Mapping of Human FOXP2 Enhancers Reveals Complex Regulation

Mutations of the FOXP2 gene cause a severe speech and language disorder, providing a molecular window into the neurobiology of language. Individuals with FOXP2 mutations have structural and functional alterations affecting brain circuits that overlap with sites of FOXP2 expression, including regions...
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Autor*in:	Martin Becker [verfasserIn] Paolo Devanna [verfasserIn] Simon E. Fisher [verfasserIn] Sonja C. Vernes [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	FOXP2 enhancer elements Genetic regulation of gene expression language language disorders

Übergeordnetes Werk:	In: Frontiers in Molecular Neuroscience - Frontiers Media S.A., 2008, 11(2018)
Übergeordnetes Werk:	volume:11 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnmol.2018.00047

Katalog-ID:	DOAJ028872541

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520			\|a Mutations of the FOXP2 gene cause a severe speech and language disorder, providing a molecular window into the neurobiology of language. Individuals with FOXP2 mutations have structural and functional alterations affecting brain circuits that overlap with sites of FOXP2 expression, including regions of the cortex, striatum, and cerebellum. FOXP2 displays complex patterns of expression in the brain, as well as in non-neuronal tissues, suggesting that sophisticated regulatory mechanisms control its spatio-temporal expression. However, to date, little is known about the regulation of FOXP2 or the genomic elements that control its expression. Using chromatin conformation capture (3C), we mapped the human FOXP2 locus to identify putative enhancer regions that engage in long-range interactions with the promoter of this gene. We demonstrate the ability of the identified enhancer regions to drive gene expression. We also show regulation of the FOXP2 promoter and enhancer regions by candidate regulators – FOXP family and TBR1 transcription factors. These data point to regulatory elements that may contribute to the temporal- or tissue-specific expression patterns of human FOXP2. Understanding the upstream regulatory pathways controlling FOXP2 expression will bring new insight into the molecular networks contributing to human language and related disorders.
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allfieldsSound	10.3389/fnmol.2018.00047 doi (DE-627)DOAJ028872541 (DE-599)DOAJe4f01b4e5f4545c8a7bd6d90e6721dd8 DE-627 ger DE-627 rakwb eng RC321-571 Martin Becker verfasserin aut Mapping of Human FOXP2 Enhancers Reveals Complex Regulation 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mutations of the FOXP2 gene cause a severe speech and language disorder, providing a molecular window into the neurobiology of language. Individuals with FOXP2 mutations have structural and functional alterations affecting brain circuits that overlap with sites of FOXP2 expression, including regions of the cortex, striatum, and cerebellum. FOXP2 displays complex patterns of expression in the brain, as well as in non-neuronal tissues, suggesting that sophisticated regulatory mechanisms control its spatio-temporal expression. However, to date, little is known about the regulation of FOXP2 or the genomic elements that control its expression. Using chromatin conformation capture (3C), we mapped the human FOXP2 locus to identify putative enhancer regions that engage in long-range interactions with the promoter of this gene. We demonstrate the ability of the identified enhancer regions to drive gene expression. We also show regulation of the FOXP2 promoter and enhancer regions by candidate regulators – FOXP family and TBR1 transcription factors. These data point to regulatory elements that may contribute to the temporal- or tissue-specific expression patterns of human FOXP2. Understanding the upstream regulatory pathways controlling FOXP2 expression will bring new insight into the molecular networks contributing to human language and related disorders. FOXP2 enhancer elements Genetic regulation of gene expression language language disorders Neurosciences. Biological psychiatry. Neuropsychiatry Martin Becker verfasserin aut Paolo Devanna verfasserin aut Simon E. Fisher verfasserin aut Simon E. Fisher verfasserin aut Sonja C. Vernes verfasserin aut Sonja C. Vernes verfasserin aut In Frontiers in Molecular Neuroscience Frontiers Media S.A., 2008 11(2018) (DE-627)579826449 (DE-600)2452967-9 16625099 nnns volume:11 year:2018 https://doi.org/10.3389/fnmol.2018.00047 kostenfrei https://doaj.org/article/e4f01b4e5f4545c8a7bd6d90e6721dd8 kostenfrei http://journal.frontiersin.org/article/10.3389/fnmol.2018.00047/full kostenfrei https://doaj.org/toc/1662-5099 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2018
language	English
source	In Frontiers in Molecular Neuroscience 11(2018) volume:11 year:2018
sourceStr	In Frontiers in Molecular Neuroscience 11(2018) volume:11 year:2018
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	FOXP2 enhancer elements Genetic regulation of gene expression language language disorders Neurosciences. Biological psychiatry. Neuropsychiatry
isfreeaccess_bool	true
container_title	Frontiers in Molecular Neuroscience
authorswithroles_txt_mv	Martin Becker @@aut@@ Paolo Devanna @@aut@@ Simon E. Fisher @@aut@@ Sonja C. Vernes @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
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callnumber-first	R - Medicine
author	Martin Becker
