Organophosphate Poisoning in a Paediatric Intensive Care Unit: A Retrospective Analysis Based on Ten Years of Experience

Abdullah Yousef,1 Waleed Albuali,1 Mohammed AlOmari,1 Abdullah AlMutairi,1 Hamad W Albuali,2 Faisal O AlQurashi,1 Hassan M Alshaqaq2 1Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 2College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi ArabiaCorrespondence: Waleed Albuali, Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Tel +96638966877 ext. 1616, 1226, Email wbualiiau.edu.sa; wbuali0000@gmail.comBackground: Organophosphate (OP) poisoning is one of the most common etiologies of poisoning in the pediatric age group.Objective: This study aimed to evaluate the demographic characteristics, clinical features, clinical course, and outcomes of children with toxicity from organophosphates admitted to the pediatric intensive care unit.Methods: A retrospective review of hospital medical records of all children aged 14 years and younger who were admitted to the PICU with a provisional diagnosis of organophosphate poisoning at King Fahad Hospital of the University (KFHU), Alkhobar, Saudi Arabia, between January 1, 2008, and December 31, 2018, was conducted. Patients with incomplete medical record information or with suspicion or evidence of one or more agents other than organophosphate were excluded from the study.Results: Thirty-one patients were enrolled in the study. The median age of the study population was 2 years, and 19 (61%) were males. The majority of patients (68%) had more than one route of organophosphate exposure. Skin exposure was reported in 26 patients (84%). Only three patients (10%) had suicidal organophosphate exposure from organophosphates, while the majority (28 patients; 90%) had accidental poisoning. Bronchorrhea was the most prevalent presenting feature, reported in 28 patients (90%). 17 patients (55%) were treated with intravenous atropine and (45%) were used a combination of pralidoxime with atropine for treatment. Five patients (16%) developed acute respiratory distress syndrome. Twelve patients (39%) needed endotracheal intubation and mechanical ventilation secondary to respiratory failure.Conclusion: The presenting features of organophosphate poisoning differ widely in children. Risk factors for mortality for PICU patients with organophosphate poisoning include delayed hospital arrival by more than 1 hour, inhalational route of exposure, need for mechanical ventilation, and high lactate levels in the first 24 hours post-exposure.Keywords: organophosphate, poisoning, toxicology, pediatric, intensive care Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Yousef A [verfasserIn] Albuali W [verfasserIn] AlOmari M [verfasserIn] AlMutairi A [verfasserIn] Albuali HW [verfasserIn] AlQurashi FO [verfasserIn] Alshaqaq HM [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	organophosphate poisoning toxicology pediatric intensive care.

Übergeordnetes Werk:	In: International Journal of General Medicine - Dove Medical Press, 2008, (2022), Seite 6269-6277
Übergeordnetes Werk:	year:2022 ; pages:6269-6277

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ02875591X

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520			\|a Abdullah Yousef,1 Waleed Albuali,1 Mohammed AlOmari,1 Abdullah AlMutairi,1 Hamad W Albuali,2 Faisal O AlQurashi,1 Hassan M Alshaqaq2 1Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 2College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi ArabiaCorrespondence: Waleed Albuali, Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Tel +96638966877 ext. 1616, 1226, Email wbualiiau.edu.sa; wbuali0000@gmail.comBackground: Organophosphate (OP) poisoning is one of the most common etiologies of poisoning in the pediatric age group.Objective: This study aimed to evaluate the demographic characteristics, clinical features, clinical course, and outcomes of children with toxicity from organophosphates admitted to the pediatric intensive care unit.Methods: A retrospective review of hospital medical records of all children aged 14 years and younger who were admitted to the PICU with a provisional diagnosis of organophosphate poisoning at King Fahad Hospital of the University (KFHU), Alkhobar, Saudi Arabia, between January 1, 2008, and