The protein encoded by the duck plague virus UL14 gene regulates virion morphogenesis and affects viral replication

ABSTRACT: To investigate the pivotal roles of the duck plague virus (DPV) tegument protein UL14 in viral replication, we generated 2 mutated viruses of DPV by using the bacterial artifcial chromosome system, the UL14-null mutant virus (CHv-BAC-ΔUL14) and the corresponding revertant virus (CHv-BAC-ΔU...
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Autor*in:	Jieyu Wan [verfasserIn] Fangjie Li [verfasserIn] Mingshu Wang [verfasserIn] Anchun Cheng [verfasserIn] Bin Tian [verfasserIn] Qiao Yang [verfasserIn] Ying Wu [verfasserIn] Xumin Ou [verfasserIn] Sai Mao [verfasserIn] Di Sun [verfasserIn] Shaqiu Zhang [verfasserIn] Juan Huang [verfasserIn] Qun Gao [verfasserIn] XinXin Zhao [verfasserIn] Shun Chen [verfasserIn] Mafeng Liu [verfasserIn] Renyong Jia [verfasserIn] Dekang Zhu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	duck enteritis virus UL14 virion morphology virus replication

Übergeordnetes Werk:	In: Poultry Science - Elsevier, 2020, 101(2022), 6, Seite 101863-
Übergeordnetes Werk:	volume:101 ; year:2022 ; number:6 ; pages:101863-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.psj.2022.101863

Katalog-ID:	DOAJ028996372

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245	1	4	\|a The protein encoded by the duck plague virus UL14 gene regulates virion morphogenesis and affects viral replication
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520			\|a ABSTRACT: To investigate the pivotal roles of the duck plague virus (DPV) tegument protein UL14 in viral replication, we generated 2 mutated viruses of DPV by using the bacterial artifcial chromosome system, the UL14-null mutant virus (CHv-BAC-ΔUL14) and the corresponding revertant virus (CHv-BAC-ΔUL14R). We found that the CHv-BAC-ΔUL14 viruses exhibited impaired virion morphogenesis in transmission electron microscopy (TEM) studies. Furthermore, CHv-BAC-ΔUL14 exhibited a plaque size reduction in duck embryo fibroblasts (DEFs). Finally, CHv-BAC-ΔUL14 exhibited a significant viral growth defect. Taken together, our findings suggest that DPV UL14 protein regulates viral morphogenesis for efficient viral replication.
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allfields	10.1016/j.psj.2022.101863 doi (DE-627)DOAJ028996372 (DE-599)DOAJb26a4001cb1c4d4fa2bdc4428e84af36 DE-627 ger DE-627 rakwb eng SF1-1100 Jieyu Wan verfasserin aut The protein encoded by the duck plague virus UL14 gene regulates virion morphogenesis and affects viral replication 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT: To investigate the pivotal roles of the duck plague virus (DPV) tegument protein UL14 in viral replication, we generated 2 mutated viruses of DPV by using the bacterial artifcial chromosome system, the UL14-null mutant virus (CHv-BAC-ΔUL14) and the corresponding revertant virus (CHv-BAC-ΔUL14R). We found that the CHv-BAC-ΔUL14 viruses exhibited impaired virion morphogenesis in transmission electron microscopy (TEM) studies. Furthermore, CHv-BAC-ΔUL14 exhibited a plaque size reduction in duck embryo fibroblasts (DEFs). Finally, CHv-BAC-ΔUL14 exhibited a significant viral growth defect. Taken together, our findings suggest that DPV UL14 protein regulates viral morphogenesis for efficient viral replication. duck enteritis virus UL14 virion morphology virus replication Animal culture Fangjie Li verfasserin aut Mingshu Wang verfasserin aut Anchun Cheng verfasserin aut Bin Tian verfasserin aut Qiao Yang verfasserin aut Ying Wu verfasserin aut Xumin Ou verfasserin aut Sai Mao verfasserin aut Di Sun verfasserin aut Shaqiu Zhang verfasserin aut Juan Huang verfasserin aut Qun Gao