Characteristics of exhaled particle production in healthy volunteers: possible implications for infectious disease transmission [v1; ref status: indexed, http://f1000r.es/xa]

The size and concentration of exhaled particles may influence respiratory infection transmission risk. We assessed variation in exhaled particle production between individuals, factors associated with high production and stability over time. We measured exhaled particle production during tidal breat...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Fatima Wurie [verfasserIn] Olivier Le Polain de Waroux [verfasserIn] Matthew Brande [verfasserIn] Wesley DeHaan [verfasserIn] Katherine Holdgate [verfasserIn] Rishi Mannan [verfasserIn] Donald Milton [verfasserIn] Daniel Swerdlow [verfasserIn] Andrew Hayward [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Respiratory Infections

Übergeordnetes Werk:	In: F1000Research - F1000 Research Ltd, 2013, 2(2013)
Übergeordnetes Werk:	volume:2 ; year:2013

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.12688/f1000research.2-14.v1

Katalog-ID:	DOAJ02871332X

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allfieldsSound	10.12688/f1000research.2-14.v1 doi (DE-627)DOAJ02871332X (DE-599)DOAJc23562ca62cc40ad88ff110a99b8d42d DE-627 ger DE-627 rakwb eng Fatima Wurie verfasserin aut Characteristics of exhaled particle production in healthy volunteers: possible implications for infectious disease transmission [v1; ref status: indexed, http://f1000r.es/xa] 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The size and concentration of exhaled particles may influence respiratory infection transmission risk. We assessed variation in exhaled particle production between individuals, factors associated with high production and stability over time. We measured exhaled particle production during tidal breathing in a sample of 79 healthy volunteers, using optical particle counter technology. Repeat measurements (several months after baseline) were obtained for 37 of the 79 participants. Multilevel linear regression models of log transformed particle production measures were used to assess risk factors for high production. Stability between measurements over time was assessed using Lin’s correlation coefficients. Ninety-nine percent of expired particles were <1μm in diameter. Considerable variation in exhaled particle production was observed between individuals and within individuals over time. Distribution of particle production was right skewed. Approximately 90% of individuals produce <150 particles per litre in normal breathing. A few individuals had measurements of over 1000 particles per litre (maximum 1456). Particle production increased with age (p<0.001) and was associated with high tree pollen counts. Particle production levels did not remain stable over time [rho 0.14 (95%CI -0.10, 0.38, p=0.238)]. Sub-micron particles conducive to airborne rather than droplet transmission form the great majority of exhaled particles in tidal breathing. There is a high level of variability between subjects but measurements are not stable over time. Production increases with age and may be influenced by airway inflammation caused by environmental irritants. Further research is needed to determine whether the observed variations in exhaled particle production affect transmission of respiratory infection. Respiratory Infections Medicine R Science Q Olivier Le Polain de Waroux verfasserin aut Matthew Brande verfasserin aut Wesley DeHaan verfasserin aut Katherine Holdgate verfasserin aut Rishi Mannan verfasserin aut Donald Milton verfasserin aut Daniel Swerdlow verfasserin aut Andrew Hayward verfasserin aut In F1000Research F1000 Research Ltd, 2013 2(2013) (DE-627)735133581 (DE-600)2699932-8 20461402 nnns volume:2 year:2013 https://doi.org/10.12688/f1000research.2-14.v1 kostenfrei https://doaj.org/article/c23562ca62cc40ad88ff110a99b8d42d kostenfrei http://f1000research.com/articles/2-14/v1 kostenfrei https://doaj.org/toc/2046-1402 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2013
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author	Fatima Wurie
spellingShingle	Fatima Wurie misc Respiratory Infections misc Medicine misc R misc Science misc Q Characteristics of exhaled particle production in healthy volunteers: possible implications for infectious disease transmission [v1; ref status: indexed, http://f1000r.es/xa]
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topic_title	Characteristics of exhaled particle production in healthy volunteers: possible implications for infectious disease transmission [v1; ref status: indexed, http://f1000r.es/xa] Respiratory Infections
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title	Characteristics of exhaled particle production in healthy volunteers: possible implications for infectious disease transmission [v1; ref status: indexed, http://f1000r.es/xa]
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title_full	Characteristics of exhaled particle production in healthy volunteers: possible implications for infectious disease transmission [v1; ref status: indexed, http://f1000r.es/xa]
author_sort	Fatima Wurie
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author_browse	Fatima Wurie Olivier Le Polain de Waroux Matthew Brande Wesley DeHaan Katherine Holdgate Rishi Mannan Donald Milton Daniel Swerdlow Andrew Hayward
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title_sort	characteristics of exhaled particle production in healthy volunteers: possible implications for infectious disease transmission [v1; ref status: indexed, http://f1000r.es/xa]
title_auth	Characteristics of exhaled particle production in healthy volunteers: possible implications for infectious disease transmission [v1; ref status: indexed, http://f1000r.es/xa]