December 31, 2018, was conducted. Patients with incomplete medical record information or with suspicion or evidence of one or more agents other than organophosphate were excluded from the study.Results: Thirty-one patients were enrolled in the study. The median age of the study population was 2 years, and 19 (61%) were males. The majority of patients (68%) had more than one route of organophosphate exposure. Skin exposure was reported in 26 patients (84%). Only three patients (10%) had suicidal organophosphate exposure from organophosphates, while the majority (28 patients; 90%) had accidental poisoning. Bronchorrhea was the most prevalent presenting feature, reported in 28 patients (90%). 17 patients (55%) were treated with intravenous atropine and (45%) were used a combination of pralidoxime with atropine for treatment. Five patients (16%) developed acute respiratory distress syndrome. Twelve patients (39%) needed endotracheal intubation and mechanical ventilation secondary to respiratory failure.Conclusion: The presenting features of organophosphate poisoning differ widely in children. Risk factors for mortality for PICU patients with organophosphate poisoning include delayed hospital arrival by more than 1 hour, inhalational route of exposure, need for mechanical ventilation, and high lactate levels in the first 24 hours post-exposure.Keywords: organophosphate, poisoning, toxicology, pediatric, intensive care
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allfields	(DE-627)DOAJ02875591X (DE-599)DOAJ66b155a170e5404b8ba99a06a00caea5 DE-627 ger DE-627 rakwb eng R5-920 Yousef A verfasserin aut Organophosphate Poisoning in a Paediatric Intensive Care Unit: A Retrospective Analysis Based on Ten Years of Experience 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abdullah Yousef,1 Waleed Albuali,1 Mohammed AlOmari,1 Abdullah AlMutairi,1 Hamad W Albuali,2 Faisal O AlQurashi,1 Hassan M Alshaqaq2 1Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 2College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi ArabiaCorrespondence: Waleed Albuali, Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Tel +96638966877 ext. 1616, 1226, Email wbualiiau.edu.sa; wbuali0000@gmail.comBackground: Organophosphate (OP) poisoning is one of the most common etiologies of poisoning in the pediatric age group.Objective: This study aimed to evaluate the demographic characteristics, clinical features, clinical course, and outcomes of children with toxicity from organophosphates admitted to the pediatric intensive care unit.Methods: A retrospective review of hospital medical records of all children aged 14 years and younger who were admitted to the PICU with a provisional diagnosis of organophosphate poisoning at King Fahad Hospital of the University (KFHU), Alkhobar, Saudi Arabia, between January 1, 2008, and December 31, 2018, was conducted. Patients with incomplete medical record information or with suspicion or evidence of one or more agents other than organophosphate were excluded from the study.Results: Thirty-one patients were enrolled in the study. The median age of the study population was 2 years, and 19 (61%) were males. The majority of patients (68%) had more than one route of organophosphate exposure. Skin exposure was reported in 26 patients (84%). Only three patients (10%) had suicidal organophosphate exposure from organophosphates, while the majority (28 patients; 90%) had accidental poisoning. Bronchorrhea was the most prevalent presenting feature, reported in 28 patients (90%). 17 patients (55%) were treated with intravenous atropine and (45%) were used a combination of pralidoxime with atropine for treatment. Five patients (16%) developed acute respiratory distress syndrome. Twelve patients (39%) needed endotracheal intubation and mechanical ventilation secondary to respiratory failure.Conclusion: The presenting features of organophosphate poisoning differ widely in children. Risk factors for mortality for PICU patients with organophosphate poisoning include delayed hospital arrival by more than 1 hour, inhalational route of exposure, need for mechanical ventilation, and high lactate levels in the first 24 hours post-exposure.Keywords: organophosphate, poisoning, toxicology, pediatric, intensive