coronary artery disease (CAD), 3 patients (0.6%) diagnosed with heart failure (HF), and 11 patients (2.1%) had stroke. The post-LT AKI group showed a higher incidence of CAD and HF than the no post-LT AKI group (4.5% versus 1.5%, <i<p</i< = 0.042; 1.7% versus 0%, <i<p</i< = 0.018; respectively), while there was no significant difference in the stroke events (2.8% versus 1.8%, <i<p</i< = 0.461). Through Cox regression analysis, history of cardiovascular disease (HR 6.51, 95% CI 2.43–17.46), post-LT AKI (HR 3.06, 95% CI 1.39–6.75), and pre-LT diabetes (HR 2.37, 95% CI 1.09–5.17) were identified as independent predictors of MACE; pre-LT chronic kidney disease (HR 9.54, 95% CI 3.49–26.10), pre-LT diabetes (HR 3.51, 95% CI 1.25–9.86), and post-LT AKI (HR 6.76, 95% CI 2.19–20.91) were risk factors for end-stage renal disease. Post-LT AKI is predictive for the development of MACE and MAKE.
abstract_unstemmed	Acute kidney injury (AKI) is a well-known risk factor for major adverse kidney events (MAKE) and major adverse cardiovascular events (MACE) in nontransplant settings. However, the association between AKI after liver transplantation (LT) and MACE/MAKE is not established. A retrospective cohort analysis including 512 LT recipients was conducted. The incidence of post-LT AKI was 35.0% (<i<n</i< = 179). In total, 13 patients (2.5%) developed de novo coronary artery disease (CAD), 3 patients (0.6%) diagnosed with heart failure (HF), and 11 patients (2.1%) had stroke. The post-LT AKI group showed a higher incidence of CAD and HF than the no post-LT AKI group (4.5% versus 1.5%, <i<p</i< = 0.042; 1.7% versus 0%, <i<p</i< = 0.018; respectively), while there was no significant difference in the stroke events (2.8% versus 1.8%, <i<p</i< = 0.461). Through Cox regression analysis, history of cardiovascular disease (HR 6.51, 95% CI 2.43–17.46), post-LT AKI (HR 3.06, 95% CI 1.39–6.75), and pre-LT diabetes (HR 2.37, 95% CI 1.09–5.17) were identified as independent predictors of MACE; pre-LT chronic kidney disease (HR 9.54, 95% CI 3.49–26.10), pre-LT diabetes (HR 3.51, 95% CI 1.25–9.86), and post-LT AKI (HR 6.76, 95% CI 2.19–20.91) were risk factors for end-stage renal disease. Post-LT AKI is predictive for the development of MACE and MAKE.
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container_issue	11, p 3100
title_short	Excess Risk of Major Adverse Cardiovascular and Kidney Events after Acute Kidney Injury following Living Donor Liver Transplantation
url	https://doi.org/10.3390/jcm11113100 https://doaj.org/article/a8264161d43a41d792bb0276ef48e9ae https://www.mdpi.com/2077-0383/11/11/3100 https://doaj.org/toc/2077-0383
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author2	Cheng-Hsi Yeh Lung-Chih Li Chao-Long Chen Chih-Chi Wang Chih-Chi Lin Aldwin D. Ong Ting-Yu Chiou Chee-Chien Yong
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up_date	2024-07-03T17:19:45.058Z
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