verfasserin aut XinXin Zhao verfasserin aut Shun Chen verfasserin aut Mafeng Liu verfasserin aut Renyong Jia verfasserin aut Dekang Zhu verfasserin aut In Poultry Science Elsevier, 2020 101(2022), 6, Seite 101863- (DE-627)320569535 (DE-600)2016331-9 15253171 nnns volume:101 year:2022 number:6 pages:101863- https://doi.org/10.1016/j.psj.2022.101863 kostenfrei https://doaj.org/article/b26a4001cb1c4d4fa2bdc4428e84af36 kostenfrei http://www.sciencedirect.com/science/article/pii/S0032579122001705 kostenfrei https://doaj.org/toc/0032-5791 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 101 2022 6 101863-
spelling	10.1016/j.psj.2022.101863 doi (DE-627)DOAJ028996372 (DE-599)DOAJb26a4001cb1c4d4fa2bdc4428e84af36 DE-627 ger DE-627 rakwb eng SF1-1100 Jieyu Wan verfasserin aut The protein encoded by the duck plague virus UL14 gene regulates virion morphogenesis and affects viral replication 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT: To investigate the pivotal roles of the duck plague virus (DPV) tegument protein UL14 in viral replication, we generated 2 mutated viruses of DPV by using the bacterial artifcial chromosome system, the UL14-null mutant virus (CHv-BAC-ΔUL14) and the corresponding revertant virus (CHv-BAC-ΔUL14R). We found that the CHv-BAC-ΔUL14 viruses exhibited impaired virion morphogenesis in transmission electron microscopy (TEM) studies. Furthermore, CHv-BAC-ΔUL14 exhibited a plaque size reduction in duck embryo fibroblasts (DEFs). Finally, CHv-BAC-ΔUL14 exhibited a significant viral growth defect. Taken together, our findings suggest that DPV UL14 protein regulates viral morphogenesis for efficient viral replication. duck enteritis virus UL14 virion morphology virus replication Animal culture Fangjie Li verfasserin aut Mingshu Wang verfasserin aut Anchun Cheng verfasserin aut Bin Tian verfasserin aut Qiao Yang verfasserin aut Ying Wu verfasserin aut Xumin Ou verfasserin aut Sai Mao verfasserin aut Di Sun verfasserin aut Shaqiu Zhang verfasserin aut Juan Huang verfasserin aut Qun Gao verfasserin aut XinXin Zhao verfasserin aut Shun Chen verfasserin aut Mafeng Liu verfasserin aut Renyong Jia verfasserin aut Dekang Zhu verfasserin aut In Poultry Science Elsevier, 2020 101(2022), 6, Seite 101863- (DE-627)320569535 (DE-600)2016331-9 15253171 nnns volume:101 year:2022 number:6 pages:101863- https://doi.org/10.1016/j.psj.2022.101863 kostenfrei https://doaj.org/article/b26a4001cb1c4d4fa2bdc4428e84af36 kostenfrei http://www.sciencedirect.com/science/article/pii/S0032579122001705 kostenfrei https://doaj.org/toc/0032-5791 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 101 2022 6 101863-
allfields_unstemmed	10.1016/j.psj.2022.101863 doi (DE-627)DOAJ028996372 (DE-599)DOAJb26a4001cb1c4d4fa2bdc4428e84af36 DE-627 ger DE-627 rakwb eng SF1-1100 Jieyu Wan verfasserin aut The protein encoded by the duck plague virus UL14 gene regulates virion morphogenesis and affects viral replication 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT: To investigate the pivotal roles of the duck plague virus (DPV) tegument protein UL14 in viral replication, we generated 2 mutated viruses of DPV by using the bacterial artifcial chromosome system, the UL14-null mutant virus (CHv-BAC-ΔUL14) and the corresponding revertant virus (CHv-BAC-ΔUL14R). We found that the CHv-BAC-ΔUL14 viruses exhibited impaired virion morphogenesis in transmission electron microscopy (TEM) studies. Furthermore, CHv-BAC-ΔUL14 exhibited a plaque size reduction in duck embryo fibroblasts (DEFs). Finally, CHv-BAC-ΔUL14 exhibited a significant viral growth defect. Taken together, our findings suggest that DPV UL14 protein regulates viral morphogenesis for efficient viral replication. duck enteritis virus