care organophosphate poisoning toxicology pediatric intensive care. Medicine (General) Albuali W verfasserin aut AlOmari M verfasserin aut AlMutairi A verfasserin aut Albuali HW verfasserin aut AlQurashi FO verfasserin aut Alshaqaq HM verfasserin aut In International Journal of General Medicine Dove Medical Press, 2008 (2022), Seite 6269-6277 (DE-627)578539691 (DE-600)2452220-X 11787074 nnns year:2022 pages:6269-6277 https://doaj.org/article/66b155a170e5404b8ba99a06a00caea5 kostenfrei https://www.dovepress.com/organophosphate-poisoning-in-a-paediatric-intensive-care-unit-a-retros-peer-reviewed-fulltext-article-IJGM kostenfrei https://doaj.org/toc/1178-7074 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2022 6269-6277
spelling	(DE-627)DOAJ02875591X (DE-599)DOAJ66b155a170e5404b8ba99a06a00caea5 DE-627 ger DE-627 rakwb eng R5-920 Yousef A verfasserin aut Organophosphate Poisoning in a Paediatric Intensive Care Unit: A Retrospective Analysis Based on Ten Years of Experience 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abdullah Yousef,1 Waleed Albuali,1 Mohammed AlOmari,1 Abdullah AlMutairi,1 Hamad W Albuali,2 Faisal O AlQurashi,1 Hassan M Alshaqaq2 1Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 2College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi ArabiaCorrespondence: Waleed Albuali, Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Tel +96638966877 ext. 1616, 1226, Email wbualiiau.edu.sa; wbuali0000@gmail.comBackground: Organophosphate (OP) poisoning is one of the most common etiologies of poisoning in the pediatric age group.Objective: This study aimed to evaluate the demographic characteristics, clinical features, clinical course, and outcomes of children with toxicity from organophosphates admitted to the pediatric intensive care unit.Methods: A retrospective review of hospital medical records of all children aged 14 years and younger who were admitted to the PICU with a provisional diagnosis of organophosphate poisoning at King Fahad Hospital of the University (KFHU), Alkhobar, Saudi Arabia, between January 1, 2008, and December 31, 2018, was conducted. Patients with incomplete medical record information or with suspicion or evidence of one or more agents other than organophosphate were excluded from the study.Results: Thirty-one patients were enrolled in the study. The median age of the study population was 2 years, and 19 (61%) were males. The majority of patients (68%) had more than one route of organophosphate exposure. Skin exposure was reported in 26 patients (84%). Only three patients (10%) had suicidal organophosphate exposure from organophosphates, while the majority (28 patients; 90%) had accidental poisoning. Bronchorrhea was the most prevalent presenting feature, reported in 28 patients (90%). 17 patients (55%) were treated with intravenous atropine and (45%) were used a combination of pralidoxime with atropine for treatment. Five patients (16%) developed acute respiratory distress syndrome. Twelve patients (39%) needed endotracheal intubation and mechanical ventilation secondary to respiratory failure.Conclusion: The presenting features of organophosphate poisoning differ widely in children. Risk factors for mortality for PICU patients with organophosphate poisoning include delayed hospital arrival by more than 1 hour, inhalational route of exposure, need for mechanical ventilation, and high lactate levels in the first 24 hours post-exposure.Keywords: organophosphate, poisoning, toxicology, pediatric, intensive care organophosphate poisoning toxicology pediatric intensive care. Medicine (General) Albuali W verfasserin aut AlOmari M verfasserin aut AlMutairi A verfasserin aut Albuali HW verfasserin aut AlQurashi FO verfasserin aut Alshaqaq HM verfasserin aut In International Journal of General Medicine Dove Medical Press, 2008 (2022), Seite 6269-6277 (DE-627)578539691 (DE-600)2452220-X 11787074 nnns year:2022 pages:6269-6277 https://doaj.org/article/66b155a170e5404b8ba99a06a00caea5 kostenfrei https://www.dovepress.com/organophosphate-poisoning-in-a-paediatric-intensive-care-unit-a-retros-peer-reviewed-fulltext-article-IJGM kostenfrei https://doaj.org/toc/1178-7074 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2022 6269-6277
