Roles of MicroRNAs in Bone Destruction of Rheumatoid Arthritis

As an important pathological result of rheumatoid arthritis (RA), bone destruction will lead to joint injury and dysfunction. The imbalance of bone metabolism caused by increased osteoclast activities and decreased osteoblast activities is the main cause of bone destruction in RA. MicroRNAs (MiRNAs)...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Hanxiao Zhao [verfasserIn] Aiping Lu [verfasserIn] Xiaojuan He [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	microRNAs rheumatoid arthritis bone destruction osteoclast osteoblast

Übergeordnetes Werk:	In: Frontiers in Cell and Developmental Biology - Frontiers Media S.A., 2014, 8(2020)
Übergeordnetes Werk:	volume:8 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fcell.2020.600867

Katalog-ID:	DOAJ028838785

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author	Hanxiao Zhao
spellingShingle	Hanxiao Zhao misc QH301-705.5 misc microRNAs misc rheumatoid arthritis misc bone destruction misc osteoclast misc osteoblast misc Biology (General) Roles of MicroRNAs in Bone Destruction of Rheumatoid Arthritis
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topic_title	QH301-705.5 Roles of MicroRNAs in Bone Destruction of Rheumatoid Arthritis microRNAs rheumatoid arthritis bone destruction osteoclast osteoblast
topic	misc QH301-705.5 misc microRNAs misc rheumatoid arthritis misc bone destruction misc osteoclast misc osteoblast misc Biology (General)
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title	Roles of MicroRNAs in Bone Destruction of Rheumatoid Arthritis
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title_full	Roles of MicroRNAs in Bone Destruction of Rheumatoid Arthritis
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title_sort	roles of micrornas in bone destruction of rheumatoid arthritis
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title_auth	Roles of MicroRNAs in Bone Destruction of Rheumatoid Arthritis
abstract	As an important pathological result of rheumatoid arthritis (RA), bone destruction will lead to joint injury and dysfunction. The imbalance of bone metabolism caused by increased osteoclast activities and decreased osteoblast activities is the main cause of bone destruction in RA. MicroRNAs (MiRNAs) play an important role in regulating bone metabolic network. Recent studies have shown that miRNAs play indispensable roles in the occurrence and development of bone-related diseases including RA. In this paper, the role of miRNAs in regulating bone destruction of RA in recent years, especially the differentiation and activities of osteoclast and osteoblast, is reviewed. Our results will not only help provide ideas for further studies on miRNAs’ roles in regulating bone destruction, but give candidate targets for miRNAs-based drugs research in bone destruction therapy of RA as well.
abstractGer	As an important pathological result of rheumatoid arthritis (RA), bone destruction will lead to joint injury and dysfunction. The imbalance of bone metabolism caused by increased osteoclast activities and decreased osteoblast activities is the main cause of bone destruction in RA. MicroRNAs (MiRNAs) play an important role in regulating bone metabolic network. Recent studies have shown that miRNAs play indispensable roles in the occurrence and development of bone-related diseases including RA. In this paper, the role of miRNAs in regulating bone destruction of RA in recent years, especially the differentiation and activities of osteoclast and osteoblast, is reviewed. Our results will not only help provide ideas for further studies on miRNAs’ roles in regulating bone destruction, but give candidate targets for miRNAs-based drugs research in bone destruction therapy of RA as well.
abstract_unstemmed	As an important pathological result of rheumatoid arthritis (RA), bone destruction will lead to joint injury and dysfunction. The imbalance of bone metabolism caused by increased osteoclast activities and decreased osteoblast activities is the main cause of bone destruction in RA. MicroRNAs (MiRNAs) play an important role in regulating bone metabolic network. Recent studies have shown that miRNAs play indispensable roles in the occurrence and development of bone-related diseases including RA. In this paper, the role of miRNAs in regulating bone destruction of RA in recent years, especially the differentiation and activities of osteoclast and osteoblast, is reviewed. Our results will not only help provide ideas for further studies on miRNAs’ roles in regulating bone destruction, but give candidate targets for miRNAs-based drugs research in bone destruction therapy of RA as well.
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title_short	Roles of MicroRNAs in Bone Destruction of Rheumatoid Arthritis
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