UL14 virion morphology virus replication Animal culture Fangjie Li verfasserin aut Mingshu Wang verfasserin aut Anchun Cheng verfasserin aut Bin Tian verfasserin aut Qiao Yang verfasserin aut Ying Wu verfasserin aut Xumin Ou verfasserin aut Sai Mao verfasserin aut Di Sun verfasserin aut Shaqiu Zhang verfasserin aut Juan Huang verfasserin aut Qun Gao verfasserin aut XinXin Zhao verfasserin aut Shun Chen verfasserin aut Mafeng Liu verfasserin aut Renyong Jia verfasserin aut Dekang Zhu verfasserin aut In Poultry Science Elsevier, 2020 101(2022), 6, Seite 101863- (DE-627)320569535 (DE-600)2016331-9 15253171 nnns volume:101 year:2022 number:6 pages:101863- https://doi.org/10.1016/j.psj.2022.101863 kostenfrei https://doaj.org/article/b26a4001cb1c4d4fa2bdc4428e84af36 kostenfrei http://www.sciencedirect.com/science/article/pii/S0032579122001705 kostenfrei https://doaj.org/toc/0032-5791 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 101 2022 6 101863-
allfieldsGer	10.1016/j.psj.2022.101863 doi (DE-627)DOAJ028996372 (DE-599)DOAJb26a4001cb1c4d4fa2bdc4428e84af36 DE-627 ger DE-627 rakwb eng SF1-1100 Jieyu Wan verfasserin aut The protein encoded by the duck plague virus UL14 gene regulates virion morphogenesis and affects viral replication 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT: To investigate the pivotal roles of the duck plague virus (DPV) tegument protein UL14 in viral replication, we generated 2 mutated viruses of DPV by using the bacterial artifcial chromosome system, the UL14-null mutant virus (CHv-BAC-ΔUL14) and the corresponding revertant virus (CHv-BAC-ΔUL14R). We found that the CHv-BAC-ΔUL14 viruses exhibited impaired virion morphogenesis in transmission electron microscopy (TEM) studies. Furthermore, CHv-BAC-ΔUL14 exhibited a plaque size reduction in duck embryo fibroblasts (DEFs). Finally, CHv-BAC-ΔUL14 exhibited a significant viral growth defect. Taken together, our findings suggest that DPV UL14 protein regulates viral morphogenesis for efficient viral replication. duck enteritis virus UL14 virion morphology virus replication Animal culture Fangjie Li verfasserin aut Mingshu Wang verfasserin aut Anchun Cheng verfasserin aut Bin Tian verfasserin aut Qiao Yang verfasserin aut Ying Wu verfasserin aut Xumin Ou verfasserin aut Sai Mao verfasserin aut Di Sun verfasserin aut Shaqiu Zhang verfasserin aut Juan Huang verfasserin aut Qun Gao verfasserin aut XinXin Zhao verfasserin aut Shun Chen verfasserin aut Mafeng Liu verfasserin aut Renyong Jia verfasserin aut Dekang Zhu verfasserin aut In Poultry Science Elsevier, 2020 101(2022), 6, Seite 101863- (DE-627)320569535 (DE-600)2016331-9 15253171 nnns volume:101 year:2022 number:6 pages:101863- https://doi.org/10.1016/j.psj.2022.101863 kostenfrei https://doaj.org/article/b26a4001cb1c4d4fa2bdc4428e84af36 kostenfrei http://www.sciencedirect.com/science/article/pii/S0032579122001705 kostenfrei https://doaj.org/toc/0032-5791 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 101 2022 6 101863-
allfieldsSound	10.1016/j.psj.2022.101863 doi (DE-627)DOAJ028996372 (DE-599)DOAJb26a4001cb1c4d4fa2bdc4428e84af36 DE-627 ger DE-627 rakwb eng SF1-1100 Jieyu Wan verfasserin aut The protein encoded by the duck plague virus UL14 gene regulates virion morphogenesis and affects viral replication 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT: To investigate the pivotal roles of the duck plague virus (DPV) tegument protein UL14 in viral replication, we generated 2 mutated viruses of DPV by using the bacterial artifcial chromosome system, the UL14-null mutant virus (CHv-BAC-ΔUL14) and the corresponding revertant virus (CHv-BAC-ΔUL14R). We found that the CHv-BAC-ΔUL14 viruses exhibited impaired virion morphogenesis in