allfields_unstemmed	(DE-627)DOAJ02875591X (DE-599)DOAJ66b155a170e5404b8ba99a06a00caea5 DE-627 ger DE-627 rakwb eng R5-920 Yousef A verfasserin aut Organophosphate Poisoning in a Paediatric Intensive Care Unit: A Retrospective Analysis Based on Ten Years of Experience 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abdullah Yousef,1 Waleed Albuali,1 Mohammed AlOmari,1 Abdullah AlMutairi,1 Hamad W Albuali,2 Faisal O AlQurashi,1 Hassan M Alshaqaq2 1Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 2College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi ArabiaCorrespondence: Waleed Albuali, Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Tel +96638966877 ext. 1616, 1226, Email wbualiiau.edu.sa; wbuali0000@gmail.comBackground: Organophosphate (OP) poisoning is one of the most common etiologies of poisoning in the pediatric age group.Objective: This study aimed to evaluate the demographic characteristics, clinical features, clinical course, and outcomes of children with toxicity from organophosphates admitted to the pediatric intensive care unit.Methods: A retrospective review of hospital medical records of all children aged 14 years and younger who were admitted to the PICU with a provisional diagnosis of organophosphate poisoning at King Fahad Hospital of the University (KFHU), Alkhobar, Saudi Arabia, between January 1, 2008, and December 31, 2018, was conducted. Patients with incomplete medical record information or with suspicion or evidence of one or more agents other than organophosphate were excluded from the study.Results: Thirty-one patients were enrolled in the study. The median age of the study population was 2 years, and 19 (61%) were males. The majority of patients (68%) had more than one route of organophosphate exposure. Skin exposure was reported in 26 patients (84%). Only three patients (10%) had suicidal organophosphate exposure from organophosphates, while the majority (28 patients; 90%) had accidental poisoning. Bronchorrhea was the most prevalent presenting feature, reported in 28 patients (90%). 17 patients (55%) were treated with intravenous atropine and (45%) were used a combination of pralidoxime with atropine for treatment. Five patients (16%) developed acute respiratory distress syndrome. Twelve patients (39%) needed endotracheal intubation and mechanical ventilation secondary to respiratory failure.Conclusion: The presenting features of organophosphate poisoning differ widely in children. Risk factors for mortality for PICU patients with organophosphate poisoning include delayed hospital arrival by more than 1 hour, inhalational route of exposure, need for mechanical ventilation, and high lactate levels in the first 24 hours post-exposure.Keywords: organophosphate, poisoning, toxicology, pediatric, intensive care organophosphate poisoning toxicology pediatric intensive care. Medicine (General) Albuali W verfasserin aut AlOmari M verfasserin aut AlMutairi A verfasserin aut Albuali HW verfasserin aut AlQurashi FO verfasserin aut Alshaqaq HM verfasserin aut In International Journal of General Medicine Dove Medical Press, 2008 (2022), Seite 6269-6277 (DE-627)578539691 (DE-600)2452220-X 11787074 nnns year:2022 pages:6269-6277 https://doaj.org/article/66b155a170e5404b8ba99a06a00caea5 kostenfrei https://www.dovepress.com/organophosphate-poisoning-in-a-paediatric-intensive-care-unit-a-retros-peer-reviewed-fulltext-article-IJGM kostenfrei https://doaj.org/toc/1178-7074 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2022 6269-6277
allfieldsGer	(DE-627)DOAJ02875591X (DE-599)DOAJ66b155a170e5404b8ba99a06a00caea5 DE-627 ger DE-627 rakwb eng R5-920 Yousef A verfasserin aut Organophosphate Poisoning in a Paediatric Intensive Care Unit: A Retrospective Analysis Based on Ten Years of Experience 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abdullah Yousef,1 Waleed Albuali,1 Mohammed AlOmari,1 Abdullah AlMutairi,1 Hamad W Albuali,2 Faisal O AlQurashi,1 Hassan M Alshaqaq2 1Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 2College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi ArabiaCorrespondence: Waleed Albuali, Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Tel +96638966877 ext. 1616, 1226, Email wbualiiau.edu.sa; wbuali0000@gmail.comBackground: Organophosphate (OP) poisoning