Review on Modification of Glucomannan as an Excipient in Solid Dosage Forms

Glucomannan (GM)—a polysaccharide generally extracted from the tuber of <i<Amorphophallus konjac</i<—has great potential as a filler–binder in direct compression, disintegrant in tablets, or gelling agent due to its strong hydrophilicity and extremely high viscosity. However, it has poor...
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Autor*in:	Nuur Aanisah [verfasserIn] Yoga W. Wardhana [verfasserIn] Anis Y. Chaerunisaa [verfasserIn] Arif Budiman [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	glucomannan chemical modification physical modification excipient

Übergeordnetes Werk:	In: Polymers - MDPI AG, 2011, 14(2022), 13, p 2550
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:13, p 2550

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/polym14132550

Katalog-ID:	DOAJ029051061

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520			\|a Glucomannan (GM)—a polysaccharide generally extracted from the tuber of <i<Amorphophallus konjac</i<—has great potential as a filler–binder in direct compression, disintegrant in tablets, or gelling agent due to its strong hydrophilicity and extremely high viscosity. However, it has poor water resistance and low mechanical strength when used as an excipient in solid form. Several physical and chemical modifications have been carried out to improve these drawbacks. Chemical modification affects the characteristics of GM based on the DS. Carboxymethylation improves GM functionality by modifying its solubility and viscosity, which in turn allows it to bind water more efficiently and thus improve its elongation and gel homogeneity. Meanwhile, physical modification enhances functionality through combination with other excipients to improve mechanical properties and modify swelling ability and drug release from the matrix. This review discusses extraction of GM and its modification to enhance its applicability as an excipient in solid form. Modified GM is a novel excipient applicable in the pharmaceutical industry for direct compression, as a tablet disintegrant, a film-forming agent, and for encapsulation of macromolecular compounds or drug carriers for controlled release.
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language	English
source	In Polymers 14(2022), 13, p 2550 volume:14 year:2022 number:13, p 2550
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format_phy_str_mv	Article
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topic_facet	glucomannan chemical modification physical modification excipient Organic chemistry
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container_title	Polymers
authorswithroles_txt_mv	Nuur Aanisah @@aut@@ Yoga W. Wardhana @@aut@@ Anis Y. Chaerunisaa @@aut@@ Arif Budiman @@aut@@
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callnumber-first	Q - Science
author	Nuur Aanisah
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topic_title	QD241-441 Review on Modification of Glucomannan as an Excipient in Solid Dosage Forms glucomannan chemical modification physical modification excipient
topic	misc QD241-441 misc glucomannan misc chemical modification misc physical modification misc excipient misc Organic chemistry
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title	Review on Modification of Glucomannan as an Excipient in Solid Dosage Forms
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title_sort	review on modification of glucomannan as an excipient in solid dosage forms
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title_auth	Review on Modification of Glucomannan as an Excipient in Solid Dosage Forms
abstract	Glucomannan (GM)—a polysaccharide generally extracted from the tuber of <i<Amorphophallus konjac</i<—has great potential as a filler–binder in direct compression, disintegrant in tablets, or gelling agent due to its strong hydrophilicity and extremely high viscosity. However, it has poor water resistance and low mechanical strength when used as an excipient in solid form. Several physical and chemical modifications have been carried out to improve these drawbacks. Chemical modification affects the characteristics of GM based on the DS. Carboxymethylation improves GM functionality by modifying its solubility and viscosity, which in turn allows it to bind water more efficiently and thus improve its elongation and gel homogeneity. Meanwhile, physical modification enhances functionality through combination with other excipients to improve mechanical properties and modify swelling ability and drug release from the matrix. This review discusses extraction of GM and its modification to enhance its applicability as an excipient in solid form. Modified GM is a novel excipient applicable in the pharmaceutical industry for direct compression, as a tablet disintegrant, a film-forming agent, and for encapsulation of macromolecular compounds or drug carriers for controlled release.
abstractGer	Glucomannan (GM)—a polysaccharide generally extracted from the tuber of <i<Amorphophallus konjac</i<—has great potential as a filler–binder in direct compression, disintegrant in tablets, or gelling agent due to its strong hydrophilicity and extremely high viscosity. However, it has poor water resistance and low mechanical strength when used as an excipient in solid form. Several physical and chemical modifications have been carried out to improve these drawbacks. Chemical modification affects the characteristics of GM based on the DS. Carboxymethylation improves GM functionality by modifying its solubility and viscosity, which in turn allows it to bind water more efficiently and thus improve its elongation and gel homogeneity. Meanwhile, physical modification enhances functionality through combination with other excipients to improve mechanical properties and modify swelling ability and drug release from the matrix. This review discusses extraction of GM and its modification to enhance its applicability as an excipient in solid form. Modified GM is a novel excipient applicable in the pharmaceutical industry for direct compression, as a tablet disintegrant, a film-forming agent, and for encapsulation of macromolecular compounds or drug carriers for controlled release.
abstract_unstemmed	Glucomannan (GM)—a polysaccharide generally extracted from the tuber of <i<Amorphophallus konjac</i<—has great potential as a filler–binder in direct compression, disintegrant in tablets, or gelling agent due to its strong hydrophilicity and extremely high viscosity. However, it has poor water resistance and low mechanical strength when used as an excipient in solid form. Several physical and chemical modifications have been carried out to improve these drawbacks. Chemical modification affects the characteristics of GM based on the DS. Carboxymethylation improves GM functionality by modifying its solubility and viscosity, which in turn allows it to bind water more efficiently and thus improve its elongation and gel homogeneity. Meanwhile, physical modification enhances functionality through combination with other excipients to improve mechanical properties and modify swelling ability and drug release from the matrix. This review discusses extraction of GM and its modification to enhance its applicability as an excipient in solid form. Modified GM is a novel excipient applicable in the pharmaceutical industry for direct compression, as a tablet disintegrant, a film-forming agent, and for encapsulation of macromolecular compounds or drug carriers for controlled release.
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