Risk Factors from Pregnancy to Adulthood in Multiple Sclerosis Outcome

Multiple sclerosis (MS) is an autoimmune disease characterized by a robust inflammatory response against myelin sheath antigens, which causes astrocyte and microglial activation and demyelination of the central nervous system (CNS). Multiple genetic predispositions and environmental factors are know...
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Autor*in:	Enrique González-Madrid [verfasserIn] Ma. Andreina Rangel-Ramírez [verfasserIn] María José Mendoza-León [verfasserIn] Oscar Álvarez-Mardones [verfasserIn] Pablo A. González [verfasserIn] Alexis M. Kalergis [verfasserIn] Ma. Cecilia Opazo [verfasserIn] Claudia A. Riedel [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	thyroid hormones gestational period hypothyroxinemia immune response risk factors multiple sclerosis

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 23(2022), 13, p 7080
Übergeordnetes Werk:	volume:23 ; year:2022 ; number:13, p 7080

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms23137080

Katalog-ID:	DOAJ029031982

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callnumber-first	Q - Science
author	Enrique González-Madrid
spellingShingle	Enrique González-Madrid misc QH301-705.5 misc QD1-999 misc thyroid hormones misc gestational period misc hypothyroxinemia misc immune response misc risk factors misc multiple sclerosis misc Biology (General) misc Chemistry Risk Factors from Pregnancy to Adulthood in Multiple Sclerosis Outcome
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topic_title	QH301-705.5 QD1-999 Risk Factors from Pregnancy to Adulthood in Multiple Sclerosis Outcome thyroid hormones gestational period hypothyroxinemia immune response risk factors multiple sclerosis
topic	misc QH301-705.5 misc QD1-999 misc thyroid hormones misc gestational period misc hypothyroxinemia misc immune response misc risk factors misc multiple sclerosis misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc thyroid hormones misc gestational period misc hypothyroxinemia misc immune response misc risk factors misc multiple sclerosis misc Biology (General) misc Chemistry
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title	Risk Factors from Pregnancy to Adulthood in Multiple Sclerosis Outcome
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title_full	Risk Factors from Pregnancy to Adulthood in Multiple Sclerosis Outcome
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author_browse	Enrique González-Madrid Ma. Andreina Rangel-Ramírez María José Mendoza-León Oscar Álvarez-Mardones Pablo A. González Alexis M. Kalergis Ma. Cecilia Opazo Claudia A. Riedel
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title_sort	risk factors from pregnancy to adulthood in multiple sclerosis outcome
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title_auth	Risk Factors from Pregnancy to Adulthood in Multiple Sclerosis Outcome
abstract	Multiple sclerosis (MS) is an autoimmune disease characterized by a robust inflammatory response against myelin sheath antigens, which causes astrocyte and microglial activation and demyelination of the central nervous system (CNS). Multiple genetic predispositions and environmental factors are known to influence the immune response in autoimmune diseases, such as MS, and in the experimental autoimmune encephalomyelitis (EAE) model. Although the predisposition to suffer from MS seems to be a multifactorial process, a highly sensitive period is pregnancy due to factors that alter the development and differentiation of the CNS and the immune system, which increases the offspring’s susceptibility to develop MS. In this regard, there is evidence that thyroid hormone deficiency during gestation, such as hypothyroidism or hypothyroxinemia, may increase susceptibility to autoimmune diseases such as MS. In this review, we discuss the relevance of the gestational period for the development of MS in adulthood.
abstractGer	Multiple sclerosis (MS) is an autoimmune disease characterized by a robust inflammatory response against myelin sheath antigens, which causes astrocyte and microglial activation and demyelination of the central nervous system (CNS). Multiple genetic predispositions and environmental factors are known to influence the immune response in autoimmune diseases, such as MS, and in the experimental autoimmune encephalomyelitis (EAE) model. Although the predisposition to suffer from MS seems to be a multifactorial process, a highly sensitive period is pregnancy due to factors that alter the development and differentiation of the CNS and the immune system, which increases the offspring’s susceptibility to develop MS. In this regard, there is evidence that thyroid hormone deficiency during gestation, such as hypothyroidism or hypothyroxinemia, may increase susceptibility to autoimmune diseases such as MS. In this review, we discuss the relevance of the gestational period for the development of MS in adulthood.
abstract_unstemmed	Multiple sclerosis (MS) is an autoimmune disease characterized by a robust inflammatory response against myelin sheath antigens, which causes astrocyte and microglial activation and demyelination of the central nervous system (CNS). Multiple genetic predispositions and environmental factors are known to influence the immune response in autoimmune diseases, such as MS, and in the experimental autoimmune encephalomyelitis (EAE) model. Although the predisposition to suffer from MS seems to be a multifactorial process, a highly sensitive period is pregnancy due to factors that alter the development and differentiation of the CNS and the immune system, which increases the offspring’s susceptibility to develop MS. In this regard, there is evidence that thyroid hormone deficiency during gestation, such as hypothyroidism or hypothyroxinemia, may increase susceptibility to autoimmune diseases such as MS. In this review, we discuss the relevance of the gestational period for the development of MS in adulthood.
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title_short	Risk Factors from Pregnancy to Adulthood in Multiple Sclerosis Outcome
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