is one of the most common etiologies of poisoning in the pediatric age group.Objective: This study aimed to evaluate the demographic characteristics, clinical features, clinical course, and outcomes of children with toxicity from organophosphates admitted to the pediatric intensive care unit.Methods: A retrospective review of hospital medical records of all children aged 14 years and younger who were admitted to the PICU with a provisional diagnosis of organophosphate poisoning at King Fahad Hospital of the University (KFHU), Alkhobar, Saudi Arabia, between January 1, 2008, and December 31, 2018, was conducted. Patients with incomplete medical record information or with suspicion or evidence of one or more agents other than organophosphate were excluded from the study.Results: Thirty-one patients were enrolled in the study. The median age of the study population was 2 years, and 19 (61%) were males. The majority of patients (68%) had more than one route of organophosphate exposure. Skin exposure was reported in 26 patients (84%). Only three patients (10%) had suicidal organophosphate exposure from organophosphates, while the majority (28 patients; 90%) had accidental poisoning. Bronchorrhea was the most prevalent presenting feature, reported in 28 patients (90%). 17 patients (55%) were treated with intravenous atropine and (45%) were used a combination of pralidoxime with atropine for treatment. Five patients (16%) developed acute respiratory distress syndrome. Twelve patients (39%) needed endotracheal intubation and mechanical ventilation secondary to respiratory failure.Conclusion: The presenting features of organophosphate poisoning differ widely in children. Risk factors for mortality for PICU patients with organophosphate poisoning include delayed hospital arrival by more than 1 hour, inhalational route of exposure, need for mechanical ventilation, and high lactate levels in the first 24 hours post-exposure.Keywords: organophosphate, poisoning, toxicology, pediatric, intensive care organophosphate poisoning toxicology pediatric intensive care. Medicine (General) Albuali W verfasserin aut AlOmari M verfasserin aut AlMutairi A verfasserin aut Albuali HW verfasserin aut AlQurashi FO verfasserin aut Alshaqaq HM verfasserin aut In International Journal of General Medicine Dove Medical Press, 2008 (2022), Seite 6269-6277 (DE-627)578539691 (DE-600)2452220-X 11787074 nnns year:2022 pages:6269-6277 https://doaj.org/article/66b155a170e5404b8ba99a06a00caea5 kostenfrei https://www.dovepress.com/organophosphate-poisoning-in-a-paediatric-intensive-care-unit-a-retros-peer-reviewed-fulltext-article-IJGM kostenfrei https://doaj.org/toc/1178-7074 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2022 6269-6277
allfieldsSound	(DE-627)DOAJ02875591X (DE-599)DOAJ66b155a170e5404b8ba99a06a00caea5 DE-627 ger DE-627 rakwb eng R5-920 Yousef A verfasserin aut Organophosphate Poisoning in a Paediatric Intensive Care Unit: A Retrospective Analysis Based on Ten Years of Experience 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abdullah Yousef,1 Waleed Albuali,1 Mohammed AlOmari,1 Abdullah AlMutairi,1 Hamad W Albuali,2 Faisal O AlQurashi,1 Hassan M Alshaqaq2 1Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 2College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi ArabiaCorrespondence: Waleed Albuali, Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Tel +96638966877 ext. 1616, 1226, Email wbualiiau.edu.sa; wbuali0000@gmail.comBackground: Organophosphate (OP) poisoning is one of the most common etiologies of poisoning in the pediatric age group.Objective: This study aimed to evaluate the demographic characteristics, clinical features, clinical course, and outcomes of children with toxicity from organophosphates admitted to the pediatric intensive care unit.Methods: A retrospective review of hospital medical records of all children aged 14 years and younger who were admitted to the PICU with a provisional diagnosis of organophosphate poisoning at King Fahad Hospital of the University (KFHU), Alkhobar, Saudi Arabia, between January 1, 2008, and December 31, 2018, was conducted. Patients with incomplete medical record information or with suspicion or evidence of one or more agents other than organophosphate were excluded from the study.Results: Thirty-one patients were enrolled in the study. The median age of the study population was 2 years, and 19 (61%) were males. The majority of patients (68%) had more than one route of organophosphate exposure. Skin exposure was reported in 26 patients (84%). Only three patients (10%) had suicidal organophosphate exposure from organophosphates, while the majority (28 patients; 90%) had accidental poisoning. Bronchorrhea was the most prevalent presenting feature, reported in 28 patients (90%). 