The Versatile Role of miR-21 in Renal Homeostasis and Diseases

MicroRNAs (miRNAs) are small, non-coding RNA species that control gene expression and confer robustness to biological processes. Over the last two decades, their important roles during kidney development, homeostasis and the treatment of diseases have been established, in particular during the onset...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Romain Larrue [verfasserIn] Sandy Fellah [verfasserIn] Cynthia Van der Hauwaert [verfasserIn] Marie-Flore Hennino [verfasserIn] Michaël Perrais [verfasserIn] Arnaud Lionet [verfasserIn] François Glowacki [verfasserIn] Nicolas Pottier [verfasserIn] Christelle Cauffiez [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	microRNA kidney cancer fibrosis

Übergeordnetes Werk:	In: Cells - MDPI AG, 2012, 11(2022), 21, p 3525
Übergeordnetes Werk:	volume:11 ; year:2022 ; number:21, p 3525

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cells11213525

Katalog-ID:	DOAJ028724798

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language	English
source	In Cells 11(2022), 21, p 3525 volume:11 year:2022 number:21, p 3525
sourceStr	In Cells 11(2022), 21, p 3525 volume:11 year:2022 number:21, p 3525
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	microRNA kidney cancer fibrosis Cytology
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container_title	Cells
authorswithroles_txt_mv	Romain Larrue @@aut@@ Sandy Fellah @@aut@@ Cynthia Van der Hauwaert @@aut@@ Marie-Flore Hennino @@aut@@ Michaël Perrais @@aut@@ Arnaud Lionet @@aut@@ François Glowacki @@aut@@ Nicolas Pottier @@aut@@ Christelle Cauffiez @@aut@@
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title	The Versatile Role of miR-21 in Renal Homeostasis and Diseases
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title_sort	versatile role of mir-21 in renal homeostasis and diseases
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title_auth	The Versatile Role of miR-21 in Renal Homeostasis and Diseases
abstract	MicroRNAs (miRNAs) are small, non-coding RNA species that control gene expression and confer robustness to biological processes. Over the last two decades, their important roles during kidney development, homeostasis and the treatment of diseases have been established, in particular during the onset and progression of various forms of acute and chronic renal disorders. In recent years, miR-21, one of the best-characterized miRNAs to date, has received much attention in renal physiology in particular given its high degree of conservation and expression in kidneys, as well as its potent pathogenic role in various debilitating renal diseases. This review summarizes the current knowledge on miR-21’s involvement in both renal homeostasis and diseases, in particular its double-edged-sword role in acute versus chronic kidney injuries. Finally, we also discuss the potential of miR-21 as a biomarker and therapeutic target in renal diseases.
abstractGer	MicroRNAs (miRNAs) are small, non-coding RNA species that control gene expression and confer robustness to biological processes. Over the last two decades, their important roles during kidney development, homeostasis and the treatment of diseases have been established, in particular during the onset and progression of various forms of acute and chronic renal disorders. In recent years, miR-21, one of the best-characterized miRNAs to date, has received much attention in renal physiology in particular given its high degree of conservation and expression in kidneys, as well as its potent pathogenic role in various debilitating renal diseases. This review summarizes the current knowledge on miR-21’s involvement in both renal homeostasis and diseases, in particular its double-edged-sword role in acute versus chronic kidney injuries. Finally, we also discuss the potential of miR-21 as a biomarker and therapeutic target in renal diseases.
abstract_unstemmed	MicroRNAs (miRNAs) are small, non-coding RNA species that control gene expression and confer robustness to biological processes. Over the last two decades, their important roles during kidney development, homeostasis and the treatment of diseases have been established, in particular during the onset and progression of various forms of acute and chronic renal disorders. In recent years, miR-21, one of the best-characterized miRNAs to date, has received much attention in renal physiology in particular given its high degree of conservation and expression in kidneys, as well as its potent pathogenic role in various debilitating renal diseases. This review summarizes the current knowledge on miR-21’s involvement in both renal homeostasis and diseases, in particular its double-edged-sword role in acute versus chronic kidney injuries. Finally, we also discuss the potential of miR-21 as a biomarker and therapeutic target in renal diseases.
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title_short	The Versatile Role of miR-21 in Renal Homeostasis and Diseases
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