transmission electron microscopy (TEM) studies. Furthermore, CHv-BAC-ΔUL14 exhibited a plaque size reduction in duck embryo fibroblasts (DEFs). Finally, CHv-BAC-ΔUL14 exhibited a significant viral growth defect. Taken together, our findings suggest that DPV UL14 protein regulates viral morphogenesis for efficient viral replication. duck enteritis virus UL14 virion morphology virus replication Animal culture Fangjie Li verfasserin aut Mingshu Wang verfasserin aut Anchun Cheng verfasserin aut Bin Tian verfasserin aut Qiao Yang verfasserin aut Ying Wu verfasserin aut Xumin Ou verfasserin aut Sai Mao verfasserin aut Di Sun verfasserin aut Shaqiu Zhang verfasserin aut Juan Huang verfasserin aut Qun Gao verfasserin aut XinXin Zhao verfasserin aut Shun Chen verfasserin aut Mafeng Liu verfasserin aut Renyong Jia verfasserin aut Dekang Zhu verfasserin aut In Poultry Science Elsevier, 2020 101(2022), 6, Seite 101863- (DE-627)320569535 (DE-600)2016331-9 15253171 nnns volume:101 year:2022 number:6 pages:101863- https://doi.org/10.1016/j.psj.2022.101863 kostenfrei https://doaj.org/article/b26a4001cb1c4d4fa2bdc4428e84af36 kostenfrei http://www.sciencedirect.com/science/article/pii/S0032579122001705 kostenfrei https://doaj.org/toc/0032-5791 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 101 2022 6 101863-
language	English
source	In Poultry Science 101(2022), 6, Seite 101863- volume:101 year:2022 number:6 pages:101863-
sourceStr	In Poultry Science 101(2022), 6, Seite 101863- volume:101 year:2022 number:6 pages:101863-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	duck enteritis virus UL14 virion morphology virus replication Animal culture
isfreeaccess_bool	true
container_title	Poultry Science
authorswithroles_txt_mv	Jieyu Wan @@aut@@ Fangjie Li @@aut@@ Mingshu Wang @@aut@@ Anchun Cheng @@aut@@ Bin Tian @@aut@@ Qiao Yang @@aut@@ Ying Wu @@aut@@ Xumin Ou @@aut@@ Sai Mao @@aut@@ Di Sun @@aut@@ Shaqiu Zhang @@aut@@ Juan Huang @@aut@@ Qun Gao @@aut@@ XinXin Zhao @@aut@@ Shun Chen @@aut@@ Mafeng Liu @@aut@@ Renyong Jia @@aut@@ Dekang Zhu @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	320569535
id	DOAJ028996372
language_de	englisch
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We found that the CHv-BAC-ΔUL14 viruses exhibited impaired virion morphogenesis in transmission electron microscopy (TEM) studies. Furthermore, CHv-BAC-ΔUL14 exhibited a plaque size reduction in duck embryo fibroblasts (DEFs). Finally, CHv-BAC-ΔUL14 exhibited a significant viral growth defect. 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callnumber-first	S - Agriculture
author	Jieyu Wan
spellingShingle	Jieyu Wan misc SF1-1100 misc duck enteritis virus misc UL14 misc virion morphology misc virus replication misc Animal culture The protein encoded by the duck plague virus UL14 gene regulates virion morphogenesis and affects viral replication
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topic_title	SF1-1100 The protein encoded by the duck plague virus UL14 gene regulates virion morphogenesis and affects viral replication duck enteritis virus UL14 virion morphology virus replication
topic	misc SF1-1100 misc duck enteritis virus misc UL14 misc virion morphology misc virus replication misc Animal culture
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title	The protein encoded by the duck plague virus UL14 gene regulates virion morphogenesis and affects viral replication
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title_full	The protein encoded by the duck plague virus UL14 gene regulates virion morphogenesis and affects viral replication
author_sort	Jieyu Wan