17 patients (55%) were treated with intravenous atropine and (45%) were used a combination of pralidoxime with atropine for treatment. Five patients (16%) developed acute respiratory distress syndrome. Twelve patients (39%) needed endotracheal intubation and mechanical ventilation secondary to respiratory failure.Conclusion: The presenting features of organophosphate poisoning differ widely in children. Risk factors for mortality for PICU patients with organophosphate poisoning include delayed hospital arrival by more than 1 hour, inhalational route of exposure, need for mechanical ventilation, and high lactate levels in the first 24 hours post-exposure.Keywords: organophosphate, poisoning, toxicology, pediatric, intensive care organophosphate poisoning toxicology pediatric intensive care. Medicine (General) Albuali W verfasserin aut AlOmari M verfasserin aut AlMutairi A verfasserin aut Albuali HW verfasserin aut AlQurashi FO verfasserin aut Alshaqaq HM verfasserin aut In International Journal of General Medicine Dove Medical Press, 2008 (2022), Seite 6269-6277 (DE-627)578539691 (DE-600)2452220-X 11787074 nnns year:2022 pages:6269-6277 https://doaj.org/article/66b155a170e5404b8ba99a06a00caea5 kostenfrei https://www.dovepress.com/organophosphate-poisoning-in-a-paediatric-intensive-care-unit-a-retros-peer-reviewed-fulltext-article-IJGM kostenfrei https://doaj.org/toc/1178-7074 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2022 6269-6277
language	English
source	In International Journal of General Medicine (2022), Seite 6269-6277 year:2022 pages:6269-6277
sourceStr	In International Journal of General Medicine (2022), Seite 6269-6277 year:2022 pages:6269-6277
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	organophosphate poisoning toxicology pediatric intensive care. Medicine (General)
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container_title	International Journal of General Medicine
authorswithroles_txt_mv	Yousef A @@aut@@ Albuali W @@aut@@ AlOmari M @@aut@@ AlMutairi A @@aut@@ Albuali HW @@aut@@ AlQurashi FO @@aut@@ Alshaqaq HM @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
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Patients with incomplete medical record information or with suspicion or evidence of one or more agents other than organophosphate were excluded from the study.Results: Thirty-one patients were enrolled in the study. The median age of the study population was 2 years, and 19 (61%) were males. The majority of patients (68%) had more than one route of organophosphate exposure. Skin exposure was reported in 26 patients (84%). Only three patients (10%) had suicidal organophosphate exposure from organophosphates, while the majority (28 patients; 90%) had accidental poisoning. Bronchorrhea was the most prevalent presenting feature, reported in 28 patients (90%). 17 patients (55%) were treated with intravenous atropine and (45%) were used a combination of pralidoxime with atropine for treatment. Five patients (16%) developed acute respiratory distress syndrome. Twelve patients (39%) needed endotracheal intubation and mechanical ventilation secondary to respiratory failure.Conclusion: The presenting features of organophosphate poisoning differ widely in children. 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topic_title	R5-920 Organophosphate Poisoning in a Paediatric Intensive Care Unit: A Retrospective Analysis Based on Ten Years of Experience organophosphate poisoning toxicology pediatric intensive care
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title	Organophosphate Poisoning in a Paediatric Intensive Care Unit: A Retrospective Analysis Based on Ten Years of Experience