abstract	The size and concentration of exhaled particles may influence respiratory infection transmission risk. We assessed variation in exhaled particle production between individuals, factors associated with high production and stability over time. We measured exhaled particle production during tidal breathing in a sample of 79 healthy volunteers, using optical particle counter technology. Repeat measurements (several months after baseline) were obtained for 37 of the 79 participants. Multilevel linear regression models of log transformed particle production measures were used to assess risk factors for high production. Stability between measurements over time was assessed using Lin’s correlation coefficients. Ninety-nine percent of expired particles were <1μm in diameter. Considerable variation in exhaled particle production was observed between individuals and within individuals over time. Distribution of particle production was right skewed. Approximately 90% of individuals produce <150 particles per litre in normal breathing. A few individuals had measurements of over 1000 particles per litre (maximum 1456). Particle production increased with age (p<0.001) and was associated with high tree pollen counts. Particle production levels did not remain stable over time [rho 0.14 (95%CI -0.10, 0.38, p=0.238)]. Sub-micron particles conducive to airborne rather than droplet transmission form the great majority of exhaled particles in tidal breathing. There is a high level of variability between subjects but measurements are not stable over time. Production increases with age and may be influenced by airway inflammation caused by environmental irritants. Further research is needed to determine whether the observed variations in exhaled particle production affect transmission of respiratory infection.
abstractGer	The size and concentration of exhaled particles may influence respiratory infection transmission risk. We assessed variation in exhaled particle production between individuals, factors associated with high production and stability over time. We measured exhaled particle production during tidal breathing in a sample of 79 healthy volunteers, using optical particle counter technology. Repeat measurements (several months after baseline) were obtained for 37 of the 79 participants. Multilevel linear regression models of log transformed particle production measures were used to assess risk factors for high production. Stability between measurements over time was assessed using Lin’s correlation coefficients. Ninety-nine percent of expired particles were <1μm in diameter. Considerable variation in exhaled particle production was observed between individuals and within individuals over time. Distribution of particle production was right skewed. Approximately 90% of individuals produce <150 particles per litre in normal breathing. A few individuals had measurements of over 1000 particles per litre (maximum 1456). Particle production increased with age (p<0.001) and was associated with high tree pollen counts. Particle production levels did not remain stable over time [rho 0.14 (95%CI -0.10, 0.38, p=0.238)]. Sub-micron particles conducive to airborne rather than droplet transmission form the great majority of exhaled particles in tidal breathing. There is a high level of variability between subjects but measurements are not stable over time. Production increases with age and may be influenced by airway inflammation caused by environmental irritants. Further research is needed to determine whether the observed variations in exhaled particle production affect transmission of respiratory infection.
abstract_unstemmed	The size and concentration of exhaled particles may influence respiratory infection transmission risk. We assessed variation in exhaled particle production between individuals, factors associated with high production and stability over time. We measured exhaled particle production during tidal breathing in a sample of 79 healthy volunteers, using optical particle counter technology. Repeat measurements (several months after baseline) were obtained for 37 of the 79 participants. Multilevel linear regression models of log transformed particle production measures were used to assess risk factors for high production. Stability between measurements over time was assessed using Lin’s correlation coefficients. Ninety-nine percent of expired particles were <1μm in diameter. Considerable variation in exhaled particle production was observed between individuals and within individuals over time. Distribution of particle production was right skewed. Approximately 90% of individuals produce <150 particles per litre in normal breathing. A few individuals had measurements of over 1000 particles per litre (maximum 1456). Particle production increased with age (p<0.001) and was associated with high tree pollen counts. Particle production levels did not remain stable over time [rho 0.14 (95%CI -0.10, 0.38, p=0.238)]. Sub-micron particles conducive to airborne rather than droplet transmission form the great majority of exhaled particles in tidal breathing. There is a high level of variability between subjects but measurements are not stable over time. Production increases with age and may be influenced by airway inflammation caused by environmental irritants. Further research is needed to determine whether the observed variations in exhaled particle production affect transmission of respiratory infection.
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title_short	Characteristics of exhaled particle production in healthy volunteers: possible implications for infectious disease transmission [v1; ref status: indexed, http://f1000r.es/xa]
url	https://doi.org/10.12688/f1000research.2-14.v1 https://doaj.org/article/c23562ca62cc40ad88ff110a99b8d42d http://f1000research.com/articles/2-14/v1 https://doaj.org/toc/2046-1402
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