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author_browse	Jieyu Wan Fangjie Li Mingshu Wang Anchun Cheng Bin Tian Qiao Yang Ying Wu Xumin Ou Sai Mao Di Sun Shaqiu Zhang Juan Huang Qun Gao XinXin Zhao Shun Chen Mafeng Liu Renyong Jia Dekang Zhu
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title_sort	protein encoded by the duck plague virus ul14 gene regulates virion morphogenesis and affects viral replication
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title_auth	The protein encoded by the duck plague virus UL14 gene regulates virion morphogenesis and affects viral replication
abstract	ABSTRACT: To investigate the pivotal roles of the duck plague virus (DPV) tegument protein UL14 in viral replication, we generated 2 mutated viruses of DPV by using the bacterial artifcial chromosome system, the UL14-null mutant virus (CHv-BAC-ΔUL14) and the corresponding revertant virus (CHv-BAC-ΔUL14R). We found that the CHv-BAC-ΔUL14 viruses exhibited impaired virion morphogenesis in transmission electron microscopy (TEM) studies. Furthermore, CHv-BAC-ΔUL14 exhibited a plaque size reduction in duck embryo fibroblasts (DEFs). Finally, CHv-BAC-ΔUL14 exhibited a significant viral growth defect. Taken together, our findings suggest that DPV UL14 protein regulates viral morphogenesis for efficient viral replication.
abstractGer	ABSTRACT: To investigate the pivotal roles of the duck plague virus (DPV) tegument protein UL14 in viral replication, we generated 2 mutated viruses of DPV by using the bacterial artifcial chromosome system, the UL14-null mutant virus (CHv-BAC-ΔUL14) and the corresponding revertant virus (CHv-BAC-ΔUL14R). We found that the CHv-BAC-ΔUL14 viruses exhibited impaired virion morphogenesis in transmission electron microscopy (TEM) studies. Furthermore, CHv-BAC-ΔUL14 exhibited a plaque size reduction in duck embryo fibroblasts (DEFs). Finally, CHv-BAC-ΔUL14 exhibited a significant viral growth defect. Taken together, our findings suggest that DPV UL14 protein regulates viral morphogenesis for efficient viral replication.
abstract_unstemmed	ABSTRACT: To investigate the pivotal roles of the duck plague virus (DPV) tegument protein UL14 in viral replication, we generated 2 mutated viruses of DPV by using the bacterial artifcial chromosome system, the UL14-null mutant virus (CHv-BAC-ΔUL14) and the corresponding revertant virus (CHv-BAC-ΔUL14R). We found that the CHv-BAC-ΔUL14 viruses exhibited impaired virion morphogenesis in transmission electron microscopy (TEM) studies. Furthermore, CHv-BAC-ΔUL14 exhibited a plaque size reduction in duck embryo fibroblasts (DEFs). Finally, CHv-BAC-ΔUL14 exhibited a significant viral growth defect. Taken together, our findings suggest that DPV UL14 protein regulates viral morphogenesis for efficient viral replication.
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title_short	The protein encoded by the duck plague virus UL14 gene regulates virion morphogenesis and affects viral replication
url	https://doi.org/10.1016/j.psj.2022.101863 https://doaj.org/article/b26a4001cb1c4d4fa2bdc4428e84af36 http://www.sciencedirect.com/science/article/pii/S0032579122001705 https://doaj.org/toc/0032-5791
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author2Str	Fangjie Li Mingshu Wang Anchun Cheng Bin Tian Qiao Yang Ying Wu Xumin Ou Sai Mao Di Sun Shaqiu Zhang Juan Huang Qun Gao XinXin Zhao Shun Chen Mafeng Liu Renyong Jia Dekang Zhu
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doi_str	10.1016/j.psj.2022.101863
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up_date	2024-07-03T20:34:10.017Z
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The protein encoded by the duck plague virus UL14 gene regulates virion morphogenesis and affects viral replication

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