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title_full	Organophosphate Poisoning in a Paediatric Intensive Care Unit: A Retrospective Analysis Based on Ten Years of Experience
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author_browse	Yousef A Albuali W AlOmari M AlMutairi A Albuali HW AlQurashi FO Alshaqaq HM
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title_sort	organophosphate poisoning in a paediatric intensive care unit: a retrospective analysis based on ten years of experience
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title_auth	Organophosphate Poisoning in a Paediatric Intensive Care Unit: A Retrospective Analysis Based on Ten Years of Experience
abstract	Abdullah Yousef,1 Waleed Albuali,1 Mohammed AlOmari,1 Abdullah AlMutairi,1 Hamad W Albuali,2 Faisal O AlQurashi,1 Hassan M Alshaqaq2 1Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 2College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi ArabiaCorrespondence: Waleed Albuali, Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Tel +96638966877 ext. 1616, 1226, Email wbualiiau.edu.sa; wbuali0000@gmail.comBackground: Organophosphate (OP) poisoning is one of the most common etiologies of poisoning in the pediatric age group.Objective: This study aimed to evaluate the demographic characteristics, clinical features, clinical course, and outcomes of children with toxicity from organophosphates admitted to the pediatric intensive care unit.Methods: A retrospective review of hospital medical records of all children aged 14 years and younger who were admitted to the PICU with a provisional diagnosis of organophosphate poisoning at King Fahad Hospital of the University (KFHU), Alkhobar, Saudi Arabia, between January 1, 2008, and December 31, 2018, was conducted. Patients with incomplete medical record information or with suspicion or evidence of one or more agents other than organophosphate were excluded from the study.Results: Thirty-one patients were enrolled in the study. The median age of the study population was 2 years, and 19 (61%) were males. The majority of patients (68%) had more than one route of organophosphate exposure. Skin exposure was reported in 26 patients (84%). Only three patients (10%) had suicidal organophosphate exposure from organophosphates, while the majority (28 patients; 90%) had accidental poisoning. Bronchorrhea was the most prevalent presenting feature, reported in 28 patients (90%). 17 patients (55%) were treated with intravenous atropine and (45%) were used a combination of pralidoxime with atropine for treatment. Five patients (16%) developed acute respiratory distress syndrome. Twelve patients (39%) needed endotracheal intubation and mechanical ventilation secondary to respiratory failure.Conclusion: The presenting features of organophosphate poisoning differ widely in children. Risk factors for mortality for PICU patients with organophosphate poisoning include delayed hospital arrival by more than 1 hour, inhalational route of exposure, need for mechanical ventilation, and high lactate levels in the first 24 hours post-exposure.Keywords: organophosphate, poisoning, toxicology, pediatric, intensive care
abstractGer	Abdullah Yousef,1 Waleed Albuali,1 Mohammed AlOmari,1 Abdullah AlMutairi,1 Hamad W Albuali,2 Faisal O AlQurashi,1 Hassan M Alshaqaq2 1Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 2College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi ArabiaCorrespondence: Waleed Albuali, Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Tel +96638966877 ext. 1616, 1226, Email wbualiiau.edu.sa; wbuali0000@gmail.comBackground: Organophosphate (OP) poisoning is one of the most common etiologies of poisoning in the pediatric age group.Objective: This study aimed to evaluate the demographic characteristics, clinical features, clinical course, and outcomes of children with toxicity from organophosphates admitted to the pediatric intensive care unit.Methods: A retrospective review of hospital medical records of all children aged 14 years and younger who were admitted to the PICU with a provisional diagnosis of organophosphate poisoning at King Fahad Hospital of the University (KFHU), Alkhobar, Saudi Arabia, between January 1, 2008, and December 31, 2018, was conducted. Patients with incomplete medical record information or with suspicion or evidence of one or more agents other than organophosphate were excluded from the study.Results: Thirty-one patients were enrolled in the study. The median age of the study population was 2 years, and 19 (61%) were males. The majority of patients (68%) had more than one route of organophosphate exposure. Skin exposure was reported in 26 patients (84%). Only three patients (10%) had suicidal organophosphate exposure from organophosphates, while the majority (28 patients; 90%) had accidental poisoning. Bronchorrhea was the most prevalent presenting feature, reported in 28 patients (90%). 