spellingShingle	Martin Becker misc RC321-571 misc FOXP2 misc enhancer elements misc Genetic misc regulation of gene expression misc language misc language disorders misc Neurosciences. Biological psychiatry. Neuropsychiatry Mapping of Human FOXP2 Enhancers Reveals Complex Regulation
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topic_title	RC321-571 Mapping of Human FOXP2 Enhancers Reveals Complex Regulation FOXP2 enhancer elements Genetic regulation of gene expression language language disorders
topic	misc RC321-571 misc FOXP2 misc enhancer elements misc Genetic misc regulation of gene expression misc language misc language disorders misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc FOXP2 misc enhancer elements misc Genetic misc regulation of gene expression misc language misc language disorders misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Mapping of Human FOXP2 Enhancers Reveals Complex Regulation
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title_full	Mapping of Human FOXP2 Enhancers Reveals Complex Regulation
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title_sort	mapping of human foxp2 enhancers reveals complex regulation
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title_auth	Mapping of Human FOXP2 Enhancers Reveals Complex Regulation
abstract	Mutations of the FOXP2 gene cause a severe speech and language disorder, providing a molecular window into the neurobiology of language. Individuals with FOXP2 mutations have structural and functional alterations affecting brain circuits that overlap with sites of FOXP2 expression, including regions of the cortex, striatum, and cerebellum. FOXP2 displays complex patterns of expression in the brain, as well as in non-neuronal tissues, suggesting that sophisticated regulatory mechanisms control its spatio-temporal expression. However, to date, little is known about the regulation of FOXP2 or the genomic elements that control its expression. Using chromatin conformation capture (3C), we mapped the human FOXP2 locus to identify putative enhancer regions that engage in long-range interactions with the promoter of this gene. We demonstrate the ability of the identified enhancer regions to drive gene expression. We also show regulation of the FOXP2 promoter and enhancer regions by candidate regulators – FOXP family and TBR1 transcription factors. These data point to regulatory elements that may contribute to the temporal- or tissue-specific expression patterns of human FOXP2. Understanding the upstream regulatory pathways controlling FOXP2 expression will bring new insight into the molecular networks contributing to human language and related disorders.
abstractGer	Mutations of the FOXP2 gene cause a severe speech and language disorder, providing a molecular window into the neurobiology of language. Individuals with FOXP2 mutations have structural and functional alterations affecting brain circuits that overlap with sites of FOXP2 expression, including regions of the cortex, striatum, and cerebellum. FOXP2 displays complex patterns of expression in the brain, as well as in non-neuronal tissues, suggesting that sophisticated regulatory mechanisms control its spatio-temporal expression. However, to date, little is known about the regulation of FOXP2 or the genomic elements that control its expression. Using chromatin conformation capture (3C), we mapped the human FOXP2 locus to identify putative enhancer regions that engage in long-range interactions with the promoter of this gene. We demonstrate the ability of the identified enhancer regions to drive gene expression. We also show regulation of the FOXP2 promoter and enhancer regions by candidate regulators – FOXP family and TBR1 transcription factors. These data point to regulatory elements that may contribute to the temporal- or tissue-specific expression patterns of human FOXP2. Understanding the upstream regulatory pathways controlling FOXP2 expression will bring new insight into the molecular networks contributing to human language and related disorders.
abstract_unstemmed	Mutations of the FOXP2 gene cause a severe speech and language disorder, providing a molecular window into the neurobiology of language. Individuals with FOXP2 mutations have structural and functional alterations affecting brain circuits that overlap with sites of FOXP2 expression, including regions of the cortex, striatum, and cerebellum. FOXP2 displays complex patterns of expression in the brain, as well as in non-neuronal tissues, suggesting that sophisticated regulatory mechanisms control its spatio-temporal expression. However, to date, little is known about the regulation of FOXP2 or the genomic elements that control its expression. Using chromatin conformation capture (3C), we mapped the human FOXP2 locus to identify putative enhancer regions that engage in long-range interactions with the promoter of this gene. We demonstrate the ability of the identified enhancer regions to drive gene expression. We also show regulation of the FOXP2 promoter and enhancer regions by candidate regulators – FOXP family and TBR1 transcription factors. These data point to regulatory elements that may contribute to the temporal- or tissue-specific expression patterns of human FOXP2. Understanding the upstream regulatory pathways controlling FOXP2 expression will bring new insight into the molecular networks contributing to human language and related disorders.
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title_short	Mapping of Human FOXP2 Enhancers Reveals Complex Regulation
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