17 patients (55%) were treated with intravenous atropine and (45%) were used a combination of pralidoxime with atropine for treatment. Five patients (16%) developed acute respiratory distress syndrome. Twelve patients (39%) needed endotracheal intubation and mechanical ventilation secondary to respiratory failure.Conclusion: The presenting features of organophosphate poisoning differ widely in children. Risk factors for mortality for PICU patients with organophosphate poisoning include delayed hospital arrival by more than 1 hour, inhalational route of exposure, need for mechanical ventilation, and high lactate levels in the first 24 hours post-exposure.Keywords: organophosphate, poisoning, toxicology, pediatric, intensive care
abstract_unstemmed	Abdullah Yousef,1 Waleed Albuali,1 Mohammed AlOmari,1 Abdullah AlMutairi,1 Hamad W Albuali,2 Faisal O AlQurashi,1 Hassan M Alshaqaq2 1Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 2College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi ArabiaCorrespondence: Waleed Albuali, Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Tel +96638966877 ext. 1616, 1226, Email wbualiiau.edu.sa; wbuali0000@gmail.comBackground: Organophosphate (OP) poisoning is one of the most common etiologies of poisoning in the pediatric age group.Objective: This study aimed to evaluate the demographic characteristics, clinical features, clinical course, and outcomes of children with toxicity from organophosphates admitted to the pediatric intensive care unit.Methods: A retrospective review of hospital medical records of all children aged 14 years and younger who were admitted to the PICU with a provisional diagnosis of organophosphate poisoning at King Fahad Hospital of the University (KFHU), Alkhobar, Saudi Arabia, between January 1, 2008, and December 31, 2018, was conducted. Patients with incomplete medical record information or with suspicion or evidence of one or more agents other than organophosphate were excluded from the study.Results: Thirty-one patients were enrolled in the study. The median age of the study population was 2 years, and 19 (61%) were males. The majority of patients (68%) had more than one route of organophosphate exposure. Skin exposure was reported in 26 patients (84%). Only three patients (10%) had suicidal organophosphate exposure from organophosphates, while the majority (28 patients; 90%) had accidental poisoning. Bronchorrhea was the most prevalent presenting feature, reported in 28 patients (90%). 17 patients (55%) were treated with intravenous atropine and (45%) were used a combination of pralidoxime with atropine for treatment. Five patients (16%) developed acute respiratory distress syndrome. Twelve patients (39%) needed endotracheal intubation and mechanical ventilation secondary to respiratory failure.Conclusion: The presenting features of organophosphate poisoning differ widely in children. Risk factors for mortality for PICU patients with organophosphate poisoning include delayed hospital arrival by more than 1 hour, inhalational route of exposure, need for mechanical ventilation, and high lactate levels in the first 24 hours post-exposure.Keywords: organophosphate, poisoning, toxicology, pediatric, intensive care
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title_short	Organophosphate Poisoning in a Paediatric Intensive Care Unit: A Retrospective Analysis Based on Ten Years of Experience
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Organophosphate Poisoning in a Paediatric Intensive Care Unit: A Retrospective Analysis Based on Ten Years of Experience

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